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Coverage of Alexion Investigation Highlights the Risk to Clinical Laboratories That Sell Blinded Medical Data
Despite blinding data and following protocols, a recent investigation in Bloomberg Businessweek shows that clinical laboratories can be at risk in deals with pharmaceutical and big data companies While big data is transforming how healthcare is both researched and applied, it also offers opportunities for clinical laboratories to create additional revenue from the endless streams […] (Source: Dark Daily)
Source: Dark Daily - June 21, 2017 Category: Laboratory Medicine Authors: jude Tags: Compliance, Legal, and Malpractice Laboratory News Laboratory Operations Laboratory Pathology Laboratory Testing Management & Operations Adam Tanner aHUS Alexion Ancestry AncestryDNA atypical hemolytic uremic syndrome big data cl Source Type: news

Pro Sports Club Recalls Yogurt Peanut Crunch Bar Because of Possible Health Risk
Pro Sports Club of Bellevue, WA is recalling 36.957 Yogurt Peanut Crunch bars because it may be contaminated with Escherichia coli H7 bacteria (E.Coli O157:H7) E Coli O157:H7 causes a diarrheal illness often with bloody stools. Although most healthy adults can recover completely within a week, some people can develop a form of kidney failure called Hemolytic Uremic Syndrome (HUS). HUS is most likely to occur in young children and the elderly. The condition can lead to serious kidney damage and even death. (Source: Food and Drug Administration)
Source: Food and Drug Administration - March 24, 2017 Category: Food Science Source Type: news

E. Coli Outbreak Likely Caused By I.M. Healthy SoyNut Butter
Twelve people, most of them children, are suffering from an E. coli outbreak that struck five states and may be linked to I.M. Healthy SoyNut Butter, health officials said. Six of the victims were hospitalized, and four developed a kind of kidney failure called hemolytic uremic syndrome, a life-threatening complication that generally affects about 5 to 10 percent of people who are sickened by E. coli bacteria. Eleven of the 12 infected people are younger than 18 years old. All of the patients live in Arizona, California, Maryland, New Jersey and Oregon.  Public health officials haven’t reported any deaths,...
Source: Healthy Living - The Huffington Post - March 3, 2017 Category: Consumer Health News Source Type: news

Adams Farm Slaughterhouse Recalls Beef, Bison And Veal Due To E.coli
Check your fridges and freezers, folks. Adams Farm Slaughterhouse, an Athol, Massachusetts-based company, recalled all beef, veal and bison packaged products due to an E. coli outbreak, according to the U.S. Department of Agriculture. The company recall includes meat packaged from July 21 to September 22, 2016 after federal officials were notified of seven illnesses traced back to the contaminated red meat across Connecticut, Massachusetts, Pennsylvania and West Virginia. The strain found in the Adams Farm outbreak ― Escherichia coli O157:H7 ― can cause dehydration, bloody diarrhea and stomach cramps fro...
Source: Science - The Huffington Post - September 26, 2016 Category: Science Source Type: news

Adams Farm Slaughterhouse Recalls Beef, Bison And Veal Due To E.coli
Check your fridges and freezers, folks. Adams Farm Slaughterhouse, an Athol, Massachusetts-based company, recalled all beef, veal and bison packaged products due to an E. coli outbreak, according to the U.S. Department of Agriculture. The company recall includes meat packaged from July 21 to September 22, 2016 after federal officials were notified of seven illnesses traced back to the contaminated red meat across Connecticut, Massachusetts, Pennsylvania and West Virginia. The strain found in the Adams Farm outbreak ― Escherichia coli O157:H7 ― can cause dehydration, bloody diarrhea and stomach cramps fro...
Source: Healthy Living - The Huffington Post - September 26, 2016 Category: Consumer Health News Source Type: news

HUS Associated With E. coli Infection in Older Adults HUS Associated With E. coli Infection in Older Adults
This case highlights the importance of recognizing hemolytic uremic syndrome associated with Shiga toxin-producing E. coli--an illness more common in children--in older persons. Journal of Medical Case Reports (Source: Medscape Critical Care Headlines)
Source: Medscape Critical Care Headlines - July 19, 2016 Category: Intensive Care Tags: Infectious Diseases Journal Article Source Type: news

HUS Associated With E. coli Infection in Older AdultsHUS Associated With E. coli Infection in Older Adults
This case highlights the importance of recognizing hemolytic uremic syndrome associated with Shiga toxin-producing E. coli--an illness more common in children--in older persons. Journal of Medical Case Reports (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - July 19, 2016 Category: Consumer Health News Tags: Infectious Diseases Journal Article Source Type: news

What is the Recurrence Risk for Clostridium difficile Infection?
Discussion Clostridium difficile infection (CDI) is a common cause of nosocomial diarrhea. Clostridium difficile is an obligate, anaerobic, gram-positive bacillus that is spore-forming and toxin producing. It is resistant to acid, heat, antibiotics and many antiseptic agents. Spores are acquired from the environment or by oral-fecal route. Once in the colon, the bacteria attach and proliferate making vegetative forms. Two main toxins are produced which disrupt the colonic integrity. Toxin A (TcdA) is an endotoxin that disrupts the mucosal cells. Toxin B (TcdB) is a cytotoxin that is 1000x more potent than TcdA and causes a...
Source: PediatricEducation.org - March 28, 2016 Category: Pediatrics Authors: pediatriceducationmin Tags: Uncategorized Source Type: news

Sub-lethal dose of shiga toxin 2 from enterohemorrhagic escherichia Coli affects balance and cerebellar cytoarchitecture - D'Alessio L, Pinto A, Cangelosi A, Geoghegan PA, Tironi-Farinati C, Brener GJ, Goldstein J.
Shiga toxin producing Escherichia coli may damage the central nervous system before or concomitantly to manifested hemolytic-uremic syndrome symptoms. The cerebellum is frequently damaged during this syndrome, however, the deleterious effects of Shiga toxi... (Source: SafetyLit)
Source: SafetyLit - March 13, 2016 Category: Global & Universal Tags: Falls Source Type: news

Early Eculizumab Treatment Improves Outcomes in Atypical HUSEarly Eculizumab Treatment Improves Outcomes in Atypical HUS
Rapid diagnosis and early initiation of eculizumab helps patients with atypical hemolytic uremic syndrome (HUS) recover normal renal function, a new analysis shows. Medscape Medical News (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - June 11, 2015 Category: Consumer Health News Tags: Nephrology News Source Type: news

Frontiere Natural Meats, LLC Recalls Ground Elk Meat Because Of Possible Health Risk
Frontiere Natural Meats, LLC, a Denver, Colorado establishment, is recalling 1,640 pounds of ground elk meat that may be contaminated with Escherichia coli O157:H7 bacteria (E. Coli O157:H7). E. coli O157:H7 causes a diarrheal illness often with bloody stools. Although most healthy adults can recover completely within a week, some people can develop a form of kidney failure called Hemolytic Uremic Syndrome (HUS). (Source: Food and Drug Administration)
Source: Food and Drug Administration - June 4, 2015 Category: Food Science Source Type: news

Horizontal gene transfer in E. coli
(Inderscience Publishers) Escherichia coli O104 is an emergent disease-causing bacterium various strains of which are becoming increasingly well known and troublesome. The pathogen causes bloody diarrhea as well as and potentially fatal kidney damage, hemolytic uremic syndrome. Infection is usually through inadvertent ingestion of contaminated and incompletely cooked food or other materials, such as animals feces. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - May 19, 2015 Category: Global & Universal Source Type: news

NICE backs drug for rare life-threatening blood disorder
The National Institute for Health and Care Excellence has recommended eculizumab (Soliris) for treating a rare life-threatening blood disorder called atypical Haemolytic Uraemic Syndrome (aHUS). (Source: Nursing Times Breaking News)
Source: Nursing Times Breaking News - January 28, 2015 Category: Nursing Source Type: news

Eculizumab Reverses Renal Damage in aHUSEculizumab Reverses Renal Damage in aHUS
Patients with atypical hemolytic uremic syndrome (aHUS) were able to discontinue dialysis after the introduction of eculizumab, regardless of transplant history. Medscape Medical News (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - June 16, 2014 Category: Consumer Health News Tags: Nephrology News Source Type: news

What is in the Differential Diagnosis of Purpura?
Discussion Children presenting with rashes are common but certain characteristics may be concerning such as descriptions of petechiae or purpura. Purpura are characterized by non-blanching skin lesions between 3-10 mm in size that are caused by bleeding into the skin. Usually they are reddish-purplish hence the name purpura coming from the Latin word. Non-blanching lesions that are 10 mm are ecchymosis. Henoch-Schönlein purpura (HSP) is a generalized vasculitis that commonly involves the gastrointestinal tract, kidneys, skin and joints, and is especially seen in children 2-11 years old. Classically HSP presents with p...
Source: PediatricEducation.org - May 5, 2014 Category: Pediatrics Authors: pediatriceducationmin Tags: Uncategorized Source Type: news

Omeros announces positive data for human monoclonal antibody OMS721
Omeros has reported positive data using OMS721 in ex vivo studies of endothelial activation relevant to the pathophysiology of human atypical haemolytic uremic syndrome (aHUS), a form of thrombotic microangiopathy (TMA). (Source: Drug Development Technology)
Source: Drug Development Technology - March 12, 2014 Category: Pharmaceuticals Source Type: news

NICE Requests More Soliris Price Analysis From Alexion
The UK National Institute for Health and Care Excellence (NICE) has issued a request to Alexion Pharmaceuticals for more information regarding its expensive drug Soliris (eculizumab). Soliris is a proven effective treatment for rare disease atypical hemolytic-uremic syndrome (aHUS). (Source: Pharmaceutical Online News)
Source: Pharmaceutical Online News - March 5, 2014 Category: Pharmaceuticals Source Type: news

Raw Milk
The trend towards using organic foods to feed our families is something we really can put our support behind.   Feeding our families preservative free, antibiotic free and non-genetically altered food reduces the body’s need to process potentially harmful substances. But not every “raw” food is necessarily a good thing.   Take unpasteurized raw milk.  Unpasteurized milk can contain bacteria and germs such as salmonella, E. coli and listeria. Whether raw milk comes from cows, sheep, or goats, the bacteria is especially dangerous to children.  Of all outbreaks that were caused ...
Source: Pediatric Health Associates - February 14, 2014 Category: Pediatrics Tags: Healthy Habits Source Type: news

Martin Barratt obituary
Paediatric nephrologist whose research led to the improved treatment of common childhood kidney diseasesMartin Barratt, who has died aged 77 from a progressive form of muscular dystrophy, was professor of paediatric nephrology at the Institute of Child Health, London, and consultant nephrologist at Great Ormond Street Hospital for Children. He was one of the first to establish a specialist service for children with kidney diseases in Britain, developing a model of interdisciplinary care that was later adopted by many other centres throughout the world. His research led to improved understanding and treatment of many common...
Source: Guardian Unlimited Science - February 3, 2014 Category: Science Authors: Michael Levin Tags: theguardian.com Children Obituaries Medical research Hospitals NHS Science Source Type: news

Haemolytic uremic syndrome following fire ant bites - Lee YC, Wang JS, Shiang JC, Tsai MK, Deng KT, Chang MY, Wang HH, Ho LC, Chen YT, Hung SY.
BACKGROUND: Haemolytic-uremic syndrome (HUS) is a severe, life-threatening disease with symptoms such as haemolytic anaemia, renal failure, and a low platelet count. Possible aetiology includes bacterial infections, medication, post-hematopoietic cell tran... (Source: SafetyLit: All (Unduplicated))
Source: SafetyLit: All (Unduplicated) - January 24, 2014 Category: Global & Universal Tags: Non-Human Animals and Insects Source Type: news

Alexion Pharma's Soliris drug obtains Japanese approval for treatment of aHUS
Alexion Pharmaceuticals has received approval from the Ministry of Health, Labour and Welfare (MHLW) in Japan for the use of its drug 'Soliris' (eculizumab) to treat paediatric and adult patients with atypical hemolytic uremic syndrome (aHUS), an ult… (Source: Drug Development Technology)
Source: Drug Development Technology - September 15, 2013 Category: Pharmaceuticals Source Type: news

Soliris a 'Game Changer' for Genetic Disorder (CME/CE)
(MedPage Today) -- Long-term treatment with the humanized monoclonal antibody eculizumab (Soliris) was highly effective in thwarting thrombotic microangiopathy and improving kidney function in atypical hemolytic-uremic syndrome, researchers found. (Source: MedPage Today Hematology/Oncology)
Source: MedPage Today Hematology/Oncology - June 5, 2013 Category: Hematology Source Type: news

Eculizumab Helps the Kidneys in Hemolytic Uremic SyndromeEculizumab Helps the Kidneys in Hemolytic Uremic Syndrome
The monoclonal antibody appears to improve renal function in patients with atypical hemolytic uremic syndrome. Medscape Medical News (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - June 3, 2013 Category: Consumer Health News Tags: Nephrology News Source Type: news

Gene Mutations Affect Kidney Disease Risk And Prognosis
Screening could help in the diagnosis and treatment of affected individuals Highlights Certain mutations and combinations of mutations in immune-related genes affect individuals' risk of developing a rare but serious kidney condition. These mutations also affect patient prognosis following different treatments. About half of patients with the condition, called atypical hemolytic uremic syndrome, develop kidney failure... (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - February 25, 2013 Category: Consumer Health News Tags: Urology / Nephrology Source Type: news

Molecular basis identified for tissue specific immune regulation in the eye and kidney
(University of Manchester) Scientists at The University of Manchester have made important advances in understanding why our immune system can attack our own tissues resulting in eye and kidney diseases. It is hoped the research will pave the way for the development of new treatments for the eye condition age-related macular degeneration and the kidney condition atypical Haemolytic Uremic Syndrome. (Source: EurekAlert! - Biology)
Source: EurekAlert! - Biology - February 20, 2013 Category: Biology Source Type: news

Advisory Group for National Specialised Services (AGNSS) issues statement on eculizumab for treatment of atypical haemolytic uraemic syndrome
Source: NHS Specialised Services Area: News The Advisory Group for National Specialised Services (AGNSS) provides advice to Ministers on which services and technologies should be nationally commissioned and which providers should be designated to deliver them. It considered the applications for eculizumab for the treatment of atypical haemolytic uraemic syndrome and concluded that it would help save lives and improve the quality of life for children (among whom the condition is particularly prevalent) and adults. However, ministers have decided not to recommend national commissioning of this treatment, and as AGNSS ceases...
Source: NeLM - News - January 24, 2013 Category: Drugs & Pharmacology Source Type: news