Hemolytic Uremic Syndrome (HUS) Research This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Detection and characterization of circulating microvesicles containing Shiga toxin type 2 in a rat model of Hemolytic Uremic Syndrome
Toxicon. 2023 Nov 16:107349. doi: 10.1016/j.toxicon.2023.107349. Online ahead of print.ABSTRACTShiga toxin producing Escherichia coli (STEC) are foodborne pathogens that release Shiga toxin (Stx), virulence factor responsible for the development of Hemolytic Uremic Syndrome (HUS). Stx causes endothelial cell damage, which leads to platelets deposition and thrombi formation within the microvasculature. It has been described that Stx activates blood cells and induces the shedding of proinflammatory and prothrombotic microvesicles (MVs) containing the toxin. In this sense, it has been postulated that MVs containing Stx2 (MVs-...
Source: Toxicon - November 18, 2023 Category: Toxicology Authors: Flavia Sacerdoti Fernando Gomez Carolina Jancic Tomas Lombardo Carla A Pascuale Marcela A Moretton Diego A Chiappetta Cristina Ibarra Mar ía Marta Amaral Source Type: research

Shiga toxin-producing Escherichia coli-associated hemolytic uremic syndrome with recurrent acute cholecystitis: a case report
In this study, we report the case of an 83-year-old Japanese man who developed recurrent acute cholecystitis associated with STEC-HUS. Prior to establishing a definite diagnosis of STEC-HUS, plasma exchange and hemodialysis were initiated, which resulted in a rapid increase in the platelet count and decrease in lactate dehydrogenase levels. The patient presented an enlarged gallbladder detected by computed tomography during the course of treatment. Due to recurrent flare-ups, the patient had to undergo several rounds of endoscopic retrograde biliary drainage and, ultimately, cholecystectomy to prevent relapse of acute chol...
Source: CEN Case Reports - November 14, 2023 Category: Urology & Nephrology Source Type: research

HUS and TTP: traversing the disease and the age spectrum
Hemolytic uremic syndrome (HUS) and thrombotic thrombocytopenia purpura (TTP) are rare diseases sharing a common pathological feature, thrombotic microangiopathy (TMA). TMA is characterized by microvascular thrombosis with consequent thrombocytopenia, microangiopathic hemolytic anemia and/or multiorgan dysfunction. In the past, the distinction between HUS and TTP was predominantly based on clinical grounds. However, clinical presentation of the two syndromes often overlaps and, the differential diagnosis is broad. (Source: Seminars in Nephrology)
Source: Seminars in Nephrology - November 9, 2023 Category: Urology & Nephrology Authors: Roberta Donadelli, Aditi Sinha, Arvind Bagga, Marina Noris, Giuseppe Remuzzi Source Type: research

Therapeutic plasma exchange in paediatric nephrology in Ireland
ConclusionsOur experience of TPE, spanning 1137 exchanges, proved a safe, well-tolerated therapy. Most complications were minor, and with therapy conducted in specialised centres, there are very low levels of adverse events. (Source: Irish Journal of Medical Science)
Source: Irish Journal of Medical Science - November 8, 2023 Category: General Medicine Source Type: research

Overlapping Atypical Hemolytic Uremic Syndrome and C3 Glomerulopathy with Mutation in CFI in a Japanese Patient: A Case Report
Intern Med. 2023 Nov 6. doi: 10.2169/internalmedicine.2713-23. Online ahead of print.ABSTRACTA 34-year-old Japanese man presented with blurred vision, headache, nausea, anemia, thrombocytopenia, and severe renal dysfunction. Thrombotic microangiopathy was initially suspected to have been caused by malignant hypertension. Antihypertensive medications did not improve his thrombocytopenia or renal dysfunction, and other diseases causing thrombotic microangiopathy were ruled out. Therefore, the patient was diagnosed with atypical hemolytic uremic syndrome. A renal biopsy revealed an overlap of thrombotic microangiopathy and C3...
Source: Internal Medicine - November 5, 2023 Category: Internal Medicine Authors: Kosuke Osawa Shuto Yamamoto Yukiko Yamano Ayako Kita Kota Okamoto Noritoshi Kato Yoshitaka Tatematsu Fumiyoshi Kojima Masaki Ohya Shigeo Hara Shin-Ichi Murata Norimitsu Inoue Shoichi Maruyama Shin-Ichi Araki Source Type: research

Bacteriophages PECP14, PECP20, and their endolysins as effective biocontrol agents for Escherichia coli O157:H7 and other foodborne pathogens
Int J Food Microbiol. 2023 Oct 22;409:110460. doi: 10.1016/j.ijfoodmicro.2023.110460. Online ahead of print.ABSTRACTEscherichia coli O157:H7 is a notorious foodborne pathogen known to cause severe illnesses such as hemolytic colitis and hemolytic uremic syndrome, with fresh produce consumption being implicated in recent outbreaks. The inappropriate use of antimicrobials to combat pathogens has led to the emergence and rapid dissemination of antimicrobial-resistant microorganisms including pathogenic E. coli, presenting a significant risk to humans. Here, we isolated two E. coli O157:H7 infecting bacteriophages, PECP14 and ...
Source: International Journal of Food Microbiology - November 5, 2023 Category: Food Science Authors: Minjin Oh Ana Cevallos-Urena Byoung Sik Kim Source Type: research