Cancers, Vol. 16, Pages 707: Polygenic Risk Score in Predicting Esophageal, Oropharyngeal, and Hypopharynx Cancer Risk among Taiwanese Population
-Chieh Chen
Esophageal cancer shares strong associations with oropharyngeal and hypopharyngeal cancers, primarily due to shared risk factors like excessive tobacco and alcohol use. This retrospective study at Taichung Veterans General Hospital involved 54,692 participants, including 385 with squamous cell carcinoma (SCC) of the esophagus, oropharynx, or hypopharynx. Using a polygenic risk score (PRS) derived from 8353 single-nucleotide polymorphisms, researchers aimed to assess its correlation with cancer incidence and prognosis. The study found a 1.83-fold higher risk of esophageal, oropharyngeal, and hypopharyngeal S...
Source: Cancers - February 7, 2024 Category: Cancer & Oncology Authors: Yu-Che Huang Ming-Ching Lee Sheng-Yang Huang Chia-Man Chou Hui-Wen Yang I-Chieh Chen Tags: Article Source Type: research
Prevalence of obstructive sleep apnea after treatment for advanced T-stage head and neck cancer
ConclusionIn this population of advanced T-stage HNC patients, the prevalence of OSA was 72%, which is considerably higher than in the general population (2 –50%). Given the high prevalence, screening of this entire subgroup for OSA may be indicated. Future studies to identify high risk factors and develop an OSA screening protocol are needed. (Source: European Archives of Oto-Rhino-Laryngology)
Source: European Archives of Oto-Rhino-Laryngology - February 7, 2024 Category: ENT & OMF Source Type: research
Cancers, Vol. 16, Pages 659: Extra-Capsular Spread of Lymph Node Metastasis in Oral, Oropharyngeal and Hypopharyngeal Cancer: A Comparative Subsite Analysis
Conclusion: LNM variables were correlated with ECS occurrence for most HNC subsites, and site-dependent primary tumor characteristics might contribute differentially to the ECS development of LNM in HNC. (Source: Cancers)
Source: Cancers - February 3, 2024 Category: Cancer & Oncology Authors: Yung Jee Kang Goeun Park Sung Yool Park Taehwan Kim Eunhye Kim Yujin Heo Changhee Lee Han-Sin Jeong Tags: Article Source Type: research
Establishment and characterization of a novel hypopharyngeal squamous cell carcinoma cell line CZH1 with genetic abnormalities
In this study, we successfully established a novel cell line, named CZH1, from the postcricoid region of a Chinese male patient with a T3N0M0 HPSCC. Short tandem repeat analysis confirmed the uniqueness of CZH1. The cell line was characterized by its phenotypes, biomarkers, and genetics. Importantly, CZH1 cells retained the typical features of epithelial malignancy, similar to the primary tumor tissue. Furthermore, CZH1 demonstrated a greater capacity for invasion and increased susceptibility to irradiation in comparison to FaDu, which is the most commonly used HPSCC cell line. Whole-exome sequencing analysis revealed that...
Source: Human Cell - January 27, 2024 Category: Cytology Source Type: research
Cancer-associated financial burden in German head and neck cancer patients
ConclusionHNC survivors suffer from significant financial burden after HNC treatment, even in Germany with a healthcare system with statutory health insurance. The findings from this study offer valuable insights for healthcare professionals and policymakers, helping them acknowledge the economic impact of HNC. (Source: Frontiers in Oncology)
Source: Frontiers in Oncology - January 26, 2024 Category: Cancer & Oncology Source Type: research
Differences in the association of time to treatment initiation and survival according to various head and neck cancer sites in a nationwide cohort
CONCLUSION: The relationship between longer TTI and decreased survival was confirmed, but slight variations in the pattern of the hazard of dying by TTI by tumour site were observed. These findings could support decisions on prioritizing treatment. However, other aspects such as extent of treatment and quality of life should be investigated further so this can also be included.PMID:38262531 | DOI:10.1016/j.radonc.2024.110107 (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - January 23, 2024 Category: Radiology Authors: Micha ël H Frank Boukje A C van Dijk Rosanne C Schoonbeek Jaap Zindler Lot A Devriese Robert J J van Es Matthias A W Merkx Remco de Bree Source Type: research
Screening and surveillance of esophageal cancer by magnifying endoscopy with narrow band imaging improves the survival of hypopharyngeal cancer patients
This study investigated the impacts of esophageal cancer screening using magnifying endoscopy with narrow-band imaging (ME-NBI) on the outcomes of hypopharyngeal cancer patients.MethodsPatients with hypopharyngeal cancer diagnosed from 2008 to 2021 in a tertiary hospital were reviewed retrospectively. Screening and surveillance using ME-NBI examination of the esophagus were divided into three patterns: (1) ME-NBI never performed or more than 6 months after diagnosis of index primary hypopharyngeal cancer, (2) ME-NBI within 6 months only, and (3) ME-NBI within 6 months and regular surveillance.ResultsA total of 261 were rev...
Source: Frontiers in Oncology - January 23, 2024 Category: Cancer & Oncology Source Type: research
Endoscopic submucosal dissection for hypopharynx lymphoepithelioma-like carcinoma
Endoscopy 2024; 56: E65-E66 DOI: 10.1055/a-2233-3082 Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, GermanyArticle in Thieme eJournals: Table of contents | open access Full text (Source: Endoscopy)
Source: Endoscopy - January 23, 2024 Category: Gastroenterology Authors: Guo, Cheng Duan, Bensong Zhang, Li Xu, Meidong Zhang, Haibin Tags: E-Videos Source Type: research
Progress in diagnosing and treating thyroid squamous cell carcinoma under the 5th edition of WHO classification
Squamous cell carcinoma of the thyroid (SCCT) is a rare thyroid gland malignancy, with only a few hundred cases reported in the literature, mostly as case reports or small sample studies. In the previous WHO classification, squamous cell carcinoma of the thyroid was defined as a carcinoma composed entirely of squamous cells without differentiated carcinoma components. It was once included in the WHO tumor classification separately. However, the 2022 WHO classification of squamous cell carcinoma of the thyroid was reclassified as a morphologic subtype of anaplastic thyroid carcinoma (ATC). The squamous cell carcinoma patter...
Source: Frontiers in Endocrinology - January 19, 2024 Category: Endocrinology Source Type: research
Prophylactic pectoralis major flap to compensate for increased risk of pharyngocutaneous fistula in laryngectomy patients with low skeletal muscle mass (PECTORALIS): study protocol for a randomized controlled trial
Total laryngectomy (TL) is a surgical procedure commonly performed on patients with advanced laryngeal or hypopharyngeal carcinoma. One of the most common postoperative complications following TL is the develo... (Source: BMC Cancer)
Source: BMC Cancer - January 15, 2024 Category: Cancer & Oncology Authors: Maartje A. van Beers, Caroline M. Speksnijder, Carla H. van Gils, Geert W.J. Frederix, Jan Willem Dankbaar and Remco de Bree Tags: Study Protocol Source Type: research
Machine learning model to preoperatively predict T2/T3 staging of laryngeal and hypopharyngeal cancer based on the CT radiomic signature
ConclusionsThe nomogram based on the radiomics model derived from contrast-enhanced CT images had good diagnostic performance for distinguishing T2/T3 staging of LHSCC.Clinical relevance statementAccurate T2/T3 staging assessment of LHSCC aids in determining whether laryngectomy or laryngeal preservation therapy should be performed. The nomogram based on the radiomics model derived from contrast-enhanced CT images has the potential to predict the T2/T3 staging of LHSCC, which can provide a non-invasive and robust approach for guiding the optimization of clinical decision-making.Key Points•Combining analysis of variance w...
Source: European Radiology - January 11, 2024 Category: Radiology Source Type: research
Predicting therapeutic responses in head and neck squamous cell carcinoma from < em > TP53 < /em > mutation detected by cell-free DNA
CONCLUSIONS: TP53 mutation could be used as a specific predictor of treatment response in patients with HNSCC. Using cfDNA to detect the TP53 mutations in patients with HSNCC is a feasible method. The results suggested that the therapeutic response in patients could be predicted by detecting TP53 mutations in cfDNA, and large-scale and prospective studies are needed to validate this hypothesis.PMID:38197078 | PMC:PMC10774070 | DOI:10.21037/tcr-23-878 (Source: Cell Research)
Source: Cell Research - January 10, 2024 Category: Cytology Authors: Mei Wei Jingtai Zhi Li Li Wei Wang Source Type: research
Development and validation of a nomogram to predict cervical lymph node metastasis in head and neck squamous cell carcinoma
ConclusionsWe established a good prediction model for cervical lymph node metastasis in head and neck squamous cell carcinoma patients which can provide reference value and auxiliary diagnosis for clinicians in making neck management decisions of HNSCC patients. (Source: Frontiers in Oncology)
Source: Frontiers in Oncology - January 4, 2024 Category: Cancer & Oncology Source Type: research
Survival in oral and pharyngeal cancers is catching up with laryngeal cancer in the NORDIC countries through a half century
Conclusions5-year survival reached about 65% for all HN cancers, except for hypopharyngeal cancer (30%). Human papilloma virus infection is becoming a dominant risk factor for the rapidly increasing oropharyngeal cancer, the prevention of which needs to emphasize oral sex as a route of infection. (Source: Cancer Medicine)
Source: Cancer Medicine - January 2, 2024 Category: Cancer & Oncology Authors: Frantisek Zitricky,
Anni I. Koskinen,
Otto Hemminki,
Asta F örsti,
Akseli Hemminki,
Kari Hemminki Tags: RESEARCH ARTICLE Source Type: research
Hypopharynx Cancer Incidence in Kazakhstan: 2017-2021
CONCLUSION: Thus, this is the first epidemiological study of HPC, which assessed the role of the influence of various factors, including demographic and risk of acquiring illness, on the dynamics of incidence, taking into account gender differences and geographical variability.PMID:38156836 | DOI:10.31557/APJCP.2023.24.12.4043 (Source: Asian Pacific Journal of Cancer Prevention)
Source: Asian Pacific Journal of Cancer Prevention - December 29, 2023 Category: Cancer & Oncology Authors: Darkhan Ahmedin Abay Makishev Zhansaya Telmanova Dulat Turebayev Dinara Tarzhanova Alina Shelestyuk Vladimir Lyust Dinara Kassenova Vladimir Grigorevskiy Gulnur Igissinova Zarina Bilyalova Nariman Syzdykov Svetlana Muratbekova Nurbek Igissinov Source Type: research
