Submental Flap for the Reconstruction of Hypopharyngectomy
Conditions: Head and Neck Cancers - Hypopharyngeal Interventions: Other: Surgical reconstruction Sponsors: Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University Recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - December 8, 2023 Category: Research Source Type: clinical trials

Neoadjuvant PD-1 Inhibitor Combined With Cetuximab and Platinum in Resectable Locally Advanced Hypopharyngeal Carcinoma
Conditions: Locally Advanced Hypopharyngeal Carcinoma Interventions: Drug: three cycles (toripalimab + cetuximab + platinum); Procedure: Radical surgery; Radiation: Radiotherapy or chemoradiotherapy Sponsors: Eye& ENT Hospital of Fudan University Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - November 30, 2023 Category: Research Source Type: clinical trials

European Larynx Organ Preservation Study (ELOS) [MK-3475-C44]
Conditions: Squamous Cell Carcinoma of Head and Neck; Hypopharyngeal Squamous Cell Carcinoma; Laryngeal Squamous Cell Carcinoma Stage III; Laryngeal Squamous Cell Carcinoma Stage IV; Squamous Cell Carcinoma of Larynx; Squamous Cell Carcinoma of the Larynx; Squamous Cell Carcinoma of the Larynx Stage III; Squamous Cell Carcinoma of the Larynx Stage IV; Laryngeal Squamous Cell Carcinoma; Laryngectomy; Status; Laryngeal Cancer; Laryngeal Neoplasms Interventions: Biological: KEYTRUDA ® Sponsors: University of Leipzig; University of G öttingen; University of Jena; University of Cologne; University of Ulm; University of Regens...
Source: ClinicalTrials.gov - November 17, 2023 Category: Research Source Type: clinical trials

Testing the Addition of an Investigational Drug, Xevinapant, to Usual Radiation Therapy Plus Cisplatin/Carboplatin for Patients With Head and Neck Cancer
Conditions: Head and Neck Squamous Cell Carcinoma; Hypopharyngeal Squamous Cell Carcinoma; Laryngeal Squamous Cell Carcinoma; Oral Cavity Squamous Cell Carcinoma; Oropharyngeal Squamous Cell Carcinoma; Stage III Cutaneous Squamous Cell Carcinoma of the Head and Neck AJCC v8; Stage III Hypopharyngeal Carcinoma AJCC v8; Stage III Laryngeal Cancer AJCC v8; Stage III Lip and Oral Cavity Cancer AJCC v8; Stage III Oropharyngeal (p16-Negative) Carcinoma AJCC v8; Stage IV Cutaneous Squamous Cell Carcinoma of the Head and Neck AJCC v8; Stage IV Hypopharyngeal Carcinoma AJCC v8; Stage IV Laryngeal Cancer AJCC v8; Stage IV Lip and Or...
Source: ClinicalTrials.gov - October 16, 2023 Category: Research Source Type: clinical trials

Neoadjuvant Chemoimmunotherapy Followed By Radiation Or Organ Preservation Surgery In Laryngeal/Hypopharyngeal Cancer
Conditions:   Larynx Cancer;   Hypopharyngeal Cancer Interventions:   Procedure: Surgery;   Radiation: Radiation;   Drug: Toripalimab Sponsors:   Fudan University;   Fudan University Eye Ear Nose and Throat Hospital;   Shanghai Zhongshan Hospital;   Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University;   Ruijin Hospital;   Xinhua Hospital, Shanghai Jiao Tong University School of Medicine Recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - September 15, 2023 Category: Research Source Type: clinical trials