Infection and antibiotic-associated changes in the fecal microbiota of < em > C. rodentium < /em > ϕ < em > stx2 < sub > dact < /sub > < /em > -infected C57BL/6 mice
Antimicrob Agents Chemother. 2024 Mar 25:e0005724. doi: 10.1128/aac.00057-24. Online ahead of print.ABSTRACTEnterohemorrhagic Escherichia coli causes watery to bloody diarrhea, which may progress to hemorrhagic colitis and hemolytic-uremic syndrome. While early studies suggested that antibiotic treatment may worsen the pathology of an enterohemorrhagic Escherichia coli (EHEC) infection, recent work has shown that certain non-Shiga toxin-inducing antibiotics avert disease progression. Unfortunately, both intestinal bacterial infections and antibiotic treatment are associated with dysbiosis. This can alleviate colonization r...
Source: Antimicrobial Agents and Chemotherapy - March 25, 2024 Category: Microbiology Authors: Sabrina M ühlen Ann Kathrin Heroven Bettina Elxnat Silke Kahl Dietmar H Pieper Petra Dersch Source Type: research

Management of pediatric hemolytic uremic syndrome
Turk J Pediatr. 2024;66(1):1-16. doi: 10.24953/turkjped.2023.596.ABSTRACTClassical clinical triad of hemolytic uremic syndrome (HUS) is microangiopathic hemolytic anemia, thrombocytopenia, and acute kidney injury associated with endothelial cell injury. Several situations, including infections, medications, malignancies, and transplantation can trigger endothelial damage. On the HUS spectrum, atypical hemolytic uremic syndrome (aHUS) deserves special attention in pediatric patients, as it can cause endstage kidney disease and mortality. A dysfunction in the alternative complement pathway, either acquired or genetic, has be...
Source: The Turkish Journal of Pediatrics - March 25, 2024 Category: Pediatrics Authors: Bora G ülhan Fatih Özaltın Kibriya Fidan Zeynep Birsin Özçakar O ğuz Söylemezoğlu Source Type: research

Management of pediatric hemolytic uremic syndrome
Turk J Pediatr. 2024;66(1):1-16. doi: 10.24953/turkjped.2023.596.ABSTRACTClassical clinical triad of hemolytic uremic syndrome (HUS) is microangiopathic hemolytic anemia, thrombocytopenia, and acute kidney injury associated with endothelial cell injury. Several situations, including infections, medications, malignancies, and transplantation can trigger endothelial damage. On the HUS spectrum, atypical hemolytic uremic syndrome (aHUS) deserves special attention in pediatric patients, as it can cause endstage kidney disease and mortality. A dysfunction in the alternative complement pathway, either acquired or genetic, has be...
Source: The Turkish Journal of Pediatrics - March 25, 2024 Category: Pediatrics Authors: Bora G ülhan Fatih Özaltın Kibriya Fidan Zeynep Birsin Özçakar O ğuz Söylemezoğlu Source Type: research

Management of pediatric hemolytic uremic syndrome
Turk J Pediatr. 2024;66(1):1-16. doi: 10.24953/turkjped.2023.596.ABSTRACTClassical clinical triad of hemolytic uremic syndrome (HUS) is microangiopathic hemolytic anemia, thrombocytopenia, and acute kidney injury associated with endothelial cell injury. Several situations, including infections, medications, malignancies, and transplantation can trigger endothelial damage. On the HUS spectrum, atypical hemolytic uremic syndrome (aHUS) deserves special attention in pediatric patients, as it can cause endstage kidney disease and mortality. A dysfunction in the alternative complement pathway, either acquired or genetic, has be...
Source: The Turkish Journal of Pediatrics - March 25, 2024 Category: Pediatrics Authors: Bora G ülhan Fatih Özaltın Kibriya Fidan Zeynep Birsin Özçakar O ğuz Söylemezoğlu Source Type: research

Management of pediatric hemolytic uremic syndrome
Turk J Pediatr. 2024;66(1):1-16. doi: 10.24953/turkjped.2023.596.ABSTRACTClassical clinical triad of hemolytic uremic syndrome (HUS) is microangiopathic hemolytic anemia, thrombocytopenia, and acute kidney injury associated with endothelial cell injury. Several situations, including infections, medications, malignancies, and transplantation can trigger endothelial damage. On the HUS spectrum, atypical hemolytic uremic syndrome (aHUS) deserves special attention in pediatric patients, as it can cause endstage kidney disease and mortality. A dysfunction in the alternative complement pathway, either acquired or genetic, has be...
Source: The Turkish Journal of Pediatrics - March 25, 2024 Category: Pediatrics Authors: Bora G ülhan Fatih Özaltın Kibriya Fidan Zeynep Birsin Özçakar O ğuz Söylemezoğlu Source Type: research

Management of pediatric hemolytic uremic syndrome
Turk J Pediatr. 2024;66(1):1-16. doi: 10.24953/turkjped.2023.596.ABSTRACTClassical clinical triad of hemolytic uremic syndrome (HUS) is microangiopathic hemolytic anemia, thrombocytopenia, and acute kidney injury associated with endothelial cell injury. Several situations, including infections, medications, malignancies, and transplantation can trigger endothelial damage. On the HUS spectrum, atypical hemolytic uremic syndrome (aHUS) deserves special attention in pediatric patients, as it can cause endstage kidney disease and mortality. A dysfunction in the alternative complement pathway, either acquired or genetic, has be...
Source: The Turkish Journal of Pediatrics - March 25, 2024 Category: Pediatrics Authors: Bora G ülhan Fatih Özaltın Kibriya Fidan Zeynep Birsin Özçakar O ğuz Söylemezoğlu Source Type: research

Management of pediatric hemolytic uremic syndrome
Turk J Pediatr. 2024;66(1):1-16. doi: 10.24953/turkjped.2023.596.ABSTRACTClassical clinical triad of hemolytic uremic syndrome (HUS) is microangiopathic hemolytic anemia, thrombocytopenia, and acute kidney injury associated with endothelial cell injury. Several situations, including infections, medications, malignancies, and transplantation can trigger endothelial damage. On the HUS spectrum, atypical hemolytic uremic syndrome (aHUS) deserves special attention in pediatric patients, as it can cause endstage kidney disease and mortality. A dysfunction in the alternative complement pathway, either acquired or genetic, has be...
Source: The Turkish Journal of Pediatrics - March 25, 2024 Category: Pediatrics Authors: Bora G ülhan Fatih Özaltın Kibriya Fidan Zeynep Birsin Özçakar O ğuz Söylemezoğlu Source Type: research

Management of pediatric hemolytic uremic syndrome
Turk J Pediatr. 2024;66(1):1-16. doi: 10.24953/turkjped.2023.596.ABSTRACTClassical clinical triad of hemolytic uremic syndrome (HUS) is microangiopathic hemolytic anemia, thrombocytopenia, and acute kidney injury associated with endothelial cell injury. Several situations, including infections, medications, malignancies, and transplantation can trigger endothelial damage. On the HUS spectrum, atypical hemolytic uremic syndrome (aHUS) deserves special attention in pediatric patients, as it can cause endstage kidney disease and mortality. A dysfunction in the alternative complement pathway, either acquired or genetic, has be...
Source: The Turkish Journal of Pediatrics - March 25, 2024 Category: Pediatrics Authors: Bora G ülhan Fatih Özaltın Kibriya Fidan Zeynep Birsin Özçakar O ğuz Söylemezoğlu Source Type: research

Management of pediatric hemolytic uremic syndrome
Turk J Pediatr. 2024;66(1):1-16. doi: 10.24953/turkjped.2023.596.ABSTRACTClassical clinical triad of hemolytic uremic syndrome (HUS) is microangiopathic hemolytic anemia, thrombocytopenia, and acute kidney injury associated with endothelial cell injury. Several situations, including infections, medications, malignancies, and transplantation can trigger endothelial damage. On the HUS spectrum, atypical hemolytic uremic syndrome (aHUS) deserves special attention in pediatric patients, as it can cause endstage kidney disease and mortality. A dysfunction in the alternative complement pathway, either acquired or genetic, has be...
Source: The Turkish Journal of Pediatrics - March 25, 2024 Category: Pediatrics Authors: Bora G ülhan Fatih Özaltın Kibriya Fidan Zeynep Birsin Özçakar O ğuz Söylemezoğlu Source Type: research

Management of pediatric hemolytic uremic syndrome
Turk J Pediatr. 2024;66(1):1-16. doi: 10.24953/turkjped.2023.596.ABSTRACTClassical clinical triad of hemolytic uremic syndrome (HUS) is microangiopathic hemolytic anemia, thrombocytopenia, and acute kidney injury associated with endothelial cell injury. Several situations, including infections, medications, malignancies, and transplantation can trigger endothelial damage. On the HUS spectrum, atypical hemolytic uremic syndrome (aHUS) deserves special attention in pediatric patients, as it can cause endstage kidney disease and mortality. A dysfunction in the alternative complement pathway, either acquired or genetic, has be...
Source: The Turkish Journal of Pediatrics - March 25, 2024 Category: Pediatrics Authors: Bora G ülhan Fatih Özaltın Kibriya Fidan Zeynep Birsin Özçakar O ğuz Söylemezoğlu Source Type: research

Management of pediatric hemolytic uremic syndrome
Turk J Pediatr. 2024;66(1):1-16. doi: 10.24953/turkjped.2023.596.ABSTRACTClassical clinical triad of hemolytic uremic syndrome (HUS) is microangiopathic hemolytic anemia, thrombocytopenia, and acute kidney injury associated with endothelial cell injury. Several situations, including infections, medications, malignancies, and transplantation can trigger endothelial damage. On the HUS spectrum, atypical hemolytic uremic syndrome (aHUS) deserves special attention in pediatric patients, as it can cause endstage kidney disease and mortality. A dysfunction in the alternative complement pathway, either acquired or genetic, has be...
Source: The Turkish Journal of Pediatrics - March 25, 2024 Category: Pediatrics Authors: Bora G ülhan Fatih Özaltın Kibriya Fidan Zeynep Birsin Özçakar O ğuz Söylemezoğlu Source Type: research

Management of pediatric hemolytic uremic syndrome
Turk J Pediatr. 2024;66(1):1-16. doi: 10.24953/turkjped.2023.596.ABSTRACTClassical clinical triad of hemolytic uremic syndrome (HUS) is microangiopathic hemolytic anemia, thrombocytopenia, and acute kidney injury associated with endothelial cell injury. Several situations, including infections, medications, malignancies, and transplantation can trigger endothelial damage. On the HUS spectrum, atypical hemolytic uremic syndrome (aHUS) deserves special attention in pediatric patients, as it can cause endstage kidney disease and mortality. A dysfunction in the alternative complement pathway, either acquired or genetic, has be...
Source: The Turkish Journal of Pediatrics - March 25, 2024 Category: Pediatrics Authors: Bora G ülhan Fatih Özaltın Kibriya Fidan Zeynep Birsin Özçakar O ğuz Söylemezoğlu Source Type: research

Management of pediatric hemolytic uremic syndrome
Turk J Pediatr. 2024;66(1):1-16. doi: 10.24953/turkjped.2023.596.ABSTRACTClassical clinical triad of hemolytic uremic syndrome (HUS) is microangiopathic hemolytic anemia, thrombocytopenia, and acute kidney injury associated with endothelial cell injury. Several situations, including infections, medications, malignancies, and transplantation can trigger endothelial damage. On the HUS spectrum, atypical hemolytic uremic syndrome (aHUS) deserves special attention in pediatric patients, as it can cause endstage kidney disease and mortality. A dysfunction in the alternative complement pathway, either acquired or genetic, has be...
Source: The Turkish Journal of Pediatrics - March 25, 2024 Category: Pediatrics Authors: Bora G ülhan Fatih Özaltın Kibriya Fidan Zeynep Birsin Özçakar O ğuz Söylemezoğlu Source Type: research

Management of pediatric hemolytic uremic syndrome
Turk J Pediatr. 2024;66(1):1-16. doi: 10.24953/turkjped.2023.596.ABSTRACTClassical clinical triad of hemolytic uremic syndrome (HUS) is microangiopathic hemolytic anemia, thrombocytopenia, and acute kidney injury associated with endothelial cell injury. Several situations, including infections, medications, malignancies, and transplantation can trigger endothelial damage. On the HUS spectrum, atypical hemolytic uremic syndrome (aHUS) deserves special attention in pediatric patients, as it can cause endstage kidney disease and mortality. A dysfunction in the alternative complement pathway, either acquired or genetic, has be...
Source: The Turkish Journal of Pediatrics - March 25, 2024 Category: Pediatrics Authors: Bora G ülhan Fatih Özaltın Kibriya Fidan Zeynep Birsin Özçakar O ğuz Söylemezoğlu Source Type: research

Management of pediatric hemolytic uremic syndrome
Turk J Pediatr. 2024;66(1):1-16. doi: 10.24953/turkjped.2023.596.ABSTRACTClassical clinical triad of hemolytic uremic syndrome (HUS) is microangiopathic hemolytic anemia, thrombocytopenia, and acute kidney injury associated with endothelial cell injury. Several situations, including infections, medications, malignancies, and transplantation can trigger endothelial damage. On the HUS spectrum, atypical hemolytic uremic syndrome (aHUS) deserves special attention in pediatric patients, as it can cause endstage kidney disease and mortality. A dysfunction in the alternative complement pathway, either acquired or genetic, has be...
Source: The Turkish Journal of Pediatrics - March 25, 2024 Category: Pediatrics Authors: Bora G ülhan Fatih Özaltın Kibriya Fidan Zeynep Birsin Özçakar O ğuz Söylemezoğlu Source Type: research