Hemolytic Uremic Syndrome (HUS) Research This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Sporadic Shiga Toxin-Producing Escherichia coli-Associated Pediatric Hemolytic Uremic Syndrome, France, 2012-2021
Emerg Infect Dis. 2023 Oct;29(10):2054-2064. doi: 10.3201/eid2910.230382.ABSTRACTShiga toxin-producing Escherichia coli-associated pediatric hemolytic uremic syndrome (STEC-HUS) remains an important public health risk in France. Cases are primarily sporadic, and geographic heterogeneity has been observed in crude incidence rates. We conducted a retrospective study of 1,255 sporadic pediatric STEC-HUS cases reported during 2012-2021 to describe spatiotemporal dynamics and geographic patterns of higher STEC-HUS risk. Annual case notifications ranged from 109 to 163. Most cases (n = 780 [62%]) were in children <3 years of ...
Source: Emerging Infectious Diseases - September 22, 2023 Category: Infectious Diseases Authors: Gabrielle Jones Patricia Mariani-Kurkdjian Aur élie Cointe St éphane Bonacorsi Sophie Lef èvre Fran çois-Xavier Weill Yann Le Strat Source Type: research

Measuring ADAMTS-13 activity to diagnose thrombotic thrombocytopenic purpura: a novel, fast fiber-optic surface plasmon resonance immunoassay
CONCLUSIONS: A fast ADAMTS-13 activity assay was designed onto automated FO-SPR technology. Optimization resulted in sensitive ADAMTS-13 activity measurements with a detection limit enabling clinical diagnosis of TTP within 3 hours. The FO-SPR assay proved strong correlation with the reference FRETS-VWF73 assay. For the first time, this assay demonstrated the capacity of FO-SPR technology to measure enzymatic activity in pre-clinical context.PMID:37711907 | PMC:PMC10497779 | DOI:10.1016/j.rpth.2023.102171 (Source: Thrombosis and Haemostasis)
Source: Thrombosis and Haemostasis - September 15, 2023 Category: Hematology Authors: Quintijn Bonnez Charlotte Dekimpe Edwige Tellier Gilles Kaplanski Peter Verhamme Claudia Tersteeg Simon F De Meyer Jeroen Lammertyn B érangère Joly Paul Coppo Agn ès Veyradier Karen Vanhoorelbeke Source Type: research

Microvascular endothelial activation/dysfunction and dysregulation of the angiopoietin-tie2 system in the pathogenesis of life-threatening infections
Trans Am Clin Climatol Assoc. 2023;133:234-246.ABSTRACTMicrovascular endothelial activation/dysfunction has emerged as an important mechanistic pathophysiological process in the development of morbidity and mortality in life-threatening infections. The angiopoietin-Tie2 system plays an integral role in the regulation of microvascular endothelial integrity. Angiopoietin-1 (Ang-1), produced by platelets and pericytes, is the cognate agonistic ligand for Tie2, promoting endothelial quiescence and inhibiting microvascular leak. Angiopoietin-2 (Ang-2), released from activated endothelial cells in Weibel-Palade bodies, competes ...
Source: Transactions of the American Clinical and Climatological Association - September 13, 2023 Category: General Medicine Authors: W Conrad Liles Source Type: research

Detection of plasma anti-lipopolysaccharide (LPS) antibodies against enterohemorrhagic Escherichia coli (EHEC) in asymptomatic kindergarten teachers from Buenos Aires province
Rev Argent Microbiol. 2023 Sep 11:S0325-7541(23)00056-1. doi: 10.1016/j.ram.2023.05.006. Online ahead of print.ABSTRACTIn Argentina, hemolytic uremic syndrome (HUS) caused by EHEC has the highest incidence in the world. EHEC infection has an endemo-epidemic behavior, causing 20-30% of acute bloody diarrhea syndrome in children under 5 years old. In the period 2016-2020, 272 new cases per year were notified to the National Health Surveillance System. Multiple factors are responsible for HUS incidence in Argentina including person-to-person transmission. In order to detect possible EHEC carriers, we carried out a preliminary...
Source: Revista Argentina de Microbiologia - September 13, 2023 Category: Microbiology Authors: Romina J Fernandez-Brando Flavia Sacerdoti Mar ía M Amaral Alan M Bernal Marcelo Da Rocha Marcela Belardo Marina S Palermo Cristina A Ibarra Source Type: research