The Adherence and Outcomes Benefits of Using a Connected, Reusable Auto-Injector for Self-Injecting Biologics: A Narrative Review
AbstractMany biologics are now self-administered by patients at home. A variety of self-injection devices are available, including vials and syringes, prefilled syringes, and spring-driven prefilled pens or auto-injectors. Each has advantages and drawbacks, and different devices suit different patients. For example, some patients have difficulty achieving consistent and successful self-injection due to poor manual dexterity, or experience anxiety at the prospect of self-injection or injection-site pain. These factors can reduce patients ’ medication adherence and overall experience. Furthermore, while self-injection brin...
Source: Advances in Therapy - October 11, 2023 Category: Drugs & Pharmacology Source Type: research
The Epidemiology of Palmoplantar Pustulosis: An Analysis of Multiple Health Insurance Claims and Electronic Health Records Databases
ConclusionsThe burden of PPP was greater in Japan than in the US. Additional studies are needed to further elucidate PPP epidemiology worldwide. (Source: Advances in Therapy)
Source: Advances in Therapy - October 11, 2023 Category: Drugs & Pharmacology Source Type: research
Efficacy and Safety of Esaxerenone in Hypertensive Patients with Diabetes Mellitus Undergoing Treatment with Sodium-Glucose Cotransporter 2 Inhibitors (EAGLE-DH)
ConclusionEsaxerenone effectively lowered BP, was safe, and showed renoprotective effects in hypertensive patients with diabetes mellitus receiving treatment with SGLT2 inhibitors. Esaxerenone and SGLT2 inhibitors did not interfere with either drug ’s efficacy and may reduce the frequency of serum potassium elevations, suggesting they are a compatible combination.Clinical Trial RegistrationjRCTs031200273. (Source: Advances in Therapy)
Source: Advances in Therapy - October 11, 2023 Category: Drugs & Pharmacology Source Type: research
Effect of Tezepelumab on Lung Function in Patients With Severe, Uncontrolled Asthma in the Phase 3 NAVIGATOR Study
ConclusionThese findings further support the benefits of tezepelumab treatment in improving airflow limitation in patients with severe, uncontrolled asthma.Clinical Trial RegistrationNAVIGATOR (NCT03347279). (Source: Advances in Therapy)
Source: Advances in Therapy - October 11, 2023 Category: Drugs & Pharmacology Source Type: research
Corticosteroid Use and Adherence in Patients Treated with Acthar Gel for Advanced Sarcoidosis
ConclusionActhar Gel is associated with reductions in corticosteroid use compared to alternatives. Better adherence is associated with greater reduction in corticosteroid exposure.Key Summary Points (Source: Advances in Therapy)
Source: Advances in Therapy - October 11, 2023 Category: Drugs & Pharmacology Source Type: research
Treatment-Related Cost Analysis of Terlipressin for Adults with Hepatorenal Syndrome with Rapid Reduction in Kidney Function
ConclusionsThe analysis shows that terlipressin is a cost-effective treatment due to its higher efficacy and administration in the non-ICU setting. Terlipressin is a value-based treatment option for appropriate adults with HRS with rapid reduction in kidney function. (Source: Advances in Therapy)
Source: Advances in Therapy - October 9, 2023 Category: Drugs & Pharmacology Source Type: research
Summary of Research: Collaboration Between Healthcare Professionals and People with Multiple Sclerosis to Develop Communication Tools to Improve the Standard of Multiple Sclerosis Care
AbstractThis is a summary of a previously published paper: Joint Healthcare Professional and Patient Development of Communication Tools to Improve the Standard of MS Care. It describes a collaboration between people with multiple sclerosis (PwMS) and healthcare professionals (HCPs) to identify challenges in multiple sclerosis (MS) care and design tools to improve communication during consultations. (Source: Advances in Therapy)
Source: Advances in Therapy - October 9, 2023 Category: Drugs & Pharmacology Source Type: research
Real-World Persistence and Treatment Patterns in Patients with Psoriatic Arthritis Treated with Anti-IL17 Therapy in Spain: The PerfIL-17 Study
ConclusionsMost of the patients with PsA treated with anti-IL17 in Spain had moderate to severe disease activity, high peripheral joint and skin involvement, and had received previous b/tsDMARDs. More than 80% of patients with a 1-year follow-up persisted on anti-IL17, with the highest rate observed in the IXE cohort, followed by the SECU150 then SECU300 cohorts. (Source: Advances in Therapy)
Source: Advances in Therapy - October 7, 2023 Category: Drugs & Pharmacology Source Type: research
Correction to: Assessing the Effects of Changing Patterns of Inhaled Corticosteroid Dosing and Adherence with Fluticasone Furoate and Budesonide on Asthma Management
(Source: Advances in Therapy)
Source: Advances in Therapy - October 7, 2023 Category: Drugs & Pharmacology Source Type: research
Long-Term Outcomes of Eladocagene Exuparvovec Compared with Standard of Care in Aromatic l-Amino Acid Decarboxylase (AADC) Deficiency: A Modelling Study
ConclusionThis study assessed long-term outcomes for patients with AADC deficiency. Patients treated with eladocagene exuparvovec were found to have improved survival and quality of life benefits compared to patients treated with BSC. (Source: Advances in Therapy)
Source: Advances in Therapy - October 6, 2023 Category: Drugs & Pharmacology Source Type: research
Baseline Demographics, Comorbidities, Treatment Patterns and Burden of Atopic Dermatitis in Adults and Adolescents from the GLOBOSTAD Long-Term Observational Study
ConclusionPatients enrolled in GLOBOSTAD demonstrated considerable multidimensional burden of disease across AD signs, symptoms and quality of life despite previous use of systemic and non-systemic AD treatments.Clinical Trial RegistrationClinicalTrials.gov identifier NCT03992417.Video Abstract (Source: Advances in Therapy)
Source: Advances in Therapy - October 6, 2023 Category: Drugs & Pharmacology Source Type: research
Association Between Bowel Wall Thickening and Long-Term Outcomes in Decompensated Liver Cirrhosis
ConclusionsColorectal wall thickening, but not small bowel wall, may be considered for the prediction of further decompensation in cirrhosis. (Source: Advances in Therapy)
Source: Advances in Therapy - October 6, 2023 Category: Drugs & Pharmacology Source Type: research
Matching-Adjusted Indirect Comparisons of Brexucabtagene Autoleucel with Alternative Standard Therapies for Relapsed/Refractory B-Cell Acute Lymphoblastic Leukemia in Adult Patients
ConclusionDespite limitations, these MAIC results suggest that brexu-cel may improve OS and EFS versus currently used therapies in this population. (Source: Advances in Therapy)
Source: Advances in Therapy - October 6, 2023 Category: Drugs & Pharmacology Source Type: research
Current and Emerging Treatment Options for Patients with Metastatic EGFR-Mutated Non-small Cell Lung Cancer After Progression on Osimertinib and Platinum-Based Chemotherapy: A Podcast Discussion
AbstractPatients with metastatic epidermal growth factor receptor (EGFR)-mutated non-small cell lung cancer (NSCLC) are widely treated with osimertinib, the preferred first-line treatment option. However, disease progression inevitably occurs, driven byEGFR-dependent orEGFR-independent mechanisms of resistance. Platinum-based chemotherapy is the recommended treatment following progression with osimertinib but responses to platinum-based chemotherapy are transient. Salvage therapies, which are used after progression on platinum-based chemotherapy, have poor clinical outcomes in addition to substantial toxicity. In this podc...
Source: Advances in Therapy - October 6, 2023 Category: Drugs & Pharmacology Source Type: research
Aortic Root Reinforcement Combined with Vascular Grafts Eversion and Built-in Procedure (XJ-Procedure) for Acute Type A Aortic Dissection Surgery
ConclusionsThe XJ-procedure did not increase 30-day mortality and effectively reduced the incidence of residual aortic root dissection during the 6-month follow-up. Subsequent studies with larger samples and prolonged follow-up are needed to evaluate it.Trial RegistrationNCT05751200.The video showed the partial process of the XJ-procedure in managing the aortic root in the ATAAD surgery. The vascular graft was folded outward about 15 mm, and the eversion was intermittently sutured to the full layers aortic wall using 2-0 pad polyester sutures. Then, the eversion of the graft and aortic wall were continuously sutured in one...
Source: Advances in Therapy - October 4, 2023 Category: Drugs & Pharmacology Source Type: research
