O-GlcNAcylation mediates H < sub > 2 < /sub > O < sub > 2 < /sub > -induced apoptosis through regulation of STAT3 and FOXO1
Acta Pharmacol Sin. 2024 Jan 8. doi: 10.1038/s41401-023-01218-z. Online ahead of print.ABSTRACTThe O-linked-β-N-acetylglucosamine (O-GlcNAc) glycosylation (O-GlcNAcylation) is a critical post-translational modification that couples the external stimuli to intracellular signal transduction networks. However, the critical protein targets of O-GlcNAcylation in oxidative stress-induced apoptosis remain to be elucidated. Here, we show that treatment with H2O2 inhibited O-GlcNAcylation, impaired cell viability, increased the cleaved caspase 3 and accelerated apoptosis of neuroblastoma N2a cells. The O-GlcNAc transferase (OGT) i...
Source: Acta Pharmacologica Sinica - January 9, 2024 Category: Drugs & Pharmacology Authors: Chen-Chun Zhang Yuan Li Chang-You Jiang Qiu-Min Le Xing Liu Lan Ma Fei-Fei Wang Source Type: research
Inhibition of PPP1R15A alleviates osteoporosis via suppressing RANKL-induced osteoclastogenesis
This study has identified PPP1R15A as a novel target for osteoclast differentiation, and genetic inhibition or allosteric inhibitors of PPP1R15A, such as Sephin1, can be used to treat osteoporosis. This study revealed that PPP1R15A expression was increased in osteoporosis in both human and mice. Inhibition of PPP1R15A by specific knockdown or an allosteric inhibitor Sephin1 mitigated murine osteoclast formation in vitro and attenuated ovariectomy-induced osteoporosis in vivo. PPP1R15A inhibition also suppressed pathogenic osteoclastogenesis in CD14+ monocytes from osteoporosis patients. These results identify PPP1R15A as a...
Source: Acta Pharmacologica Sinica - January 9, 2024 Category: Drugs & Pharmacology Authors: Zong-Bao Ding Yan Chen Yu-Rong Zheng Yi-Yuan Wang Wen-de Deng Jie-Huang Zheng Qin Yang Zi-Ye Chen Li-Hong Li Hui Jiang Xiao-Juan Li Source Type: research
Structural and functional insights into the epigenetic regulator MRG15
Acta Pharmacol Sin. 2024 Jan 8. doi: 10.1038/s41401-023-01211-6. Online ahead of print.ABSTRACTMORF4-related gene on chromosome 15 (MRG15), a chromatin remodeller, is evolutionally conserved and ubiquitously expressed in mammalian tissues and cells. MRG15 plays vital regulatory roles in DNA damage repair, cell proliferation and division, cellular senescence and apoptosis by regulating both gene activation and gene repression via associations with specific histone acetyltransferase and histone deacetylase complexes. Recently, MRG15 has also been shown to rhythmically regulate hepatic lipid metabolism and suppress carcinoma ...
Source: Acta Pharmacologica Sinica - January 9, 2024 Category: Drugs & Pharmacology Authors: Nan Jiang Yong-Bo Li Jia-Yu Jin Jie-Yu Guo Qiu-Rong Ding Dan Meng Xiu-Ling Zhi Source Type: research
New horizons for the role of RNA N6-methyladenosine modification in hepatocellular carcinoma
Acta Pharmacol Sin. 2024 Jan 9. doi: 10.1038/s41401-023-01214-3. Online ahead of print.ABSTRACTHepatocellular carcinoma (HCC) is one of the most common malignancy, presenting a formidable challenge to the medical community owing to its intricate pathogenic mechanisms. Although current prevention, surveillance, early detection, diagnosis, and treatment have achieved some success in preventing HCC and controlling overall disease mortality, the imperative to explore novel treatment modalities for HCC remains increasingly urgent. Epigenetic modification has emerged as pivotal factors in the etiology of cancer. Among these, RNA...
Source: Acta Pharmacologica Sinica - January 9, 2024 Category: Drugs & Pharmacology Authors: Yu-Jia Li Yang-Ling Qiu Meng-Ran Li Min Shen Feng Zhang Jiang-Juan Shao Xue-Fen Xu Zi-Li Zhang Shi-Zhong Zheng Source Type: research
O-GlcNAcylation mediates H < sub > 2 < /sub > O < sub > 2 < /sub > -induced apoptosis through regulation of STAT3 and FOXO1
Acta Pharmacol Sin. 2024 Jan 8. doi: 10.1038/s41401-023-01218-z. Online ahead of print.ABSTRACTThe O-linked-β-N-acetylglucosamine (O-GlcNAc) glycosylation (O-GlcNAcylation) is a critical post-translational modification that couples the external stimuli to intracellular signal transduction networks. However, the critical protein targets of O-GlcNAcylation in oxidative stress-induced apoptosis remain to be elucidated. Here, we show that treatment with H2O2 inhibited O-GlcNAcylation, impaired cell viability, increased the cleaved caspase 3 and accelerated apoptosis of neuroblastoma N2a cells. The O-GlcNAc transferase (OGT) i...
Source: Acta Pharmacologica Sinica - January 9, 2024 Category: Drugs & Pharmacology Authors: Chen-Chun Zhang Yuan Li Chang-You Jiang Qiu-Min Le Xing Liu Lan Ma Fei-Fei Wang Source Type: research
Inhibition of PPP1R15A alleviates osteoporosis via suppressing RANKL-induced osteoclastogenesis
This study has identified PPP1R15A as a novel target for osteoclast differentiation, and genetic inhibition or allosteric inhibitors of PPP1R15A, such as Sephin1, can be used to treat osteoporosis. This study revealed that PPP1R15A expression was increased in osteoporosis in both human and mice. Inhibition of PPP1R15A by specific knockdown or an allosteric inhibitor Sephin1 mitigated murine osteoclast formation in vitro and attenuated ovariectomy-induced osteoporosis in vivo. PPP1R15A inhibition also suppressed pathogenic osteoclastogenesis in CD14+ monocytes from osteoporosis patients. These results identify PPP1R15A as a...
Source: Acta Pharmacologica Sinica - January 9, 2024 Category: Drugs & Pharmacology Authors: Zong-Bao Ding Yan Chen Yu-Rong Zheng Yi-Yuan Wang Wen-de Deng Jie-Huang Zheng Qin Yang Zi-Ye Chen Li-Hong Li Hui Jiang Xiao-Juan Li Source Type: research
Structural and functional insights into the epigenetic regulator MRG15
Acta Pharmacol Sin. 2024 Jan 8. doi: 10.1038/s41401-023-01211-6. Online ahead of print.ABSTRACTMORF4-related gene on chromosome 15 (MRG15), a chromatin remodeller, is evolutionally conserved and ubiquitously expressed in mammalian tissues and cells. MRG15 plays vital regulatory roles in DNA damage repair, cell proliferation and division, cellular senescence and apoptosis by regulating both gene activation and gene repression via associations with specific histone acetyltransferase and histone deacetylase complexes. Recently, MRG15 has also been shown to rhythmically regulate hepatic lipid metabolism and suppress carcinoma ...
Source: Acta Pharmacologica Sinica - January 9, 2024 Category: Drugs & Pharmacology Authors: Nan Jiang Yong-Bo Li Jia-Yu Jin Jie-Yu Guo Qiu-Rong Ding Dan Meng Xiu-Ling Zhi Source Type: research
New horizons for the role of RNA N6-methyladenosine modification in hepatocellular carcinoma
Acta Pharmacologica Sinica, Published online: 09 January 2024; doi:10.1038/s41401-023-01214-3New horizons for the role of RNA N6-methyladenosine modification in hepatocellular carcinoma (Source: Acta Pharmacologica Sinica)
Source: Acta Pharmacologica Sinica - January 9, 2024 Category: Drugs & Pharmacology Authors: Yu-jia Li Yang-ling Qiu Meng-ran Li Min Shen Feng Zhang Jiang-juan Shao Xue-fen Xu Zi-li Zhang Shi-zhong Zheng Source Type: research
Inhibition of PPP1R15A alleviates osteoporosis via suppressing RANKL-induced osteoclastogenesis
Acta Pharmacologica Sinica, Published online: 08 January 2024; doi:10.1038/s41401-023-01209-0Inhibition of PPP1R15A alleviates osteoporosis via suppressing RANKL-induced osteoclastogenesis (Source: Acta Pharmacologica Sinica)
Source: Acta Pharmacologica Sinica - January 8, 2024 Category: Drugs & Pharmacology Authors: Zong-bao Ding Yan Chen Yu-rong Zheng Yi-yuan Wang Wen-de Deng Jie-huang Zheng Qin Yang Zi-ye Chen Li-hong Li Hui Jiang Xiao-juan Li Source Type: research
O-GlcNAcylation mediates H2O2-induced apoptosis through regulation of STAT3 and FOXO1
Acta Pharmacologica Sinica, Published online: 08 January 2024; doi:10.1038/s41401-023-01218-zO-GlcNAcylation mediates H2O2-induced apoptosis through regulation of STAT3 and FOXO1 (Source: Acta Pharmacologica Sinica)
Source: Acta Pharmacologica Sinica - January 8, 2024 Category: Drugs & Pharmacology Authors: Chen-chun Zhang Yuan Li Chang-you Jiang Qiu-min Le Xing Liu Lan Ma Fei-fei Wang Source Type: research
Structural and functional insights into the epigenetic regulator MRG15
Acta Pharmacologica Sinica, Published online: 08 January 2024; doi:10.1038/s41401-023-01211-6Structural and functional insights into the epigenetic regulator MRG15 (Source: Acta Pharmacologica Sinica)
Source: Acta Pharmacologica Sinica - January 8, 2024 Category: Drugs & Pharmacology Authors: Nan Jiang Yong-bo Li Jia-yu Jin Jie-yu Guo Qiu-rong Ding Dan Meng Xiu-ling Zhi Source Type: research
Second messenger 2'3'-cyclic GMP-AMP (2'3'-cGAMP): the cell autonomous and non-autonomous roles in cancer progression
Acta Pharmacol Sin. 2024 Jan 4. doi: 10.1038/s41401-023-01210-7. Online ahead of print.ABSTRACTCytosolic double-stranded DNA (dsDNA) is frequently accumulated in cancer cells due to chromosomal instability or exogenous stimulation. Cyclic GMP-AMP synthase (cGAS) acts as a cytosolic DNA sensor, which is activated upon binding to dsDNA to synthesize the crucial second messenger 2'3'-cyclic GMP-AMP (2'3'-cGAMP) that in turn triggers stimulator of interferon genes (STING) signaling. The canonical role of cGAS-cGAMP-STING pathway is essential for innate immunity and viral defense. Recent emerging evidence indicates that 2'3'-cG...
Source: Acta Pharmacologica Sinica - January 4, 2024 Category: Drugs & Pharmacology Authors: Xiao-Yu Ma Man-Man Chen Ling-Hua Meng Source Type: research
Second messenger 2'3'-cyclic GMP-AMP (2'3'-cGAMP): the cell autonomous and non-autonomous roles in cancer progression
Acta Pharmacol Sin. 2024 Jan 4. doi: 10.1038/s41401-023-01210-7. Online ahead of print.ABSTRACTCytosolic double-stranded DNA (dsDNA) is frequently accumulated in cancer cells due to chromosomal instability or exogenous stimulation. Cyclic GMP-AMP synthase (cGAS) acts as a cytosolic DNA sensor, which is activated upon binding to dsDNA to synthesize the crucial second messenger 2'3'-cyclic GMP-AMP (2'3'-cGAMP) that in turn triggers stimulator of interferon genes (STING) signaling. The canonical role of cGAS-cGAMP-STING pathway is essential for innate immunity and viral defense. Recent emerging evidence indicates that 2'3'-cG...
Source: Acta Pharmacologica Sinica - January 4, 2024 Category: Drugs & Pharmacology Authors: Xiao-Yu Ma Man-Man Chen Ling-Hua Meng Source Type: research
Second messenger 2'3'-cyclic GMP-AMP (2'3'-cGAMP): the cell autonomous and non-autonomous roles in cancer progression
Acta Pharmacol Sin. 2024 Jan 4. doi: 10.1038/s41401-023-01210-7. Online ahead of print.ABSTRACTCytosolic double-stranded DNA (dsDNA) is frequently accumulated in cancer cells due to chromosomal instability or exogenous stimulation. Cyclic GMP-AMP synthase (cGAS) acts as a cytosolic DNA sensor, which is activated upon binding to dsDNA to synthesize the crucial second messenger 2'3'-cyclic GMP-AMP (2'3'-cGAMP) that in turn triggers stimulator of interferon genes (STING) signaling. The canonical role of cGAS-cGAMP-STING pathway is essential for innate immunity and viral defense. Recent emerging evidence indicates that 2'3'-cG...
Source: Acta Pharmacologica Sinica - January 4, 2024 Category: Drugs & Pharmacology Authors: Xiao-Yu Ma Man-Man Chen Ling-Hua Meng Source Type: research
Second messenger 2'3'-cyclic GMP-AMP (2'3'-cGAMP): the cell autonomous and non-autonomous roles in cancer progression
Acta Pharmacol Sin. 2024 Jan 4. doi: 10.1038/s41401-023-01210-7. Online ahead of print.ABSTRACTCytosolic double-stranded DNA (dsDNA) is frequently accumulated in cancer cells due to chromosomal instability or exogenous stimulation. Cyclic GMP-AMP synthase (cGAS) acts as a cytosolic DNA sensor, which is activated upon binding to dsDNA to synthesize the crucial second messenger 2'3'-cyclic GMP-AMP (2'3'-cGAMP) that in turn triggers stimulator of interferon genes (STING) signaling. The canonical role of cGAS-cGAMP-STING pathway is essential for innate immunity and viral defense. Recent emerging evidence indicates that 2'3'-cG...
Source: Acta Pharmacologica Sinica - January 4, 2024 Category: Drugs & Pharmacology Authors: Xiao-Yu Ma Man-Man Chen Ling-Hua Meng Source Type: research
