Factors Associated With Guideline-concordant and Excessive Cervical Cancer Screening: A Mixed Methods Study
National guidelines recommend cervical cancer screening with Papanicolaou (Pap) testing at 3-year intervals or with human papillomavirus (HPV) testing alone or HPV/Pap cotesting at 5-year intervals for average-risk individuals aged 30 –65 years. (Source: Womens Health Issues)
Source: Womens Health Issues - February 20, 2024 Category: Primary Care Authors: Rebecca B. Perkins, Lindsay Fuzzell, Paige Lake, Naomi C. Brownstein, Holly B. Fontenot, Alexandra Michel, Ashley Whitmer, Susan T. Vadaparampil Tags: Original Article Source Type: research
Development of a Study Tool to Measure Awareness of Human Papillomavirus Vaccine Among Cancer Patients and Their Intention to Recommend the Vaccine
ConclusionsThe study tool could effectively measure individual constructs of awareness and intention. Notably, our findings indicate a weak correlation between awareness and one component of intention (capability), within this population. This aspect, rigorously measured and validated by our study tool, holds significance as it implies that despite a low level of awareness in this population, they may still be considered as potentially influential advocates for the HPV vaccine. (Source: The Journal of Obstetrics and Gynecology of India)
Source: The Journal of Obstetrics and Gynecology of India - February 19, 2024 Category: OBGYN Source Type: research
AmpFire HPV and ScreenFire RS HPV validation trial
CONCLUSIONS: The excellent intra- and interlaboratory reproducibility and the established clinical performance, together with the platforms' simplicity, make these assays particularly applicable to low-resource settings.PMID:38365314 | DOI:10.1093/ajcp/aqad181 (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - February 16, 2024 Category: Pathology Authors: Jun Hou Jerome L Belinson Hui Du Changzhong Li Wei Zhang Lijie Zhang Yi Zhang Xinfeng Qu Ruifang Wu Source Type: research
AmpFire HPV and ScreenFire RS HPV validation trial
CONCLUSIONS: The excellent intra- and interlaboratory reproducibility and the established clinical performance, together with the platforms' simplicity, make these assays particularly applicable to low-resource settings.PMID:38365314 | DOI:10.1093/ajcp/aqad181 (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - February 16, 2024 Category: Pathology Authors: Jun Hou Jerome L Belinson Hui Du Changzhong Li Wei Zhang Lijie Zhang Yi Zhang Xinfeng Qu Ruifang Wu Source Type: research
Viruses, Vol. 16, Pages 303: Association between the Mode of Delivery and Vertical Transmission of Human Papillomavirus
Carceller
François Coutlée
Helen Trottier
Human papillomavirus (HPV) can be vertically transmitted. Our objective was to measure the association between the mode of delivery and the detection of HPV in infants. We used data collected from pregnant women during the HERITAGE study. Self-collected vaginal samples from the first and third trimester were obtained for HPV testing. Specimens from oral, pharyngeal, conjunctival and anogenital mucosa were collected from infants 36–48 h after delivery and at 3 months of age. All samples were tested for HPV DNA by the Linear Array assay. Adjusted odd ratios (...
Source: Viruses - February 16, 2024 Category: Virology Authors: Émilie Nantel Marie-H élène Mayrand Fran çois Audibert Joseph Niyibizi Paul Brassard Louise Laporte Julie Lacaille Monica Zahreddine William Fraser Diane Francoeur Marie-Jos ée Bédard Isabelle Girard Jacques Lacroix Ana Maria Carceller Fran çois Co Tags: Article Source Type: research
Exploring the potential prompting role of cervical human papilloma virus detection in vulvar lesions: a cross-sectional study in China
ConclusionsChinese women may be at specific, high risk for HPV infection types associated with VIN or CIN. The use of cervical cell HPV detection along with vulvar presentation during cervical cancer screening may also contribute to vulvar lesion detection. (Source: Frontiers in Oncology)
Source: Frontiers in Oncology - February 15, 2024 Category: Cancer & Oncology Source Type: research
Viruses, Vol. 16, Pages 298: Association between Human Papillomavirus 16 Viral Load in Pregnancy and Preterm Birth
This study aimed to measure the association between HPV16 viral load during pregnancy and preterm birth. We used data from participants in the HERITAGE study. The Linear Array assay was used for HPV DNA testing on vaginal samples collected during the first and third trimesters of pregnancy. The HPV16 viral load was measured with a real-time polymerase chain reaction. We used logistic regression to measure the associations between HPV16 viral load during pregnancy and preterm birth (defined as birth before 37 weeks of gestation). The adjusted odd ratios (aORs) and the 95% confidence intervals [CIs] were estimated with inver...
Source: Viruses - February 15, 2024 Category: Virology Authors: Pranamika Khayargoli Marie-H élène Mayrand Joseph Niyibizi Fran çois Audibert Louise Laporte Julie Lacaille Ana Maria Carceller Jacques Lacroix Émilie Comète Fran çois Coutlée Trottier Tags: Article Source Type: research
Assessing the feasibility of a multimodal liquid biopsy for the diagnosis of HPV-associated oropharyngeal squamous cell carcinoma
CONCLUSIONS: Compared to HPV RNA ISH, HPV serology and ctHPVDNA are sensitive and highly specific biomarkers for HPV-associated OPSCC at the time of presentation.PMID:38349613 | DOI:10.1093/ajcp/aqad185 (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - February 13, 2024 Category: Pathology Authors: James S Lewis Saskia Naegele Vasileios Efthymiou Mitra Mehrad Kim A Ely Tim Waterboer Krystle A Lang Kuhs Seth J Davis Kelsey Richard Dipon Das Daniel L Faden Source Type: research
Assessing the feasibility of a multimodal liquid biopsy for the diagnosis of HPV-associated oropharyngeal squamous cell carcinoma
CONCLUSIONS: Compared to HPV RNA ISH, HPV serology and ctHPVDNA are sensitive and highly specific biomarkers for HPV-associated OPSCC at the time of presentation.PMID:38349613 | DOI:10.1093/ajcp/aqad185 (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - February 13, 2024 Category: Pathology Authors: James S Lewis Saskia Naegele Vasileios Efthymiou Mitra Mehrad Kim A Ely Tim Waterboer Krystle A Lang Kuhs Seth J Davis Kelsey Richard Dipon Das Daniel L Faden Source Type: research
Assessing the feasibility of a multimodal liquid biopsy for the diagnosis of HPV-associated oropharyngeal squamous cell carcinoma
CONCLUSIONS: Compared to HPV RNA ISH, HPV serology and ctHPVDNA are sensitive and highly specific biomarkers for HPV-associated OPSCC at the time of presentation.PMID:38349613 | DOI:10.1093/ajcp/aqad185 (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - February 13, 2024 Category: Pathology Authors: James S Lewis Saskia Naegele Vasileios Efthymiou Mitra Mehrad Kim A Ely Tim Waterboer Krystle A Lang Kuhs Seth J Davis Kelsey Richard Dipon Das Daniel L Faden Source Type: research
A validated polyclonal antiserum-based immunoassay for assessment of HPV 16 L1 relative potency
Biologicals. 2024 Feb 8;85:101742. doi: 10.1016/j.biologicals.2023.101742. Online ahead of print.ABSTRACTVaccine potency is typically evaluated using an assay that acts as a surrogate for biological activity. Although in vivo vaccines better represent human immunological responses, in vitro assays are preferred due to lower variability, higher throughput, easier validation and ethical considerations. In in vitro determination of Human Papillomavirus (HPV), Virus-like particle (VLP) vaccine potency currently depends on monoclonal antibody assays. However, these reagents are hard to obtain and currently are not available com...
Source: Biologicals : Journal of the International Association of Biological Standardization - February 10, 2024 Category: Biotechnology Authors: Reihaneh Mirhassani Ehsan Seyedjafari Behrouz Vaziri Source Type: research
Single-tube four-target lateral flow assay detects human papillomavirus types associated with majority of cervical cancers
In this study, we developed a multiplexed loop-mediated isothermal amplification (LAMP) reaction to detect the three most common hrHPV types that cause cervical cancer (HPV16, HPV18, and HPV45) and a cellular control for sample adequacy. First, we characterized the assay limit of detection (LOD) in a real-time reaction with fluorescence readout; after 30 min of amplification the LOD was 100, 10, and 10 copies/reaction of HPV16, HPV18, and HPV45, respectively, and 0.1 ng/reaction of human genomic DNA (gDNA). Next, we implemented the assay on lateral flow strips, and the LOD was maintained for HPV16 and HPV18, but increased ...
Source: Analytical Biochemistry - February 8, 2024 Category: Biochemistry Authors: Maria Barra Megan Chang Mila P Salcedo Kathleen Schmeler Michael Scheurer Mauricio Maza Leticia Lopez Karla Alfaro Rebecca Richards-Kortum Source Type: research
Impact of human papillomavirus age-related prevalence and vaccination levels on interpretation of cervical screening modalities: a modelling study
Conclusions
HPV-reflex tests outperform LBC tests across all age profiles, resulting in greater test accuracy. This improvement is especially pronounced as HPV infection rates fall and suggests HPV-reflex modalities are robust to future changes in the epidemiology of HPV. (Source: BMJ Open)
Source: BMJ Open - February 2, 2024 Category: General Medicine Authors: Grimes, D. R. Tags: Open access, Public health Source Type: research
News at a glance: Mars helicopter ’s final flight, grants for U.K. diversity, and a nonopioid pain drug
PLANETARY SCIENCE
Breakdown finally grounds Mars helicopter
After 72 flights on Mars—67 more than originally planned—NASA’s Ingenuity helicopter flew its final sortie last month. The tiny helicopter (above), a technology demonstration deployed from the Perseverance rover, lasted for 3 years, covering 17 kilometers during more than 2 hours of flight, until at least one of its carbon-fiber blades fractured during a crash landing. Ingenuity served as a scout for Perseverance as it climbed toward the rim of Jezero crater, helping it avoid hazardous terrain and collect rock samples. The mission coul...
Source: Science of Aging Knowledge Environment - February 1, 2024 Category: Geriatrics Source Type: research
Calendar-period trends in cervical precancer and cancer diagnoses since the introduction of human papillomavirus and cytology co-testing into routine cervical cancer screening at Kaiser Permanente Northern California
CONCLUSIONS: Since its introduction at KPNC, co-testing increased the detection of CIN3 over time, which likely caused a subsequent reduction of SCC. However, there has been no observed decrease in ADC. One possible explanation for lack of effectiveness against ADC is the underdiagnosis of AIS. Novel strategies to identify and treat women at high risk of ADC need to be developed and clinically validated.PMID:38301311 | DOI:10.1016/j.ygyno.2024.01.038 (Source: Gynecologic Oncology)
Source: Gynecologic Oncology - February 1, 2024 Category: Cancer & Oncology Authors: Brian Befano Nicolas Wentzensen Thomas Lorey Nancy Poitras Li C Cheung Mark Schiffman Megan A Clarke Camryn Cohen Walter Kinney Alex Locke Philip E Castle Source Type: research
