Anti-Beta-Amyloid Passive Immunotherapy for Alzheimer ’ s Dementia and Amyloid Related Imaging Abnormalities (ARIA): What ’ s Next? (Day 2)
This workshop brings together leading experts and researchers from around the world to discuss the latest advancements and challenges in the field of anti-beta amyloid passive immunotherapy. Goals of this workshop are to identify scientific gaps and opportunities, discuss potential animal models, learn how to identify patients at risk for serious adverse events, understand the role for comorbidities and their treatments, and identify potential biomarkers or targets to protect patients at risk.Air date: 9/29/2023 8:30:00 AM (Source: Videocast - All Events)
Source: Videocast - All Events - August 29, 2023 Category: General Medicine Tags: Upcoming Events Source Type: video
Anti-Beta-Amyloid Passive Immunotherapy for Alzheimer ’ s Dementia and Amyloid Related Imaging Abnormalities (ARIA): What ’ s Next? (Day 1)
This workshop brings together leading experts and researchers from around the world to discuss the latest advancements and challenges in the field of anti-beta amyloid passive immunotherapy. Goals of this workshop are to identify scientific gaps and opportunities, discuss potential animal models, learn how to identify patients at risk for serious adverse events, understand the role for comorbidities and their treatments, and identify potential biomarkers or targets to protect patients at risk.Air date: 9/28/2023 8:30:00 AM (Source: Videocast - All Events)
Source: Videocast - All Events - August 29, 2023 Category: General Medicine Tags: Upcoming Events Source Type: video
The dark side of DNA - how the immune system senses DNA as a danger signal
Zhijian “ James ” Chen ’ s research into complex cellular biochemistry has led to the discovery of pathways and proteins that trigger immune and stress responses. Chen has identified proteins, such as the mitochondrial protein MAVS, that are crucial to the body ’ s defense against RNA viruses such as influenza and Ebola. Now, Chen and his team are dissecting a signaling pathway involving a novel DNA sensor – cyclic GMP-AMP (cGAMP) synthase, or cGAS – which activates an interferon response that may play a role in immune defense against pathogens and malignant cells, as well as in autoimmune diseases such as lupu...
Source: Videocast - All Events - July 26, 2023 Category: General Medicine Tags: Upcoming Events Source Type: video
Sleuthing the Microbiome Reveals Undercover Agents of Oncogenesis
The annual Astute Clinician Lecture was established in 1998 through a gift from the late Dr. Robert W. Miller and his wife, Haruko. It honors U.S. scientists who have observed unusual clinical occurrences and, by investigating them, have opened an important new avenue of research. The lectureship exemplifies how astute clinical observations can lead to innovative research. Speakers are proposed by members of the Medical Executive Committee (MEC) with voting for the top three candidates. Selection from this slate of candidates is made by the NIH Director.
An expert in foodborne and intestinal infections, Cynthia Sears is ...
Source: Videocast - All Events - July 19, 2023 Category: General Medicine Tags: Upcoming Events Source Type: video
IIG Seminar - CD3z ITAMs mediate TCR ligand discrimination
Dr Guillaume Gaud is the IIG ’ s selected trainee for the 2022-2023 seminar series. Dr. Gaud completed his PhD in molecular oncology at the University of Tours before joining the laboratory of Dr. Saoudi at Inserm where he described the role of CD226 signaling in the amplification of CD4+ T-cell TCR signaling. As a Research Fellow in the laboratory of Paul Love at NICHD, Dr. Gaud has continued to research constituents of the TCR signaling complex. Dr. Gaud has recently demonstrated that T cells expressing TCRs containing inactivated (non-signaling) CD3z ITAMs (6F-CD3z) lose their ability to discriminate between low and h...
Source: Videocast - All Events - June 5, 2023 Category: General Medicine Tags: Upcoming Events Source Type: video
NIH/FDA IIG Seminar - Enfu Hui
Dr. Hui is an associate professor at UCSD, leading a research laboratory on investigating the mechanisms of immune checkpoints, using cell-free membrane reconstitution, time-resolved live cell microscopy and cutting-edge cell biology approaches. Dr. Hui ’ s laboratory recently uncovered two novel aspects of PD-L1/PD-1 signaling. Intracellularly, Dr. Hui and his group showed that the T cell costimulatory receptor CD28 is a primary target of PD-1 associated phosphatases. Extracellularly, they discovered that PD-L1, a key weapon of tumor cells, can be neutralized in cis by PD-1 expressed on the same cells. Dr. Hui continues...
Source: Videocast - All Events - April 4, 2023 Category: General Medicine Tags: Upcoming Events Source Type: video
NIH Director's Seminar Series: Developing novel immunotherapy strategies for HPV-associated respiratory papillomatosis
Recurrent respiratory papillomatosis (RRP) is a rare disorder that manifests as progressively growing aerodigestive tract papillomas that cause profound voice disturbance and airway obstruction. The disorder is caused by chronic infection with HPV type 6 or 11. One research interest of the Allen lab is to develop and study novel, rationally designed therapeutic approaches for RRP. In this lecture, Dr. Allen will highlight newly identified mechanisms of immune escape utilized by HPV6 or 11 to escape innate and adaptive immunity and discuss the results of prospective immunotherapy clinical trials conducted at the NIH Clinica...
Source: Videocast - All Events - March 7, 2023 Category: General Medicine Tags: Upcoming Events Source Type: video
Engineered biomaterials for lymph node drug delivery and disease modeling enable next-generation approaches in cancer immunotherapy
The advent of the cancer immunotherapy era has created wide-reaching new opportunities for drug delivery and biomaterial technologies to impact cancer therapy. Major barriers to the safer and more effective treatment of cancer using immunotherapy include achieving sufficient drug doses in target tissues at appropriate time scales as well as enabling drug synergies by co-delivery of combination therapies. More effective modeling of immunotherapy effects in disease-relevant preclinical models also represents a critical hurdle to the effective translation of newly developed therapies, that could likewise enable the developmen...
Source: Videocast - All Events - March 2, 2023 Category: General Medicine Tags: Upcoming Events Source Type: video
IIG Seminar - The tumor antigenic landscape associated with T cell infiltration and immunoediting.
The Bassani-Sternberg lab focuses on identifying clinically relevant cancer-specific Human Leukocyte Antigen (HLA) ligands that will guide the development of personalized cancer immunotherapy using mass-spectrometry (MS), currently the only methodology to identify unbiasedly HLA binding peptides that are presented in vivo to cytotoxic T cells. Her group has developed proteogenomics and MS-based immunopeptidomics analytical and computational approaches to identify HLA ligands derived from tumor-associated proteins, mutated neoantigens, non-canonical ORFs and post translationally modified peptides. In the clinic, the Bassani...
Source: Videocast - All Events - March 1, 2023 Category: General Medicine Tags: Upcoming Events Source Type: video
Clinical Center Grand Rounds: Regulatory B cells and Exosomes: Emerging Immunotherapies for Uveitis, Multiple Sclerosis and Graft-Versus-Host Disease
Charles E. Egwuagu, MPH, PhD, Chief, Molecular Immunology Section, Laboratory of Immunology National Eye Institute, NEIFor more information go tohttps://clinicalcenter.nih.gov/about/news/grcurrent.htmlAir date: 4/19/2023 12:00:00 PM (Source: Videocast - All Events)
Source: Videocast - All Events - February 24, 2023 Category: General Medicine Tags: Upcoming Events Source Type: video
INSPIRED Symposium: Insights in Pediatric CAR T-cell Immunotherapy: Recent Advances and Future Directions
With the primary goal to bring together the expanding pediatric and young adult CAR T-cell community, in addressing major clinical advances achieved over the last decade and outstanding gaps warranting further focus, we aim to reflect on the 10+ year experience of CAR T-cell delivery to pediatric and young adults with B-cell malignancies. Based on experience gained over this time, this conference will focus on highlighting current best practices, opportunities to address unmet needs, and areas where future research is needed or ongoing. Our primary goal for this conference is to allow for cross-fertilization and collaborat...
Source: Videocast - All Events - February 23, 2023 Category: General Medicine Tags: Upcoming Events Source Type: video
CCR Grand Rounds - Personalized Cellular Therapy for Cancer
CCR Grand Rounds
Antoni Ribas, M.D., Ph.D. is Professor of Medicine, Professor of Surgery, and Professor of Molecular and Medical Pharmacology at the University of California Los Angeles (UCLA), Director of the Tumor Immunology Program at the Jonsson Comprehensive Cancer Center (JCCC), Director of the Parker Inst itute for Cancer Immunotherapy (PICI) Center at UCLA. Dr Ribas is a physician-scientist who conducts laboratory and clinical research in malignant melanoma, focusing on gene engineered T cells, PD-1 blockade and BRAF targeted therapies.
His National Cancer Institute (NCI), State of California and fo undation-sup...
Source: Videocast - All Events - February 2, 2023 Category: General Medicine Tags: Upcoming Events Source Type: video
CCR Grand Rounds
“ Personalized Celular Therapy for Cancer ”
Antoni Ribas, M.D., Ph.D.
PROFESSOR OF MEDICINE WITH TENURE
PROFESSOR OF SURGERY
PROFESSOR OF MOLECULAR AND MEDICAL PHARMACOLOGY
UNIVERSITY OF CALIFORNIA LOS ANGELES (UCLA)
Friday, February 3, 2023
12:00 – 1:00 p.m.
Lipsett Amphitheater
(Masks required)
Also available to view via NIH Videocast.
Antoni Ribas, M.D., Ph.D. is Professor of Medicine, Professor of Surgery, and Professor of Molecular and Medical Pharmacology at the University of California Los Angeles (UCLA), Director of the Tumor Immunology Program at the Jonsson Com prehensive Cancer Center (JCCC), D...
Source: Videocast - All Events - January 24, 2023 Category: General Medicine Tags: Upcoming Events Source Type: video
Modeling Vaccine Responses and Tumor Immunity Using Lymph Nodes and Microfluidics
Predicting the response of the immune system to a new vaccine, immunotherapy, or infection remains a grand challenge of biomedical science. Current models of immunity largely rely
on in vivo animal studies that are difficult to control and analyze over time, or simple in vitro cultures that lack the spatial organization and cell-cell interactions of the body. Here, I will
share our laboratory ’ s development of technology to model immunity outside the body. By combining intact, live cultures of ex vivo lymph node tissue with microfluidic devices, we can
test the impact of localized drug delivery or the effect of cocul...
Source: Videocast - All Events - January 13, 2023 Category: General Medicine Tags: Upcoming Events Source Type: video
IIG Seminar - Tissue-Resident Memory T cells in cancer.
The Mami-Choua ï b laboratory has identified several constitutive elements of the tumor environment (TME) involved in the regulation of antitumor T-cell response. In particular: the influence of TGF- β on the expression and signaling of CD103 in CD8+ resident memory T cells (TRM), and the role of this integrin to sustain specific cytotoxicity and to promote T-cell recruitment within epithelial tumor regions; the role of hypoxia, epithelial-mesenchymal transition (EMT) and p53 in controlling tumor cell susceptibility to T-cell-mediated killing; and the effect of Von Hippel-Lindau (VHL) gene mutations in promoting PD-L1 ex...
Source: Videocast - All Events - January 9, 2023 Category: General Medicine Tags: Upcoming Events Source Type: video
