Kelsey Moody Presenting on the LysoClear Program at Ending Age-Related Diseases 2019
Kelsey Moody of Ichor Therapeutics presented on the LysoClear development program at the Ending Age-Related Diseases conference organized by the Life Extension Advocacy Foundation earlier this year. LysoClear is an example of the commercial development of a rejuvenation therapy, taken all the way from the starting point of the discovery of microbial enzymes capable of breaking down certain forms of harmful age-related molecular waste that contribute to aging and age-related diseases. The actual research is largely done, and the task now is to focus on manufacture, regulatory approval, and entry into the clinic.
Take...
Source: Fight Aging! - October 14, 2019 Category: Research Authors: Reason Tags: Healthy Life Extension Community Source Type: blogs
AI competitions don ’t produce useful models
By LUKE OAKDEN-RAYNER
A huge new CT brain dataset was released the other day, with the goal of training models to detect intracranial haemorrhage. So far, it looks pretty good, although I haven’t dug into it in detail yet (and the devil is often in the detail).
The dataset has been released for a competition, which obviously lead to the usual friendly rivalry on Twitter:
Of course, this lead to cynicism from the usual suspects as well.
And the conversation continued from there, with thoughts ranging from “but since there is a hold out test set, how can you overfit?” to “the proposed so...
Source: The Health Care Blog - September 27, 2019 Category: Consumer Health News Authors: Christina Liu Tags: Health Tech AI Luke Oakden-Rayner Source Type: blogs
Fight Aging! Newsletter, September 9th 2019
We examined human lung tissue from COPD patients and normal control subjects, and found a substantial increase in p16-expressing alveolar cells in COPD patients. Using a transgenic mouse deficient for p16, we demonstrated that lungs of mice lacking p16 were structurally and functionally resistant to CS-induced emphysema due to activation of IGF1/Akt regenerative and protective signaling.
Fat Tissue Surrounds Skeletal Muscle to Accelerate Atrophy in Aging and Obesity
https://www.fightaging.org/archives/2019/09/fat-tissue-surrounds-skeletal-muscle-to-accelerate-atrophy-in-aging-and-obesity/
Researchers he...
Source: Fight Aging! - September 8, 2019 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Greater Reductions in Blood Pressure in Hypertensive Patients Further Reduce Stroke Risk
The data reported in this study can be added to the considerable weight of prior evidence showing that greater sustained reductions of blood pressure in hypertensive patients is better for long term health. Blood pressure should be lowered more aggressively than has been the case in the past, in other words. This is old news in some respects. The medical community has already adjusted its recommendations in recent years, reducing the pressure thresholds at which blood pressure is considered harmful and a risk to future health.
Raised blood pressure, hypertension, is very influential on the trajectory of age-related ...
Source: Fight Aging! - September 4, 2019 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
What is the differential of this very unusual ECG?
Take a look at this ECG first without clinical context:What do you think?There is sinus bradycardia with very unusual shortened QT interval (approximately 400 ms), for a QTc (Bazett) 358 ms. The T-waves have high amplitude and narrow bases, reminiscent of hyperkalemia, maybe also with hypercalcemia. The T-waves are not bulky or fat, and are therefore not hyperacute regardless of their amplitude.Short QTc is rare, but has been described as less than 360 ms for males and less than 370 ms for females. Furthermore, less than 330 ms (males) or less than 340 ms (females) can be termed " very short QTc " and, in the absence of re...
Source: Dr. Smith's ECG Blog - September 1, 2019 Category: Cardiology Authors: Pendell Source Type: blogs
Funtabulously Frivolous Friday Five 290
Dr Mark Corden Funtabulously Frivolous Friday Five 290
It's Friday. Boggle your brain with FFFF challenge and some old fashioned trivia. Funtabulously Frivolous Friday Five 290 (Source: Life in the Fast Lane)
Source: Life in the Fast Lane - August 16, 2019 Category: Emergency Medicine Authors: Dr Mark Corden Tags: FFFF 50 years acute eosinophilic pneumonia anaesthetics ASA boiled lobster coronary heart disease Death diffuse alveolar haemorrhage e-cigarettes emergency sedation fasting GRIM hypersensitivity inhalation injury mortality Pa Source Type: blogs
Are Radiologists Prepared for The Future?
This article originally appeared on Medium here. (Source: The Health Care Blog)
Source: The Health Care Blog - August 9, 2019 Category: Consumer Health News Authors: Christina Liu Tags: Health Technology Medical Practice Physicians AI Alex Logsdon Artificial intelligence Radiology Source Type: blogs
Thunderclap headache: The “worst headache of my life”
Not all headache disorders are the same. An excruciating, sudden-onset headache known as thunderclap headache (TCH) is a medical emergency, very different from more common headache disorders such as migraine and tension headache. If you develop TCH, you should call 911 or immediately go to the closest hospital.
TCH is associated with a variety of causes, ranging from benign to potentially fatal. Urgent evaluation in an emergency setting is needed to quickly identify and treat any underlying condition.
Diagnosing and treating secondary thunderclap headache
When you arrive at the hospital, the medical team will want to confi...
Source: Harvard Health Blog - June 25, 2019 Category: Consumer Health News Authors: Aneesh Singhal, MD Tags: Headache Health Source Type: blogs
IRRAS Rolling Out New Irrigating Cerebrospinal Fluid Catheter System for Hydrocephalus
Swedish medical device company IRRAS is attempting to change the way neurosurgeons and neurointensivists handle the problem of acute hydrocephalus. Hydrocephalus is the abnormal accumulation of cerebrospinal fluid (CSF) in the brain, and is often caused by hemorrhage, tumor, infection, or traumatic brain injury. Traditionally, surgeons use an external ventricular drain (EVD) catheter, that is placed into the brain’s fluid spaces to drain the excess CSF. However, current ventricular catheter technology is limited to passive draining of fluid, and catheter obstructions are not uncommon.
IRRAS’ first commercial product, I...
Source: Medgadget - May 9, 2019 Category: Medical Devices Authors: Kurt Yaeger Tags: Critical Care Neurology Neurosurgery Source Type: blogs
Snake Bite and Radiology
Discussion-Local manifestations of snake bite are soft-tissue swelling from edema, necrosis, and hemorrhage. Common long-term sequelae of envenomation is soft-tissue atrophy distal to the bite, particularly in the digits.-Systemic signs and symptoms after a venomous snake bite are due to anticoagulant/procoagulant activity or neurotoxicity. Cerebral hypoxia can occur due to hypotensive shock that may accompany some snake bite envenomations. Neuromuscular disorders with damage of the peripheral nervous system can with blockage of synaptic transmission, at either presynaptic or postsynaptic levels.Common neuro...
Source: Sumer's Radiology Site - March 21, 2019 Category: Radiology Authors: Sumer Sethi Source Type: blogs
Pseudo subarachnoid hemorrhage in post anoxic brain injury
(Source: Notes from Dr. RW)
Source: Notes from Dr. RW - March 15, 2019 Category: Internal Medicine Tags: critical care neurology Source Type: blogs
AI in Healthcare: Interview with Chris Gough, GM Health and Life Sciences, Intel Corporation
Intel has developed a suite of AI technologies and has been collaborating with numerous medtech providers to create new healthcare solutions based on data-driven strategies. AI has come on in leaps and bounds, and is beginning to make an impact in various healthcare fields. Intel aims to be at the forefront of this AI revolution.
For instance, Intel has collaborated with Novartis to perform high content drug screening. The company uses Intel neural network technology to analyze thousands of images of cells to identify promising drug candidates. Previously, technicians analyzed these images manually, which was tedious and ...
Source: Medgadget - February 27, 2019 Category: Medical Devices Authors: Conn Hastings Tags: Exclusive Informatics Medicine Public Health Source Type: blogs
Fight Aging! Newsletter, January 14th 2019
In conclusion, reduction of LDL-C to less than 50 mg/dl seems safe and provides greater CV benefits compared with higher levels. Data for achieved LDL-C lower than 20-25 mg/dl is limited, although findings from the above mentioned studies are encouraging. However, further evaluation is needed for future studies and post-hoc analyses.
Wary of the Beautiful Fairy Tale of Near Term Rejuvenation
https://www.fightaging.org/archives/2019/01/wary-of-the-beautiful-fairy-tale-of-near-term-rejuvenation/
One might compare this interview with researcher Leonid Peshkin to last year's discussion with Vadim Gladyshev....
Source: Fight Aging! - January 13, 2019 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Is it Safe to Greatly Reduce LDL Cholesterol, Far Below Normal Levels?
In conclusion, reduction of LDL-C to less than 50 mg/dl seems safe and provides greater CV benefits compared with higher levels. Data for achieved LDL-C lower than 20-25 mg/dl is limited, although findings from the above mentioned studies are encouraging. However, further evaluation is needed for future studies and post-hoc analyses. (Source: Fight Aging!)
Source: Fight Aging! - January 9, 2019 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
The 4 Physiologic Etiologies of Shock, and the 3 Etiologies of Cardiogenic Shock
A 60-something presented with hypotension, bradycardia, chest pain and back pain.She had a h/o aortic aneurysm, aortic insufficiency, peripheral vascular disease, and hypertension. She had a mechanical aortic valve. She was on anti-hypertensives including atenolol, and on coumadin, with an INR of 2.3. She was ill appearing. BP was 70/49, pulse 60.A bedside echo showed good ejection fraction and normal right ventricle and no pericardial fluid. Here is the initial ECG:What do you think?This ECG actually looks like a left main occlusion (which rarely presents to the ED alive): ST Elevation in...
Source: Dr. Smith's ECG Blog - November 30, 2018 Category: Cardiology Authors: Steve Smith Source Type: blogs
