Radiofrequency radiation reshapes tumor immune microenvironment into antitumor phenotype in pulmonary metastatic melanoma by inducing active transformation of tumor-infiltrating CD8 < sup > + < /sup > T and NK cells
In this study we investigated the effects of noninvasive radiofrequency radiation (RFR) exposure on tumor progression and TIME phenotype, as well as the antitumor potential of PD-1 blockage in a model of pulmonary metastatic melanoma (PMM). Mouse model of PMM was established by tail vein injection of B16F10 cells. From day 3 after injection, the mice were exposed to RFR at an average specific absorption rate of 9.7 W/kg for 1 h per day for 14 days. After RFR exposure, lung tissues were harvested and RNAs were extracted for transcriptome sequencing; PMM-infiltrating immune cells were isolated for single-cell RNA-seq analysi...
Source: Acta Pharmacologica Sinica - March 28, 2024 Category: Drugs & Pharmacology Authors: Jia-Zheng Jiao Yang Zhang Wen-Juan Zhang Min-di He Meng Meng Tao Liu Qin-Long Ma Ya Xu Peng Gao Chun-Hai Chen Lei Zhang Hui-Feng Pi Ping Deng Yong-Zhong Wu Zhou Zhou Zheng-Ping Yu You-Cai Deng Yong-Hui Lu Source Type: research
ROCK1 inhibition improves wound healing in diabetes via RIPK4/AMPK pathway
Acta Pharmacol Sin. 2024 Mar 27. doi: 10.1038/s41401-024-01246-3. Online ahead of print.ABSTRACTRefractory wounds are a severe complication of diabetes mellitus that often leads to amputation because of the lack of effective treatments and therapeutic targets. The pathogenesis of refractory wounds is complex, involving many types of cells. Rho-associated protein kinase-1 (ROCK1) phosphorylates a series of substrates that trigger downstream signaling pathways, affecting multiple cellular processes, including cell migration, communication, and proliferation. The present study investigated the role of ROCK1 in diabetic wound ...
Source: Acta Pharmacologica Sinica - March 28, 2024 Category: Drugs & Pharmacology Authors: Tianru Huyan Lu Fan Zhong-Yuan Zheng Jing-Hui Zhao Zhen-Ru Han Pin Wu Qun Ma Ya-Qin Du Yun-di Shi Chun-Yan Gu Xue-Jun Li Wen-Hui Wang Long Zhang Lu Tie Source Type: research
The marine-derived compound TAG alleviates Parkinson's disease by restoring RUBCN-mediated lipid metabolism homeostasis
In this study, tetrahydroauroglaucin (TAG), a polyketide isolated from a marine sponge, was found to have notable neuroprotective effects on MPTP/MPP+-induced neurotoxicity. RNA sequencing analysis and metabolomics revealed that TAG significantly improved lipid metabolism disorder in PD models. Further investigation indicated that TAG markedly decreased the accumulation of lipid droplets (LDs), downregulated the expression of RUBCN, and promoted autophagic flux. Moreover, conditional knockdown of Rubcn notably attenuated PD-like symptoms and the accumulation of LDs, accompanied by blockade of the neuroprotective effect of ...
Source: Acta Pharmacologica Sinica - March 28, 2024 Category: Drugs & Pharmacology Authors: Pei Yang Yang Liu Zhi-Wu Tong Qian-Hui Huang Xia-Hong Xie Shi-Yu Mao Jian-Hua Ding Ming Lu Ren-Xiang Tan Gang Hu Source Type: research
Radiofrequency radiation reshapes tumor immune microenvironment into antitumor phenotype in pulmonary metastatic melanoma by inducing active transformation of tumor-infiltrating CD8 < sup > + < /sup > T and NK cells
In this study we investigated the effects of noninvasive radiofrequency radiation (RFR) exposure on tumor progression and TIME phenotype, as well as the antitumor potential of PD-1 blockage in a model of pulmonary metastatic melanoma (PMM). Mouse model of PMM was established by tail vein injection of B16F10 cells. From day 3 after injection, the mice were exposed to RFR at an average specific absorption rate of 9.7 W/kg for 1 h per day for 14 days. After RFR exposure, lung tissues were harvested and RNAs were extracted for transcriptome sequencing; PMM-infiltrating immune cells were isolated for single-cell RNA-seq analysi...
Source: Acta Pharmacologica Sinica - March 28, 2024 Category: Drugs & Pharmacology Authors: Jia-Zheng Jiao Yang Zhang Wen-Juan Zhang Min-di He Meng Meng Tao Liu Qin-Long Ma Ya Xu Peng Gao Chun-Hai Chen Lei Zhang Hui-Feng Pi Ping Deng Yong-Zhong Wu Zhou Zhou Zheng-Ping Yu You-Cai Deng Yong-Hui Lu Source Type: research
ROCK1 inhibition improves wound healing in diabetes via RIPK4/AMPK pathway
Acta Pharmacol Sin. 2024 Mar 27. doi: 10.1038/s41401-024-01246-3. Online ahead of print.ABSTRACTRefractory wounds are a severe complication of diabetes mellitus that often leads to amputation because of the lack of effective treatments and therapeutic targets. The pathogenesis of refractory wounds is complex, involving many types of cells. Rho-associated protein kinase-1 (ROCK1) phosphorylates a series of substrates that trigger downstream signaling pathways, affecting multiple cellular processes, including cell migration, communication, and proliferation. The present study investigated the role of ROCK1 in diabetic wound ...
Source: Acta Pharmacologica Sinica - March 28, 2024 Category: Drugs & Pharmacology Authors: Tianru Huyan Lu Fan Zhong-Yuan Zheng Jing-Hui Zhao Zhen-Ru Han Pin Wu Qun Ma Ya-Qin Du Yun-di Shi Chun-Yan Gu Xue-Jun Li Wen-Hui Wang Long Zhang Lu Tie Source Type: research
The marine-derived compound TAG alleviates Parkinson's disease by restoring RUBCN-mediated lipid metabolism homeostasis
In this study, tetrahydroauroglaucin (TAG), a polyketide isolated from a marine sponge, was found to have notable neuroprotective effects on MPTP/MPP+-induced neurotoxicity. RNA sequencing analysis and metabolomics revealed that TAG significantly improved lipid metabolism disorder in PD models. Further investigation indicated that TAG markedly decreased the accumulation of lipid droplets (LDs), downregulated the expression of RUBCN, and promoted autophagic flux. Moreover, conditional knockdown of Rubcn notably attenuated PD-like symptoms and the accumulation of LDs, accompanied by blockade of the neuroprotective effect of ...
Source: Acta Pharmacologica Sinica - March 28, 2024 Category: Drugs & Pharmacology Authors: Pei Yang Yang Liu Zhi-Wu Tong Qian-Hui Huang Xia-Hong Xie Shi-Yu Mao Jian-Hua Ding Ming Lu Ren-Xiang Tan Gang Hu Source Type: research
Radiofrequency radiation reshapes tumor immune microenvironment into antitumor phenotype in pulmonary metastatic melanoma by inducing active transformation of tumor-infiltrating CD8 < sup > + < /sup > T and NK cells
In this study we investigated the effects of noninvasive radiofrequency radiation (RFR) exposure on tumor progression and TIME phenotype, as well as the antitumor potential of PD-1 blockage in a model of pulmonary metastatic melanoma (PMM). Mouse model of PMM was established by tail vein injection of B16F10 cells. From day 3 after injection, the mice were exposed to RFR at an average specific absorption rate of 9.7 W/kg for 1 h per day for 14 days. After RFR exposure, lung tissues were harvested and RNAs were extracted for transcriptome sequencing; PMM-infiltrating immune cells were isolated for single-cell RNA-seq analysi...
Source: Acta Pharmacologica Sinica - March 28, 2024 Category: Drugs & Pharmacology Authors: Jia-Zheng Jiao Yang Zhang Wen-Juan Zhang Min-di He Meng Meng Tao Liu Qin-Long Ma Ya Xu Peng Gao Chun-Hai Chen Lei Zhang Hui-Feng Pi Ping Deng Yong-Zhong Wu Zhou Zhou Zheng-Ping Yu You-Cai Deng Yong-Hui Lu Source Type: research
ROCK1 inhibition improves wound healing in diabetes via RIPK4/AMPK pathway
Acta Pharmacol Sin. 2024 Mar 27. doi: 10.1038/s41401-024-01246-3. Online ahead of print.ABSTRACTRefractory wounds are a severe complication of diabetes mellitus that often leads to amputation because of the lack of effective treatments and therapeutic targets. The pathogenesis of refractory wounds is complex, involving many types of cells. Rho-associated protein kinase-1 (ROCK1) phosphorylates a series of substrates that trigger downstream signaling pathways, affecting multiple cellular processes, including cell migration, communication, and proliferation. The present study investigated the role of ROCK1 in diabetic wound ...
Source: Acta Pharmacologica Sinica - March 28, 2024 Category: Drugs & Pharmacology Authors: Tianru Huyan Lu Fan Zhong-Yuan Zheng Jing-Hui Zhao Zhen-Ru Han Pin Wu Qun Ma Ya-Qin Du Yun-di Shi Chun-Yan Gu Xue-Jun Li Wen-Hui Wang Long Zhang Lu Tie Source Type: research
The marine-derived compound TAG alleviates Parkinson's disease by restoring RUBCN-mediated lipid metabolism homeostasis
In this study, tetrahydroauroglaucin (TAG), a polyketide isolated from a marine sponge, was found to have notable neuroprotective effects on MPTP/MPP+-induced neurotoxicity. RNA sequencing analysis and metabolomics revealed that TAG significantly improved lipid metabolism disorder in PD models. Further investigation indicated that TAG markedly decreased the accumulation of lipid droplets (LDs), downregulated the expression of RUBCN, and promoted autophagic flux. Moreover, conditional knockdown of Rubcn notably attenuated PD-like symptoms and the accumulation of LDs, accompanied by blockade of the neuroprotective effect of ...
Source: Acta Pharmacologica Sinica - March 28, 2024 Category: Drugs & Pharmacology Authors: Pei Yang Yang Liu Zhi-Wu Tong Qian-Hui Huang Xia-Hong Xie Shi-Yu Mao Jian-Hua Ding Ming Lu Ren-Xiang Tan Gang Hu Source Type: research
Radiofrequency radiation reshapes tumor immune microenvironment into antitumor phenotype in pulmonary metastatic melanoma by inducing active transformation of tumor-infiltrating CD8 < sup > + < /sup > T and NK cells
In this study we investigated the effects of noninvasive radiofrequency radiation (RFR) exposure on tumor progression and TIME phenotype, as well as the antitumor potential of PD-1 blockage in a model of pulmonary metastatic melanoma (PMM). Mouse model of PMM was established by tail vein injection of B16F10 cells. From day 3 after injection, the mice were exposed to RFR at an average specific absorption rate of 9.7 W/kg for 1 h per day for 14 days. After RFR exposure, lung tissues were harvested and RNAs were extracted for transcriptome sequencing; PMM-infiltrating immune cells were isolated for single-cell RNA-seq analysi...
Source: Acta Pharmacologica Sinica - March 28, 2024 Category: Drugs & Pharmacology Authors: Jia-Zheng Jiao Yang Zhang Wen-Juan Zhang Min-di He Meng Meng Tao Liu Qin-Long Ma Ya Xu Peng Gao Chun-Hai Chen Lei Zhang Hui-Feng Pi Ping Deng Yong-Zhong Wu Zhou Zhou Zheng-Ping Yu You-Cai Deng Yong-Hui Lu Source Type: research
Radiofrequency radiation reshapes tumor immune microenvironment into antitumor phenotype in pulmonary metastatic melanoma by inducing active transformation of tumor-infiltrating CD8+ T and NK cells
Acta Pharmacologica Sinica, Published online: 27 March 2024; doi:10.1038/s41401-024-01260-5Radiofrequency radiation reshapes tumor immune microenvironment into antitumor phenotype in pulmonary metastatic melanoma by inducing active transformation of tumor-infiltrating CD8+ T and NK cells (Source: Acta Pharmacologica Sinica)
Source: Acta Pharmacologica Sinica - March 27, 2024 Category: Drugs & Pharmacology Authors: Jia-zheng Jiao Yang Zhang Wen-juan Zhang Min-di He Meng Meng Tao Liu Qin-long Ma Ya Xu Peng Gao Chun-hai Chen Lei Zhang Hui-feng Pi Ping Deng Yong-zhong Wu Zhou Zhou Zheng-ping Yu You-cai Deng Yong-hui Lu Source Type: research
ROCK1 inhibition improves wound healing in diabetes via RIPK4/AMPK pathway
Acta Pharmacologica Sinica, Published online: 27 March 2024; doi:10.1038/s41401-024-01246-3ROCK1 inhibition improves wound healing in diabetes via RIPK4/AMPK pathway (Source: Acta Pharmacologica Sinica)
Source: Acta Pharmacologica Sinica - March 27, 2024 Category: Drugs & Pharmacology Authors: Tianru Huyan Lu Fan Zhong-yuan Zheng Jing-hui Zhao Zhen-ru Han Pin Wu Qun Ma Ya-qin Du Yun-di Shi Chun-yan Gu Xue-jun Li Wen-hui Wang Long Zhang Lu Tie Source Type: research
The marine-derived compound TAG alleviates Parkinson’s disease by restoring RUBCN-mediated lipid metabolism homeostasis
Acta Pharmacologica Sinica, Published online: 27 March 2024; doi:10.1038/s41401-024-01259-yThe marine-derived compound TAG alleviates Parkinson’s disease by restoring RUBCN-mediated lipid metabolism homeostasis (Source: Acta Pharmacologica Sinica)
Source: Acta Pharmacologica Sinica - March 27, 2024 Category: Drugs & Pharmacology Authors: Pei Yang Yang Liu Zhi-wu Tong Qian-hui Huang Xia-hong Xie Shi-yu Mao Jian-hua Ding Ming Lu Ren-xiang Tan Gang Hu Source Type: research
Disfunction of dorsal raphe nucleus-hippocampus serotonergic-HTR3 transmission results in anxiety phenotype of Neuroplastin 65-deficient mice
Acta Pharmacol Sin. 2024 Mar 25. doi: 10.1038/s41401-024-01252-5. Online ahead of print.ABSTRACTAnxiety disorders are the most common psychiatric condition, but the etiology of anxiety disorders remains largely unclear. Our previous studies have shown that neuroplastin 65 deficiency (NP65-/-) mice exhibit abnormal social and mental behaviors and decreased expression of tryptophan hydroxylase 2 (TPH2) protein. However, whether a causal relationship between TPH2 reduction and anxiety disorders exists needs to be determined. In present study, we found that replenishment of TPH2 in dorsal raphe nucleus (DRN) enhanced 5-HT leve...
Source: Acta Pharmacologica Sinica - March 26, 2024 Category: Drugs & Pharmacology Authors: Jie Cheng Ling Chen Ya-Ni Zheng Juan Liu Lei Zhang Xiao-Ming Zhang Liang Huang Qiong-Lan Yuan Source Type: research
Disfunction of dorsal raphe nucleus-hippocampus serotonergic-HTR3 transmission results in anxiety phenotype of Neuroplastin 65-deficient mice
Acta Pharmacol Sin. 2024 Mar 25. doi: 10.1038/s41401-024-01252-5. Online ahead of print.ABSTRACTAnxiety disorders are the most common psychiatric condition, but the etiology of anxiety disorders remains largely unclear. Our previous studies have shown that neuroplastin 65 deficiency (NP65-/-) mice exhibit abnormal social and mental behaviors and decreased expression of tryptophan hydroxylase 2 (TPH2) protein. However, whether a causal relationship between TPH2 reduction and anxiety disorders exists needs to be determined. In present study, we found that replenishment of TPH2 in dorsal raphe nucleus (DRN) enhanced 5-HT leve...
Source: Acta Pharmacologica Sinica - March 26, 2024 Category: Drugs & Pharmacology Authors: Jie Cheng Ling Chen Ya-Ni Zheng Juan Liu Lei Zhang Xiao-Ming Zhang Liang Huang Qiong-Lan Yuan Source Type: research
