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< sup > 18 < /sup > F-FDG PET/CT Parameters Enhance MRI Radiomics for Predicting Human Papilloma Virus Status in Oropharyngeal Squamous Cell Carcinoma
CONCLUSION: When combined with an MRI radiomics model, 18F-FDG PET/CT exhibits incremental value in predicting HPV status in patients with OPSCC.PMID:37992746 | PMC:PMC10681825 | DOI:10.3349/ymj.2023.0187 (Source: Yonsei Medical Journal)
Source: Yonsei Medical Journal - November 22, 2023 Category: Universities & Medical Training Authors: Kwan Hyeong Jo Jinna Kim Hojin Cho Won Jun Kang Seung-Koo Lee Beomseok Sohn Source Type: research

Liquid Biopsies for Head and Neck Cancers —Any Hope for Human Papillomavirus–Negative Disease?—Reply
In Reply We appreciate the opportunity to respond to the letter by Smith et al regarding our recent study. In reference to the question and comments posed, the initial adoption of the commercially available tumor tissue –modified viral (TTMV)-human papillomavirus (HPV) DNA test at our institution was sporadic and generally performed ad hoc for patients with HPV-associated cancers either preoperatively or during surveillance. Over time, through multidisciplinary collaboration and the design of the SIRS 2.0 trial, testing transitioned to coincide with standard of care surveillance visits in accordance with the National Com...
Source: JAMA Otolaryngology - Head and Neck Surgery - November 16, 2023 Category: ENT & OMF Source Type: research

Liquid Biopsies for Head and Neck Cancers
To the Editor Ferrandino et al report clinical performance of plasma tumor tissue –modified viral (TTMV)-human papillomavirus (HPV) DNA in diagnosis and surveillance of HPV-associated oropharyngeal squamous cell carcinoma (OPSCC). The findings highlight the promise of liquid biopsies for improving patient care and the uncertainties around how to integrate these assays with imag ing, clinical examinations, and conventional biopsy. The variable time points for plasma TTMV-HPV DNA monitoring limited estimates of lead time detection, suggesting an opportunity for further standardizing timing of liquid biopsy testing protocol...
Source: JAMA Otolaryngology - Head and Neck Surgery - November 16, 2023 Category: ENT & OMF Source Type: research

Assessing the burden of HPV-related head and neck cancers in mainland China: protocol of a nationwide, multisite, cross-sectional study
Background Persistent human papillomavirus (HPV) infection is a known cause of a subset of head and neck cancers (HNCs). In the last two decades, the proportion of HNCs attributable to HPV infection has increased worldwide, notably the oropharyngeal cancers. However, the trend of HPV-related HNC burden is not clearly understood yet in China. Thus, the absolute burden of HPV-related head and neck cancers in China (BROADEN-China) will be conducted to estimate the proportion of HNCs attributable to HPV infection, per anatomic site, by genotype, in three time periods (2008–2009, 2013–2014 and 2018–2019). Met...
Source: BMJ Open - November 15, 2023 Category: General Medicine Authors: Wang, W., Song, C., Su, Z., Kothari, S., Chen, Y.-T., Liu, Y., Wu, S.-Y., Panchal, R., Morais, E., Zhang, S.-K., Yin, J., Qiao, Y.-L., Roberts, C. Tags: Open access, Infectious diseases Source Type: research

Development of a proficiency testing program for HPV serology assays used to evaluate antibody responses in vaccine trials
In this study, a proficiency panel was created for evaluation of assay performance and inter- and intra-laboratory assay comparisons, especially the ability to accurately measure negative, low, intermediate, and high levels of HPV type-specific antibodies. Comprised of 80 deidentified samples, this panel is designed for individual labs to evaluate assay performance characteristics on a biennial basis, to promote standardization of methodology and harmonization of data from human papillomavirus (HPV) serology tests in vaccine trials. The proficiency panel was qualified using 2 types of assays (singleplex Enzyme-Linked Immun...
Source: Journal of Immunological Methods - November 10, 2023 Category: Allergy & Immunology Authors: Cheryl Miller Troy J Kemp Ligia A Pinto Source Type: research