A novel role of PSMB9 in endothelial cells and atherosclerosis: beyond its canonical function in immunoproteasome
Acta Pharmacologica Sinica, Published online: 03 April 2024; doi:10.1038/s41401-024-01267-yA novel role of PSMB9 in endothelial cells and atherosclerosis: beyond its canonical function in immunoproteasome (Source: Acta Pharmacologica Sinica)
Source: Acta Pharmacologica Sinica - April 3, 2024 Category: Drugs & Pharmacology Authors: Xiaolei Liu Esteban Delgado Source Type: research
Decreasing mitochondrial fission ameliorates HIF-1 α-dependent pathological retinal angiogenesis
In this study, we investigated the role of mitochondrial dynamics in pathological retinal angiogenesis. We showed that treatment with vascular endothelial growth factor (VEGF; 20 ng/ml) induced mitochondrial fission in HUVECs by promoting the phosphorylation of dynamin-related protein 1 (DRP1). DRP1 knockdown or pretreatment with the DRP1 inhibitor Mdivi-1 (5 μM) blocked VEGF-induced cell migration, proliferation, and tube formation in HUVECs. We demonstrated that VEGF treatment increased mitochondrial ROS production in HUVECs, which was necessary for HIF-1α-dependent glycolysis, as well as proliferation, migration, and ...
Source: Acta Pharmacologica Sinica - April 2, 2024 Category: Drugs & Pharmacology Authors: Shu-Qi Huang Kai-Xiang Cao Cai-Ling Wang Pei-Ling Chen Yi-Xin Chen Yu-Ting Zhang Shi-Hui Yu Zai-Xia Bai Shuai Guo Mu-Xi Liao Qiao-Wen Li Guo-Qi Zhang Jun He Yi-Ming Xu Source Type: research
Decreasing mitochondrial fission ameliorates HIF-1α-dependent pathological retinal angiogenesis
Acta Pharmacologica Sinica, Published online: 02 April 2024; doi:10.1038/s41401-024-01262-3Decreasing mitochondrial fission ameliorates HIF-1α-dependent pathological retinal angiogenesis (Source: Acta Pharmacologica Sinica)
Source: Acta Pharmacologica Sinica - April 2, 2024 Category: Drugs & Pharmacology Authors: Shu-qi Huang Kai-xiang Cao Cai-ling Wang Pei-ling Chen Yi-xin Chen Yu-ting Zhang Shi-hui Yu Zai-xia Bai Shuai Guo Mu-xi Liao Qiao-wen Li Guo-qi Zhang Jun He Yi-ming Xu Source Type: research
ROCK1 inhibition improves wound healing in diabetes via RIPK4/AMPK pathway
Acta Pharmacol Sin. 2024 Mar 27. doi: 10.1038/s41401-024-01246-3. Online ahead of print.ABSTRACTRefractory wounds are a severe complication of diabetes mellitus that often leads to amputation because of the lack of effective treatments and therapeutic targets. The pathogenesis of refractory wounds is complex, involving many types of cells. Rho-associated protein kinase-1 (ROCK1) phosphorylates a series of substrates that trigger downstream signaling pathways, affecting multiple cellular processes, including cell migration, communication, and proliferation. The present study investigated the role of ROCK1 in diabetic wound ...
Source: Acta Pharmacologica Sinica - March 28, 2024 Category: Drugs & Pharmacology Authors: Tianru Huyan Lu Fan Zhong-Yuan Zheng Jing-Hui Zhao Zhen-Ru Han Pin Wu Qun Ma Ya-Qin Du Yun-di Shi Chun-Yan Gu Xue-Jun Li Wen-Hui Wang Long Zhang Lu Tie Source Type: research
The marine-derived compound TAG alleviates Parkinson's disease by restoring RUBCN-mediated lipid metabolism homeostasis
In this study, tetrahydroauroglaucin (TAG), a polyketide isolated from a marine sponge, was found to have notable neuroprotective effects on MPTP/MPP+-induced neurotoxicity. RNA sequencing analysis and metabolomics revealed that TAG significantly improved lipid metabolism disorder in PD models. Further investigation indicated that TAG markedly decreased the accumulation of lipid droplets (LDs), downregulated the expression of RUBCN, and promoted autophagic flux. Moreover, conditional knockdown of Rubcn notably attenuated PD-like symptoms and the accumulation of LDs, accompanied by blockade of the neuroprotective effect of ...
Source: Acta Pharmacologica Sinica - March 28, 2024 Category: Drugs & Pharmacology Authors: Pei Yang Yang Liu Zhi-Wu Tong Qian-Hui Huang Xia-Hong Xie Shi-Yu Mao Jian-Hua Ding Ming Lu Ren-Xiang Tan Gang Hu Source Type: research
Radiofrequency radiation reshapes tumor immune microenvironment into antitumor phenotype in pulmonary metastatic melanoma by inducing active transformation of tumor-infiltrating CD8 < sup > + < /sup > T and NK cells
In this study we investigated the effects of noninvasive radiofrequency radiation (RFR) exposure on tumor progression and TIME phenotype, as well as the antitumor potential of PD-1 blockage in a model of pulmonary metastatic melanoma (PMM). Mouse model of PMM was established by tail vein injection of B16F10 cells. From day 3 after injection, the mice were exposed to RFR at an average specific absorption rate of 9.7 W/kg for 1 h per day for 14 days. After RFR exposure, lung tissues were harvested and RNAs were extracted for transcriptome sequencing; PMM-infiltrating immune cells were isolated for single-cell RNA-seq analysi...
Source: Acta Pharmacologica Sinica - March 28, 2024 Category: Drugs & Pharmacology Authors: Jia-Zheng Jiao Yang Zhang Wen-Juan Zhang Min-di He Meng Meng Tao Liu Qin-Long Ma Ya Xu Peng Gao Chun-Hai Chen Lei Zhang Hui-Feng Pi Ping Deng Yong-Zhong Wu Zhou Zhou Zheng-Ping Yu You-Cai Deng Yong-Hui Lu Source Type: research
ROCK1 inhibition improves wound healing in diabetes via RIPK4/AMPK pathway
Acta Pharmacol Sin. 2024 Mar 27. doi: 10.1038/s41401-024-01246-3. Online ahead of print.ABSTRACTRefractory wounds are a severe complication of diabetes mellitus that often leads to amputation because of the lack of effective treatments and therapeutic targets. The pathogenesis of refractory wounds is complex, involving many types of cells. Rho-associated protein kinase-1 (ROCK1) phosphorylates a series of substrates that trigger downstream signaling pathways, affecting multiple cellular processes, including cell migration, communication, and proliferation. The present study investigated the role of ROCK1 in diabetic wound ...
Source: Acta Pharmacologica Sinica - March 28, 2024 Category: Drugs & Pharmacology Authors: Tianru Huyan Lu Fan Zhong-Yuan Zheng Jing-Hui Zhao Zhen-Ru Han Pin Wu Qun Ma Ya-Qin Du Yun-di Shi Chun-Yan Gu Xue-Jun Li Wen-Hui Wang Long Zhang Lu Tie Source Type: research
The marine-derived compound TAG alleviates Parkinson's disease by restoring RUBCN-mediated lipid metabolism homeostasis
In this study, tetrahydroauroglaucin (TAG), a polyketide isolated from a marine sponge, was found to have notable neuroprotective effects on MPTP/MPP+-induced neurotoxicity. RNA sequencing analysis and metabolomics revealed that TAG significantly improved lipid metabolism disorder in PD models. Further investigation indicated that TAG markedly decreased the accumulation of lipid droplets (LDs), downregulated the expression of RUBCN, and promoted autophagic flux. Moreover, conditional knockdown of Rubcn notably attenuated PD-like symptoms and the accumulation of LDs, accompanied by blockade of the neuroprotective effect of ...
Source: Acta Pharmacologica Sinica - March 28, 2024 Category: Drugs & Pharmacology Authors: Pei Yang Yang Liu Zhi-Wu Tong Qian-Hui Huang Xia-Hong Xie Shi-Yu Mao Jian-Hua Ding Ming Lu Ren-Xiang Tan Gang Hu Source Type: research
Radiofrequency radiation reshapes tumor immune microenvironment into antitumor phenotype in pulmonary metastatic melanoma by inducing active transformation of tumor-infiltrating CD8 < sup > + < /sup > T and NK cells
In this study we investigated the effects of noninvasive radiofrequency radiation (RFR) exposure on tumor progression and TIME phenotype, as well as the antitumor potential of PD-1 blockage in a model of pulmonary metastatic melanoma (PMM). Mouse model of PMM was established by tail vein injection of B16F10 cells. From day 3 after injection, the mice were exposed to RFR at an average specific absorption rate of 9.7 W/kg for 1 h per day for 14 days. After RFR exposure, lung tissues were harvested and RNAs were extracted for transcriptome sequencing; PMM-infiltrating immune cells were isolated for single-cell RNA-seq analysi...
Source: Acta Pharmacologica Sinica - March 28, 2024 Category: Drugs & Pharmacology Authors: Jia-Zheng Jiao Yang Zhang Wen-Juan Zhang Min-di He Meng Meng Tao Liu Qin-Long Ma Ya Xu Peng Gao Chun-Hai Chen Lei Zhang Hui-Feng Pi Ping Deng Yong-Zhong Wu Zhou Zhou Zheng-Ping Yu You-Cai Deng Yong-Hui Lu Source Type: research
ROCK1 inhibition improves wound healing in diabetes via RIPK4/AMPK pathway
Acta Pharmacol Sin. 2024 Mar 27. doi: 10.1038/s41401-024-01246-3. Online ahead of print.ABSTRACTRefractory wounds are a severe complication of diabetes mellitus that often leads to amputation because of the lack of effective treatments and therapeutic targets. The pathogenesis of refractory wounds is complex, involving many types of cells. Rho-associated protein kinase-1 (ROCK1) phosphorylates a series of substrates that trigger downstream signaling pathways, affecting multiple cellular processes, including cell migration, communication, and proliferation. The present study investigated the role of ROCK1 in diabetic wound ...
Source: Acta Pharmacologica Sinica - March 28, 2024 Category: Drugs & Pharmacology Authors: Tianru Huyan Lu Fan Zhong-Yuan Zheng Jing-Hui Zhao Zhen-Ru Han Pin Wu Qun Ma Ya-Qin Du Yun-di Shi Chun-Yan Gu Xue-Jun Li Wen-Hui Wang Long Zhang Lu Tie Source Type: research
The marine-derived compound TAG alleviates Parkinson's disease by restoring RUBCN-mediated lipid metabolism homeostasis
In this study, tetrahydroauroglaucin (TAG), a polyketide isolated from a marine sponge, was found to have notable neuroprotective effects on MPTP/MPP+-induced neurotoxicity. RNA sequencing analysis and metabolomics revealed that TAG significantly improved lipid metabolism disorder in PD models. Further investigation indicated that TAG markedly decreased the accumulation of lipid droplets (LDs), downregulated the expression of RUBCN, and promoted autophagic flux. Moreover, conditional knockdown of Rubcn notably attenuated PD-like symptoms and the accumulation of LDs, accompanied by blockade of the neuroprotective effect of ...
Source: Acta Pharmacologica Sinica - March 28, 2024 Category: Drugs & Pharmacology Authors: Pei Yang Yang Liu Zhi-Wu Tong Qian-Hui Huang Xia-Hong Xie Shi-Yu Mao Jian-Hua Ding Ming Lu Ren-Xiang Tan Gang Hu Source Type: research
Radiofrequency radiation reshapes tumor immune microenvironment into antitumor phenotype in pulmonary metastatic melanoma by inducing active transformation of tumor-infiltrating CD8 < sup > + < /sup > T and NK cells
In this study we investigated the effects of noninvasive radiofrequency radiation (RFR) exposure on tumor progression and TIME phenotype, as well as the antitumor potential of PD-1 blockage in a model of pulmonary metastatic melanoma (PMM). Mouse model of PMM was established by tail vein injection of B16F10 cells. From day 3 after injection, the mice were exposed to RFR at an average specific absorption rate of 9.7 W/kg for 1 h per day for 14 days. After RFR exposure, lung tissues were harvested and RNAs were extracted for transcriptome sequencing; PMM-infiltrating immune cells were isolated for single-cell RNA-seq analysi...
Source: Acta Pharmacologica Sinica - March 28, 2024 Category: Drugs & Pharmacology Authors: Jia-Zheng Jiao Yang Zhang Wen-Juan Zhang Min-di He Meng Meng Tao Liu Qin-Long Ma Ya Xu Peng Gao Chun-Hai Chen Lei Zhang Hui-Feng Pi Ping Deng Yong-Zhong Wu Zhou Zhou Zheng-Ping Yu You-Cai Deng Yong-Hui Lu Source Type: research
ROCK1 inhibition improves wound healing in diabetes via RIPK4/AMPK pathway
Acta Pharmacol Sin. 2024 Mar 27. doi: 10.1038/s41401-024-01246-3. Online ahead of print.ABSTRACTRefractory wounds are a severe complication of diabetes mellitus that often leads to amputation because of the lack of effective treatments and therapeutic targets. The pathogenesis of refractory wounds is complex, involving many types of cells. Rho-associated protein kinase-1 (ROCK1) phosphorylates a series of substrates that trigger downstream signaling pathways, affecting multiple cellular processes, including cell migration, communication, and proliferation. The present study investigated the role of ROCK1 in diabetic wound ...
Source: Acta Pharmacologica Sinica - March 28, 2024 Category: Drugs & Pharmacology Authors: Tianru Huyan Lu Fan Zhong-Yuan Zheng Jing-Hui Zhao Zhen-Ru Han Pin Wu Qun Ma Ya-Qin Du Yun-di Shi Chun-Yan Gu Xue-Jun Li Wen-Hui Wang Long Zhang Lu Tie Source Type: research
The marine-derived compound TAG alleviates Parkinson's disease by restoring RUBCN-mediated lipid metabolism homeostasis
In this study, tetrahydroauroglaucin (TAG), a polyketide isolated from a marine sponge, was found to have notable neuroprotective effects on MPTP/MPP+-induced neurotoxicity. RNA sequencing analysis and metabolomics revealed that TAG significantly improved lipid metabolism disorder in PD models. Further investigation indicated that TAG markedly decreased the accumulation of lipid droplets (LDs), downregulated the expression of RUBCN, and promoted autophagic flux. Moreover, conditional knockdown of Rubcn notably attenuated PD-like symptoms and the accumulation of LDs, accompanied by blockade of the neuroprotective effect of ...
Source: Acta Pharmacologica Sinica - March 28, 2024 Category: Drugs & Pharmacology Authors: Pei Yang Yang Liu Zhi-Wu Tong Qian-Hui Huang Xia-Hong Xie Shi-Yu Mao Jian-Hua Ding Ming Lu Ren-Xiang Tan Gang Hu Source Type: research
Radiofrequency radiation reshapes tumor immune microenvironment into antitumor phenotype in pulmonary metastatic melanoma by inducing active transformation of tumor-infiltrating CD8 < sup > + < /sup > T and NK cells
In this study we investigated the effects of noninvasive radiofrequency radiation (RFR) exposure on tumor progression and TIME phenotype, as well as the antitumor potential of PD-1 blockage in a model of pulmonary metastatic melanoma (PMM). Mouse model of PMM was established by tail vein injection of B16F10 cells. From day 3 after injection, the mice were exposed to RFR at an average specific absorption rate of 9.7 W/kg for 1 h per day for 14 days. After RFR exposure, lung tissues were harvested and RNAs were extracted for transcriptome sequencing; PMM-infiltrating immune cells were isolated for single-cell RNA-seq analysi...
Source: Acta Pharmacologica Sinica - March 28, 2024 Category: Drugs & Pharmacology Authors: Jia-Zheng Jiao Yang Zhang Wen-Juan Zhang Min-di He Meng Meng Tao Liu Qin-Long Ma Ya Xu Peng Gao Chun-Hai Chen Lei Zhang Hui-Feng Pi Ping Deng Yong-Zhong Wu Zhou Zhou Zheng-Ping Yu You-Cai Deng Yong-Hui Lu Source Type: research
