Clinical factors associated with severe surgical complications in patients with hypopharyngeal cancer: a single-center case-cohort study
CONCLUSIONS AND SIGNIFICANCE: T3/4 stage, RT, nonprimary closure, and DM were independent predisposing factors for severe surgical complications in our study population of hypopharyngeal cancer patients. Taking measures to lower the tumor stage and simplify the surgical procedure may be crucial in reducing the incidence of severe surgical complications among these patients.PMID:37982754 | DOI:10.1080/00016489.2023.2265981 (Source: Acta Oto-Laryngologica)
Source: Acta Oto-Laryngologica - November 20, 2023 Category: ENT & OMF Authors: Yun-He Liu Hui Huang Dan-Gui Yan Song Ni Shao-Yan Liu Source Type: research
Personalized neck irradiation guided by sentinel lymph node biopsy in patients with squamous cell carcinoma of the oropharynx, larynx or hypopharynx with a clinically negative neck: (Chemo)radiotherapy to the PRIMary tumor only. Protocol of the PRIMO study
DISCUSSION: If this trial demonstrates that the experimental treatment is non-inferior to the standard treatment in terms of regional recurrence and is superior in terms of xerostomia-related quality of life, this will become the new standard of care.PMID:37965060 | PMC:PMC10641572 | DOI:10.1016/j.ctro.2023.100696 (Source: Cancer Control)
Source: Cancer Control - November 15, 2023 Category: Cancer & Oncology Authors: S van den Bosch R P Takes M de Ridder R de Bree A Al-Mamgani W H Schreuder F J P Hoebers S van Weert J B W Elbers J A Hardillo T W H Meijer B E C Plaat M A de Jong J C Jansen D J Wellenstein G B van den Broek W V Vogel A I J Arens J H A M Kaanders Source Type: research
ESCO2 promotes hypopharyngeal carcinoma progression in a STAT1-dependent manner
The establishment of sister chromatid cohesion N-acetyltransferase 2 (ESCO2) is involved in the development of multiple malignancies. However, its role in hypopharyngeal carcinoma (HPC) progression remains unc... (Source: BMC Cancer)
Source: BMC Cancer - November 15, 2023 Category: Cancer & Oncology Authors: Juan Hu, Jing Yan, Yijie Chen, Xiaohui Li, Liu Yang, Haiyu Di, Huihui Zhang, Yewen Shi, Junjie Zhao, Yanxia Shi, Yinglong Xu, Xiaoyong Ren and Zhenghui Wang Tags: Research Source Type: research
Induction Toripalimab And Chemotherapy For Organ Preservation In Locally Advanced Laryngeal And Hypopharyngeal Cancer: A Single-Arm Phase 2 Clinical Trial
CONCLUSIONS: Induction toripalimab combined with chemotherapy provided encouraging activity, promising larynx preservation rate and acceptable toxicity in this cohort of extensively locally advanced laryngeal and hypopharyngeal cancer.PMID:37955629 | DOI:10.1158/1078-0432.CCR-23-2398 (Source: Clinical Cancer Research)
Source: Clinical Cancer Research - November 13, 2023 Category: Cancer & Oncology Authors: Xiaomin Ou Ruiping Zhai Wenjun Wei Jiaying Chen Dan Ou Tian Liao Tingting Xu Yongxue Zhu Yulong Wang Shenglin Huang Rongliang Shi Bin Wu Tongzhen Chen Yuan Li Zhongyi Yang Changming Zhou Yuan Liu Ziting Jiang Min Zeng Xin Liu Dongmei Ji Hongmei Ying Zhen Source Type: research
Season of radiotherapy and outcomes of head & neck cancer patients in the MACH-NC & MARCH meta-analyses
Head and neck squamous cell cancer (HNSCC) accounts for approximately 800,000 cases and 400,000 deaths annually worldwide [1]. The standard of care for locally-advanced disease for oral cavity, oropharynx, hypopharynx, and larynx subsites is a multimodality treatment with permutations of radiation therapy (RT), chemotherapy (CT), and surgery, in function of tumor localization. Treatment sequelae in these highly functional zones may significantly affect quality of life; and despite optimal treatment, mortality remains high. (Source: Radiotherapy and Oncology)
Source: Radiotherapy and Oncology - November 10, 2023 Category: Radiology Authors: Elaine LIMKIN, Pierre BLANCHARD, Benjamin LACAS, Jean BOURHIS, Mahesh PARMAR, Lisa LICITRA, Quynh-Thu LE, Sue YOM, Catherine FORTPIED, Johannes LANGENDIJK, Jan B VERMORKEN, Jacques BERNIER, Jens OVERGAARD, Jonathan HARRIS, Jean-Pierre PIGNON, Anne AUPERIN Tags: Original Article Source Type: research
lncRNA HOXC-AS2 promotes the progression of hypopharyngeal cancer by binding to the P62 protein mediating the autophagy process
In conclusion, our findings suggest that HOXC-AS2 regulates the progression of hypopharyngeal cancer by regulating autophagy and is abnormally highly expressed in hypopharyngeal cancer tissues. HOXC-AS2 may become a new target for the diagnosis and treatment of hypopharyngeal cancer.PMID:37944249 | DOI:10.18632/aging.205192 (Source: Aging)
Source: Aging - November 9, 2023 Category: Biomedical Science Authors: Yuandi Xiang Guoquan Huang Jie Wang Qingquan Hua Source Type: research
lncRNA HOXC-AS2 promotes the progression of hypopharyngeal cancer by binding to the P62 protein mediating the autophagy process
In conclusion, our findings suggest that HOXC-AS2 regulates the progression of hypopharyngeal cancer by regulating autophagy and is abnormally highly expressed in hypopharyngeal cancer tissues. HOXC-AS2 may become a new target for the diagnosis and treatment of hypopharyngeal cancer.PMID:37944249 | DOI:10.18632/aging.205192 (Source: Aging)
Source: Aging - November 9, 2023 Category: Biomedical Science Authors: Yuandi Xiang Guoquan Huang Jie Wang Qingquan Hua Source Type: research
lncRNA HOXC-AS2 promotes the progression of hypopharyngeal cancer by binding to the P62 protein mediating the autophagy process
In conclusion, our findings suggest that HOXC-AS2 regulates the progression of hypopharyngeal cancer by regulating autophagy and is abnormally highly expressed in hypopharyngeal cancer tissues. HOXC-AS2 may become a new target for the diagnosis and treatment of hypopharyngeal cancer.PMID:37944249 | DOI:10.18632/aging.205192 (Source: Aging)
Source: Aging - November 9, 2023 Category: Biomedical Science Authors: Yuandi Xiang Guoquan Huang Jie Wang Qingquan Hua Source Type: research
The Role of Open Conservation Surgery in the Era of Minimally Invasive Surgery for Hypopharyngeal Cancer
Conclusions: We found that pre-epiglottic space invasion negatively impacted disease control after open conservation surgery, emphasizing the crucial role played by a preoperative evaluation during patient selection.PMID:37893591 | DOI:10.3390/medicina59101873 (Source: Cancer Control)
Source: Cancer Control - October 28, 2023 Category: Cancer & Oncology Authors: Jooin Bang Oh-Hyeong Lee Geun-Jeon Kim Dong-Il Sun Sang-Yeon Kim Source Type: research
The Role of Open Conservation Surgery in the Era of Minimally Invasive Surgery for Hypopharyngeal Cancer
Conclusions: We found that pre-epiglottic space invasion negatively impacted disease control after open conservation surgery, emphasizing the crucial role played by a preoperative evaluation during patient selection.PMID:37893591 | DOI:10.3390/medicina59101873 (Source: Medicina (Kaunas))
Source: Medicina (Kaunas) - October 28, 2023 Category: Universities & Medical Training Authors: Jooin Bang Oh-Hyeong Lee Geun-Jeon Kim Dong-Il Sun Sang-Yeon Kim Source Type: research
The Role of Open Conservation Surgery in the Era of Minimally Invasive Surgery for Hypopharyngeal Cancer
Conclusions: We found that pre-epiglottic space invasion negatively impacted disease control after open conservation surgery, emphasizing the crucial role played by a preoperative evaluation during patient selection.PMID:37893591 | DOI:10.3390/medicina59101873 (Source: Medicina (Kaunas))
Source: Medicina (Kaunas) - October 28, 2023 Category: Universities & Medical Training Authors: Jooin Bang Oh-Hyeong Lee Geun-Jeon Kim Dong-Il Sun Sang-Yeon Kim Source Type: research
The Role of Open Conservation Surgery in the Era of Minimally Invasive Surgery for Hypopharyngeal Cancer
Conclusions: We found that pre-epiglottic space invasion negatively impacted disease control after open conservation surgery, emphasizing the crucial role played by a preoperative evaluation during patient selection.PMID:37893591 | PMC:PMC10608416 | DOI:10.3390/medicina59101873 (Source: Medicina (Kaunas))
Source: Medicina (Kaunas) - October 28, 2023 Category: Universities & Medical Training Authors: Jooin Bang Oh-Hyeong Lee Geun-Jeon Kim Dong-Il Sun Sang-Yeon Kim Source Type: research
The Role of Open Conservation Surgery in the Era of Minimally Invasive Surgery for Hypopharyngeal Cancer
Conclusions: We found that pre-epiglottic space invasion negatively impacted disease control after open conservation surgery, emphasizing the crucial role played by a preoperative evaluation during patient selection.PMID:37893591 | PMC:PMC10608416 | DOI:10.3390/medicina59101873 (Source: Medicina (Kaunas))
Source: Medicina (Kaunas) - October 28, 2023 Category: Universities & Medical Training Authors: Jooin Bang Oh-Hyeong Lee Geun-Jeon Kim Dong-Il Sun Sang-Yeon Kim Source Type: research
The Role of Open Conservation Surgery in the Era of Minimally Invasive Surgery for Hypopharyngeal Cancer
Conclusions: We found that pre-epiglottic space invasion negatively impacted disease control after open conservation surgery, emphasizing the crucial role played by a preoperative evaluation during patient selection.PMID:37893591 | PMC:PMC10608416 | DOI:10.3390/medicina59101873 (Source: Medicina (Kaunas))
Source: Medicina (Kaunas) - October 28, 2023 Category: Universities & Medical Training Authors: Jooin Bang Oh-Hyeong Lee Geun-Jeon Kim Dong-Il Sun Sang-Yeon Kim Source Type: research
The Role of Open Conservation Surgery in the Era of Minimally Invasive Surgery for Hypopharyngeal Cancer
Conclusions: We found that pre-epiglottic space invasion negatively impacted disease control after open conservation surgery, emphasizing the crucial role played by a preoperative evaluation during patient selection.PMID:37893591 | PMC:PMC10608416 | DOI:10.3390/medicina59101873 (Source: Medicina (Kaunas))
Source: Medicina (Kaunas) - October 28, 2023 Category: Universities & Medical Training Authors: Jooin Bang Oh-Hyeong Lee Geun-Jeon Kim Dong-Il Sun Sang-Yeon Kim Source Type: research
