Outcome Measures of Adjustable Transobturator Male System with Pre-attached Scrotal Port for Male Stress Urinary Incontinence After Radical Prostatectomy: A Prospective Study
The objective of this study was to report outcome measures with third-generation pre-attached scrotal port adjustable transobturator male system (ATOMS) for male stress urinary incontinence (SUI) after radical prostatectomy.MethodsA prospective open study was conducted on consecutive patients. Evaluation included cough test, urethroscopy, filling and voiding cystometry, 24-h pad count and pad test, patient-reported outcomes (ICIQ-SF, IIQ-7, PGI, GRA, and VAS), complications according to the Clavien –Dindo system, operative results, number of adjustments, and filling of the system.ResultsThirty-four patients with medi...
Source: Advances in Therapy - April 12, 2017 Category: Drugs & Pharmacology Source Type: research

The Rituximab Biosimilar CT-P10 in Rheumatology and Cancer: A Budget Impact Analysis in 28 European Countries
ConclusionsThe model predicted that the introduction of CT-P10 in the EU will be associated with significant budget savings, the reallocation of which will enable many more patients to access rituximab treatment. This is likely to have a significant impact on health gains at patient and societal levels.Funding: CELLTRION Healthcare Co., Ltd. sponsored the development and analysis of the budget impact analysis model. (Source: Advances in Therapy)
Source: Advances in Therapy - April 10, 2017 Category: Drugs & Pharmacology Source Type: research

Secukinumab is Efficacious and Safe in Hispanic Patients with Moderate-to-Severe Plaque Psoriasis: Pooled Analysis of Four Phase 3 Trials
ConclusionsSecukinumab is highly effective for clearing psoriasis in both Hispanic and non-Hispanic patients.FundingNovartis Pharmaceutical Corporation. (Source: Advances in Therapy)
Source: Advances in Therapy - April 10, 2017 Category: Drugs & Pharmacology Source Type: research

Disease Burden of Mild Asthma: Findings from a Cross-Sectional Real-World Survey
ConclusionMild asthma imposes a substantial burden on patients, establishing the need for comprehensive management plans and ongoing support for treatment adherence.FundingAstraZeneca. (Source: Advances in Therapy)
Source: Advances in Therapy - April 8, 2017 Category: Drugs & Pharmacology Source Type: research

Evaluation of the Efficacy of Sorafenib on Overall Survival in Patients with Hepatocellular Carcinoma using FT Rate: A Devised Index
AbstractIntroductionTranscatheter arterial chemoembolization (TACE) is the first-line treatment for intermediate stage hepatocellular carcinoma (HCC) and prolongs survival in HCC patients. However, repeated TACE results in diminished therapeutic response. In addition, the superiority of sorafenib to TACE monotherapy or combined therapy in patients with HCC is still controversial. The prognosis of HCC has many variables and, thus, the effect of a specific treatment is difficult to evaluate. The frequency of treatments per year (FT rate) used in this study was obtained by dividing the total number of radiofrequency ablations...
Source: Advances in Therapy - April 7, 2017 Category: Drugs & Pharmacology Source Type: research

Long-Acting Injectable Antipsychotics in Schizophrenia: Literature Review and Practical Perspective, with a Focus on Aripiprazole Once-Monthly
ConclusionResults across the “full spectrum” of efficacy in traditional clinical trials as well as those encompassing the concept of effectiveness in a more naturalistic setting of real-life clinical practice support the use of AOM 400 as a valid long-term treatment option in schizophrenia overall, as well as earlier in the treatment course, and not solely in situations of poor adherence or when oral antipsychotics have failed. (Source: Advances in Therapy)
Source: Advances in Therapy - April 5, 2017 Category: Drugs & Pharmacology Source Type: research

Targeting Schlemm ’s Canal in the Medical Therapy of Glaucoma: Current and Future Considerations
AbstractSchlemm ’s canal (SC) is a unique, complex vascular structure responsible for maintaining fluid homeostasis within the anterior segment of the eye by draining the excess of aqueous humour. In glaucoma, a heterogeneous group of eye disorders afflicting approximately 60 million individuals worldwide, the no rmal outflow of aqueous humour into SC is progressively hindered, leading to a gradual increase in outflow resistance, which gradually results in elevated intraocular pressure (IOP). By and large available antiglaucoma therapies do not target the site of the pathology (SC), but rather aim to decreas e IOP by...
Source: Advances in Therapy - March 27, 2017 Category: Drugs & Pharmacology Source Type: research

Clinical Utility of Cxbladder for the Diagnosis of Urothelial Carcinoma
ConclusionsUrologists made compelling changes to their clinical decision-making when they were provided with Cxbladder results for patients presenting with hematuria. Cxbladder provides an increase in clinical utility by focusing the use of invasive diagnostic procedures to appropriate patients, reducing both the total number and number of invasive procedures used in the clinical management of patients with hematuria, thereby improving the diagnostic experience and outcomes for patients.FundingPacific Edge Ltd. (Source: Advances in Therapy)
Source: Advances in Therapy - March 24, 2017 Category: Drugs & Pharmacology Source Type: research

A Case Series of Dacryoendoscopy in Childhood: A Diagnostic and Therapeutic Alternative for Complex Congenital Nasolacrimal Duct Obstruction Even in the First Year of Life
ConclusionDE is a diagnostic and therapeutic option for complex CNLDO in patients before the age of 1  year. The outcome of DE in the 3 months follow-up is highly indicative of positive final results in terms of patency of the lacrimal duct. (Source: Advances in Therapy)
Source: Advances in Therapy - March 24, 2017 Category: Drugs & Pharmacology Source Type: research

Otorhinolaryngological Toxicities of New Drugs in Oncology
AbstractMany new or relatively new cancer drugs —personalized anticancer agents—have been approved for use in various clinical settings in oncology or are still under evaluation in clinical trials. Targeted therapies as well as new immune checkpoint blockers have toxicity profiles that differ from conventional cytotoxic chemotherapy, and many can cause adverse effects that affect the mouth and pharynx, the nasal cavities, and the larynx. This review aims to provide an overview of current knowledge concerning these side effects and contemporary management. Adverse effects of the mouth/pharynx, nasal cavities, la...
Source: Advances in Therapy - March 17, 2017 Category: Drugs & Pharmacology Source Type: research

Maintaining Weight Loss by Decreasing Sedentary Time: A Patient and Physician ’s Perspective
This article, co-authored by a patient living with obesity and his obesity medicine specialist, reviews how the patient has successfully lost 200  lb and maintained that loss for over a decade. This was achieved primarily with a behavioral intervention including support visits, a structured food plan, and changes in his physical activity. He did not undergo bariatric surgery. For the majority of this time, he was not treated with anti-obesit y medication. This article will review how the patient lost the weight and kept it off, particularly in relationship to the importance of decreasing sedentary time. (Source: Advances in Therapy)
Source: Advances in Therapy - March 17, 2017 Category: Drugs & Pharmacology Source Type: research

The Impact of Antibiotic Stewardship Programs in Combating Quinolone Resistance: A Systematic Review and Recommendations for More Efficient Interventions
AbstractQuinolones are among the most commonly prescribed antibiotics worldwide. A clear relationship has been demonstrated between excessive quinolone use and the steady increase in the incidence of quinolone-resistant bacterial pathogens, both in hospital and community sites. In addition, exposure to quinolones has been associated with colonization and infection with healthcare-associated pathogens such as methicillin-resistantStaphylococcus aureus andClostridium difficile in hospitalized patients. Therefore, the management of quinolone prescribing in hospitals through antibiotic stewardship programs is considered crucia...
Source: Advances in Therapy - March 16, 2017 Category: Drugs & Pharmacology Source Type: research

Fixed-Dose Triple Combination of Antihypertensive Drugs Improves Blood Pressure Control: From Clinical Trials to Clinical Practice
This study compared the efficacy of a fixed-dose triple combination (FDTC) of antihypertensive drugs with that of a free combination of three antihypertensives in patients with uncontrolled hypertension.MethodsNinety-two patients (mean age 60.8 ± 12.1, 58.0% male) with uncontrolled essential hypertension (office systolic BP ≥ 140 or diastolic BP ≥ 90 mmHg) previously treated with a renin–angiotensin–aldosterone system (RAAS) inhibitor plus hydrochlorothiazide were switched to once-daily FDTC therapy with perindopril/indapamid e/amlodipine (5–10/1.25–2.5/5–...
Source: Advances in Therapy - March 15, 2017 Category: Drugs & Pharmacology Source Type: research

A New Approach to the Management of Anemia in CKD Patients: A Review on Roxadustat
This article informs the reader of the current information available on a novel therapeutic agent and new class of drug for the treatment of anemia. The data show promising results for alternative erythropoietin-stimulating agents and offers a time line of when Phase III data will be available. The information on this new drug and new drug class will change how nephrologists approach treating anemia within their patients. (Source: Advances in Therapy)
Source: Advances in Therapy - March 13, 2017 Category: Drugs & Pharmacology Source Type: research

The Value and Evaluability of the PCA3 Urine Assay in Prostate Carcinoma is Independent of the Tumor Localization
ConclusionThe location of the tumor mass in the prostate with respect to the urethra or the seminal colliculus did not to affect the PCA3 score. Hence, the location of the tumor does not limit the validity of the PCA3 score, and even for exclusively peripherall y located tumors, this possible influencing factor did not lead to an artificial modulation of the PCA3 score. (Source: Advances in Therapy)
Source: Advances in Therapy - March 13, 2017 Category: Drugs & Pharmacology Source Type: research

A Review of the Ahmed Glaucoma Valve Implant and Comparison with Other Surgical Operations
AbstractThe Ahmed glaucoma valve (AGV) is a popular glaucoma drainage implant used for the control of intraocular pressure in patients with glaucoma. While in the past AGV implantation was reserved for glaucoma patients poorly controlled after one or more filtration procedures, mounting evidence has recently encouraged its use as a primary surgery in selected cases. AGV has been demonstrated to be safe and effective in reducing intraocular pressure in patients with primary or secondary refractory glaucoma. Compared to other glaucoma surgeries, AGV implantation has shown favorable efficacy and safety. The aim of this articl...
Source: Advances in Therapy - March 11, 2017 Category: Drugs & Pharmacology Source Type: research

The Potential Role for Early Biomarker Testing as Part of a Modern, Multidisciplinary Approach to Sj ögren’s Syndrome Diagnosis
AbstractSj ögren’s syndrome (SS) is a chronic and progressive multisystem autoimmune disease typically managed by rheumatologists. Diagnostic delays are common, due in large part to the non-specific and variable nature of SS symptoms and the slow progression of disease. The hallmark characteristics of SS ar e dry eye and dry mouth, but there are a broad range of other possible symptoms such as joint and muscle pain, skin rashes, chronic dry cough, vaginal dryness, extremity numbness or tingling, and disabling fatigue. Given that dry eye and dry mouth are typically the earliest presenting complaints, ey e care cl...
Source: Advances in Therapy - March 10, 2017 Category: Drugs & Pharmacology Source Type: research

Evaluation of the Short-Term Cost-Effectiveness of IDegLira Versus Continued Up-Titration of Insulin Glargine U100 in Patients with Type 2 Diabetes in the USA
ConclusionThe significantly greater clinical efficacy in terms of bringing patients to treatment targets identified in the DUAL V study results in lower cost of control values for IDegLira versus continued up-titration of insulin glargine U100 in the USA. This suggests IDegLira is a cost-effective treatment option in the USA.FundingNovo Nordisk A/S and Novo Nordisk Inc. (Source: Advances in Therapy)
Source: Advances in Therapy - March 9, 2017 Category: Drugs & Pharmacology Source Type: research

Expert System for Bone Scan Interpretation Improves Progression Assessment in Bone Metastatic Prostate Cancer
AbstractIntroductionThe bone scan index (BSI) was introduced as a quantitative tool for tumor involvement in bone of patients with metastatic prostate cancer (mPCa). The computer-aided diagnosis device for BSI analysis EXINIboneBSI seems to represent technical progress for the quantitative assessment of bone involvement. But it is not yet clear if the automated BSI (aBSI) could contribute to improved evaluation of progression in patients under antiandrogens or chemotherapy in contrast to the visual interpretation and/or conventional biomarkers such as the prostate-specific antigen (PSA).MethodsIn 49 mPCa patients, bone sca...
Source: Advances in Therapy - March 7, 2017 Category: Drugs & Pharmacology Source Type: research

Efficacy of Zofenopril vs. Irbesartan in Combination with a Thiazide Diuretic in Hypertensive Patients with Multiple Risk Factors not Controlled by a Previous Monotherapy: A Review of the Double-Blind, Randomized “Z” Studies
AbstractCombinations between an angiotensin converting enzyme (ACE) inhibitor or an angiotensin II receptor blocker (ARB) and hydrochlorothiazide (HCTZ) are among the recommended treatments for hypertensive patients uncontrolled by monotherapy. Four randomized, double-blind, parallel group studies with a similar design, including 1469 hypertensive patients uncontrolled by a previous monotherapy and with ≥1 cardiovascular risk factor, compared the efficacy of a combination of a sulfhydryl ACE inhibitor (zofenopril at 30 or 60 mg) or an ARB (irbesartan at 150 or 300 mg) plus HCTZ 12.5 mg. The extent of bloo...
Source: Advances in Therapy - March 4, 2017 Category: Drugs & Pharmacology Source Type: research

Benign Prostatic Obstruction Relief in Patients with Lower Urinary Tract Symptoms Suggestive of Benign Prostatic Enlargement Undergoing Endoscopic Surgical Procedures or Therapy with Alpha-Blockers: A Review of Urodynamic Studies
AbstractBenign prostatic obstruction (BPO) contributes to the genesis of lower urinary tract symptoms as well as to pathologic remodeling of the lower and upper urinary tract in patients with benign prostate enlargement. Urodynamic studies demonstrate that both medical therapy with alpha-blockers (ABs) and endoscopic surgical procedures provide BPO relief. However, the magnitude of improvement is higher after surgery. Among ABs, silodosin is associated with the highest improvement of bladder outlet obstruction index (BOOI). A complex relationship exists between BOOI improvement and variations of both maximum urinary flow (...
Source: Advances in Therapy - March 2, 2017 Category: Drugs & Pharmacology Source Type: research

Retrospective Study on the Impact of Adherence in Achieving Glycemic Goals in Type 2 Diabetes Mellitus Patients Receiving Canagliflozin
We examined the impact of real-world adherence on glycemic control in T2DM patients treated with canagliflozin.MethodsThis retrospective study used US administrative claims data from commercial and Medicare Advantage healthcare enrollees. Study subjects were adult T2DM patients with baseline HbA1c ≥7.0% and a pharmacy claim for canagliflozin between April 01, 2013 and August 31, 2014. Outcomes included treatment patterns, HbA1c reductions and goal attainment, pharmacy costs, and patient characteristics. Adherence, measured by the proportion of days covered (PDC), was calculated as the numbe r of days of canagliflozin av...
Source: Advances in Therapy - March 1, 2017 Category: Drugs & Pharmacology Source Type: research

A Review of Minimally Invasive Strabismus Surgery (MISS): Is This the Way Forward?
This article reviews the principles and different techniques employed to perform minimally invasive strabismus surgery (MISS). In these techniques, strabismus surgery is performed through keyhole openings, thus reducing the risk of postoperative corneal complications, minimizing postoperative discomfort, and better preserving muscle function. MISS can be used to perform all types of strabismus surgery, namely rectus muscle recessions, resections, plications, reoperations, retroequatorial myopexy, transpositions, oblique muscle recessions, or plications even in the presence of limited motility. Of note, ocular alignment out...
Source: Advances in Therapy - March 1, 2017 Category: Drugs & Pharmacology Source Type: research

Deep Neuromuscular Blockade Improves Laparoscopic Surgical Conditions: A Randomized, Controlled Study
AbstractIntroductionSustained deep neuromuscular blockade (NMB) during laparoscopic surgery may facilitate optimal surgical conditions. This exploratory study assessed whether deep NMB improves surgical conditions and, in doing so, allows use of lower insufflation pressures during laparoscopic cholecystectomy. We further assessed whether use of low insufflation pressure improves patient pain scores after surgery.MethodsThis randomized, controlled, blinded study (NCT01728584) compared use of deep (1 –2 post-tetanic-counts) or moderate (train-of-four ratio 10%) NMB, and lower (8 mmHg) or higher (12 mmHg; &lsq...
Source: Advances in Therapy - March 1, 2017 Category: Drugs & Pharmacology Source Type: research

Erratum to: A Randomized, Clinical Trial to Evaluate Efficacy and Tolerability of Trypsin:Chymotrypsin as Compared to Serratiopeptidase and Trypsin:Bromelain:Rutoside in Wound Management
(Source: Advances in Therapy)
Source: Advances in Therapy - February 28, 2017 Category: Drugs & Pharmacology Source Type: research

Protocol for a Randomized Phase II Trial for Mesh Optimization by Autologous Plasma Coating in Prolapse Repair: IDEAL Stage 3
ConclusionThe protocol for this randomized clinical trial represents the conditions to assess the surgical innovation of plasma coating of meshes in order to improve the meshes ’ biocompatibility at stage 3 according to the IDEAL recommendations. (Source: Advances in Therapy)
Source: Advances in Therapy - February 23, 2017 Category: Drugs & Pharmacology Source Type: research

How Phenotype Guides Management of the Most Common Malignant Salivary Neoplasms of the Larynx?
AbstractSalivary gland carcinomas of the larynx are uncommon. Adenoid cystic carcinoma is the most prevalent type of salivary gland carcinoma in this region, although other histologies such as mucoepidermoid carcinoma and adenocarcinomas have been reported. These tumors may present with advanced-stage due to nonspecific symptoms and their relatively slow-growing nature. The index of suspicion for a non-squamous cell carcinoma entity should be high when a submucosal mass is present. An accurate diagnosis is mandatory due to the impact each biologic entity has on treatment and outcome. Data concerning treatment and outcome a...
Source: Advances in Therapy - February 21, 2017 Category: Drugs & Pharmacology Source Type: research

Real-world Evidence for the Antianginal Efficacy of Trimetazidine from  the Russian Observational CHOICE-2 Study
AbstractIntroductionThe guidelines recommend a beta-blocker or calcium channel blocker as the first-line medication for angina, supplemented by other agents for additional symptoms. One such agent is trimetazidine (TMZ), which has been shown to reduce the frequency of anginal episodes and improve exercise performance without affecting haemodynamic parameters. However, extensive real-world evidence for its efficacy in combination with first-line therapies has been lacking.MethodsThe aim of this large-scale, Russian, multicentre, 6-month, open-label, prospective observational study was to assess the effect of adding TMZ modi...
Source: Advances in Therapy - February 20, 2017 Category: Drugs & Pharmacology Source Type: research

Pooled Analysis of Four Non-Interventional Studies: Effectiveness and Tolerability of the Antidepressant Agomelatine in Daily Practice
ConclusionIn this pooled data analysis, 9601 depressed patients of clinical practice were evaluated over 12  weeks and subpopulations were also analyzed over 24 and 52 weeks. Agomelatine effectively reduced depressive symptoms (CGI-response and remission) with good general tolerability. (Source: Advances in Therapy)
Source: Advances in Therapy - February 18, 2017 Category: Drugs & Pharmacology Source Type: research

The Role of the Pharmacist in Managing Type 2 Diabetes with Glucagon-Like Peptide-1 Receptor Agonists as Add-On Therapy
This article discusses the role of the pharmacist in the management of patients with T2D, particularly with respect to the use of GLP-1RAs to achieve glycemic control. GLP-1RAs are a class of injectable agents used as an adjunct to diet and exercise to improve glycemic control in adults with T2D. GLP-1RAs have been shown to lower glucose levels, slow gastric emptying, enhance satiety, and reduce body weight without increasing the risk of hypoglycemia. GLP-1RAs currently approved in the USA include exenatide twice daily, liraglutide once daily, and albiglutide, dulaglutide, and exenatide once weekly. Pharmacists can work wi...
Source: Advances in Therapy - February 16, 2017 Category: Drugs & Pharmacology Source Type: research

Analyzing Health-Related Quality of Life Data to Estimate Parameters for Cost-Effectiveness Models: An Example Using Longitudinal EQ-5D Data from the SHIFT Randomized Controlled Trial
ConclusionThe mixed model explained variation in EQ-5D data according to key clinical outcomes and patient characteristics, providing essential information for long-term predictions of patient HRQoL in the cost-effectiveness model. This model was also used to estimate the loss in HRQoL associated with hospitalizations. In SHIFT many hospitalizations did not occur close to EQ-5D visits; hence, any temporary changes in HRQoL associated with such events would not be captured fully in observed RCT evidence, but could be predicted in our cost-effectiveness analysis using the mixed model. Given the large reduction in hospitaliza...
Source: Advances in Therapy - February 15, 2017 Category: Drugs & Pharmacology Source Type: research

Effectiveness of Calcifediol in Improving Muscle Function in Post-Menopausal Women: A Prospective Cohort Study
AbstractIntroductionThe role of vitamin D supplementation on muscle function and physical performance is still debated. Calcifediol is an available treatment for hypovitaminosis D, particularly for extra-skeletal effects. Aim of this prospective cohort study was to evaluate the effectiveness of calcifediol on serum levels of 25(OH)D3, appendicular muscle strength, physical performance, and prevention of falls in post-menopausal women.MethodsWe recruited post-menopausal women aged ≥50 years, referring to an outpatient service for the management of osteoporosis over a 18-month period. We included women with a diagnos...
Source: Advances in Therapy - February 15, 2017 Category: Drugs & Pharmacology Source Type: research

Edoxaban in Atrial Fibrillation and Venous Thromboembolism —Ten Key Questions and Answers: A Practical Guide
AbstractEdoxaban is the fourth non-vitamin K antagonist oral anticoagulant now available for clinical use in the prevention of stroke/systemic embolism in atrial fibrillation (AF) and in the treatment of venous thromboembolism (VTE), after the completion of large-scale randomized comparative clinical trials with the vitamin K antagonist warfarin. Edoxaban has some peculiar pharmacological properties and outcome data. Here a group of experts in AF and VTE answers a set of questions on its practical use, trying to define the profile of patients that would be most appropriate for its use. (Source: Advances in Therapy)
Source: Advances in Therapy - February 13, 2017 Category: Drugs & Pharmacology Source Type: research

The Clinical Effectiveness of Ranibizumab Treat and Extend Regimen in nAMD: Systematic Review and Network Meta-Analysis
ConclusionThis study used novel repeated-measures NMA to synthesize efficacy results when treatment effects were reported at multiple follow-up times. This repeated-measures NMA suggests that treating patients with the ranibizumab T&E regimen yields similar effectiveness compared to other approved ranibizumab and aflibercept dosing regimens for nAMD treatment.Funding: Novartis Pharmaceuticals UK Ltd, Surrey, UK. (Source: Advances in Therapy)
Source: Advances in Therapy - February 10, 2017 Category: Drugs & Pharmacology Source Type: research

Erratum to: Advances in Therapy
(Source: Advances in Therapy)
Source: Advances in Therapy - February 9, 2017 Category: Drugs & Pharmacology Source Type: research

A Clinic-based Survey of Clinical Characteristics and Practice Pattern of Dry Eye in Japan
ConclusionThe two most common DED subtypes were aqueous-deficient and short-BUT-type dry eye. Shortened TBUT is the most common feature of dry eye, regardless of subtype. The current treatment choice mainly consisted of hyaluronic acid, two novel mucin secretagogues, diquafosol and rebamipide, and steroidal eye drops.Trial Registration: University Hospital Medical Information Network: UMIN (registries no. UMIN 000015890).Funding: Japan Dry Eye Society, Tokyo, Japan, and Santen Pharmaceutical Co., Ltd., Osaka, Japan. (Source: Advances in Therapy)
Source: Advances in Therapy - February 8, 2017 Category: Drugs & Pharmacology Source Type: research

When People with Opioid-Induced Constipation Speak: A Patient Survey
ConclusionsPatients are willing and able to comment on the problems OIC cause them, using a variety of terms and phrases. Their comments concerning impacts on their lives will often refer to physical consequences, psychological effects, or practical implications. These insights provide healthcare practitioners guidance on how to engage patients about OIC. (Source: Advances in Therapy)
Source: Advances in Therapy - February 8, 2017 Category: Drugs & Pharmacology Source Type: research

A Retrospective Study of Ranibizumab Treatment Regimens for Neovascular Age-Related Macular Degeneration (nAMD) in Australia and the United Kingdom
AbstractIntroductionNeovascular age-related macular degeneration (nAMD) is the leading cause of vision loss among persons aged 65  years and older. Anti-vascular endothelial growth factor (anti-VEGF) treatment is the recommended standard of care. The current study compares the effectiveness of ranibizumab in routine clinical practice in two countries that generally apply two different treatment regimens, treat-and-extend (T&E) in Australia or pro re nata (PRN) in the UK.MethodsThis retrospective, comparative, non-randomised cohort study is based on patients ’ data from electronic medical record (EMR) databas...
Source: Advances in Therapy - January 31, 2017 Category: Drugs & Pharmacology Source Type: research

The Impact of a Single Nucleotide Polymorphism in SIGMAR1 on Depressive Symptoms in Major Depressive Disorder and Bipolar Disorder
ConclusionThe present findings are the first to propose the putative role of genetic variants within SIGMAR1 and sigma-1 receptor in BD. Sigma-1 receptor can modulate a number of central neurotransmitter systems as well as some other signaling pathways (e.g., neurotrophin and growth factor signaling) which are seemingly involved in BD and other mood disorders. (Source: Advances in Therapy)
Source: Advances in Therapy - January 31, 2017 Category: Drugs & Pharmacology Source Type: research

Impact of Adalimumab on Work Productivity and Activity Impairment in Japanese Patients with Rheumatoid Arthritis: Large-Scale, Prospective, Single-Cohort ANOUVEAU Study
AbstractIntroductionThe Adalimumab Non-interventional Trial for Up-verified Effects and Utility (ANOUVEAU) was a large-scale, multicenter, prospective, observational, single-cohort study that evaluated the effects of adalimumab (ADA) on rheumatoid arthritis (RA)-related work productivity and activity impairment (RA-related WPAI) and disease activity in routine rheumatology care in Japan.MethodsPatients with RA were categorized as paid workers (PWs, ≥35 h/week), part-time workers (PTWs,
Source: Advances in Therapy - January 31, 2017 Category: Drugs & Pharmacology Source Type: research

Erratum to: Chronic Obstructive Pulmonary Disease Individualized Therapy: Tailored Approach to Symptom Management
(Source: Advances in Therapy)
Source: Advances in Therapy - January 31, 2017 Category: Drugs & Pharmacology Source Type: research

Effectiveness and Persistence of Liraglutide Treatment Among Patients with Type 2 Diabetes Treated in Primary Care and Specialist Settings: A Subgroup Analysis from the EVIDENCE Study, a Prospective, 2-Year Follow-up, Observational, Post-Marketing Study
The objective of this subgroup analysis is to investigate the effectiveness of liraglutide in people with type 2 diabetes (T2D) treated within the primary care physician (PCP) and specialist care settings.MethodsEVIDENCE is a prospective, observational study of 3152 adults with T2D recently starting or about to start liraglutide treatment in France. We followed patients in the PCP and specialist settings for 2  years to evaluate the effectiveness of liraglutide in glycemic control and body weight reduction. Furthermore, we evaluated the changes in combined antihyperglycemic treatments, the reasons for prescribing lira...
Source: Advances in Therapy - January 30, 2017 Category: Drugs & Pharmacology Source Type: research

Chronic Wound Healing: A Review of Current Management and Treatments
This article will review wound healing physiology and discuss current approaches for treating a wound. (Source: Advances in Therapy)
Source: Advances in Therapy - January 21, 2017 Category: Drugs & Pharmacology Source Type: research

Behavior Modification: A Patient and Physician ’s Perspective
This article, co-authored by a patient affected by obesity and an obesity medicine specialist, discusses the patient ’s experience of living with the disease and using many different weight loss approaches until finding a lifestyle program that was appropriate for her metabolism. The physician discusses the scientific basis of insulin resistance, and why the chosen lifestyle program worked so well for this indiv idual. (Source: Advances in Therapy)
Source: Advances in Therapy - January 20, 2017 Category: Drugs & Pharmacology Source Type: research

Comment on “Efficacy and Treatment Costs of Monotherapy with bDMARDs in the Treatment of Rheumatoid Arthritis in Patients Intolerant to or Inappropriate to Continue Treatment with Methotrexate”
(Source: Advances in Therapy)
Source: Advances in Therapy - January 20, 2017 Category: Drugs & Pharmacology Source Type: research

Optimizing the Use of Linaclotide in Patients with Constipation-Predominant Irritable Bowel Syndrome: An Expert Consensus Report
ConclusionsThis document seeks to lay down a set of recommendations and to identify key issues that may be useful for the clinical management of IBS-C patients treated with linaclotide. (Source: Advances in Therapy)
Source: Advances in Therapy - January 12, 2017 Category: Drugs & Pharmacology Source Type: research

Glucagon-Like Peptide-1 Receptor Agonist (GLP-1RA) Therapy Adherence for Patients with Type 2 Diabetes in a Medicare Population
AbstractIntroductionAnti-diabetes medication regimen adherence is a clinical challenge in elderly patients with type 2 diabetes (T2D) and other comorbidities associated with aging. Glucagon-like peptide-1 receptor agonists (GLP-1RA) therapies such as exenatide once weekly (QW), exenatide twice daily (BID), and liraglutide once daily (QD) are an increasingly used class of drugs with proven efficacy and tolerability. Real-world evidence on adherence to GLP-1RAs in elderly or disabled patients is limited. To further the understanding of this drug class, the current study examined medication adherence in Medicare patients aged...
Source: Advances in Therapy - January 11, 2017 Category: Drugs & Pharmacology Source Type: research

Pharmacokinetic Evaluation of Once-Weekly and Once-Monthly Buprenorphine Subcutaneous Injection Depots (CAM2038) Versus Intravenous and Sublingual Buprenorphine in Healthy Volunteers Under Naltrexone Blockade: An Open-Label Phase 1 Study
ConclusionsThe pharmacokinetic profiles of CAM2038 q1w and q4w versus sublingual buprenorphine support expected treatment efficacy with once-weekly and once-monthly dosing, respectively. CAM2038 formulations were safe and showed good local tolerability.Trial registration: ISRCTN24987553.Funding: Camurus AB. (Source: Advances in Therapy)
Source: Advances in Therapy - January 9, 2017 Category: Drugs & Pharmacology Source Type: research

Efficacy and Safety of Vedolizumab in Ulcerative Colitis and Crohn ’s Disease Patients Stratified by Age
AbstractIntroductionThe efficacy and safety of vedolizumab, a gut-selective α4β7 integrin antibody, were demonstrated in the GEMINI 1 and GEMINI 2 clinical trials of adults aged 18 –80 years. We investigated the efficacy and safety of vedolizumab in patients stratified by age from the GEMINI trials.MethodsSafety and efficacy, including clinical response, clinical remission, and corticosteroid-free remission, at week 6 and/or 52 were determined post hoc in patients aged
Source: Advances in Therapy - January 9, 2017 Category: Drugs & Pharmacology Source Type: research

Modulation of Neuroinflammation in the Central Nervous System: Role of Chemokines and Sphingolipids
AbstractNeuroinflammation is a process involved in the pathogenesis of different disorders, both autoimmune, such as neuropsychiatric systemic lupus erythematosus, and degenerative, such as Alzheimer ’s and Parkinson’s disease. In the central nervous system, the local milieu is tightly regulated by different mediators, among which are chemoattractant cytokines, also known as chemokines. These small molecules are able to modulate trafficking of immune cells in the course of nervous system dev elopment or in response to tissue damage, and different patterns of chemokine molecule and receptor expression have been ...
Source: Advances in Therapy - January 4, 2017 Category: Drugs & Pharmacology Source Type: research