The Opposite Functions of CD30 Ligand Isoforms
This study aims to elucidate the properties and signaling functions of the second CD30 ligand isoform. We have found mRNA expression of both isoforms in the PBMCs of all six healthy donors tested. Through methods in cell biology and biochemistry, we were able to discover that the second CD30 ligand isoform has no discernable pro-inflammatory function and, in fact, isoform 2 can restrict the capacity of the canonical isoform to signal through the CD30 receptor by preventing their interaction. This discovery has implications for the future development of therapeutics targeting the CD30/CD30 ligand signaling pair in cancer an...
Source: Current Issues in Molecular Biology - March 27, 2024 Category: Molecular Biology Authors: Ignat Printsev Elyas Alalli Janine Bilsborough Source Type: research
The Opposite Functions of CD30 Ligand Isoforms
This study aims to elucidate the properties and signaling functions of the second CD30 ligand isoform. We have found mRNA expression of both isoforms in the PBMCs of all six healthy donors tested. Through methods in cell biology and biochemistry, we were able to discover that the second CD30 ligand isoform has no discernable pro-inflammatory function and, in fact, isoform 2 can restrict the capacity of the canonical isoform to signal through the CD30 receptor by preventing their interaction. This discovery has implications for the future development of therapeutics targeting the CD30/CD30 ligand signaling pair in cancer an...
Source: Mol Biol Cell - March 27, 2024 Category: Molecular Biology Authors: Ignat Printsev Elyas Alalli Janine Bilsborough Source Type: research
Extranodal NK/T-cell lymphoma with localized relapse in bone marrow of lower leg detected using PET-CT
We present two patients with ENKTL, wherein positron emission tomography-computed tomography (PET-CT) with total-body coverage after induction therapy, detected newly relapsed regions in the bone marrow of the lower leg prior to progression. Case 1: A 47-year-old woman with nasal obstruction, showing 18F-fluoro-deoxyglucose (FDG) uptake in the nasal cavity (Lugano stage IE). After induction therapy (RT-2/3 DeVIC), PET-CT revealed abnormal uptake only in the right fibula. Case 2: A 68-year-old man with a skin nodule/ulcer and an enlarged right inguinal lymph node was diagnosed with advanced ENKTL. A PET-CT scan revealed abn...
Source: Journal of Clinical and Experimental Hematopathology : JCEH - March 27, 2024 Category: Hematology Authors: Takahisa Nakamura Hiro Tatetsu Yusuke Higuchi Shinya Endo Shinya Shiraishi Koichi Kawanaka Daisuke Imakane Miyu Sonoda Rie Furuta Takafumi Shichijo Yumi Honda Kennosuke Karube Yoshiki Mikami Kisato Nosaka Masao Matsuoka Jun-Ichirou Yasunaga Source Type: research
