Differential Characteristics of Ischemic and Hemorrhagic Stroke in Patients with Cerebral Small Vessel Disease
Conclusion: Identification of differential clinical and prognostic profile between ischemic and hemorrhagic consequences of underlying cerebral SVD is useful for risk stratification in the current process pursuing precision medicine. (Source: Neurology India)
Source: Neurology India - February 24, 2021 Category: Neurology Authors: Mireia Bernal Paula Escarcena Adri & #224; Arboix Lluis Garcia-Eroles Enric Verg & #233;s Laura D & #237;ez Joan Massons Source Type: research

Clinico-Epidemiological Profile, Etiology, and Imaging in Neonatal Stroke: An Observational Study from Eastern India
Conclusion: NS is an acute emergency with high morbidity and mortality. Magnetic resonance imaging helps in diagnosis and prognostication in the absence or paucity of focal neurological signs in neonates. (Source: Neurology India)
Source: Neurology India - February 24, 2021 Category: Neurology Authors: Devdeep Mukherjee Dolly Kalita Dipankar Das Tarun Kumar Ritabrata Kundu Source Type: research

Seizures and Epilepsy After Stroke: Epidemiology, Biomarkers and Management
AbstractStroke is the leading cause of seizures and epilepsy in older adults. Patients who have larger and more severe strokes involving the cortex, are younger, and have acute symptomatic seizures and intracerebral haemorrhage are at highest risk of developing post-stroke epilepsy. Prognostic models, including the SeLECT and CAVE scores, help gauge the risk of epileptogenesis. Early electroencephalogram and blood-based biomarkers can provide information additional to the clinical risk factors of post-stroke epilepsy. The management of acute versus remote symptomatic seizures after stroke is markedly different. The choice ...
Source: Drugs and Aging - February 23, 2021 Category: Geriatrics Source Type: research

Delayed-onset motor aphasia succeeds Holmes' tremor and neuropathic pain after left thalamic hemorrhage
Although most neurological symptoms related to cerebrovascular diseases appear immediately after the events, some delayed-onset neurological symptoms, such as Holmes' tremor or central post-stroke pain (CPSP), can occur after a certain period of time [1]. The alterations in the neural networks caused by maladaptative neuroplasticity have been hypothesized to underlie this pathophysiology [2]. Here we report on a 53-year-old male patient who presented with a rare, delayed-onset motor aphasia caused by a left thalamic hemorrhage. (Source: Journal of the Neurological Sciences)
Source: Journal of the Neurological Sciences - February 23, 2021 Category: Neurology Authors: Tomoyo Shimada, Wataru Uchida, Atsuhiko Shindo, Koji Kamagata, Nobutaka Hattori, Taiji Tsunemi Tags: Letter to the Editor Source Type: research

Using ESN-Smartphone Application to Maximize AIS Reperfusion Therapy in Alexandria Stroke Network: A Stroke Chain of Survival Organizational Model
Conclusion: Our pilot experience demonstrated that the use of the ESN-app expedited the stroke treatment workflow and facilitated tele-connection between registered stroke facilities. Additionally, its use might be associated with achieving higher rates of excellent outcomes at 90 days, where a larger scale study is needed for more confirmation. (Source: Frontiers in Neurology)
Source: Frontiers in Neurology - February 23, 2021 Category: Neurology Source Type: research

The role of complement in brain injury following intracerebral hemorrhage: A review
Exp Neurol. 2021 Feb 19:113654. doi: 10.1016/j.expneurol.2021.113654. Online ahead of print.ABSTRACTIntracerebral hemorrhage (ICH) is a significant cause of death and disability and current treatment is limited to supportive measures to reduce brain edema and secondary hematoma expansion. Current evidence suggests that the complement cascade is activated early after hemorrhage and contributes to brain edema/injury in multiple ways. The aim of this review is to summarize the most recent literature about the role of the complement cascade after ICH. Primary literature demonstrating complement mediated brain edema and neurolo...
Source: Experimental Neurology - February 22, 2021 Category: Neurology Authors: Katherine Holste Fan Xia Hugh J L Garton Shu Wan Ya Hua Richard F Keep Guohua Xi Source Type: research

Pre-treatment of Single and Double Antiplatelet and Anticoagulant With Intravenous Thrombolysis for Older Adults With Acute Ischemic Stroke: The TTT-AIS Experience
Conclusion: For older adults with higher baseline severity of acute ischemic stroke, DAPP may increase the risk of SICH and mortality post IVT. However, DAPP is still not an indication to withdraw IVT and to prescribe low-dose IVT for older adults. (Source: Frontiers in Neurology)
Source: Frontiers in Neurology - February 22, 2021 Category: Neurology Source Type: research

Symptomatic intracranial hemorrhage in patients with admission hyperglycemia and diabetes after mechanical thrombectomy: A systematic review and meta-analysis
Symptomatic intracranial hemorrhage (sICH) is a severe complication of revascularization therapy. We aimed to investigate the association of admission hyperglycemia and sICH after mechanical thrombectomy in patients with acute ischemic stroke. (Source: The American Journal of Emergency Medicine)
Source: The American Journal of Emergency Medicine - February 22, 2021 Category: Emergency Medicine Authors: Lin Zang, Dan Zhang, Yanyan Yao, Yujie Wang Source Type: research

Complications Following Decompressive Craniectomy
Conclusions The incidence of complications following DC is high. However, we did not confirm a significant impact of complications on outcome. We emphasize that some phenomena are so frequent that they can be considered a consequence of primary injury or natural sequelae of the DC rather than its direct complication. [...] Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, GermanyArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: Journal of Neurological Surgery Part A: Central European Neurosurgery)
Source: Journal of Neurological Surgery Part A: Central European Neurosurgery - February 22, 2021 Category: Neurosurgery Authors: Mra ček, Jan Mork, Jan Dostal, Jiri Tupy, Radek Mrackova, Jolana Priban, Vladimir Tags: Original Article Source Type: research

Efficacy of BRAF Inhibitors in Combination With Stereotactic Radiosurgery for the Treatment of Melanoma Brain Metastases: A Systematic Review and Meta-Analysis
BackgroundBRAF inhibitors have improved the outcome for patients with BRAF mutant metastatic melanoma and have shown intracranial responses in melanoma brain metastases. Stereotactic radiosurgery (SRS) is being used as a local treatment for melanoma brain metastasis (MBM) with better local control and survival. We searched for studies comparing the combination of two treatments with SRS alone to detect any clinical evidence of synergism.Materials and MethodsPubMed, EMBASE, Medline, and Cochrane library were searched until May 2020 for studies with desired comparative outcomes. Outcomes of interest that were obtained for me...
Source: Frontiers in Oncology - February 22, 2021 Category: Cancer & Oncology Source Type: research

[Diagnosis and treatment of acute ischemic insults].
Authors: Diener HC, Wachter R Abstract In cases of stroke a distinction is made between a transient ischemic attack (TIA), a manifest ischemic infarction and cerebral hemorrhage. Cerebral ischemia can be caused by large vessel disease, small vessel disease, embolic causes, rare causes or stroke of unknown etiology. Acute diagnostic tests include a neurological examination, computed tomography (CT) and/or magnetic resonance imaging (MRI) with angiography, electrocardiography (ECG), and laboratory tests. The basic treatment of patients with TIA or acute ischemic infarction is performed in the stroke unit and inc...
Source: Herz - February 21, 2021 Category: Cardiology Tags: Herz Source Type: research

Recurrent Stroke Incidence and Etiology in Patients with Embolic Stroke of Undetermined Source and Other Stroke Subtypes.
CONCLUSIONS: Although the risk of recurrence was comparable between patients with ESUS and CE and intermediate between patients with LAA and SVD, in the acute admission unit, the risk in outpatients was similar among all subtypes. ESUS was the most recurrent stroke subtype in outpatients with ESUS. The risk of hemorrhagic stroke was significant in patients with SVD and ESUS. PMID: 33597329 [PubMed - as supplied by publisher] (Source: Journal of Atherosclerosis and Thrombosis)
Source: Journal of Atherosclerosis and Thrombosis - February 21, 2021 Category: Cardiology Tags: J Atheroscler Thromb Source Type: research

Seaweed Intake and Risk of Cardiovascular Disease: The Circulatory Risk in Communities Study (CIRCS).
CONCLUSIONS: We found an inverse association between seaweed intake and risk of total stroke, especially that from cerebral infarction, among Japanese men. PMID: 33597328 [PubMed - as supplied by publisher] (Source: Journal of Atherosclerosis and Thrombosis)
Source: Journal of Atherosclerosis and Thrombosis - February 21, 2021 Category: Cardiology Tags: J Atheroscler Thromb Source Type: research

Preliminary development of a prediction model for daily stroke occurrences based on meteorological and calendar information using deep learning framework (Prediction One; Sony Network Communications Inc., Japan).
Conclusion: Our preliminary results suggested a probability of the DL-based prediction models for stroke occurrence only by meteorological and calendar factors. In the future, by synchronizing a variety of medical information among the electronic medical records and personal smartphones as well as integrating the physical activities or meteorological conditions in real time, the prediction of stroke occurrence could be performed with high accuracy, to save medical resources, to have patients care for themselves, and to perform efficient medicine. PMID: 33598347 [PubMed] (Source: Surgical Neurology International)
Source: Surgical Neurology International - February 21, 2021 Category: Neurosurgery Tags: Surg Neurol Int Source Type: research

Pseudosubarachnoid hemorrhage: A systematic review of causes, diagnostic modalities, and outcomes in patients who present with pseudosubarachnoid hemorrhage.
Conclusion: This study is the first systematic review of causes, diagnostic modalities, and outcomes in patients who present with pSAH. A diagnosis of pSAH may be considered following assessment of CT densities following cardiac arrest. PMID: 33598345 [PubMed] (Source: Surgical Neurology International)
Source: Surgical Neurology International - February 21, 2021 Category: Neurosurgery Tags: Surg Neurol Int Source Type: research

Visual deficits after traumatic brain injury.
Discussion of current advancements in TBI animal models and the recent pathophysiological findings related to the neuro-glia-vascular unit (NVU) will help elucidate novel targets for potential therapeutics lines. Only over the past decade have newer pharmaceutical and stem cell-based treatments begun to come to light. The potency for these new lines of TBI specific curatives will be discussed along with the review of current blast-induced TBI models, providing potential directions for future research. PMID: 33599281 [PubMed - as supplied by publisher] (Source: Histology and Histopathology)
Source: Histology and Histopathology - February 20, 2021 Category: Cytology Tags: Histol Histopathol Source Type: research

Delayed intracranial hemorrhage after trauma.
Authors: Mitra B, Ruggles T, Seah J, Miller C, Fitzgerald MC Abstract Introduction: Delayed Intracranial Hemorrhage (D-ICH), defined as finding of ICH on subsequent imaging after a normal computed tomography of the brain (CTB), is a feared complication after head trauma. The aim of this study was to determine the incidence and severity of D-ICH. Methods: This retrospective cohort study included patients that presented directly from the scene of injury to an adult major trauma center from Jan 2013 to Dec 2018. Results: There were 6536 patients who had an initial normal CTB and 23 (0.3%; 95%CI: 0.20-0.47) had D-ICH. ...
Source: Brain Injury - February 20, 2021 Category: Neurology Tags: Brain Inj Source Type: research

Detection of symptoms of late complications after stroke in young survivors with active surveillance versus usual care
CONCLUSIONS: Active surveillance leads to higher rates of early symptom detection of non-motor LCAS in young stroke survivors. Implications for rehabilitation Young stroke survivors frequently have late complications after stroke (LCAS) that impair return to pre-stroke responsibilities. Active surveillance for LCAS symptoms with a semi-structured interview increases detection of non-motor late complications. A bundled approach to screening for LCAS symptoms is pragmatic as a majority of young stroke survivors have at least one symptom but no single symptom is present in all stroke survivors.PMID:33605166 | DOI:10.1080/0963...
Source: Disability and Rehabilitation - February 19, 2021 Category: Rehabilitation Authors: Sarah D Gans Elena Michaels David E Thaler Lester Y Leung Source Type: research

Utility of serum NOX4 as a potential prognostic biomarker for aneurysmal subarachnoid hemorrhage
CONCLUSIONS: Serum NOX4 concentrations, in close correlation with hemorrhagic severity, were independently associated with DCI and poor clinical outcome after hemorrhagic stroke, substantializing serum NOX4 as a promising prognostic biomarker for aSAH.PMID:33607069 | DOI:10.1016/j.cca.2021.02.007 (Source: International Journal of Clinical Chemistry)
Source: International Journal of Clinical Chemistry - February 19, 2021 Category: Chemistry Authors: Jianwei Pan Lingdi Lao Jian Shen Sichong Huang Tiesong Zhang Weijian Fan Ming Yan Jun Gu Wenchao Liu Source Type: research

Neurobiology of COVID-19: how can the virus affect the brain?
Braz J Psychiatry. 2021 Feb 10:S1516-44462021005003203. doi: 10.1590/1516-4446-2020-1488. Online ahead of print.ABSTRACTSevere acute respiratory syndrome-related coronavirus-2 (SARS-CoV-2) causes the coronavirus disease 2019 (COVID-19), which has been declared a public health emergency of international interest, with confirmed cases in most countries. COVID-19 presents manifestations that can range from asymptomatic or mild infections up to severe manifestations that lead to hospitalization and death. A growing amount of evidence indicates that the virus may cause neuroinvasion. Postmortem brain study findings have include...
Source: Revista Brasileira de Psiquiatria - February 19, 2021 Category: Psychiatry Authors: Jaqueline S Generoso Jo ão L Barichello de Quevedo Matias Cattani Bruna F Lodetti Lucas Sousa Allan Collodel Alexandre P Diaz Felipe Dal-Pizzol Source Type: research

GSE163256 Longitudinal transcriptomics define the stages of myeloid activation in the living human brain after intracerebral hemorrhage
Contributors : Lauren H Sansing ; Alex K Shalek ; J C Love ; Michael H Askenase ; Britany A GoodsSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensLongitudinal transcriptomic profiling of myeloid cells from cerebral hemorrhage patients reveals conserved features of the inflammatory response and highlights the potential importance of cellular metabolism in guiding macrophage functions and improved patient outcomes. (Source: GEO: Gene Expression Omnibus)
Source: GEO: Gene Expression Omnibus - February 19, 2021 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research

Sweet Twitches: An Unusual Cause of Abnormal Unilateral Movements in a Patient with Diabetes
We present a case of diabetic striatopathy, a rare hyperglycemic syndrome with pathognomonic imaging findings, often initially misdiagnosed as intracerebral hemorrhage. (Source: The Journal of Emergency Medicine)
Source: The Journal of Emergency Medicine - February 19, 2021 Category: Emergency Medicine Authors: George T. Kannarkat, Jeffrey M. McCue, Daniel S. Brenner Tags: Visual Diagnosis in Emergency Medicine Source Type: research

Neurological Disorders Associated With COVID-19 Hospital Admissions: Experience of a Single Tertiary Healthcare Center
Conclusion: Although the exact prevalence and etiology remain unclear, new onset of neurological disorders, in addition to anosmia, is non-sporadic during the acute COVID-19-infection. Longitudinal follow-up of these patients is required to determine the clinical and functional outcome, treatment response and long-term effects of the SARS-CoV-2 infection. (Source: Frontiers in Neurology)
Source: Frontiers in Neurology - February 19, 2021 Category: Neurology Source Type: research

Detection of symptoms of late complications after stroke in young survivors with active surveillance versus usual care.
CONCLUSIONS: Active surveillance leads to higher rates of early symptom detection of non-motor LCAS in young stroke survivors. Implications for rehabilitation Young stroke survivors frequently have late complications after stroke (LCAS) that impair return to pre-stroke responsibilities. Active surveillance for LCAS symptoms with a semi-structured interview increases detection of non-motor late complications. A bundled approach to screening for LCAS symptoms is pragmatic as a majority of young stroke survivors have at least one symptom but no single symptom is present in all stroke survivors. PMID: 33605166 [PubMed - a...
Source: Disability and Rehabilitation - February 19, 2021 Category: Rehabilitation Authors: Gans SD, Michaels E, Thaler DE, Leung LY Tags: Disabil Rehabil Source Type: research

Early Outcomes and Complications of Endovascular Treatment of Cerebral Arteriovenous Malformations in Pediatric Patients
Discussion: This single-surgeon single-center experience suggests that endovascular treatment is a safe and efficient treatment for pediatric AVMs. Pediatric prognostic scores for a suitable selection of candidates are needed. Further studies are required to validate these results.Pediatr Neurosurg (Source: Pediatric Neurosurgery)
Source: Pediatric Neurosurgery - February 18, 2021 Category: Neurosurgery Source Type: research

[ASAP] Efficient Iron and ROS Nanoscavengers for Brain Protection after Intracerebral Hemorrhage
ACS Applied Materials& InterfacesDOI: 10.1021/acsami.1c00491 (Source: ACS Applied Materials and Interfaces)
Source: ACS Applied Materials and Interfaces - February 18, 2021 Category: Materials Science Authors: Fang Zhu, Liu Zi, Peng Yang, Yang Wei, Rui Zhong, Yan Wang, Chao You, Yiwen Li, Meng Tian, and Zhipeng Gu Source Type: research

The trigeminal system: The meningovascular complex- A review.
x C Abstract Supratentorial sensory perception, including pain, is subserved by the trigeminal nerve, in particular, by the branches of its ophthalmic division, which provide an extensive innervation of the dura mater and of the major brain blood vessels. In addition, contrary to previous assumptions, studies on awake patients during surgery have demonstrated that the mechanical stimulation of the pia mater and small cerebral vessels can also produce pain. The trigeminovascular system, located at the interface between the nervous and vascular systems, is therefore perfectly positioned to detect sensory inputs and ...
Source: Journal of Anatomy - February 18, 2021 Category: Anatomy Authors: Terrier LM, Hadjikhani N, Velut S, Magnain C, Amelot A, Bernard F, Zöllei L, Destrieux C Tags: J Anat Source Type: research

Anticoagulant-related intracranial haemorrhage: time to anticoagulant reversal improving but still slower than thrombolysis for ischaemic stroke.
This study aims to determine whether door-to-needle times (DNT) for reversal of anticoagulant-associated intracerebral haemorrhage (ICH) (1) have improved over time, (2) differ between warfarin and dabigatran and (3) are comparable to ischaemic stroke (IS) thrombolysis DNT, and (4) whether reversal is monitored. METHODS: Retrospective review of all warfarin- and dabigatran-associated ICH presenting to Christchurch Hospital over a 15-year period. DNT data from 2013-2018 were compared between warfarin-related ICH (WRICH), dabigatran-related ICH (DRICH) and IS thrombolysis. RESULTS: 172 WRICH were identified. Over tim...
Source: New Zealand Medical Journal - February 17, 2021 Category: General Medicine Tags: N Z Med J Source Type: research

Neurological associations of SARS-CoV-2 infection: A Systematic Review
CNS Neurol Disord Drug Targets. 2021 Feb 16. doi: 10.2174/1871527320666210216121211. Online ahead of print.ABSTRACTBACKGROUND: The current ongoing COVID-19 pandemic has compelled us to scrutinize major outbreaks in the past two decades, severe acute respiratory syndrome (SARS), in 2002, and Middle East respiratory syndrome (MERS), in 2012. We aimed to assess the associated neurological manifestations with SARS CoV-2 infection.METHODS: In this systematic review, a search was carried out by key-electronic databases, controlled vocabulary, and indexing of trials to evaluate the available pertinent studies which included both ...
Source: CNS and Neurological Disorders Drug Targets - February 17, 2021 Category: Drugs & Pharmacology Authors: Amaan Javed Source Type: research

Risk of intracranial hemorrhage with direct oral anticoagulants: a systematic review and meta-analysis of randomized controlled  trials
ConclusionAll DOACs had a lower risk of ICH than VKAs. In terms of the risk of ICH, DOACs were overall as safe as LMWHs, and apixaban and dabigatran were as safe as aspirin, but rivaroxaban was not. For secondary prevention stroke, the risk of ICH with DOACs was overall lower than warfarin and similar to aspirin, but it should be noted that compared with aspirin, rivaroxaban may increase the risk of ICH. This is the first pair-wise meta-analysis that compares the risk of ICH between DOACs and other antithrombotic drugs in detail across all diseases, which may have certain significance for patients with high risk of ICH to ...
Source: Journal of Neurology - February 17, 2021 Category: Neurology Source Type: research

Comparison of the Efficacy and Safety Outcomes of Edoxaban in 8040 Women Versus 13 065 Men With Atrial Fibrillation in the ENGAGE AF-TIMI 48 Trial.
This study aimed to examine the efficacy and safety profile of edoxaban in women versus men. METHODS: The ENGAGE AF-TIMI 48 trial (Effective Anticoagulation with Factor Xa Next Generation in Atrial Fibrillation-Thrombolysis in Myocardial Infarction 48) randomly assigned 21 105 patients (8040 women) with atrial fibrillation and CHADS2 score ≥2 either to a higher-dose edoxaban regimen, a lower-dose edoxaban regimen, or warfarin. The primary end points of the trial were the composite of stroke or systemic embolic events (efficacy), and International Society on Thrombosis and Haemostasis-defined major bleeding (...
Source: Circulation - February 16, 2021 Category: Cardiology Authors: Zelniker TA, Ardissino M, Andreotti F, O'Donoghue ML, Yin O, Park JG, Murphy SA, Ruff CT, Lanz HJ, Antman EM, Braunwald E, Giugliano RP, Merlini PA Tags: Circulation Source Type: research

Stenting for Symptomatic Intracranial Vertebrobasilar Artery Stenosis in Northeast of China: A Single-Center Study
Conclusion: A high technical success rate of IVBS stenting could be achieved, and the safety was acceptable, whereas Mori C lesions were more vulnerable to endovascular procedure and showed a higher rate of complications than A and B types. (Source: Frontiers in Neurology)
Source: Frontiers in Neurology - February 16, 2021 Category: Neurology Source Type: research

Early recurrent ischemic events after mechanical thrombectomy: effect of post-treatment intracranial hemorrhage
AbstractObjectivePatients with intracranial hemorrhages (ICH) after mechanical thrombectomy (MT) may have a higher risk of early recurrent embolism (ERE) because of delayed initiation of anticoagulants. We assessed the rate of ischemic events in the early period after MT and the association with post-MT ICH.MethodsPatients who underwent MT in our institute were retrospectively reviewed. ERE was defined as recurrent ischemic stroke and systemic embolism within 14  days after MT. The association between ERE and parenchymal hematoma (PH) was assessed. Multivariable regression analysis and inverse probability of treatment...
Source: Journal of Neurology - February 16, 2021 Category: Neurology Source Type: research

Activated Microglia Exosomes Mediated miR-383-3p Promotes Neuronal Necroptosis Through Inhibiting ATF4 Expression in Intracerebral Hemorrhage.
In this study, ICH model was construct in rats and cells. Injury of cells in brain was detected by PI staining. Necroptosis in rats and cells was detected by western blot and flow cytometry. The expression of miR-383-3p was detected by RT-qPCR. The roles of activated microglia-secreted exosomes and exosome-contained miR-383-3p were detected through co-culturing medium or exosomes with neurons. The target gene of miR-383-3p was determined by luciferase assay and the expression of target gene was detected by western blot. Rescue experiments were used to confirm the mechanism of miR-383-3p in neurons necroptosis. The miR-383-...
Source: Neurochemical Research - February 16, 2021 Category: Neuroscience Authors: Wei M, Li C, Yan Z, Hu Z, Dong L, Zhang J, Wang X, Li Y, Zhang H Tags: Neurochem Res Source Type: research

Neurological associations of SARS-CoV-2 infection: A Systematic Review.
Abstract BACKGROUND: The current ongoing COVID-19 pandemic has compelled us to scrutinize major outbreaks in the past two decades, severe acute respiratory syndrome (SARS), in 2002, and Middle East respiratory syndrome (MERS), in 2012. We aimed to assess the associated neurological manifestations with SARS CoV-2 infection. METHODS: In this systematic review, a search was carried out by key-electronic databases, controlled vocabulary, and indexing of trials to evaluate the available pertinent studies which included both medical subject headings (MeSH) and advance electronic databases comprising of PubMed, Emba...
Source: CNS and Neurological Disorders Drug Targets - February 16, 2021 Category: Drugs & Pharmacology Authors: Javed A Tags: CNS Neurol Disord Drug Targets Source Type: research

Utility of serum NOX4 as a potential prognostic biomarker for aneurysmal subarachnoid hemorrhage.
CONCLUSIONS: Serum NOX4 concentrations, in close correlation with hemorrhagic severity, were independently associated with DCI and poor clinical outcome after hemorrhagic stroke, substantializing serum NOX4 as a promising prognostic biomarker for aSAH. PMID: 33607069 [PubMed - as supplied by publisher] (Source: International Journal of Clinical Chemistry)
Source: International Journal of Clinical Chemistry - February 16, 2021 Category: Chemistry Authors: Pan J, Lao L, Shen J, Huang S, Zhang T, Fan W, Yan M, Gu J, Liu W Tags: Clin Chim Acta Source Type: research

A 56-Year-Old Woman with Recurrent Strokes: A Clear Case with a Therapeutic Dilemma
A 56-year-old woman with a history of cerebral amyloid angiopathy (CAA) complicated by prior intracranial hemorrhage (ICH) was evaluated for an asymptomatic ischemic stroke discovered on screening brain MRI. On echocardiogram, she was found to have a mass on her mitral valve and strongly positive antiphospholipid antibodies. She was diagnosed with nonbacterial thrombotic (Libman-Sacks) endocarditis associated with the primary antiphospholipid syndrome (APS). The treatment decision was complicated by the history of CAA with ICH within the last year with very high risk for bleeding complications if on anticoagulation. A mult...
Source: Case Reports in Neurology - February 15, 2021 Category: Neurology Source Type: research

Association Between Ultrasound Parameters and History of Ischemic or Hemorrhagic Stroke in Patients With Moyamoya Disease
Conclusions: Ultrasound parameters of EICA and PCA are independently associated with history of previous ipsilateral ischemic or hemorrhagic stroke in patients with MMD. The present ultrasound-based nomogram might provide information to identify MMD patients with high risk of stroke. Future long-term follow-up studies are needed to prove the predictive value in other independent cohorts.Clinical Trial Registration:http://www.chictr.org.cn/index.aspx. Unique Identifier: ChiCTR1900026075. (Source: Frontiers in Neurology)
Source: Frontiers in Neurology - February 15, 2021 Category: Neurology Source Type: research

Cost-Effectiveness of Direct Non-Vitamin K Oral Anticoagulants Versus Vitamin K Antagonists for the Management of Patients with Non-Valvular Atrial Fibrillation Based on Available “Real-World” Evidence: The Italian National Health System Perspective
ConclusionsThe beneficial effect of DOACs on containing events showed in RWE had the potential to offset drug-related costs, thus improving the sustainability of treatment for non-valvular AF in daily clinical practice. (Source: Clinical Drug Investigation)
Source: Clinical Drug Investigation - February 15, 2021 Category: Drugs & Pharmacology Source Type: research

The Changes of Leukocytes in Brain and Blood After Intracerebral Hemorrhage
In conclusion, our findings emphasize the significance of intracerebral infiltrating immunocytes in ICH and demonstrate that ICH is a systemic disease affected by peripheral blood. The hub genes identified might be promising therapeutic targets. We also provide a reference on how to use bioinformatics approaches to explore non-neoplastic immune-related diseases. (Source: Frontiers in Immunology)
Source: Frontiers in Immunology - February 15, 2021 Category: Allergy & Immunology Source Type: research

Magnetic Resonance Imaging (MRI) and neurological manifestations in SARS-CoV-2 patients.
CONCLUSIONS: The neurologic manifestations of SARS-CoV-2 patients are highly variable. The SARS-COV-2 exerts its damaging effects on the nervous system and special senses by developing determinant numerous neurological and special senses' clinical manifestations. Physicians with the help of MRI must rule out the neurological and special senses manifestations among SARS-CoV-2 patients. PMID: 33577067 [PubMed - as supplied by publisher] (Source: European Review for Medical and Pharmacological Sciences)
Source: European Review for Medical and Pharmacological Sciences - February 14, 2021 Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research

Novel COL4A2 mutation causing familial malformations of cortical development.
CONCLUSIONS: The phenotypic spectrum associated with COL4A2 mutations has not been extensively described in the literature. Testing for COL4A mutations is indicated in patients with malformations of cortical development, particularly in the presence of familial conditions, even in the absence of porencephaly or early hemorrhagic strokes. PMID: 33577044 [PubMed - as supplied by publisher] (Source: European Review for Medical and Pharmacological Sciences)
Source: European Review for Medical and Pharmacological Sciences - February 14, 2021 Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research

Analysis of risk factors and prognosis of post-stroke pulmonary infection in integrated ICU.
Authors: Xu CY, Ye HW, Chen B, Wu YF, Cao Z, Ding Z, Yao YP, Gao Y, Li J, Zhu JJ, He S Abstract OBJECTIVE: The incidence of SAP (stroke-associated pneumonia) is high in integrated ICU (Intensive Care Unit), and it might result in sepsis, which exacerbates the clinical outcome and increases mortality. It is necessary to investigate the epidemiological features of post-stroke infection and sepsis, identify the risk factors and analyze the prognosis. PATIENTS AND METHODS: We retrospectively analyzed the data of 329 patients with cerebral infarction or cerebral hemorrhage, from seven tertiary university hospitals i...
Source: European Review for Medical and Pharmacological Sciences - February 14, 2021 Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research

Microglia-derived interleukin-10 accelerates post-intracerebral hemorrhage hematoma clearance by regulating CD36
Publication date: Available online 13 February 2021Source: Brain, Behavior, and ImmunityAuthor(s): Qian Li, Xi Lan, Xiaoning Han, Frederick Durham, Jieru Wan, Abigail Weiland, Raymond C. Koehler, Jian Wang (Source: Brain, Behavior, and Immunity)
Source: Brain, Behavior, and Immunity - February 14, 2021 Category: Neurology Source Type: research

A Brief Review of Brain's Blood Flow –Metabolism Coupling and Pressure Autoregulation
Conclusion Although fragmentation of cerebral autoregulation in separate and distinct from each other mechanisms is somewhat arbitrary, such a scheme is useful for reasons of simplification and to better understand their overall effect. Comprehension of cerebral autoregulation is imperative for clinicians in order for them to mitigate consequences of its impairment in the context of traumatic brain injury, subarachnoid hemorrhage, stroke, or other pathological conditions. [...] Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, GermanyArticle in Thieme eJournals: Table of contents  | &...
Source: Journal of Neurological Surgery Part A: Central European Neurosurgery - February 14, 2021 Category: Neurosurgery Authors: Papasilekas, Themistoklis Themistoklis, Konstantinos Michail Melanis, Konstantinos Patrikelis, Panayiotis Spartalis, Eleftherios Korfias, Stefanos Sakas, Damianos Tags: Review Article Source Type: research

Physiology of Human Hemorrhage and Compensation.
Authors: Convertino VA, Koons NJ, Suresh MR Abstract Hemorrhage is a leading cause of death following traumatic injuries in the United States. Much of the previous work in assessing the physiology and pathophysiology underlying blood loss has focused on descriptive measures of hemodynamic responses such as blood pressure, cardiac output, stroke volume, heart rate, and vascular resistance as indicators of changes in organ perfusion. More recent work has shifted the focus toward understanding mechanisms of compensation for reduced systemic delivery and cellular utilization of oxygen as a more comprehensive approach t...
Source: Comprehensive Physiology - February 13, 2021 Category: Physiology Tags: Compr Physiol Source Type: research

Shenfu injection improves cerebral microcirculation and reduces brain injury in a porcine model of hemorrhagic shock; SFI reduces brain injury after hemorrhagic shock
CONCLUSIONS: Combined application of SFI with volume resuscitation after HS can improve cerebral microcirculation and reduce brain injury.PMID:33579831 | DOI:10.3233/CH-211100 (Source: Clinical Hemorheology and Microcirculation)
Source: Clinical Hemorheology and Microcirculation - February 13, 2021 Category: Hematology Authors: Junyuan Wu Zhiwei Li Wei Yuan Qiang Zhang Yong Liang Mingqing Zhang Hongjie Qin Chunsheng Li Source Type: research

Cerebrovascular manifestations in hematological diseases: an update
AbstractPatients with hematological diseases often experience cerebrovascular complications including ischemic stroke, intracerebral and subarachnoid hemorrhage, microbleeds, posterior reversible encephalopathy syndrome, and dural sinus and cerebral vein thrombosis (CVT). In this update, we will review recent advances in the management of cerebrovascular diseases in the context of myeloproliferative neoplasms, leukemias, lymphomas, multiple myeloma, POEMS, paroxysmal nocturnal hemoglobinuria (PNH), thrombotic thrombocytopenic purpura (TTP), and sickle-cell disease. In acute ischemic stroke associated with hematological dis...
Source: Journal of Neurology - February 13, 2021 Category: Neurology Source Type: research

Shenfu injection improves cerebral microcirculation and reduces brain injury in a porcine model of hemorrhagic shock; SFI reduces brain injury after hemorrhagic shock.
CONCLUSIONS: Combined application of SFI with volume resuscitation after HS can improve cerebral microcirculation and reduce brain injury. PMID: 33579831 [PubMed - as supplied by publisher] (Source: Clinical Hemorheology and Microcirculation)
Source: Clinical Hemorheology and Microcirculation - February 12, 2021 Category: Hematology Authors: Wu J, Li Z, Yuan W, Zhang Q, Liang Y, Zhang M, Qin H, Li C Tags: Clin Hemorheol Microcirc Source Type: research

Microglia-derived interleukin-10 accelerates post-intracerebral hemorrhage hematoma clearance by regulating CD36.
Abstract Hematoma size after intracerebral hemorrhage (ICH) significantly affects patient outcome. However, our knowledge of endogenous mechanisms that underlie hematoma clearance and the potential role of the anti-inflammatory cytokine interleukin-10 (IL-10) is limited. Using organotypic hippocampal slice cultures and a collagenase-induced ICH mouse model, we investigated the role of microglial IL-10 in phagocytosis ex vivo and hematoma clearance in vivo. In slice culture, exposure to hemoglobin induced IL-10 expression in microglia and enhanced phagocytosis that depended on IL-10-regulated expression of CD36. Fo...
Source: Brain, Behavior, and Immunity - February 12, 2021 Category: Neurology Authors: Li Q, Lan X, Han X, Durham F, Wan J, Weiland A, Koehler RC, Wang J Tags: Brain Behav Immun Source Type: research