Radiotherapy with or without chemotherapy for locally advanced head and neck cancer in elderly patients: analysis of the Head and Neck Cancer Registry of Japan
ConclusionAlthough aggressive CRT is administered to elderly patients in Japan, its effectiveness is uncertain. Further prospective randomized trials are needed to verify whether CRT is superior to RT alone for elderly patients. (Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - December 29, 2023 Category: Cancer & Oncology Source Type: research
Development of a nomogram for predicting pharyngocutaneous fistula based on skeletal muscle mass and systemic inflammation indices
CONCLUSIONS: The nomogram we constructed may help clinicians predict PCF risk early in the postoperative period, pending external validation.PMID:38124665 | DOI:10.1002/hed.27614 (Source: Cancer Control)
Source: Cancer Control - December 21, 2023 Category: Cancer & Oncology Authors: Ce Wu Xudong Yan Feng Xie Xiaolong Lai Lin Wang Yan Jiang Source Type: research
Radiomics analysis for the prediction of locoregional recurrence of locally advanced oropharyngeal cancer and hypopharyngeal cancer
ConclusionsThe image-based radiomic approach could provide a reliable LR prediction model in locally advanced OPC and HPC. Early identification of those prone to post-treatment recurrence would be helpful for appropriate adjustments to treatment strategies and post-treatment surveillance. (Source: European Archives of Oto-Rhino-Laryngology)
Source: European Archives of Oto-Rhino-Laryngology - December 21, 2023 Category: ENT & OMF Source Type: research
Implications of oral dysbiosis and HPV infection in head and neck cancer: from molecular and cellular mechanisms to early diagnosis and therapy
Head and neck cancer (HNC) is the sixth most common type of cancer, with more than half a million new cases annually. This review focuses on the role of oral dysbiosis and HPV infection in HNCs, presenting the involved taxons, molecular effectors and pathways, as well as the HPV-associated particularities of genetic and epigenetic changes and of the tumor microenvironment occurred in different stages of tumor development. Oral dysbiosis is associated with the evolution of HNCs, through multiple mechanisms such as inflammation, genotoxins release, modulation of the innate and acquired immune response, carcinogens and antica...
Source: Frontiers in Oncology - December 18, 2023 Category: Cancer & Oncology Source Type: research
Cancers, Vol. 15, Pages 5890: Identifying Lymph Nodes and Their Statuses from Pretreatment Computer Tomography Images of Patients with Head and Neck Cancer Using a Clinical-Data-Driven Deep Learning Algorithm
Conclusions: The model showed a convincible lymph node detection on clinical images. We will evaluate and further improve the model in collaboration with clinical physicians. (Source: Cancers)
Source: Cancers - December 18, 2023 Category: Cancer & Oncology Authors: Sheng-Yao Huang Wen-Lin Hsu Dai-Wei Liu Edzer L. Wu Yu-Shao Peng Zhe-Ting Liao Ren-Jun Hsu Tags: Article Source Type: research
Caffeic acid phenethyl ester: Unveiling its potential as a potent apoptosis inducer for combating hypopharyngeal squamous cell carcinoma
The objective of the present study was to examine the ability of caffeic acid phenethyl ester (CAPE), which is an active compound found in propolis, to combat HSCC tumor growth. CAPE exerted its tumor‑suppressive activity in HSCC cell lines through the induction of apoptosis. Mechanistically, the CAPE‑mediated apoptotic process was attributed to the perturbation of the mitochondrial membrane potential and the activation of caspase‑9. CAPE also modulated survivin and X‑linked inhibitor of apoptosis, which are potent members of the inhibitors of apoptosis protein family, either through transcriptional or post‑trans...
Source: Oncology Reports - December 15, 2023 Category: Cancer & Oncology Authors: Hyun-Ji Kim Min-Hye Ahn Ji-Ae Shin Su-Jung Choi Hyun-Ju Yu Sung-Dae Cho Source Type: research
