The importance of adjuvant treatment and primary anatomical site in head and neck basaloid squamous cell carcinoma survival: an analysis of the National Cancer Database
ConclusionThis study illustrated that tumors in the oropharynx, lower age, adjuvant chemoradiation and radiation, and microscopic margins were associated with greater survival. (Source: Clinical and Translational Oncology)
Source: Clinical and Translational Oncology - October 21, 2020 Category: Cancer & Oncology Source Type: research

Comparison of Quality of Life among Patients with Oro-Hypopharyngeal Cancer after Tonsillectomy and Panscopy Using Transoral Robotic Surgery: A Pilot Study
Studies have shown lower treatment-related morbidity when using transoral robotic surgery (TORS) compared to conventional surgery. Patients investigated for oro- and hypopharyngeal cancer (T1, T2) were compared concerning quality of life (QoL) after tonsillectomy and TORS using validated QoL questionnaires: QLQ-C30 and QLQ-Hamp;N35. The patients treated with TORS showed a higher pain score and thus also a higher need for painkillers, whereas they had lower values on self-assessment of anxiety/depression using the Hospital Anxiety and Depression Scale score. The pre- and postoperative information given did not meet the expe...
Source: Case Reports in Oncology - October 21, 2020 Category: Cancer & Oncology Source Type: research

Common gene signatures and key pathways in hypopharyngeal and esophageal squamous cell carcinoma: Evidence from bioinformatic analysis
Conclusion: The common gene signatures and functional pathways identified in the study may contribute to understanding the molecular mechanisms involved in the carcinogenesis and progression of HSCC and ESCC, and provide potential diagnostic and therapeutic targets. (Source: Medicine)
Source: Medicine - October 16, 2020 Category: Internal Medicine Tags: Research Article: Systematic Review and Meta-Analysis Source Type: research

A 10-Year Study on Larynx Preservation Compared With Surgical Resection in Patients With Locally Advanced Laryngeal and Hypopharyngeal Cancers
ConclusionsThis is the largest sample size study on larynx preservation treatment for laryngeal and hypopharyngeal cancers in China. Our results indicated that larynx preservation treatments did not jeopardize the survival of patients with advanced resectable laryngeal or hypopharyngeal cancers. Efficacy assessment should be emphasized in induction chemotherapy. (Source: Frontiers in Oncology)
Source: Frontiers in Oncology - October 15, 2020 Category: Cancer & Oncology Source Type: research

Suppressing UVRAG Induces Radiosensitivity by Triggering Lysosomal Membrane Permeabilization in Hypopharyngeal Squamous Cell Carcinoma
(Source: OncoTargets and Therapy)
Source: OncoTargets and Therapy - October 12, 2020 Category: Cancer & Oncology Tags: OncoTargets and Therapy Source Type: research

Montgomery Salivary Bypass Tube in Head and Neck Cancer: The Experience of Our Otolaryngology Clinic.
CONCLUSION: According to our experience, the MSBT is an affordable, easy to apply and well-tolerated tool. Although it is generally used for PCF treatment, it can also be used intraoperatively for PCF and PES prevention. PMID: 33044843 [PubMed - as supplied by publisher] (Source: Ear, Nose and Throat Journal)
Source: Ear, Nose and Throat Journal - October 12, 2020 Category: ENT & OMF Authors: Minni A, Ralli M, Di Cianni S, Cialente F, Candelori F, Colizza A, Cambria F, de Vincentiis M Tags: Ear Nose Throat J Source Type: research

Machine learning-based FDG PET-CT radiomics for outcome prediction in larynx and hypopharynx squamous cell carcinoma
To determine whether machine learning-based radiomic feature analysis of baseline integrated 2-[18F]-fluoro-2-deoxy-d-glucose (FDG) positron-emission tomography (PET) computed tomography (CT) predicts disease progression in patients with locally advanced larynx and hypopharynx squamous cell carcinoma (SCC) receiving (chemo)radiotherapy. (Source: Clinical Radiology)
Source: Clinical Radiology - October 5, 2020 Category: Radiology Authors: J. Zhong, R. Frood, P. Brown, H. Nelstrop, R. Prestwich, G. McDermott, S. Currie, S. Vaidyanathan, A.F. Scarsbrook Source Type: research

RP11 ‑156L14.1 regulates SSR1 expression by competitively binding to miR‑548ao‑3p in hypopharyngeal squamous cell carcinoma.
RP11‑156L14.1 regulates SSR1 expression by competitively binding to miR‑548ao‑3p in hypopharyngeal squamous cell carcinoma. Oncol Rep. 2020 Nov;44(5):2080-2092 Authors: Yan J, Wang ZH, Yan Y, Luo HN, Ren XY, Li N, Zheng GX, Hou J Abstract Emerging studies have demonstrated that long non‑coding RNAs (lncRNAs) play essential roles in tumorigenesis. However, the role and function of lncRNAs in hypopharyngeal squamous cell carcinoma (HSCC) have not been completely elucidated. The present study explored the function of a novel lncRNA, RP11‑156L14.1, in HSCC. RP11‑156L14.1 was revealed to be high...
Source: Oncology Reports - October 3, 2020 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Analysis of vascular-associated factors and the prognosis of poorly differentiated hypopharyngeal carcinoma.
Authors: Guo W, Yin G, Liu H, Duan H, Huang Z Abstract The aim of the present study was to analyze the characteristics of angiogenic factors in patients with hypopharyngeal cancer, and to study the effects of these factors on induction chemotherapy, patient prognosis and survival. Data from 60 eligible patients with hypopharyngeal cancer that were treated between January 2012 and December 2016 were collected retrospectively. The differential expression of angiogenic factors in tumor and peritumoral tissues was analyzed retrospectively to assess the association between five differentially expressed genes, including ...
Source: Oncology Letters - October 1, 2020 Category: Cancer & Oncology Tags: Oncol Lett Source Type: research

First-Line Surgery Is Associated with Longer Overall Survival in Locoregionally Advanced Hypopharyngeal Cancer in the National Cancer Database
The objective of this study was to use the American College of Surgeons National Cancer Database to examine the association between primary treatment and overall survival among patients with locoregionally advanced hypopharyngeal cancer. (Source: Journal of the American College of Surgeons)
Source: Journal of the American College of Surgeons - September 30, 2020 Category: Surgery Authors: Colleen Gabrielle Hochfelder, Aileen P. McGinn, Vikas Mehta, Enrico Castellucci, Rafi Kabarriti, Thomas Julian Ow Tags: Otolaryngology Source Type: research

Inhibition of long non-coding RNA MALAT1 elevates microRNA-429 to suppress the progression of hypopharyngeal squamous cell carcinoma by reducing ZEB1
Publication date: Available online 25 September 2020Source: Life SciencesAuthor(s): Xiuling Liu, Weixia Zhao, Xuehai Wang (Source: Life Sciences)
Source: Life Sciences - September 30, 2020 Category: Biology Source Type: research

Phase I trial of Debio 1143, an antagonist of inhibitor of apoptosis proteins, combined with cisplatin-chemoradiotherapy in patients with locally advanced squamous cell carcinoma of the head & neck.
CONCLUSIONS: The RP2D of Debio 1143 is 200 mg/day for 14 days, q3w when combined with concomitant high-dose cisplatin chemoradiotherapy in LA-SCCHN. Debio 1143 addition to chemoradiotherapy was safe and manageable. Preliminary efficacy is encouraging and supports further development. PMID: 32994295 [PubMed - as supplied by publisher] (Source: Clinical Cancer Research)
Source: Clinical Cancer Research - September 28, 2020 Category: Cancer & Oncology Authors: Le Tourneau C, Tao Y, Gomez-Roca C, Cristina V, Borcoman E, Deutsch E, Bahleda R, Calugaru V, Modesto A, Rouits E, Gollmer K, Vuagniaux G, Crompton P, Zanna C, Szyldergemajn S, Delord JP, Bourhis J Tags: Clin Cancer Res Source Type: research

The Clinical Impacts of Pretreatment Peripheral Blood Ratio on Lymphocytes, Monocytes, and Neutrophils Among Patients with Laryngeal/Hypopharyngeal Cancer Treated by Chemoradiation/Radiation
(Source: Cancer Management and Research)
Source: Cancer Management and Research - September 24, 2020 Category: Cancer & Oncology Tags: Cancer Management and Research Source Type: research

MiR-338-3p inhibits cell migration and invasion in human hypopharyngeal cancer via downregulation of ADAM17
In conclusion, our results demonstrate for the first time that miR-338-3p targets ADAM17 and blocks the development of hypopharyngeal carcinoma involving the wnt/β-catenin signaling pathway, which may be a new target for clinical intervention in human cancer. (Source: Anti-Cancer Drugs)
Source: Anti-Cancer Drugs - September 18, 2020 Category: Cancer & Oncology Tags: Preclinical Reports Source Type: research

The temporal effects of topical NF- κB inhibition, in the in vivo prevention of bile-related oncogenic mRNA and miRNA phenotypes in murine hypopharyngeal mucosa: a preclinical model.
The temporal effects of topical NF-κB inhibition, in the in vivo prevention of bile-related oncogenic mRNA and miRNA phenotypes in murine hypopharyngeal mucosa: a preclinical model. Oncotarget. 2020 Sep 01;11(35):3303-3314 Authors: Vageli DP, Kasle D, Doukas SG, Doukas PG, Sasaki CT Abstract Supraesophageal bile reflux at strongly acidic pH can cause hypopharyngeal squamous cell cancer, through activation of the oncogenic NF-κB-related pathway. We hypothesize that topical pre- or post-application of pharmacologic NF-κB inhibitor, BAY 11-7082 (0.25 μmol), on murine (C57BL/6J) HM (tw...
Source: Oncotarget - September 18, 2020 Category: Cancer & Oncology Tags: Oncotarget Source Type: research

The Pattern of Cervical Lymph Node Metastasis and Risk Factors of Retropharyngeal Lymph Node Metastasis Based on Magnetic Resonance Imaging in Different Sites of Hypopharyngeal Carcinoma
(Source: Cancer Management and Research)
Source: Cancer Management and Research - September 17, 2020 Category: Cancer & Oncology Tags: Cancer Management and Research Source Type: research

Evaluation of the usefulness of upper gastrointestinal endoscopy and the Valsamouth Ⓡ by an otolaryngologist in patients with Hypopharyngeal cancer
The aim of this retrospective study is to evaluate the usefulness of upper gastrointestinal endoscopy and the Valsamouth Ⓡ by an otolaryngologist in patients with hypopharyngeal cancer to assess the risk. (Source: Auris, Nasus, Larynx)
Source: Auris, Nasus, Larynx - September 16, 2020 Category: ENT & OMF Authors: Hiroshi Hosono, Chikatoshi Katada, Koichi Kano, Akari Kimura, Shohei Tsutsumi, Syunsuke Miyamoto, Masaaki Ichinoe, Yasuaki Furue, Satoshi Tanabe, Wasaburo Koizumi, Taku Yamashita Tags: Original Article Source Type: research

The incidence of newly diagnosed secondary cancer; sub-analysis the prospective study of the second-look procedure for transoral surgery in patients with T1 and T2 head and neck cancer
ConclusionsEarly stages of laryngeal, oropharyngeal, and hypopharyngeal cancer had a risk of secondary cancer, especially hypopharyngeal cancer. Attention to the secondary cancer has to be paid during the follow-up period after controlling the early-stage disease. These findings highlight the need for awareness of the incidence of secondary cancer in cases of early-stage primary head and neck cancer. (Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - September 13, 2020 Category: Cancer & Oncology Source Type: research

Myosin light chain kinase is a potential target for hypopharyngeal cancer treatment
Publication date: November 2020Source: Biomedicine & Pharmacotherapy, Volume 131Author(s): Feng Cao, Le Zhu, Jing Zhang, Pawin Pongkorpsakol, Wei-Ting Kuo, Jerrold R. Turner, Qing Zhou, Yuan Wang, Feihu Chen, Yehai Liu, Li Zuo (Source: Biomedicine and Pharmacotherapy)
Source: Biomedicine and Pharmacotherapy - September 11, 2020 Category: Drugs & Pharmacology Source Type: research

Relationship between the Levels of mRNA Expression for Protein Phosphatase 1B and Proteins Involved in Cytoskeleton Remodeling in Squamous Cell Carcinoma of the Larynx and Hypopharynx
We analyzed the expression of genes encoding proteins involved in cytoskeleton remodeling (RND3, SNAI1, vimentin, cofilin, adenylate cyclase-associated protein 1, ezrin, and profilin) depending on the level of expression of protein phosphatase 1B (PPM1B) mRNA on the example of squamous cell carcinoma of the larynx and hypopharynx. Against the background of a high level ofPPM1B expression, a significantly high level of profilin expression was noted. Metastasis correlated with the level ofsnai1 expression, while relapse after combination treatment was negatively associated with the level of vimentin expression. The obtained ...
Source: Bulletin of Experimental Biology and Medicine - September 10, 2020 Category: Biology Source Type: research

Dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) for pretreatment prediction of neoadjuvant chemotherapy response in locally advanced hypopharyngeal cancer.
Conclusion:DCE-MRI especially pretreatment Ktrans can potentially predict the treatment response to neoadjuvant chemotherapy for hypopharyngeal cancer.Advances in knowledge:Few studies of DCE-MRI on hypopharyngeal cancer treated with chemoradiation reported. The results demonstrate that DCE-MRI especially pretreatment Ktrans may be more potential value in predicting the treatment response to neoadjuvant chemotherapy for hypopharyngeal cancer. PMID: 32915647 [PubMed - as supplied by publisher] (Source: The British Journal of Radiology)
Source: The British Journal of Radiology - September 10, 2020 Category: Radiology Authors: Guo W, Zhang Y, Luo D, Yuan H Tags: Br J Radiol Source Type: research

The investigation of salvage endoscopic laryngopharyngeal surgery after chemoradiotherapy.
Conclusions: If salvage ELPS is performed after radiation therapy, patients should be followed up on an outpatient basis to monitor the onset of subsequent cancers. Complications may become severe; therefore, postoperative management should be performed cautiously. In particular, vulnerable sites, such as the piriform sinus, may not be indicated for surgery. At this stage, the expectation is that patients need to be methodically selected. PMID: 32904634 [PubMed - as supplied by publisher] (Source: Videosurgery and Other Miniinvasive Techniques)
Source: Videosurgery and Other Miniinvasive Techniques - September 10, 2020 Category: Surgery Tags: Wideochir Inne Tech Maloinwazyjne Source Type: research

Dose-Response Model for Severe Late Laryngeal Toxicity after Stereotactic Body Radiation Therapy for Previously Irradiated Head and Neck Cancer
Prior studies have demonstrated elevated risk of late grade ≥3 toxicity following stereotactic body radiation therapy (SBRT) for re-irradiation of recurrent head and neck cancer (rHNC) affecting the larynx or hypopharynx. Laryngeal toxicity, which can manifest as dysphagia, aspiration, laryngeal edema, or laryngeal stenosis, is one of the most commonly rep orted toxicities after SBRT for rHNC. At this time, no validated dose-volume constraints for the larynx exist to guide SBRT treatment planning. (Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - September 10, 2020 Category: Radiology Authors: Diane Ling, John Vargo, Rachel Grimm, Brian Gebhardt, David Clump, Robert Ferris, James Ohr, Dwight Heron Source Type: research

Is There a Racial Disparity in the Prognosis of Hypopharyngeal Carcinoma? 25-Year Experience from a Tertiary Care Medical Center in The United States
Racial disparities exist in many cancers between African American and Caucasian patients in terms of incidence, stage of presentation and prognosis. Hypopharyngeal carcinoma is a rare malignancy which contributes to approximately 3 to 5% of head and neck carcinomas. The prevalence of racial disparities has not been evaluated well among patients with hypopharyngeal carcinoma due to the rare nature of the disease. (Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - September 10, 2020 Category: Radiology Authors: Toms Vengaloor Thomas, Teessa Perekattu Kuruvilla, Eldrin Bhanat, Mary Nittala, Srinivasan Vijayakumar Source Type: research

Treatment Outcomes for Advanced Stage Hypopharyngeal Cancer Treated without a GTV to CTV Expansion
Squamous cell carcinoma of the hypopharynx is associated with poor prognosis with high rates of local recurrence as well as nodal and submucosal spread. Consensus radiation treatment guidelines recommend a 0.5 cm expansion from GTV to CTV70. We have typically treated hypopharyngeal tumors without this specific expansion, however with generous high risk CTV60 volumes that surround all GTVs and overall treatment volumes are concordant with consensus guidelines. (Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - September 10, 2020 Category: Radiology Authors: Adam Burr, Paul Harari, Alex Griffith, Randall Kimple, Matthew Witek Source Type: research

Advanced – Stage Hypopharyngeal Carcinoma Management: 25 years of Single Institutional Experience
Hypopharyngeal carcinoma is a rare malignancy which contributes to approximately 3 to 5% of head and neck carcinomas. Majority of these patients (70 to 85%) present with advanced-stage disease (stage III& IV). Regarding the treatment options, definitive surgery or laryngeal preservation using chemoradiotherapy are considered the standard of care, but there is a continuing debate on the outcomes due to conflicting data. (Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - September 10, 2020 Category: Radiology Authors: Toms Vengaloor Thomas, Mary Nittala, Eldrin Bhanat, Teessa Perekattu Kuruvilla, Srinivasan Vijayakumar Source Type: research

Myosin light chain kinase is a potential target for hypopharyngeal cancer treatment.
In conclusion, MLCK is a novel prognostic marker and therapeutic target for hypopharyngeal cancer. By targeting MLCK, ATPR exhibits its potential application in the treatment of this type of cancer. PMID: 32920510 [PubMed - as supplied by publisher] (Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie)
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - September 9, 2020 Category: Drugs & Pharmacology Authors: Cao F, Zhu L, Zhang J, Pongkorpsakol P, Kuo WT, Turner JR, Zhou Q, Wang Y, Chen F, Liu Y, Zuo L Tags: Biomed Pharmacother Source Type: research

Impact of Magnetic Field on Dose Distribution in MR-Guided Radiotherapy of Head and Neck Cancer
ConclusionThe presence of a 1.5-T magnetic field had an apparent impact on the dose distribution, in particular, a significant increase in the skin dose. The plan quality of plan1.5T_reOpt was similar to that of the original plan0T when the same cost function was used. (Source: Frontiers in Oncology)
Source: Frontiers in Oncology - September 7, 2020 Category: Cancer & Oncology Source Type: research

Minocycline-induced black thyroid with black pigmentation of the thyroid cartilage, cricoid cartilage, and trachea found during reconstructive surgery for hypopharyngeal cancer
We present the case of a 72-year-old man diagnosed with T3N3bM0 stage IVB hypopharyngeal squamous cell carcinoma who had been taking minocycline for approximately 18 months as a treatment for prurigo chronica multiformis. Initial treatment consisted of total pharyngolaryngoesophagectomy, bilateral neck dissection, total thyroidectomy, pharyngeal reconstruction using a free jejunal autograft, and creation of a permanent tracheostoma. (Source: Auris, Nasus, Larynx)
Source: Auris, Nasus, Larynx - September 6, 2020 Category: ENT & OMF Authors: Takahito Kondo, Munehide Nakatsugawa, Yuji Hirai, Atsuo Takeda, Naiue Kikawada, Yusuke Aihara, Yuujin Chiba, Akira Okimura, Hiroshi Hirano, Yasuo Ogawa, Kiyoaki Tsukahara Source Type: research

Functional Outcomes and Complications After Salvage Total Laryngectomy for Residual, Recurrent, and Second Primary Squamous Cell Carcinoma of the Larynx and Hypopharynx: A Multicenter Retrospective Cohort Study
Background/Purpose: We analyzed complications and functional outcomes and aimed at identifying prognostic factors for functional outcomes and complications in patients who underwent salvage total laryngectomy (STL) for residual, recurrent, and second primary squamous cell carcinoma (SCC) of the larynx and hypopharynx after initial (chemo)radiation.Methods: Retrospective cohort study of patients who underwent STL in four major Belgian reference hospitals between 2002 and 2018. Prognostic factors for functional outcomes and complications were identified with uni- and multivariable analysis.Results: A total of 405 patients we...
Source: Frontiers in Oncology - September 1, 2020 Category: Cancer & Oncology Source Type: research

Cancers, Vol. 12, Pages 2478: Genotype of Null Polymorphisms in Genes GSTM1, GSTT1, CYP1A1, and CYP1A1*2A (rs4646903 T & gt;C)/CYP1A1*2C (rs1048943 A & gt;G) in Patients with Larynx Cancer in Southeast Spain
Conclusions: patients with larynx cancer present more gene GSTM1 and GSTT1 null polymorphisms, and CYP1A1 rs4646903 T>C polymorphisms. (Source: Cancers)
Source: Cancers - August 31, 2020 Category: Cancer & Oncology Authors: Mariano S ánchez-Siles Juan Pablo Pelegr ín-Hernández Diego Hellin-Meseguer Yolanda Guerrero-S ánchez Andr és Corno-Caparrós Juan Cabezas-Herrera Francisco Pastor-Quirante Jos é Alberto Fernández-Ruiz Alfonso Aliaga-S ánchez Mayra Lucero-Berdugo Tags: Article Source Type: research

TP53 and PTEN as driver mutations in Zenker's carcinoma —a clinical presentation
We report for the first time about the genetic examination of this rare entity. The revealed mutations show genetic similarities with HPV(‐)HNSCC which suggests that well‐known therapeutic strategies may be applicable for this disease (Source: Clinical Case Reports)
Source: Clinical Case Reports - August 31, 2020 Category: General Medicine Authors: Zsanett Noel, Sylvia Hoeller, Michel Bihl, Laurent Muller Tags: CASE REPORT Source Type: research

Carotid blowout —a rare but fatal complication of endoscopic submucosal dissection of superficial hypopharyngeal carcinoma after radiotherapy
Endoscopic submucosal dissection (ESD) has gained wide acceptance as a minimally invasive and curative surgery for superficial head and neck carcinoma. However, the safety of ESD for superficial pharyngeal carcinoma after radiotherapy has not been elucidated. Superficial hypopharyngeal carcinoma of the left pyriform sinus developed in a 76-year-old man who had undergone concurrent chemoradiotherapy for T2N2bM0 pyriform sinus carcinoma on the opposite side 12 months before. He underwent ESD without complications. (Source: Auris, Nasus, Larynx)
Source: Auris, Nasus, Larynx - August 30, 2020 Category: ENT & OMF Authors: Ryuichi Okabe, Yushi Ueki, Takeshi Takahashi, Ryusuke Shodo, Keisuke Yamazaki, Satoru Hashimoto, Arata Horii Source Type: research

Prediction of Results of Radiotherapy With Ku70 Expression and an Artificial Neural Network
Conclusion: We demonstrated a possibility to predict the radiotherapy treatment results in prostate and hypopharyngeal cancer using ANN in combination with Ku70 expression and clinical factors as inputs. (Source: In Vivo)
Source: In Vivo - August 30, 2020 Category: Research Authors: HASEGAWA, T., SOMEYA, M., HORI, M., TSUCHIYA, T., FUKUSHIMA, Y., MATSUMOTO, Y., SAKATA, K.-I. Tags: Clinical Studies Source Type: research

Prediction of Therapeutic Effects from One Course of TPF Chemotherapy for Advanced Hypopharyngeal Laryngeal Cancer
Conclusion: PFS rate in this study may have been improved by selecting surgical treatment for patients for whom chemoradiotherapy seemed less effective. One cycle of TPF in induction chemotherapy appeared effective for chemoselection. (Source: In Vivo)
Source: In Vivo - August 30, 2020 Category: Research Authors: MARUYAMA, R., OKAMOTO, I., SATO, H., KATSUBE, Y., KONDO, T., TSUKAHARA, K. Tags: Clinical Studies Source Type: research

Discovery and Validation of a CT-Based Radiomic Signature for Preoperative Prediction of Early Recurrence in Hypopharyngeal Carcinoma.
Conclusions: Using the radiomic signature, we developed a radiomic signature to preoperatively predict early recurrence in patients with HSCC, which may serve as a potential noninvasive tool to guide personalized treatment. PMID: 32851071 [PubMed - in process] (Source: Biomed Res)
Source: Biomed Res - August 29, 2020 Category: Research Authors: Li W, Wei D, Wushouer A, Cao S, Zhao T, Yu D, Lei D Tags: Biomed Res Int Source Type: research

Death unrelated to cancer and death from aspiration pneumonia after definitive radiotherapy for head and neck cancer
The incidence of hypopharyngeal and supraglottic cancer (HSC) is high in Japan and accounts for 27% of all head and neck cancers (HNCs) [1]. Hypopharyngeal and supraglottic cancers present similar characteristics including close proximity to each other and high rate of lymph node metastasis [2]. The main laryngeal preservation approach for HSC is radiotherapy (RT). Dysphagia in patients with HNC treated with RT is a serious late side effect [3 –9]. Severe dysphagia may lead to aspiration pneumonia [3–5], and nearly 25% of elderly patients may go on to develop aspiration pneumonia within 5 years after receiving ...
Source: Radiotherapy and Oncology - August 27, 2020 Category: Radiology Authors: Naoyuki Kanayama, Shinji Otozai, Tadashi Yoshii, Masayasu Toratani, Toshiki Ikawa, Kentaro Wada, Takero Hirata, Masahiro Morimoto, Koji Konishi, Kazuhiko Ogawa, Takashi Fujii, Teruki Teshima Tags: Original Article Source Type: research

Death unrelated to cancer and death from aspiration pneumonia after definitive radiotherapy for head and neck cancer.
This study aimed to retrospectively identify risk factors for death unrelated to cancer and death from aspiration pneumonia after definitive radiotherapy (RT) for HSC. MATERIALS AND METHODS: Overall, 391 patients who began definitive RT for HSC between 2006 and 2014 were identified from the Osaka International Cancer Institute electronic database. Among 391 patients, 33 had a history of surgery for esophageal cancer (EC) and 19 received simultaneous RT for synchronous EC. The cause of death was divided into 3 main categories: "cancer under study," "other malignancy," and "unrelated to cancer.&...
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - August 27, 2020 Category: Radiology Authors: Kanayama N, Otozai S, Yoshii T, Toratani M, Ikawa T, Wada K, Hirata T, Morimoto M, Konishi K, Ogawa K, Fujii T, Teshima T Tags: Radiother Oncol Source Type: research

Cancers, Vol. 12, Pages 2431: Lymphoepithelial Carcinoma of Larynx and Hypopharynx: A Rare Clinicopathological Entity
Conclusions: Lymphoepithelial carcinoma of the hypopharynx is an aggressive tumor with a strong predilection for regional and distant metastasis. Surgery, in combination with adjuvant therapy, provides promising results. Immunohistochemistry helps in differentiating LEC from other pathologies. (Source: Cancers)
Source: Cancers - August 26, 2020 Category: Cancer & Oncology Authors: Muhammad Faisal Sabrina Hartenbach Annemarie Schratter Wolfgang J. K östler Hannes Kaufmann Rudolf Seemann Claudia Lill Sasan Hamzavi Arno Wutzl Boban M. Erovic Tags: Review Source Type: research

Head and neck squamous cell carcinoma in cigar smokers. Distinctive epidemiological and prognostic characteristics.
CONCLUSIONS: A 2.4% of patients with HNSCC had a history of regular consumption of cigars. Disease-specific survival of cigar smokers was lower than that of other patients. PMID: 32861455 [PubMed - as supplied by publisher] (Source: Acta Otorrinolaringologica Espanola)
Source: Acta Otorrinolaringologica Espanola - August 25, 2020 Category: ENT & OMF Authors: León X, Pujals G, Bulboa C, García J, López M, Quer M Tags: Acta Otorrinolaringol Esp Source Type: research

The Efficacy of Low Postoperative Radiation Dose in Patients with Advanced Hypopharyngeal Cancer without High-Risk Factors
(Source: Cancer Management and Research)
Source: Cancer Management and Research - August 20, 2020 Category: Cancer & Oncology Tags: Cancer Management and Research Source Type: research

Design and application of submental island flap to reconstruct non-circumferential defect after hypopharyngeal carcinoma resection: a prospective study of 27 cases.
CONCLUSION: The submental flap reconstruction for moderately sized non-circumferential hypopharyngeal defects is a recommended treatment option. PMID: 32808843 [PubMed - as supplied by publisher] (Source: Acta Oto-Laryngologica)
Source: Acta Oto-Laryngologica - August 17, 2020 Category: ENT & OMF Authors: Pang W, Zhang A, Lu C, Tian J, Li WX, Wang Z, Dong Y, Yuan S, Niu Z, Zhu Y, Quraishi MS, Liu L Tags: Acta Otolaryngol Source Type: research

Preservation of Internal Branch of Superior Laryngeal Nerve during Surgery for Hypopharyngeal Cancer.
CONCLUSIONS: Our results showed that preservation of the ibSLN during surgery for HSCC is feasible and important in the recovery of sensation in the hypopharyngeal mucosa. PMID: 32804572 [PubMed - as supplied by publisher] (Source: Ear, Nose and Throat Journal)
Source: Ear, Nose and Throat Journal - August 16, 2020 Category: ENT & OMF Authors: Sun W, Wen WP, Zhu XL Tags: Ear Nose Throat J Source Type: research

Independent Validation of Tumor Budding Activity and Cell Nest Size as Determinants of Patient Outcome in Squamous Cell Carcinoma of the Uterine Cervix
In this study, we appraise this grading system in an institutional cohort of cervical SCC to assess its prognostic value in an independent dataset. Our study cohort consisted of 94 consecutive, surgically excised, neoadjuvant therapy-naive cases of SCC of the uterine cervix, stage pT1b or higher. Tumor budding activity and cell nest size were scored on each case, the sum of which formed the basis for assigning a grade in the 3-tiered grading system hereafter referred to as the “tumor budding/nest size” (TBNS) system. As individual variables, both high tumor budding and small nest size were each associated with ...
Source: The American Journal of Surgical Pathology - August 14, 2020 Category: Pathology Tags: Original Articles Source Type: research

Circumferential pharyngectomy in laryngectomised patient and pharyngeal reconstruction by tubed free flap
ConclusionSelected laryngectomised patients presenting with early stage hypopharyngeal metachronous tumours can benefit from a safe carcinologic resection and reconstruction. (Source: European Archives of Oto-Rhino-Laryngology)
Source: European Archives of Oto-Rhino-Laryngology - August 12, 2020 Category: ENT & OMF Source Type: research

Molecules, Vol. 25, Pages 3609: Involvement of Differentially Expressed microRNAs in the PEGylated Liposome Encapsulated 188Rhenium-Mediated Suppression of Orthotopic Hypopharyngeal Tumor
In this study, a theranostic 188Re-liposome was prepared to treat orthotopic HPC tumors and analyze the deregulated microRNA expressive profiles. The therapeutic efficacy of 188Re-liposome on HPC tumors was evaluated using bioluminescent imaging followed by next generation sequencing (NGS) analysis, in order to address the deregulated microRNAs and associated signaling pathways. The differentially expressed microRNAs were also confirmed using clinical HNSCC samples and clinical information from The Cancer Genome Atlas (TCGA) database. Repeated doses of 188Re-liposome were administrated to tumor-bearing mice, and the tumor ...
Source: Molecules - August 7, 2020 Category: Chemistry Authors: Bing-Ze Lin Shen-Ying Wan Min-Ying Lin Chih-Hsien Chang Ting-Wen Chen Muh-Hwa Yang Yi-Jang Lee Tags: Article Source Type: research

Pepsin and laryngeal and hypopharyngeal carcinomas.
Authors: Yin CY, Zhang SS, Zhong JT, Zhou SH Abstract Laryngeal and hypopharyngeal carcinomas are common malignant tumors of the head and neck, which are both exhibiting increasing incidences. Laryngopharyngeal reflux is the retrograde flow of gastric contents into the larynx, oropharynx, and/or nasopharynx. There remains controversy regarding whether laryngopharyngeal reflux is a risk factor for laryngeal and hypopharyngeal cancers. The refluxing substances mainly include hydrochloric acid, pepsin, and occasionally bile acids and bile salts, as well as bacteria that colonize the gastrointestinal tract. Loss of epi...
Source: Clinical and Experimental Otorhinolaryngology - August 1, 2020 Category: ENT & OMF Tags: Clin Exp Otorhinolaryngol Source Type: research

Clinical relevance of endoscopic treatment for superficial pharyngeal cancer: feasibility of techniques corresponding to each location and long-term outcomes
Superficial pharyngeal cancers are being detected and treated using endoscopy in many medical facilities with increasing frequency. However, those reports focus on the hypopharynx. We identified reliable treatments by adapting the method for each region of the pharynx. Here, we introduce our methods for treating various pharyngeal regions and show their long-term results. (Source: Gastrointestinal Endoscopy)
Source: Gastrointestinal Endoscopy - July 24, 2020 Category: Gastroenterology Authors: Toshiro Iizuka, Daisuke Kikuchi, Yugo Suzuki, Masami Tanaka, Hidehiko Takeda Source Type: research

Induction and Regulation of the Immunoproteasome Subunit β5i (PSMB8) in Laryngeal and Hypopharyngeal Carcinoma Cells.
CONCLUSIONS Ionizing radiation can significantly upregulate the mRNA and protein levels of PSMB8, which happens through the upregulation of its splicing isoform E2. The proto-oncogene c-Abl and its kinetic kinase protein product can regulate the transcription and protein expression levels of PSMB8 and its alternatively spliced isoforms. PMID: 32680979 [PubMed - as supplied by publisher] (Source: Medical Science Monitor)
Source: Medical Science Monitor - July 20, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Molecules, Vol. 25, Pages 3291: Royal Jelly —A Traditional and Natural Remedy for Postmenopausal Symptoms and Aging-Related Pathologies
Molecules, Vol. 25, Pages 3291: Royal Jelly—A Traditional and Natural Remedy for Postmenopausal Symptoms and Aging-Related Pathologies Molecules doi: 10.3390/molecules25143291 Authors: Andreea Bălan Marius Alexandru Moga Lorena Dima Sebastian Toma Andrea Elena Neculau Costin Vlad Anastasiu Women’s life stages are based on their reproductive cycle. This cycle begins with menstruation and ends with menopause. Aging is a natural phenomenon that affects all humans, and it is associated with a decrease in the overall function of the organism. In women, aging is related with and starts with...
Source: Molecules - July 19, 2020 Category: Chemistry Authors: Andreea B ălan Marius Alexandru Moga Lorena Dima Sebastian Toma Andrea Elena Neculau Costin Vlad Anastasiu Tags: Review Source Type: research