Notes from the Field: Cardiac Dysrhythmias After Loperamide Abuse — New York, 2008–2016
(Source: CDC Morbidity and Mortality Weekly Report)
Source: CDC Morbidity and Mortality Weekly Report - November 17, 2016 Category: American Health Source Type: news
Missing loperamide (Imodium) abuse can be a fatal mistake
3 out of 5 stars
Epidemiologic Trends in Loperamide Abuse and Misuse. Vakkalanka JP et al. Ann Emerg Med 2016 Nov 4 [Epub ahead of print]
Abstract
This paper reviews loperamide exposures reported to the National Poison Data System over the 6-year period from 2010 through 2015. Because of the well-recognized limitations involved in retrospective analysis of poison center data, there is not much clinically useful information revealed by their study. The authors did find — unsurprisingly — that reported exposures to loperamide went up from 2010 to 2015, increasing by 91%.
As we’ve discussed before, loperamide i...
Source: The Poison Review - November 15, 2016 Category: Toxicology Authors: Leon Gussow Tags: Medical cardiotoxicity fatality imodium loperamide overdose prolonged QT syndrome Source Type: news
Epidemiologic trends in loperamide abuse and misuse - Vakkalanka JP, Charlton NP, Holstege CP.
STUDY OBJECTIVE: Loperamide abuse has been increasing in the United States as a potential alternative to manage opioid withdrawal symptoms or to achieve euphoric effects of opioid use. In June 2016, the Food and Drug Administration warned health care provi... (Source: SafetyLit)
Source: SafetyLit - November 11, 2016 Category: Global & Universal Tags: Alcohol and Other Drugs Source Type: news
Imodium (Loperamide Hcl) - updated on RxList
(Source: RxList - New and Updated Drug Monographs)
Source: RxList - New and Updated Drug Monographs - October 18, 2016 Category: Drugs & Pharmacology Source Type: news
Loperamide-related deaths in North Carolina - Bishop-Freeman SC, Feaster MS, Beal J, Miller A, Hargrove RL, Brower JO, Winecker RE.
Loperamide (Imodium ®) has been accepted as a safe, effective, over-the-counter anti-diarrheal drug with low potential for abuse. It is a synthetic opioid that lacks central nervous system activity at prescribed doses, rendering it ineffective for abuse. S... (Source: SafetyLit)
Source: SafetyLit - August 7, 2016 Category: Global & Universal Tags: Alcohol and Other Drugs Source Type: news
Loperamide (Imodium) overdose can cause fatal cardiac toxicity
A recent paper described two fatalities associated with overdose of the anti-diarrhea drug loperamide (Imodium.) This drug, once available by prescription only, had been thought so safe that in 1988 it was approved for purchase over-the-counter. Here are some important questions regarding this medication:
Why is it sometimes called the “poor man’s methadone”?
Why, despite having typical opiate μ-receptor activity, does it generally not cause respiratory or mental status depression?
Why is P-glycoprotein (P-gp) important for understanding the pharmacokinetics of loperamide, and what does that have to do ...
Source: The Poison Review - July 4, 2016 Category: Toxicology Authors: Leon Gussow Tags: Medical cardiotoxicity imodium loperamide opiate P-glycoprotein Source Type: news
Toxicology Rounds: Opioid Abusers Using Loperamide to Get High or Alleviate Withdrawal, with Fatal Consequences
No abstract available (Source: Emergency Medicine News)
Source: Emergency Medicine News - July 1, 2016 Category: Emergency Medicine Tags: Toxicology Rounds Source Type: news
This month ’s toughest USMLE Step 2 question to master
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Getting ready for the United States Medical Licensing Examination ® (USMLE®) Step 2 is no easy feat, but we’re sharing expert insights to help give you a leg up. Take a look at the exclusive scoop on this month’s most-missed USMLE Step 2 test prep question. Think you have what it takes to rise above your peers? Test your USMLE knowledge, and view an expert v ideo explanation of the answer from Kaplan Medical. < /p > < p >
Once you ’ve got this question under your belt, be sure to test your knowledge with < a href= " http://www.ama-assn.org/ama/ama-wire/blog/USMLE_Prep/1 " target= " _self " > other post...
Source: AMA Wire - June 28, 2016 Category: Journals (General) Authors: Troy Parks Source Type: news
This month’s toughest USMLE Step 2 question to master
Getting ready for the United States Medical Licensing Examination® (USMLE®) Step 2 is no easy feat, but we’re sharing expert insights to help give you a leg up. Take a look at the exclusive scoop on this month’s most-missed USMLE Step 2 test prep question. Think you have what it takes to rise above your peers? Test your USMLE knowledge, and view an expert video explanation of the answer from Kaplan Medical.
Once you’ve got this question under your belt, be sure to test your knowledge with other posts in this series.
Ready. Set. Go.
This month’s question that stumped most students:
A 70-year-old woman pre...
Source: AMA Wire - June 28, 2016 Category: Journals (General) Authors: Troy Parks Source Type: news
La FDA advierte de problemas cardiacos graves con dosis altas del medicamento antidiarreico loperamida (Imodium), incluyendo por su consumo excesivo e indebido
La Administración de Alimentos y Medicamentos de los Estados Unidos (FDA, por sus siglas en inglés) advierte que tomar dosis más altas que las recomendadas del medicamento común de venta con o sin receta médica para la diarrea, loperamida (Imodium), incluso por un uso excesivo o indebido del producto, puede causar problemas cardiacos graves que pueden conducir a la muerte. (Source: FDA Center for Drug Evaluation and Research - What's New)
Source: FDA Center for Drug Evaluation and Research - What's New - June 14, 2016 Category: Drugs & Pharmacology Source Type: news
Why FDA is warning people about Imodium overdoses
Higher-than-recommended doses of the antidiarrheal medicine loperamide, sold under the brand name Imodium, can lead to serious heart problems and even death, the U.S. Food and Drug Administration warned this week. The warning applies to both over-the-counter and prescription strength medications, which are also sold under other generic names. (Source: CNN.com - Health)
Source: CNN.com - Health - June 9, 2016 Category: Consumer Health News Source Type: news
High Doses of Imodium Linked to Cardiac Problems and Death (FREE)
By Kelly Young
Edited by David G. Fairchild, MD, MPH, and Lorenzo Di Francesco, MD, FACP, FHM
The FDA is cautioning that higher-than-recommended doses of the antidiarrheal drug loperamide (Imodium) are associated with potentially fatal … (Source: Physician's First Watch current issue)
Source: Physician's First Watch current issue - June 7, 2016 Category: Primary Care Source Type: news
Abuse, Misuse of Antidiarrheal Linked to Serious Heart ProblemsAbuse, Misuse of Antidiarrheal Linked to Serious Heart Problems
Abuse and misuse of the commonly available antidiarrheal medication loperamide has been linked to life-threatening cardiac events, according to a warning issued by the US Food and Drug Administration. News Alerts (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - June 7, 2016 Category: Consumer Health News Tags: Psychiatry News Alert Source Type: news
FDA Warns of Heart Risk with Loperamide Overdose
(MedPage Today) -- Permanent and fatal arrhythmias tied to misuse of loperamide (Source: MedPage Today Public Health)
Source: MedPage Today Public Health - June 7, 2016 Category: American Health Source Type: news
FDA Warns of Heart Risk with Imodium
(MedPage Today) -- Permanent and fatal arrhythmias tied to misuse of loperamide (Source: MedPage Today Gastroenterology)
Source: MedPage Today Gastroenterology - June 7, 2016 Category: Gastroenterology Source Type: news
