OTUD1 promotes hypertensive kidney fibrosis and injury by deubiquitinating CDK9 in renal epithelial cells
Acta Pharmacologica Sinica, Published online: 18 December 2023; doi:10.1038/s41401-023-01192-6OTUD1 promotes hypertensive kidney fibrosis and injury by deubiquitinating CDK9 in renal epithelial cells (Source: Acta Pharmacologica Sinica)
Source: Acta Pharmacologica Sinica - December 18, 2023 Category: Drugs & Pharmacology Authors: Meng-yang Wang Tian-xiang Yu Qin-yan Wang Xue Han Xiang Hu Shi-ju Ye Xiao-hong Long Yi Wang Hong Zhu Wu Luo Guang Liang Source Type: research
Nucleic acid and protein methylation modification in renal diseases
Acta Pharmacol Sin. 2023 Dec 15. doi: 10.1038/s41401-023-01203-6. Online ahead of print.ABSTRACTAlthough great efforts have been made to elucidate the pathological mechanisms of renal diseases and potential prevention and treatment targets that would allow us to retard kidney disease progression, we still lack specific and effective management methods. Epigenetic mechanisms are able to alter gene expression without requiring DNA mutations. Accumulating evidence suggests the critical roles of epigenetic events and processes in a variety of renal diseases, involving functionally relevant alterations in DNA methylation, histo...
Source: Acta Pharmacologica Sinica - December 15, 2023 Category: Drugs & Pharmacology Authors: Juan Jin Xue-Mei Liu Wei Shao Xiao-Ming Meng Source Type: research
Nucleic acid and protein methylation modification in renal diseases
Acta Pharmacol Sin. 2023 Dec 15. doi: 10.1038/s41401-023-01203-6. Online ahead of print.ABSTRACTAlthough great efforts have been made to elucidate the pathological mechanisms of renal diseases and potential prevention and treatment targets that would allow us to retard kidney disease progression, we still lack specific and effective management methods. Epigenetic mechanisms are able to alter gene expression without requiring DNA mutations. Accumulating evidence suggests the critical roles of epigenetic events and processes in a variety of renal diseases, involving functionally relevant alterations in DNA methylation, histo...
Source: Acta Pharmacologica Sinica - December 15, 2023 Category: Drugs & Pharmacology Authors: Juan Jin Xue-Mei Liu Wei Shao Xiao-Ming Meng Source Type: research
Nucleic acid and protein methylation modification in renal diseases
Acta Pharmacol Sin. 2023 Dec 15. doi: 10.1038/s41401-023-01203-6. Online ahead of print.ABSTRACTAlthough great efforts have been made to elucidate the pathological mechanisms of renal diseases and potential prevention and treatment targets that would allow us to retard kidney disease progression, we still lack specific and effective management methods. Epigenetic mechanisms are able to alter gene expression without requiring DNA mutations. Accumulating evidence suggests the critical roles of epigenetic events and processes in a variety of renal diseases, involving functionally relevant alterations in DNA methylation, histo...
Source: Acta Pharmacologica Sinica - December 15, 2023 Category: Drugs & Pharmacology Authors: Juan Jin Xue-Mei Liu Wei Shao Xiao-Ming Meng Source Type: research
Nucleic acid and protein methylation modification in renal diseases
Acta Pharmacologica Sinica, Published online: 15 December 2023; doi:10.1038/s41401-023-01203-6Nucleic acid and protein methylation modification in renal diseases (Source: Acta Pharmacologica Sinica)
Source: Acta Pharmacologica Sinica - December 15, 2023 Category: Drugs & Pharmacology Authors: Juan Jin Xue-mei Liu Wei Shao Xiao-ming Meng Source Type: research
Sigma-1 receptor activation mediates the sustained antidepressant effect of ketamine in mice via increasing BDNF levels
In this study, we investigated whether the antidepressant action of ketamine was related to S1R activation. Depression state was evaluated in the tail suspension test (TST) and a chronic corticosterone (CORT) procedure was used to induce despair-like behavior in mice. The neuronal activities and structural changes of pyramidal neurons in medial prefrontal cortex (mPFC) were assessed using fiber-optic recording and immunofluorescence staining, respectively. We showed that pharmacological manipulation of S1R modulated ketamine-induced behavioral effect. Furthermore, pretreatment with an S1R antagonist BD1047 (3 mg·kg-1·d-1...
Source: Acta Pharmacologica Sinica - December 14, 2023 Category: Drugs & Pharmacology Authors: Hui Ma Jin-Feng Li Xin Qiao Yue Zhang Xiao-Juan Hou Hai-Xia Chang Hong-Lei Chen Yong Zhang Yun-Feng Li Source Type: research
Zonisamide attenuates pressure overload-induced myocardial hypertrophy in mice through proteasome inhibition
In this study, we investigated whether zonisamide prevented pressure overload-caused myocardial hypertrophy through suppressing proteasome. Pressure overload-caused myocardial hypertrophy was induced in mice by trans-aortic constriction (TAC) surgery. Two days after the surgery, the mice were administered zonisamide (10, 20, 40 mg·kg-1·d-1, i.g.) for four weeks. We showed that zonisamide administration significantly mitigated impaired cardiac function. Furthermore, zonisamide administration significantly inhibited proteasome activity as well as the expression levels of proteasome subunit beta types (PSMB) of the 20 S pro...
Source: Acta Pharmacologica Sinica - December 14, 2023 Category: Drugs & Pharmacology Authors: Qian Wu Wan-Jie Liu Xin-Yu Ma Ji-Shuo Chang Xiao-Ya Zhao Ying-Hua Liu Xi-Yong Yu Source Type: research
Autoimmune diseases: targets, biology, and drug discovery
Acta Pharmacol Sin. 2023 Dec 14. doi: 10.1038/s41401-023-01207-2. Online ahead of print.ABSTRACTAutoimmune diseases (AIDs) arise from a breakdown in immunological self-tolerance, wherein the adaptive immune system mistakenly attacks healthy cells, tissues and organs. AIDs impose excessive treatment costs and currently rely on non-specific and universal immunosuppression, which only offer symptomatic relief without addressing the underlying causes. AIDs are driven by autoantigens, targeting the autoantigens holds great promise in transforming the treatment of these diseases. To achieve this goal, a comprehensive understandi...
Source: Acta Pharmacologica Sinica - December 14, 2023 Category: Drugs & Pharmacology Authors: Shu-Jie Li Yan-Li Wu Juan-Hua Chen Shi-Yi Shen Jia Duan H Eric Xu Source Type: research
Sigma-1 receptor activation mediates the sustained antidepressant effect of ketamine in mice via increasing BDNF levels
In this study, we investigated whether the antidepressant action of ketamine was related to S1R activation. Depression state was evaluated in the tail suspension test (TST) and a chronic corticosterone (CORT) procedure was used to induce despair-like behavior in mice. The neuronal activities and structural changes of pyramidal neurons in medial prefrontal cortex (mPFC) were assessed using fiber-optic recording and immunofluorescence staining, respectively. We showed that pharmacological manipulation of S1R modulated ketamine-induced behavioral effect. Furthermore, pretreatment with an S1R antagonist BD1047 (3 mg·kg-1·d-1...
Source: Acta Pharmacologica Sinica - December 14, 2023 Category: Drugs & Pharmacology Authors: Hui Ma Jin-Feng Li Xin Qiao Yue Zhang Xiao-Juan Hou Hai-Xia Chang Hong-Lei Chen Yong Zhang Yun-Feng Li Source Type: research
Zonisamide attenuates pressure overload-induced myocardial hypertrophy in mice through proteasome inhibition
In this study, we investigated whether zonisamide prevented pressure overload-caused myocardial hypertrophy through suppressing proteasome. Pressure overload-caused myocardial hypertrophy was induced in mice by trans-aortic constriction (TAC) surgery. Two days after the surgery, the mice were administered zonisamide (10, 20, 40 mg·kg-1·d-1, i.g.) for four weeks. We showed that zonisamide administration significantly mitigated impaired cardiac function. Furthermore, zonisamide administration significantly inhibited proteasome activity as well as the expression levels of proteasome subunit beta types (PSMB) of the 20 S pro...
Source: Acta Pharmacologica Sinica - December 14, 2023 Category: Drugs & Pharmacology Authors: Qian Wu Wan-Jie Liu Xin-Yu Ma Ji-Shuo Chang Xiao-Ya Zhao Ying-Hua Liu Xi-Yong Yu Source Type: research
Autoimmune diseases: targets, biology, and drug discovery
Acta Pharmacol Sin. 2023 Dec 14. doi: 10.1038/s41401-023-01207-2. Online ahead of print.ABSTRACTAutoimmune diseases (AIDs) arise from a breakdown in immunological self-tolerance, wherein the adaptive immune system mistakenly attacks healthy cells, tissues and organs. AIDs impose excessive treatment costs and currently rely on non-specific and universal immunosuppression, which only offer symptomatic relief without addressing the underlying causes. AIDs are driven by autoantigens, targeting the autoantigens holds great promise in transforming the treatment of these diseases. To achieve this goal, a comprehensive understandi...
Source: Acta Pharmacologica Sinica - December 14, 2023 Category: Drugs & Pharmacology Authors: Shu-Jie Li Yan-Li Wu Juan-Hua Chen Shi-Yi Shen Jia Duan H Eric Xu Source Type: research
Sigma-1 receptor activation mediates the sustained antidepressant effect of ketamine in mice via increasing BDNF levels
Acta Pharmacologica Sinica, Published online: 14 December 2023; doi:10.1038/s41401-023-01201-8Sigma-1 receptor activation mediates the sustained antidepressant effect of ketamine in mice via increasing BDNF levels (Source: Acta Pharmacologica Sinica)
Source: Acta Pharmacologica Sinica - December 14, 2023 Category: Drugs & Pharmacology Authors: Hui Ma Jin-feng Li Xin Qiao Yue Zhang Xiao-juan Hou Hai-xia Chang Hong-lei Chen Yong Zhang Yun-feng Li Source Type: research
Zonisamide attenuates pressure overload-induced myocardial hypertrophy in mice through proteasome inhibition
Acta Pharmacologica Sinica, Published online: 14 December 2023; doi:10.1038/s41401-023-01191-7Zonisamide attenuates pressure overload-induced myocardial hypertrophy in mice through proteasome inhibition (Source: Acta Pharmacologica Sinica)
Source: Acta Pharmacologica Sinica - December 14, 2023 Category: Drugs & Pharmacology Authors: Qian Wu Wan-jie Liu Xin-yu Ma Ji-shuo Chang Xiao-ya Zhao Ying-hua Liu Xi-yong Yu Source Type: research
Autoimmune diseases: targets, biology, and drug discovery
Acta Pharmacologica Sinica, Published online: 14 December 2023; doi:10.1038/s41401-023-01207-2Autoimmune diseases: targets, biology, and drug discovery (Source: Acta Pharmacologica Sinica)
Source: Acta Pharmacologica Sinica - December 14, 2023 Category: Drugs & Pharmacology Authors: Shu-jie Li Yan-li Wu Juan-hua Chen Shi-yi Shen Jia Duan H. Eric Xu Source Type: research
Chemokine CCL2 promotes cardiac regeneration and repair in myocardial infarction mice via activation of the JNK/STAT3 axis
In conclusion, this study suggests that CCL2 promotes cardiac regeneration via activation of STAT3 signaling, underscoring its potential as a therapeutic agent for managing MI and associated heart failure.PMID:38086898 | DOI:10.1038/s41401-023-01198-0 (Source: Acta Pharmacologica Sinica)
Source: Acta Pharmacologica Sinica - December 12, 2023 Category: Drugs & Pharmacology Authors: Wei Wang Xiao-Kang Chen Lu Zhou Feng Wang Yan-Ji He Bing-Jun Lu Ze-Gang Hu Zhu-Xin Li Xue-Wei Xia Wei Eric Wang Chun-Yu Zeng Liang-Peng Li Source Type: research
