Sigma-1 receptor activation mediates the sustained antidepressant effect of ketamine in mice via increasing BDNF levels
Acta Pharmacologica Sinica, Published online: 14 December 2023; doi:10.1038/s41401-023-01201-8Sigma-1 receptor activation mediates the sustained antidepressant effect of ketamine in mice via increasing BDNF levels (Source: Acta Pharmacologica Sinica)
Source: Acta Pharmacologica Sinica - December 14, 2023 Category: Drugs & Pharmacology Authors: Hui Ma Jin-feng Li Xin Qiao Yue Zhang Xiao-juan Hou Hai-xia Chang Hong-lei Chen Yong Zhang Yun-feng Li Source Type: research

Zonisamide attenuates pressure overload-induced myocardial hypertrophy in mice through proteasome inhibition
Acta Pharmacologica Sinica, Published online: 14 December 2023; doi:10.1038/s41401-023-01191-7Zonisamide attenuates pressure overload-induced myocardial hypertrophy in mice through proteasome inhibition (Source: Acta Pharmacologica Sinica)
Source: Acta Pharmacologica Sinica - December 14, 2023 Category: Drugs & Pharmacology Authors: Qian Wu Wan-jie Liu Xin-yu Ma Ji-shuo Chang Xiao-ya Zhao Ying-hua Liu Xi-yong Yu Source Type: research

Autoimmune diseases: targets, biology, and drug discovery
Acta Pharmacologica Sinica, Published online: 14 December 2023; doi:10.1038/s41401-023-01207-2Autoimmune diseases: targets, biology, and drug discovery (Source: Acta Pharmacologica Sinica)
Source: Acta Pharmacologica Sinica - December 14, 2023 Category: Drugs & Pharmacology Authors: Shu-jie Li Yan-li Wu Juan-hua Chen Shi-yi Shen Jia Duan H. Eric Xu Source Type: research

Chemokine CCL2 promotes cardiac regeneration and repair in myocardial infarction mice via activation of the JNK/STAT3 axis
In conclusion, this study suggests that CCL2 promotes cardiac regeneration via activation of STAT3 signaling, underscoring its potential as a therapeutic agent for managing MI and associated heart failure.PMID:38086898 | DOI:10.1038/s41401-023-01198-0 (Source: Acta Pharmacologica Sinica)
Source: Acta Pharmacologica Sinica - December 12, 2023 Category: Drugs & Pharmacology Authors: Wei Wang Xiao-Kang Chen Lu Zhou Feng Wang Yan-Ji He Bing-Jun Lu Ze-Gang Hu Zhu-Xin Li Xue-Wei Xia Wei Eric Wang Chun-Yu Zeng Liang-Peng Li Source Type: research

Chemokine CCL2 promotes cardiac regeneration and repair in myocardial infarction mice via activation of the JNK/STAT3 axis
In conclusion, this study suggests that CCL2 promotes cardiac regeneration via activation of STAT3 signaling, underscoring its potential as a therapeutic agent for managing MI and associated heart failure.PMID:38086898 | DOI:10.1038/s41401-023-01198-0 (Source: Acta Pharmacologica Sinica)
Source: Acta Pharmacologica Sinica - December 12, 2023 Category: Drugs & Pharmacology Authors: Wei Wang Xiao-Kang Chen Lu Zhou Feng Wang Yan-Ji He Bing-Jun Lu Ze-Gang Hu Zhu-Xin Li Xue-Wei Xia Wei Eric Wang Chun-Yu Zeng Liang-Peng Li Source Type: research

Chemokine CCL2 promotes cardiac regeneration and repair in myocardial infarction mice via activation of the JNK/STAT3 axis
In conclusion, this study suggests that CCL2 promotes cardiac regeneration via activation of STAT3 signaling, underscoring its potential as a therapeutic agent for managing MI and associated heart failure.PMID:38086898 | DOI:10.1038/s41401-023-01198-0 (Source: Acta Pharmacologica Sinica)
Source: Acta Pharmacologica Sinica - December 12, 2023 Category: Drugs & Pharmacology Authors: Wei Wang Xiao-Kang Chen Lu Zhou Feng Wang Yan-Ji He Bing-Jun Lu Ze-Gang Hu Zhu-Xin Li Xue-Wei Xia Wei Eric Wang Chun-Yu Zeng Liang-Peng Li Source Type: research

Chemokine CCL2 promotes cardiac regeneration and repair in myocardial infarction mice via activation of the JNK/STAT3 axis
Acta Pharmacologica Sinica, Published online: 12 December 2023; doi:10.1038/s41401-023-01198-0Chemokine CCL2 promotes cardiac regeneration and repair in myocardial infarction mice via activation of the JNK/STAT3 axis (Source: Acta Pharmacologica Sinica)
Source: Acta Pharmacologica Sinica - December 12, 2023 Category: Drugs & Pharmacology Authors: Wei Wang Xiao-kang Chen Lu Zhou Feng Wang Yan-ji He Bing-jun Lu Ze-gang Hu Zhu-xin Li Xue-wei Xia Wei Eric Wang Chun-yu Zeng Liang-peng Li Source Type: research

Lonicerin promotes wound healing in diabetic rats by enhancing blood vessel regeneration through Sirt1-mediated autophagy
This study highlights the potential of LCR as a therapeutic agent for the treatment of diabetic wounds and provides insights into the molecular mechanisms underlying its effects.PMID:38066346 | DOI:10.1038/s41401-023-01193-5 (Source: Acta Pharmacologica Sinica)
Source: Acta Pharmacologica Sinica - December 8, 2023 Category: Drugs & Pharmacology Authors: Zhen Lin Lu-Yao Li Lu Chen Chen Jin Yue Li Lan Yang Chang-Zhou Li Cai-Yu Qi Yu-Yang Gan Jia-Rui Zhang Piao Wang Li-Bin Ni Gao-Feng Wang Source Type: research

Lonicerin promotes wound healing in diabetic rats by enhancing blood vessel regeneration through Sirt1-mediated autophagy
This study highlights the potential of LCR as a therapeutic agent for the treatment of diabetic wounds and provides insights into the molecular mechanisms underlying its effects.PMID:38066346 | DOI:10.1038/s41401-023-01193-5 (Source: Acta Pharmacologica Sinica)
Source: Acta Pharmacologica Sinica - December 8, 2023 Category: Drugs & Pharmacology Authors: Zhen Lin Lu-Yao Li Lu Chen Chen Jin Yue Li Lan Yang Chang-Zhou Li Cai-Yu Qi Yu-Yang Gan Jia-Rui Zhang Piao Wang Li-Bin Ni Gao-Feng Wang Source Type: research

Lonicerin promotes wound healing in diabetic rats by enhancing blood vessel regeneration through Sirt1-mediated autophagy
This study highlights the potential of LCR as a therapeutic agent for the treatment of diabetic wounds and provides insights into the molecular mechanisms underlying its effects.PMID:38066346 | DOI:10.1038/s41401-023-01193-5 (Source: Acta Pharmacologica Sinica)
Source: Acta Pharmacologica Sinica - December 8, 2023 Category: Drugs & Pharmacology Authors: Zhen Lin Lu-Yao Li Lu Chen Chen Jin Yue Li Lan Yang Chang-Zhou Li Cai-Yu Qi Yu-Yang Gan Jia-Rui Zhang Piao Wang Li-Bin Ni Gao-Feng Wang Source Type: research

Lonicerin promotes wound healing in diabetic rats by enhancing blood vessel regeneration through Sirt1-mediated autophagy
Acta Pharmacologica Sinica, Published online: 08 December 2023; doi:10.1038/s41401-023-01193-5Lonicerin promotes wound healing in diabetic rats by enhancing blood vessel regeneration through Sirt1-mediated autophagy (Source: Acta Pharmacologica Sinica)
Source: Acta Pharmacologica Sinica - December 8, 2023 Category: Drugs & Pharmacology Authors: Zhen Lin Lu-yao Li Lu Chen Chen Jin Yue Li Lan Yang Chang-zhou Li Cai-yu Qi Yu-yang Gan Jia-rui Zhang Piao Wang Li-bin Ni Gao-feng Wang Source Type: research

SMAD4 endows TGF- β1-induced highly invasive tumor cells with ferroptosis vulnerability in pancreatic cancer
This study provides new ideas for the treatment of PDAC, especially SMAD4-positive PDAC.PMID:38057506 | DOI:10.1038/s41401-023-01199-z (Source: Acta Pharmacologica Sinica)
Source: Acta Pharmacologica Sinica - December 6, 2023 Category: Drugs & Pharmacology Authors: Hai-di Chen Zeng Ye Hai-Feng Hu Gui-Xiong Fan Yu-Heng Hu Zheng Li Bo-Rui Li Shun-Rong Ji Chen-Jie Zhou Xiao-Wu Xu Xian-Jun Yu Yi Qin Source Type: research

SMAD4 endows TGF- β1-induced highly invasive tumor cells with ferroptosis vulnerability in pancreatic cancer
This study provides new ideas for the treatment of PDAC, especially SMAD4-positive PDAC.PMID:38057506 | DOI:10.1038/s41401-023-01199-z (Source: Acta Pharmacologica Sinica)
Source: Acta Pharmacologica Sinica - December 6, 2023 Category: Drugs & Pharmacology Authors: Hai-di Chen Zeng Ye Hai-Feng Hu Gui-Xiong Fan Yu-Heng Hu Zheng Li Bo-Rui Li Shun-Rong Ji Chen-Jie Zhou Xiao-Wu Xu Xian-Jun Yu Yi Qin Source Type: research

SMAD4 endows TGF- β1-induced highly invasive tumor cells with ferroptosis vulnerability in pancreatic cancer
This study provides new ideas for the treatment of PDAC, especially SMAD4-positive PDAC.PMID:38057506 | DOI:10.1038/s41401-023-01199-z (Source: Acta Pharmacologica Sinica)
Source: Acta Pharmacologica Sinica - December 6, 2023 Category: Drugs & Pharmacology Authors: Hai-di Chen Zeng Ye Hai-Feng Hu Gui-Xiong Fan Yu-Heng Hu Zheng Li Bo-Rui Li Shun-Rong Ji Chen-Jie Zhou Xiao-Wu Xu Xian-Jun Yu Yi Qin Source Type: research

SMAD4 endows TGF-β1-induced highly invasive tumor cells with ferroptosis vulnerability in pancreatic cancer
Acta Pharmacologica Sinica, Published online: 06 December 2023; doi:10.1038/s41401-023-01199-zSMAD4 endows TGF-β1-induced highly invasive tumor cells with ferroptosis vulnerability in pancreatic cancer (Source: Acta Pharmacologica Sinica)
Source: Acta Pharmacologica Sinica - December 6, 2023 Category: Drugs & Pharmacology Authors: Hai-di Chen Zeng Ye Hai-feng Hu Gui-xiong Fan Yu-heng Hu Zheng Li Bo-rui Li Shun-rong Ji Chen-jie Zhou Xiao-wu Xu Xian-jun Yu Yi Qin Source Type: research