Combination Immunotherapy in HPV Associated Malignancies and Other Solid Tumors
CCR Grand Rounds
Dr. Strauss received his M.D. from Stony Brook University Medical Center School of Medicine in 2010 and completed his internal medicine residency at Montefiore Medical Center in 2013. He joined the NCI Medical Oncology Service as a Medical Oncology Fellow in 2013. Dr. Strauss was the Co-Director o f the Clinical Trials Group of the Laboratory of Tumor Immunology and Biology, NCI. He is currently the Clinical Director of CIO Combination Immunotherapy Group. He is board certified in medical oncology and internal medicine. Dr. Strauss was part of the larger effort of the Laboratory of Tumor Immu nology and B...
Source: Videocast - All Events - November 17, 2022 Category: General Medicine Tags: Upcoming Events Source Type: video
NIH Director's Seminar Series: Development of targeted and immune-based therapies for urothelial carcinomas and rare genitourinary tumors
Dr. Apolo ’ s work has focused on the development of targeted therapies, with a focus on angiogenesis, MET inhibitors, and immunotherapies for the treatment of urothelial cancer and rare genitourinary tumors, and to further our understanding of the pathways driving these diseases. She has investigated the patterns of oncogenic tyrosine-kinase pathway-related alterations in bladder cancer for targeted therapy approaches and has demonstrated the innate and adaptive immunomodulatory properties of cabozantinib. From these mechanisms, she has conducted pioneering research into novel therapies for bladder, kidney, and rare gen...
Source: Videocast - All Events - September 26, 2022 Category: General Medicine Tags: Upcoming Events Source Type: video
Biomaterials for combination immunotherapy
Biomedical Engineering Scientific Interest Group(BMESIG) seminar series: Lecture by Dr.Natalie Artzi, Assistant Professor of Medicine, Brigham and Women ’ s Hospital, Harvard Medical School; Principal Research Scientist, MIT; Associate Member, Broad Institute of Harvard and MIT. The power of leveraging the patient ’ s own immune system to fight diseases is increasingly being recognized. This talk will explore medical technologies being developed that harness lessons from biomaterial development for drug delivery systems to those that will reprogram the immune system to generate robust and long-lasting curative outcomes...
Source: Videocast - All Events - October 27, 2021 Category: General Medicine Tags: Upcoming Events Source Type: video
Lasker Scholar lecture: Cell Therapy for Epithelial Cancers
Lasker Scholar lecture
Cell therapy is an emerging treatment modality that is highly effective in hematological cancers. Research by Dr. Hinrichs ’ s team has demonstrated the potential to extend cell therapy to the treatment of common epithelial cancers. Treatment of patients with human papillomavirus (HPV)-associated cancers with tumor-infiltrating lymphocytes showed durable, complete tumor responses, apparently curing some patients with metastatic cancer. A more “ off the shelf ” approach with peripheral blood T cells genetically engineered to target the HPV E7 antigen also demonstrated robust clinical activity wi...
Source: Videocast - All Events - April 19, 2021 Category: General Medicine Tags: Upcoming Events Source Type: video
Protective and Pathogenic B Cell Responses: COVID-19 and Autoimmunity
Dr. Sanz's research interest is in understanding how the immune system goes awry in autoimmune diseases and ends up attacking our own tissues rather than concentrating on fighting infections. In particular, he is very interested in understanding the roles played in autoimmune diseases by B cells and their effector progeny, the plasma cells responsible for producing the autoantibodies that in many cases cause the disease. His research concentrates on systemic lupus erythematosus, but he is also investigating other autoimmune diseases such as Sjogren's syndrome, rheumatoid arthritis and type 1 diabetes. His work also has app...
Source: Videocast - All Events - January 19, 2021 Category: General Medicine Tags: Upcoming Events Source Type: video
Immune Profiling to Understand COVID-19 Pathogenesis
Dr. Wherry ’ s research focuses on T cell exhaustion in chronic infections and cancer and on the mechanisms by which immunoregulatory “ checkpoint ” pathways, such as PD-1, control T cell exhaustion. His work has advanced our understanding of how gene expression changes affect this exhaustion, which has led to strategies to improve the effectiveness of T cell targeting immunotherapies.Air date: 11/5/2020 12:00:00 PM (Source: Videocast - All Events)
Source: Videocast - All Events - October 5, 2020 Category: General Medicine Tags: Upcoming Events Source Type: video
IIG Seminar - Immunological Mechanisms of Cancer Defense: Reining in Dynamic Cancer Cell and Microenvironment Reciprocity
IIG Seminar
The immune system employs two distinct defense strategies against infections: microbe-directed pathogen destruction typified by type 1 immunity, and host-directed pathogen containment exemplified by type 2 immunity in induction of tissue repair. Akin to infectious diseases, cancer progresses with cancer cell acquisition of microorganism-like behavior propagating at the expense of the host. While immunological mechanisms of cancer cell destruction are well defined, whether immune-mediated cancer cell containment can be induced is poorly understood. In this presentation, I will discuss how type 2 immunity can be ...
Source: Videocast - All Events - June 25, 2020 Category: General Medicine Tags: Upcoming Events Source Type: video
Immunological Mechanisms of Cancer Defense: Reining in Dynamic Cancer Cell and Microenvironment Reciprocity
IIG Seminar
The immune system employs two distinct defense strategies against infections: microbe-directed pathogen destruction typified by type 1 immunity, and host-directed pathogen containment exemplified by type 2 immunity in induction of tissue repair. Akin to infectious diseases, cancer progresses with cancer cell acquisition of microorganism-like behavior propagating at the expense of the host. While immunological mechanisms of cancer cell destruction are well defined, whether immune-mediated cancer cell containment can be induced is poorly understood. In this presentation, I will discuss how type 2 immunity can be ...
Source: Videocast - All Events - June 8, 2020 Category: General Medicine Tags: Upcoming Events Source Type: video
Cancer, Autoimmunity and Immunology 2020 (Day 2)
This event brings together clinicians from multiple disciplines and basic research scientists to discuss the latest findings on how autoimmunity impacts the latest approaches in immunotherapy to treat cancer. Clinical trials will be highlighted and the development of unexpected autoimmunity will be discussed in the context of the approaches that are being currently utilized for cancer therapy.Air date: 3/24/2020 8:00:00 AM (Source: Videocast - All Events)
Source: Videocast - All Events - February 24, 2020 Category: General Medicine Tags: Upcoming Events Source Type: video
Cancer, Autoimmunity and Immunology 2020 (Day 1)
This event brings together clinicians from multiple disciplines and basic research scientists to discuss the latest findings on how autoimmunity impacts the latest approaches in immunotherapy to treat cancer. Clinical trials will be highlighted and the development of unexpected autoimmunity will be discussed in the context of the approaches that are being currently utilized for cancer therapy.Air date: 3/23/2020 8:00:00 AM (Source: Videocast - All Events)
Source: Videocast - All Events - February 24, 2020 Category: General Medicine Tags: Upcoming Events Source Type: video
Rear Admiral (Upper Half) Richard W. Childs Flag Promotion Ceremony
The United States Public Health Service Flag Promotion ceremony for Rear Admiral (RADM) Richard W. Childs, promoted to RADM Upper Half O-8 in January 2020, is being webcast live on 3/27/2020 from Masur Auditorium. Richard Childs, MD serves as the Clinical Director of the National Heart, Lung, and Blood Institute (NHLBI) at the National Institutes of Health (NIH). He was commissioned in the USPHS Commissioned Corps as a Lieutenant in 1995 when joined the NCI as an Oncology Fellow. Following fellowship training, he was appointed a tenure-track investigator in the Hematology Branch of the NHLBI where he continues to conduct r...
Source: Videocast - All Events - February 24, 2020 Category: General Medicine Tags: Upcoming Events Source Type: video
Cellular Therapy Targeting Malignant Brain Tumors
CCR Grand Rounds
Duane A. Mitchell, M.D., Ph.D. is Co-Director of the Preston A. Wells Jr. Center for Brain Tumor Therapy and Director of the UF Brain Tumor Immunotherapy Program. He is the Phyllis Kottler Friedman Professor in the Department of Neurosurgery and the State of Florida Endowed Cancer Research Chair at the University of Florida College of Medicine.
Dr. Mitchell graduated from Rutgers College in New Brunswick, New Jersey with a bachelor ’ s degree in biology before receiving his medical degree and doctorate degree in immunology from Duke University in Durham, North Carolina in 2001. He completed post-graduate...
Source: Videocast - All Events - February 24, 2020 Category: General Medicine Tags: Upcoming Events Source Type: video
Demystifying Medicine - Encephalitis and the Immune System
Demystifying Medicine Lecture Series
Encephalitis, the inflammation of the brain, can be brought on by viral, bacterial and fungal infections, autoimmune diseases, and immunosuppression. Many diseases causing encephalitis are transmitted by mosquitos and ticks. As such, encephalitis is sadly pervasive, affecting more than 4 million people annually worldwide and causing upwards of 150,000 deaths. Symptoms range from mild headaches and nausea to debilitating seizures, hallucinations, and difficulty speaking and remembering.
The patient volunteers at the NIH Clinical Center, many of whom are immunocompromised, are at a height...
Source: Videocast - All Events - February 6, 2020 Category: General Medicine Tags: Upcoming Events Source Type: video
CC Grand Rounds: Immunotherapies for Progressive Multifocal Leukoencephalopathy
For more information go tohttps://www.cc.nih.gov/about/news/grcurrent.htmlAir date: 1/29/2020 12:00:00 PM (Source: Videocast - All Events)
Source: Videocast - All Events - December 20, 2019 Category: General Medicine Tags: Upcoming Events Source Type: video
Metabolic Barriers to Effective Cancer Immunotherapy
NCI ’ s Center for Cancer Research (CCR) Grand Rounds
Dr. Delgoffe is a tenured Associate Professor of Immunology at the University of Pittsburgh School of Medicine and the University of Pittsburgh Medical Center Hillman Cancer Center. Dr. Delgoffe graduated summa cum laude from Western Michigan University in 2004 before completing doctoral training at the Johns Hopkins School of Medicine in 2010. His Ph.D research, under the direction of Dr. Jonathan Powell, made seminal discoveries regarding the role of nutrient sensing in T cell function and fate, resulting in several first-author contributions in high impact journals...
Source: Videocast - All Events - December 2, 2019 Category: General Medicine Tags: Upcoming Events Source Type: video
