Mechanistic basis of cancer immunotherapy
NIH Director's Wednesday Afternoon Lecture Series
My group ’ s long interest in understanding the cellular mechanisms of the immune response has increasingly focused on the problem of cancer immunology and immunotherapy. We have now established an entire department devoted to this effort, and postdocs in my group seek to understand how checkpoint inhibitors (eg anti-PD-L1), vaccines, immune agonists and their combinations work to produce durable anti-cancer responses.For more information go tohttps://oir.nih.gov/wals/2017-2018/Air date: 4/18/2018 3:00:00 PM (Source: Videocast - All Events)
Source: Videocast - All Events - February 14, 2018 Category: General Medicine Tags: Upcoming Events Source Type: video
Autotherapies: Enhancing Our Innate Healing Capacity
Autotherapies are treatments based on the body ’ s natural ability to heal and protect itself. For example, immunotherapy harnesses the body ’ s immune cells to fight cancer and is now in clinical use. In the dental, oral, and craniofacial region, autotherapies could be used to selectively signal the body to repair and regenerate tissue, trigger immune responses, and restore a natural microbial balance. These strategies might also help to heal damaged or diseased tissues in other parts of the body, prevent or treat infections, fight cancer, treat autoimmune conditions, and enhance overall health.
Advancing the developm...
Source: Videocast - All Events - December 18, 2017 Category: General Medicine Tags: Upcoming Events Source Type: video
David L. Rimm, MD, PhD - The Present and the Future of Cancer Immunotherapy Biomarkers: Challenges, Opportunities, and Implications for Pathologists
The Present and the Future of Cancer Immunotherapy Biomarkers: Challenges, Opportunities, and Implications for Pathologists (Source: PeerView CME/CE Video Podcast - Oncology)
Source: PeerView CME/CE Video Podcast - Oncology - December 13, 2017 Category: Cancer & Oncology Authors: PVI, PeerView Institute for Medical Education Tags: Science, Medicine Source Type: video
T Cell-Based Immunotherapy Approaches for Gliomas
NCI's Center for Cancer Research (CCR) Grand Rounds
As a physician – scientist, Dr. Okada has been dedicated to brain tumor immunology and development of effective immunotherapy for brain tumor patients for over 20 years. His team was one of very first to discover cytotoxic T lymphocyte (CTL) epitopes in glioma-associated and glioma-specific antigens. Dr. Okada also found critical roles for the integrin receptor very late activation antigen (VLA)-4 and the chemokine CXCL10 in facilitating entry of CTLs to the brain tumor site. Dr. Okada has translated these discoveries into a number of innovative immunotherapy clinical s...
Source: Videocast - All Events - December 11, 2017 Category: General Medicine Tags: Upcoming Events Source Type: video
Robert L. Ferris, MD, PhD - Understanding the Impact of Immunotherapy on Head and Neck Cancer: A Look at the Science, Practice, and Future of Multimodal Treatment
Understanding the Impact of Immunotherapy on Head and Neck Cancer: A Look at the Science, Practice, and Future of Multimodal Treatment (Source: Peerview CME/CE Video Podcast - Internal Medicine International)
Source: Peerview CME/CE Video Podcast - Internal Medicine International - November 27, 2017 Category: Internal Medicine Authors: PVI, PeerView Institute for Medical Education Tags: Science, Medicine Source Type: video
Monocyte Heterogeneity: Implications for Cancer
Immunonology IG Seminar
Monocytes are key cells that drive the rapid innate immune response. We discovered that a subset of monocytes, nonclassical monocytes (CD14dim in humans and Ly6C- in mice), function in the vasculature to recognize metastasizing tumor cells. Once these cells recognize tumor cells, they orchestrate the killing of these cells to prevent metastasis. This presentation will discuss how nonclassical monocytes regulate tumor cell killing, and will discuss the possible use of nonclassical monocytes in cancer immunotherapy.Air date: 11/29/2017 4:15:00 PM (Source: Videocast - All Events)
Source: Videocast - All Events - November 20, 2017 Category: General Medicine Tags: Upcoming Events Source Type: video
2018 Demystifying Medicine: The New Frontier: Immunotherapy of cancer
The Demystifying Medicine Lecture Series is designed to help bridge the gap between advances in biology and their applications to major human diseases. The lectures include presentations of patients, pathology, diagnosis, and therapy in the context of major diseases and current research. All clinicians, trainees including fellows, medical students, Ph.D. students, and other healthcare and research professionals are welcome to attend.For more information go tohttps://demystifyingmedicine.od.nih.gov/Air date: 2/6/2018 4:00:00 PM (Source: Videocast - All Events)
Source: Videocast - All Events - November 2, 2017 Category: General Medicine Tags: Upcoming Events Source Type: video
The two faces of the IL-15- Janus Kinase-Stat system: implications for the immunotherapy of autoimmune diseases and cancer
NIH Director's Wednesday Afternoon Lecture Series
Dr. Walmann will present the annual William Paul lecture. Dr. Waldmann defined the IL-2 receptor alpha and beta subunits using the daclizumab antibody he discovered, an antibody that is approved by the FDA. He co-discovered IL-15 and performed the first in-human clinical trial with this agent in patients with malignancy. Furthermore, Waldmann defined molecular abnormalities of the common gamma cytokine, Jak/Stat signaling pathway in HTLV-1 associated adult T-cell lymphoma and translated this discovery with a trial of a Jak inhibitor in patients with this disorder.For more i...
Source: Videocast - All Events - October 26, 2017 Category: General Medicine Tags: Upcoming Events Source Type: video
The development and Function of Regulatory T cells
Immunology Interest Group Seminar Series
Dr. Chen ’ s research focuses on elucidating mechanisms of T-cell immunity and tolerance and manipulating T-cell immunity versus tolerance in animal models to understand the pathogenesis of and develop immunotherapy for autoimmunity, cancer and infectious diseases. Among his many scientific contributions to biomedical research, Dr. Chen is the first to discover that TGF-beta induces Foxp3 gene in naive CD4+ T cells and converts them into regulatory T cells (iTregs, pTregs). The paper describing this finding has been cited for more than 4000 times. He has also demonstrated that TGF...
Source: Videocast - All Events - September 25, 2017 Category: General Medicine Tags: Upcoming Events Source Type: video
Cancer Immunology and Immunotherapy: From Conception to Delivery (Day 2)
This two-day national symposium addresses recent advances in the field and should be an exciting forum for discussion and debate on the current understanding of cancer and immunology and immunotherapy.
Sessions will include:
-Fundamentals of CAR-based Therapies I& II-The Basis of Tumor Recognition-Checkpoint Modulators-Fundamental Biology of T Lymphocytes-Cancer Vaccines and Their ContextFor more information go tohttps://ncifrederick.cancer.gov/events/CancerImmunology2017/default.aspAir date: 10/13/2017 8:30:00 AM (Source: Videocast - All Events)
Source: Videocast - All Events - August 9, 2017 Category: General Medicine Tags: Upcoming Events Source Type: video
Cancer Immunology and Immunotherapy: From Conception to Delivery (Day 1)
This two-day national symposium addresses recent advances in the field and should be an exciting forum for discussion and debate on the current understanding of cancer and immunology and immunotherapy.
Sessions will include:
-Fundamentals of CAR-based Therapies I& II-The Basis of Tumor Recognition-Checkpoint Modulators-Fundamental Biology of T Lymphocytes-Cancer Vaccines and Their ContextFor more information go tohttps://ncifrederick.cancer.gov/events/CancerImmunology2017/default.aspAir date: 10/12/2017 8:30:00 AM (Source: Videocast - All Events)
Source: Videocast - All Events - August 9, 2017 Category: General Medicine Tags: Upcoming Events Source Type: video
NCI Center for Strategic Scientific Initiatives (CCSI) Science Day 2017
Since 2013, the NCI Center for Strategic Scientific Initiatives (CSSI) has hosted Science Day meetings to convene extramural investigators and NIH/NCI program staff with the goal of facilitating scientific conversations and identifying needs and opportunities across cancer research. The 2017 meeting is focused on cancer technology needs over the next 5-10 years and is aligned with three thematic areas: health data and computation, prevention and early detection, and immunotherapy. The meeting is supported by the CSSI Office of the Director, Office of Cancer Nanotechnology Research, Office of Cancer Clinical Proteomics Rese...
Source: Videocast - All Events - June 12, 2017 Category: General Medicine Tags: Upcoming Events Source Type: video
Michael J. Overman, MD - Interdisciplinary Approaches to Personalizing Immunotherapy in Metastatic CRC Using Advances in Molecular Markers
Interdisciplinary Approaches to Personalizing Immunotherapy in Metastatic CRC Using Advances in Molecular Markers (Source: PeerView CME/CE Video Podcast - Oncology)
Source: PeerView CME/CE Video Podcast - Oncology - June 9, 2017 Category: Cancer & Oncology Authors: PVI, PeerView Institute for Medical Education Tags: Science, Medicine Source Type: video
Naiyer Rizvi, MD - New Concepts in Immunotherapy for Solid Tumors: Novel Immune Approaches, Biomarkers, & Immune-Based Combinations
New Concepts in Immunotherapy for Solid Tumors: Novel Immune Approaches, Biomarkers, & Immune-Based Combinations (Source: Peerview CME/CE Video Podcast - Internal Medicine International)
Source: Peerview CME/CE Video Podcast - Internal Medicine International - June 2, 2017 Category: Internal Medicine Authors: PVI, PeerView Institute for Medical Education Tags: Science, Medicine Source Type: video
The Abscopal Effect: Optimal Radiation Dose and Fractionation
NCI ’ s Center for Cancer Research (CCR) Grand Rounds
Dr. Formenti is the Chair of Radiation Oncology at Weill Cornell Medical College and the Associate Director of the Cancer Center. Trained as a medical and radiation oncologist she devoted her career to translate novel preclinical information to the clinic. Key to her formation was a year spent in Malcolm Mitchell ’ s laboratory at USC, in cancer immunology. Her initial research on how to best combine radiation and systemic therapy, both pre-clinically and clinically evolved on focusing on the systemic effects of radiotherapy, particularly on the immune system. Her l...
Source: Videocast - All Events - May 15, 2017 Category: General Medicine Tags: Upcoming Events Source Type: video
