Chronic vascular pathogenesis results in the reduced serum Metrnl levels in ischemic stroke patients
Acta Pharmacologica Sinica, Published online: 22 January 2024; doi:10.1038/s41401-023-01204-5Chronic vascular pathogenesis results in the reduced serum Metrnl levels in ischemic stroke patients (Source: Acta Pharmacologica Sinica)
Source: Acta Pharmacologica Sinica - January 22, 2024 Category: Drugs & Pharmacology Authors: Zhu-wei Miao Nuo Wang Wen-jun Hu Si-li Zheng Dong-sheng Wang Fu-qiang Chang Zhi Wang Jia-sheng Tian Xiao-hui Dong Tao Wu Chao-yu Miao Source Type: research
The dual function of cGAS-STING signaling axis in liver diseases
In conclusion, STING signaling remains a highly promising therapeutic target, and the development of STING pathway modulators holds great potential for the treatment of liver diseases.PMID:38233527 | DOI:10.1038/s41401-023-01220-5 (Source: Acta Pharmacologica Sinica)
Source: Acta Pharmacologica Sinica - January 17, 2024 Category: Drugs & Pharmacology Authors: Xiao-Jiao-Yang Li Jiao-Rong Qu Yin-Hao Zhang Run-Ping Liu Source Type: research
The dual function of cGAS-STING signaling axis in liver diseases
Acta Pharmacologica Sinica, Published online: 17 January 2024; doi:10.1038/s41401-023-01220-5The dual function of cGAS-STING signaling axis in liver diseases (Source: Acta Pharmacologica Sinica)
Source: Acta Pharmacologica Sinica - January 17, 2024 Category: Drugs & Pharmacology Authors: Xiao-jiao-yang Li Jiao-rong Qu Yin-hao Zhang Run-ping Liu Source Type: research
CCDC92 promotes podocyte injury by regulating PA28 α/ABCA1/cholesterol efflux axis in type 2 diabetic mice
In this study, we found that Ccdc92 was significantly induced in glomeruli from type 2 diabetic mice, especially in podocytes. Importantly, upregulation of Ccdc92 in glomeruli was positively correlated with an increased urine albumin-to-creatinine ratio (UACR) and podocyte loss. Functionally, podocyte-specific deletion of Ccdc92 attenuated proteinuria, glomerular expansion and podocyte injury in mice with DKD. We further demonstrated that Ccdc92 contributed to lipid accumulation by inhibiting cholesterol efflux, finally promoting podocyte injury. Mechanistically, Ccdc92 promoted the degradation of ABCA1 by regulating PA28Î...
Source: Acta Pharmacologica Sinica - January 16, 2024 Category: Drugs & Pharmacology Authors: Fu-Wen Zuo Zhi-Yong Liu Ming-Wei Wang Jun-Yao Du Peng-Zhong Ding Hao-Ran Zhang Wei Tang Yu Sun Xiao-Jie Wang Yan Zhang Yu-Sheng Xie Ji-Chao Wu Min Liu Zi-Ying Wang Fan Yi Source Type: research
Targeted inhibition of the HNF1A/SHH axis by triptolide overcomes paclitaxel resistance in non-small cell lung cancer
This study suggests the potential clinical application of triptolide and provides promising prospects in targeting the HNF1A/SHH pathway as a therapeutic strategy for NSCLC patients with paclitaxel resistance. Schematic diagram showing that triptolide overcomes paclitaxel resistance by mediating inhibition of the HNF1A/SHH/ABCB1 axis.PMID:38228910 | DOI:10.1038/s41401-023-01219-y (Source: Acta Pharmacologica Sinica)
Source: Acta Pharmacologica Sinica - January 16, 2024 Category: Drugs & Pharmacology Authors: Ling-Bing Li Ling-Xiao Yang Lei Liu Fan-Rong Liu Alex H Li Yi-Lin Zhu Hao Wen Xia Xue Zhong-Xian Tian Hong Sun Pei-Chao Li Xiao-Gang Zhao Source Type: research
Correction to: EPHA2 feedback activation limits the response to PDE δ inhibition in KRAS-dependent cancer cells
Acta Pharmacol Sin. 2024 Jan 16. doi: 10.1038/s41401-023-01208-1. Online ahead of print.NO ABSTRACTPMID:38228911 | DOI:10.1038/s41401-023-01208-1 (Source: Acta Pharmacologica Sinica)
Source: Acta Pharmacologica Sinica - January 16, 2024 Category: Drugs & Pharmacology Authors: Yue-Hong Chen Hao Lv Ning Shen Xiao-Min Wang Shuai Tang Bing Xiong Jian Ding Mei-Yu Geng Min Huang Source Type: research
CCDC92 promotes podocyte injury by regulating PA28α/ABCA1/cholesterol efflux axis in type 2 diabetic mice
Acta Pharmacologica Sinica, Published online: 16 January 2024; doi:10.1038/s41401-023-01213-4CCDC92 promotes podocyte injury by regulating PA28α/ABCA1/cholesterol efflux axis in type 2 diabetic mice (Source: Acta Pharmacologica Sinica)
Source: Acta Pharmacologica Sinica - January 16, 2024 Category: Drugs & Pharmacology Authors: Fu-wen Zuo Zhi-yong Liu Ming-wei Wang Jun-yao Du Peng-zhong Ding Hao-ran Zhang Wei Tang Yu Sun Xiao-jie Wang Yan Zhang Yu-sheng Xie Ji-chao Wu Min Liu Zi-ying Wang Fan Yi Source Type: research
Targeted inhibition of the HNF1A/SHH axis by triptolide overcomes paclitaxel resistance in non-small cell lung cancer
Acta Pharmacologica Sinica, Published online: 16 January 2024; doi:10.1038/s41401-023-01219-yTargeted inhibition of the HNF1A/SHH axis by triptolide overcomes paclitaxel resistance in non-small cell lung cancer (Source: Acta Pharmacologica Sinica)
Source: Acta Pharmacologica Sinica - January 16, 2024 Category: Drugs & Pharmacology Authors: Ling-bing Li Ling-xiao Yang Lei Liu Fan-rong Liu Alex H. Li Yi-lin Zhu Hao Wen Xia Xue Zhong-xian Tian Hong Sun Pei-chao Li Xiao-gang Zhao Source Type: research
Correction to: EPHA2 feedback activation limits the response to PDEδ inhibition in KRAS-dependent cancer cells
Acta Pharmacologica Sinica, Published online: 16 January 2024; doi:10.1038/s41401-023-01208-1Correction to: EPHA2 feedback activation limits the response to PDEδ inhibition in KRAS-dependent cancer cells (Source: Acta Pharmacologica Sinica)
Source: Acta Pharmacologica Sinica - January 16, 2024 Category: Drugs & Pharmacology Authors: Yue-hong Chen Hao Lv Ning Shen Xiao-min Wang Shuai Tang Bing Xiong Jian Ding Mei-yu Geng Min Huang Source Type: research
Corynoxine promotes TFEB/TFE3-mediated autophagy and alleviates A β pathology in Alzheimer's disease models
In this study, we investigated the effect of Cory on AD models in vivo and in vitro. We found that Cory improved learning and memory function, increased neuronal autophagy and lysosomal biogenesis, and reduced pathogenic APP-CTFs levels in 5xFAD mice model. Cory activated TFEB/TFE3 by inhibiting AKT/mTOR signaling and stimulating lysosomal calcium release via transient receptor potential mucolipin 1 (TRPML1). Moreover, we demonstrated that TFEB/TFE3 knockdown abolished Cory-induced APP-CTFs degradation in N2aSwedAPP cells. Our findings suggest that Cory promotes TFEB/TFE3-mediated autophagy and alleviates Aβ pathology in ...
Source: Acta Pharmacologica Sinica - January 15, 2024 Category: Drugs & Pharmacology Authors: Xin-Jie Guan Zhi-Qiang Deng Jia Liu Cheng-Fu Su Benjamin Chun-Kit Tong Zhou Zhu Sravan Gopalkrishnashetty Sreenivasmurthy Yu-Xuan Kan Ke-Jia Lu Carol Pui-Kei Chu Rong-Biao Pi King-Ho Cheung Ashok Iyaswamy Ju-Xian Song Min Li Source Type: research
Macrophages promote the transition from myocardial ischemia reperfusion injury to cardiac fibrosis in mice through GMCSF/CCL2/CCR2 and phenotype switching
This study confirms that the acute injury to chronic fibrosis transition after MIR in mice is mediated by GMCSF/CCL2/CCR2 signaling in macrophages through NLRP3 inflammatory cascade and the phenotype switching.PMID:38225394 | DOI:10.1038/s41401-023-01222-3 (Source: Acta Pharmacologica Sinica)
Source: Acta Pharmacologica Sinica - January 15, 2024 Category: Drugs & Pharmacology Authors: Shi-Chun Shen Jie Xu Cheng Cheng Xin-Jian Xiang Bao-Yu Hong Meng Zhang Chen Gong Li-Kun Ma Source Type: research
Mangiferin alleviates diabetic pulmonary fibrosis in mice via inhibiting endothelial-mesenchymal transition through AMPK/FoxO3/SIRT3 axis
In this study, we investigated whether long-term diabetes shock induces DPF, and explored whether MF had a protective effect against DPF. We first examined the lung tissues and sections of 20 diabetic patients obtained from discarded lung surgical resection specimens and found that pulmonary fibrosis mainly accumulated around the pulmonary vessels, accompanied by significantly enhanced endothelial-mesenchymal transition (EndMT). We established a mouse model of DPF by STZ injections. Ten days after the final STZ injection, the mice were administered MF (20, 60 mg/kg, i.g.) every 3 days for 4 weeks, and kept feeding until 16...
Source: Acta Pharmacologica Sinica - January 15, 2024 Category: Drugs & Pharmacology Authors: Ting-Lv Fu Guo-Rui Li Dong-Hang Li Ru-Yuan He Bo-Hao Liu Rui Xiong Chen-Zhen Xu Zi-Long Lu Cong-Kuan Song Hong-Liang Qiu Wen-Jie Wang Shi-Shi Zou Ke Yi Ning Li Qing Geng Source Type: research
Corynoxine promotes TFEB/TFE3-mediated autophagy and alleviates Aβ pathology in Alzheimer’s disease models
Acta Pharmacologica Sinica, Published online: 15 January 2024; doi:10.1038/s41401-023-01197-1Corynoxine promotes TFEB/TFE3-mediated autophagy and alleviates Aβ pathology in Alzheimer’s disease models (Source: Acta Pharmacologica Sinica)
Source: Acta Pharmacologica Sinica - January 15, 2024 Category: Drugs & Pharmacology Authors: Xin-jie Guan Zhi-qiang Deng Jia Liu Cheng-fu Su Benjamin Chun-Kit Tong Zhou Zhu Sravan Gopalkrishnashetty Sreenivasmurthy Yu-xuan Kan Ke-jia Lu Carol Pui-Kei Chu Rong-biao Pi King-ho Cheung Ashok Iyaswamy Ju-xian Song Min Li Source Type: research
Macrophages promote the transition from myocardial ischemia reperfusion injury to cardiac fibrosis in mice through GMCSF/CCL2/CCR2 and phenotype switching
Acta Pharmacologica Sinica, Published online: 15 January 2024; doi:10.1038/s41401-023-01222-3Macrophages promote the transition from myocardial ischemia reperfusion injury to cardiac fibrosis in mice through GMCSF/CCL2/CCR2 and phenotype switching (Source: Acta Pharmacologica Sinica)
Source: Acta Pharmacologica Sinica - January 15, 2024 Category: Drugs & Pharmacology Authors: Shi-chun Shen Jie Xu Cheng Cheng Xin-jian Xiang Bao-yu Hong Meng Zhang Chen Gong Li-kun Ma Source Type: research
Mangiferin alleviates diabetic pulmonary fibrosis in mice via inhibiting endothelial-mesenchymal transition through AMPK/FoxO3/SIRT3 axis
Acta Pharmacologica Sinica, Published online: 15 January 2024; doi:10.1038/s41401-023-01202-7Mangiferin alleviates diabetic pulmonary fibrosis in mice via inhibiting endothelial-mesenchymal transition through AMPK/FoxO3/SIRT3 axis (Source: Acta Pharmacologica Sinica)
Source: Acta Pharmacologica Sinica - January 15, 2024 Category: Drugs & Pharmacology Authors: Ting-lv Fu Guo-rui Li Dong-hang Li Ru-yuan He Bo-hao Liu Rui Xiong Chen-zhen Xu Zi-long Lu Cong-kuan Song Hong-liang Qiu Wen-jie Wang Shi-shi Zou Ke Yi Ning Li Qing Geng Source Type: research
