Prebiotic diet normalizes aberrant immune and behavioral phenotypes in a mouse model of autism spectrum disorder
In this study, we investigated whether a diet containing specific prebiotic fibers, namely, 3% galacto-oligosaccharide/fructo-oligosaccharide (GOS/FOS; 9:1), can mitigate the adverse effects of in utero exposure to valproic acid (VPA) in mice. Pregnant BALB/cByJ dams were injected with VPA (600 mg/kg, sc.) or phosphate-buffered saline (PBS) on gestational day 11 (G11). Male offspring were divided into four groups: (1) in utero PBS-exposed with a control diet, (2) in utero PBS-exposed with GOS/FOS diet, (3) in utero VPA-exposed with a control diet, and (4) in utero VPA-exposed with GOS/FOS diet. Dietary intervention started...
Source: Acta Pharmacologica Sinica - April 8, 2024 Category: Drugs & Pharmacology Authors: Naika Prince Lucia N Peralta Marzal Anastasia Markidi Sabbir Ahmed Youri Adolfs R Jeroen Pasterkamp Himanshu Kumar Guus Roeselers Johan Garssen Aletta D Kraneveld Paula Perez-Pardo Source Type: research
Neutrophil extracellular traps promote acetaminophen-induced acute liver injury in mice via AIM2
In this study we investigated whether NETs were involved in hepatocyte injury and contributed to APAP-induced ALI progression. ALI mouse model was established by injecting overdose (350 mg/kg) of APAP. After 24 h, blood and livers were harvested for analyses. We showed that excessive APAP induced multiple programmed cell deaths of hepatocytes including pyroptosis, apoptosis and necroptosis, accompanied by significantly increased NETs markers (MPO, citH3) in the liver tissue and serum. Preinjection of DNase1 (10 U, i.p.) for two consecutive days significantly inhibited NETs formation, reduced PANoptosis and consequently all...
Source: Acta Pharmacologica Sinica - April 8, 2024 Category: Drugs & Pharmacology Authors: Fan-le Zeng Yuan Zhang Zhong-Hao Wang Hui Zhang Xue-Teng Meng Yi-Qin Wu Zhen-Zhen Qian Yu-Hao Ding Jun Li Tao-Tao Ma Cheng Huang Source Type: research
Exosomes derived from induced cardiopulmonary progenitor cells alleviate acute lung injury in mice
This study provides a potential new method for the prevention and treatment of cardiopulmonary injury, especially lung injury, and provides a new cell model for drug screening.PMID:38589686 | DOI:10.1038/s41401-024-01253-4 (Source: Acta Pharmacologica Sinica)
Source: Acta Pharmacologica Sinica - April 8, 2024 Category: Drugs & Pharmacology Authors: Luo-Xing Xia Ying-Ying Xiao Wen-Jing Jiang Xiang-Yu Yang Hua Tao Safur Rehman Mandukhail Jian-Feng Qin Qian-Rong Pan Yu-Guang Zhu Li-Xin Zhao Li-Juan Huang Zhan Li Xi-Yong Yu Source Type: research
Indoxyl sulphate-TNF α axis mediates uremic encephalopathy in rodent acute kidney injury
In this study we investigated the CNS behaviors and expression/function of BBB OAT3 in AKI rats and mice, which received intraperitoneal injection of cisplatin 8 and 20 mg/kg, respectively. We showed that cisplatin treatment significantly inhibited the expressions of OAT3, synaptophysin and microtubule-associated protein 2 (MAP2), impaired locomotor and exploration activities, and increased accumulation of uremic toxins in the brain of AKI rats and mice. In vitro studies showed that uremic toxins neither alter OAT3 expression in human cerebral microvascular endothelial cells, nor synaptophysin and MAP2 expressions in human...
Source: Acta Pharmacologica Sinica - April 8, 2024 Category: Drugs & Pharmacology Authors: Ling Jiang Xue-Ying Sun Si-Qian Wang Yan-Lin Liu Ling-Jue Lu Wen-Han Wu Hao Zhi Zhong-Yan Wang Xiao-Dong Liu Li Liu Source Type: research
Inhibition of USP7 enhances CD8 < sup > + < /sup > T cell activity in liver cancer by suppressing PRDM1-mediated FGL1 upregulation
In this study we investigated the role of USP7 in modulation of FGL1-mediated liver cancer immune evasion. We showed that knockdown of USP7 or treatment with USP7 inhibitor P5091 suppressed liver cancer growth by promoting CD8+ T cell activity in Hepa1-6 xenograft mice and in HepG2 or Huh7 cells co-cultured with T cells, whereas USP7 overexpression produced the opposite effect. We found that USP7 upregulated FGL1 in HepG2 and Huh7 cells by deubiquitination of transcriptional factor PR domain zinc finger protein 1 (PRDM1), which transcriptionally activated FGL1, and attenuated the CD8+ T cell activity, leading to the liver ...
Source: Acta Pharmacologica Sinica - April 8, 2024 Category: Drugs & Pharmacology Authors: Lin-Lin Sun Li-Na Zhao Jiao Sun Hong-Feng Yuan Yu-Fei Wang Chun-Yu Hou Pan Lv Hui-Hui Zhang Guang Yang Ning-Ning Zhang Xiao-Dong Zhang Wei Lu Source Type: research
Empagliflozin and liraglutide ameliorate HFpEF in mice via augmenting the Erbb4 signaling pathway
In this study, we explored the anti-HFpEF effects of empagliflozin and liraglutide and the underlying molecular mechanisms in a mouse model of HFpEF. This model was established by high-fat diet (HFD) feeding plus Nω-nitro-L-arginine methyl ester (L-NAME) treatment. The mice were treated with empagliflozin (20 mg·kg-1·d-1, i.g.) or liraglutide (0.3 mg·kg-1·d-1, i.p.) or their combination for 4 weeks. At the end of the experimental protocol, cardiac function was measured using ultrasound, then mice were euthanized and heart, liver, and kidney tissues were collected. Nuclei were isolated from frozen mouse ventricular tis...
Source: Acta Pharmacologica Sinica - April 8, 2024 Category: Drugs & Pharmacology Authors: Xia-Yun Ni Xiao-Jun Feng Zhi-Hua Wang Yang Zhang Peter J Little Yang Cao Suo-Wen Xu Li-Qin Tang Jian-Ping Weng Source Type: research
Prebiotic diet normalizes aberrant immune and behavioral phenotypes in a mouse model of autism spectrum disorder
In this study, we investigated whether a diet containing specific prebiotic fibers, namely, 3% galacto-oligosaccharide/fructo-oligosaccharide (GOS/FOS; 9:1), can mitigate the adverse effects of in utero exposure to valproic acid (VPA) in mice. Pregnant BALB/cByJ dams were injected with VPA (600 mg/kg, sc.) or phosphate-buffered saline (PBS) on gestational day 11 (G11). Male offspring were divided into four groups: (1) in utero PBS-exposed with a control diet, (2) in utero PBS-exposed with GOS/FOS diet, (3) in utero VPA-exposed with a control diet, and (4) in utero VPA-exposed with GOS/FOS diet. Dietary intervention started...
Source: Acta Pharmacologica Sinica - April 8, 2024 Category: Drugs & Pharmacology Authors: Naika Prince Lucia N Peralta Marzal Anastasia Markidi Sabbir Ahmed Youri Adolfs R Jeroen Pasterkamp Himanshu Kumar Guus Roeselers Johan Garssen Aletta D Kraneveld Paula Perez-Pardo Source Type: research
Neutrophil extracellular traps promote acetaminophen-induced acute liver injury in mice via AIM2
In this study we investigated whether NETs were involved in hepatocyte injury and contributed to APAP-induced ALI progression. ALI mouse model was established by injecting overdose (350 mg/kg) of APAP. After 24 h, blood and livers were harvested for analyses. We showed that excessive APAP induced multiple programmed cell deaths of hepatocytes including pyroptosis, apoptosis and necroptosis, accompanied by significantly increased NETs markers (MPO, citH3) in the liver tissue and serum. Preinjection of DNase1 (10 U, i.p.) for two consecutive days significantly inhibited NETs formation, reduced PANoptosis and consequently all...
Source: Acta Pharmacologica Sinica - April 8, 2024 Category: Drugs & Pharmacology Authors: Fan-le Zeng Yuan Zhang Zhong-Hao Wang Hui Zhang Xue-Teng Meng Yi-Qin Wu Zhen-Zhen Qian Yu-Hao Ding Jun Li Tao-Tao Ma Cheng Huang Source Type: research
Exosomes derived from induced cardiopulmonary progenitor cells alleviate acute lung injury in mice
This study provides a potential new method for the prevention and treatment of cardiopulmonary injury, especially lung injury, and provides a new cell model for drug screening.PMID:38589686 | DOI:10.1038/s41401-024-01253-4 (Source: Acta Pharmacologica Sinica)
Source: Acta Pharmacologica Sinica - April 8, 2024 Category: Drugs & Pharmacology Authors: Luo-Xing Xia Ying-Ying Xiao Wen-Jing Jiang Xiang-Yu Yang Hua Tao Safur Rehman Mandukhail Jian-Feng Qin Qian-Rong Pan Yu-Guang Zhu Li-Xin Zhao Li-Juan Huang Zhan Li Xi-Yong Yu Source Type: research
Indoxyl sulphate-TNF α axis mediates uremic encephalopathy in rodent acute kidney injury
In this study we investigated the CNS behaviors and expression/function of BBB OAT3 in AKI rats and mice, which received intraperitoneal injection of cisplatin 8 and 20 mg/kg, respectively. We showed that cisplatin treatment significantly inhibited the expressions of OAT3, synaptophysin and microtubule-associated protein 2 (MAP2), impaired locomotor and exploration activities, and increased accumulation of uremic toxins in the brain of AKI rats and mice. In vitro studies showed that uremic toxins neither alter OAT3 expression in human cerebral microvascular endothelial cells, nor synaptophysin and MAP2 expressions in human...
Source: Acta Pharmacologica Sinica - April 8, 2024 Category: Drugs & Pharmacology Authors: Ling Jiang Xue-Ying Sun Si-Qian Wang Yan-Lin Liu Ling-Jue Lu Wen-Han Wu Hao Zhi Zhong-Yan Wang Xiao-Dong Liu Li Liu Source Type: research
Inhibition of USP7 enhances CD8 < sup > + < /sup > T cell activity in liver cancer by suppressing PRDM1-mediated FGL1 upregulation
In this study we investigated the role of USP7 in modulation of FGL1-mediated liver cancer immune evasion. We showed that knockdown of USP7 or treatment with USP7 inhibitor P5091 suppressed liver cancer growth by promoting CD8+ T cell activity in Hepa1-6 xenograft mice and in HepG2 or Huh7 cells co-cultured with T cells, whereas USP7 overexpression produced the opposite effect. We found that USP7 upregulated FGL1 in HepG2 and Huh7 cells by deubiquitination of transcriptional factor PR domain zinc finger protein 1 (PRDM1), which transcriptionally activated FGL1, and attenuated the CD8+ T cell activity, leading to the liver ...
Source: Acta Pharmacologica Sinica - April 8, 2024 Category: Drugs & Pharmacology Authors: Lin-Lin Sun Li-Na Zhao Jiao Sun Hong-Feng Yuan Yu-Fei Wang Chun-Yu Hou Pan Lv Hui-Hui Zhang Guang Yang Ning-Ning Zhang Xiao-Dong Zhang Wei Lu Source Type: research
Empagliflozin and liraglutide ameliorate HFpEF in mice via augmenting the Erbb4 signaling pathway
In this study, we explored the anti-HFpEF effects of empagliflozin and liraglutide and the underlying molecular mechanisms in a mouse model of HFpEF. This model was established by high-fat diet (HFD) feeding plus Nω-nitro-L-arginine methyl ester (L-NAME) treatment. The mice were treated with empagliflozin (20 mg·kg-1·d-1, i.g.) or liraglutide (0.3 mg·kg-1·d-1, i.p.) or their combination for 4 weeks. At the end of the experimental protocol, cardiac function was measured using ultrasound, then mice were euthanized and heart, liver, and kidney tissues were collected. Nuclei were isolated from frozen mouse ventricular tis...
Source: Acta Pharmacologica Sinica - April 8, 2024 Category: Drugs & Pharmacology Authors: Xia-Yun Ni Xiao-Jun Feng Zhi-Hua Wang Yang Zhang Peter J Little Yang Cao Suo-Wen Xu Li-Qin Tang Jian-Ping Weng Source Type: research
Prebiotic diet normalizes aberrant immune and behavioral phenotypes in a mouse model of autism spectrum disorder
In this study, we investigated whether a diet containing specific prebiotic fibers, namely, 3% galacto-oligosaccharide/fructo-oligosaccharide (GOS/FOS; 9:1), can mitigate the adverse effects of in utero exposure to valproic acid (VPA) in mice. Pregnant BALB/cByJ dams were injected with VPA (600 mg/kg, sc.) or phosphate-buffered saline (PBS) on gestational day 11 (G11). Male offspring were divided into four groups: (1) in utero PBS-exposed with a control diet, (2) in utero PBS-exposed with GOS/FOS diet, (3) in utero VPA-exposed with a control diet, and (4) in utero VPA-exposed with GOS/FOS diet. Dietary intervention started...
Source: Acta Pharmacologica Sinica - April 8, 2024 Category: Drugs & Pharmacology Authors: Naika Prince Lucia N Peralta Marzal Anastasia Markidi Sabbir Ahmed Youri Adolfs R Jeroen Pasterkamp Himanshu Kumar Guus Roeselers Johan Garssen Aletta D Kraneveld Paula Perez-Pardo Source Type: research
Indoxyl sulphate-TNFα axis mediates uremic encephalopathy in rodent acute kidney injury
Acta Pharmacologica Sinica, Published online: 08 April 2024; doi:10.1038/s41401-024-01251-6Indoxyl sulphate-TNFα axis mediates uremic encephalopathy in rodent acute kidney injury (Source: Acta Pharmacologica Sinica)
Source: Acta Pharmacologica Sinica - April 8, 2024 Category: Drugs & Pharmacology Authors: Ling Jiang Xue-ying Sun Si-qian Wang Yan-lin Liu Ling-jue Lu Wen-han Wu Hao Zhi Zhong-yan Wang Xiao-dong Liu Li Liu Source Type: research
Prebiotic diet normalizes aberrant immune and behavioral phenotypes in a mouse model of autism spectrum disorder
Acta Pharmacologica Sinica, Published online: 08 April 2024; doi:10.1038/s41401-024-01268-xPrebiotic diet normalizes aberrant immune and behavioral phenotypes in a mouse model of autism spectrum disorder (Source: Acta Pharmacologica Sinica)
Source: Acta Pharmacologica Sinica - April 8, 2024 Category: Drugs & Pharmacology Authors: Naika Prince Lucia N Peralta Marzal Anastasia Markidi Sabbir Ahmed Youri Adolfs R Jeroen Pasterkamp Himanshu Kumar Guus Roeselers Johan Garssen Aletta D Kraneveld Paula Perez-Pardo Source Type: research
