Airborne indoor allergen serine proteases and their contribution to sensitisation and activation of innate immunity in allergic airway disease
Common airborne allergens (pollen, animal dander and those from fungi and insects) are the main triggers of type I allergic disorder in the respiratory system and are associated with allergic rhinitis, allergic asthma, as well as immunoglobulin E (IgE)-mediated allergic bronchopulmonary aspergillosis. These allergens promote IgE crosslinking, vasodilation, infiltration of inflammatory cells, mucosal barrier dysfunction, extracellular matrix deposition and smooth muscle spasm, which collectively cause remodelling of the airways. Fungus and insect (house dust mite and cockroaches) indoor allergens are particularly rich in pr...
Source: European Respiratory Review - April 24, 2024 Category: Respiratory Medicine Authors: Ouyang, X., Reihill, J. A., Douglas, L. E. J., Martin, S. L. Tags: Epidemiology, occupational and environmental lung disease, Asthma and allergy Reviews Source Type: research
Clinical characteristics of local allergic rhinitis sensitized to house dust mites in Asia
ConclusionClinical history and nasal symptoms are very similar in LAR-HDM and AR-HDM. Clinicians should take more care to differentiate them. LAR-HDM should also be considered in patients with persistent and severe nasal symptoms without systemic atopy. (Source: European Archives of Oto-Rhino-Laryngology)
Source: European Archives of Oto-Rhino-Laryngology - April 23, 2024 Category: ENT & OMF Source Type: research
MiR-4454 in Combined Allergic Rhinitis and Asthma Syndrome (CARAS): Clinical significance and mechanistic insights into airway inflammation
This study found that inhibiting the expression of miR-4454 can improve HDM-induced cell injury, which may be related to miR-4454 regulating the activation of IL-17/NF-кB inflammatory axis.PMID:38650129 | DOI:10.14715/cmb/2024.70.3.34 (Source: Cellular and Molecular Biology)
Source: Cellular and Molecular Biology - April 23, 2024 Category: Molecular Biology Authors: Zhiguang Liu Chuang Sun Yujia Shi Zhipeng Wang Lianzheng Zhou Qian Zhang Zhengdao Mao Source Type: research
Nasal nitric oxide measurement in allergic rhinitis and non-allergic rhinitis: a meta-analysis
Acta Otorhinolaryngol Ital. 2024 Apr;44(2):100-112. doi: 10.14639/0392-100X-N2634.ABSTRACTThe goal of this meta-analysis was to study nasal nitric oxide (nNO) measurements in allergic rhinitis (AR) and non-allergic rhinitis (non-AR). The protocol was registered with PROSPERO (no: CRD4202124828). Electronic databases from PubMed, Google Scholar, Scopus, Web of Science, and Cochrane were all thoroughly searched and studies were chosen based on the qualifying requirements. The quality of the studies was evaluated by Joanna Briggs Institute evaluation tools, and publication bias using funnel plots. The meta-analysis included 1...
Source: Acta Otorhinolaryngologica Italica - April 23, 2024 Category: ENT & OMF Authors: Ahmad Faiz Dahlan Md Asiful Islam Norasnieda Md Shukri Baharudin Abdullah Source Type: research
A systematic review of randomised controlled trials on topical nasal steroids
CONCLUSIONS: BDP nasal spray is one of the most frequently prescribed INC for rhinitis and rhinosinusitis. Treatment with BDP resulted in significant and clinically meaningful improvements in nasal symptoms associated with AR and CRS. BDP is well tolerated, and the safety profile is similar to that of placebo in most patients. These results, in conjunction with the significant benefit reported in subjects with CRS and AR, provide convincing evidence of the overall effectiveness of BDP for the treatment of the full spectrum of sinonasal disease.PMID:38651550 | DOI:10.14639/0392-100X-N2745 (Source: Acta Otorhinolaryngologica Italica)
Source: Acta Otorhinolaryngologica Italica - April 23, 2024 Category: ENT & OMF Authors: Chiara Zeroli Armela Gorica Giulia Monti Paolo Giocondo Maria Castelnuovo Maurizio Bignami Alberto Macchi Source Type: research
MiR-4454 in Combined Allergic Rhinitis and Asthma Syndrome (CARAS): Clinical significance and mechanistic insights into airway inflammation
This study found that inhibiting the expression of miR-4454 can improve HDM-induced cell injury, which may be related to miR-4454 regulating the activation of IL-17/NF-кB inflammatory axis.PMID:38650129 | DOI:10.14715/cmb/2024.70.3.34 (Source: Mol Biol Cell)
Source: Mol Biol Cell - April 23, 2024 Category: Molecular Biology Authors: Zhiguang Liu Chuang Sun Yujia Shi Zhipeng Wang Lianzheng Zhou Qian Zhang Zhengdao Mao Source Type: research
MiR-4454 in Combined Allergic Rhinitis and Asthma Syndrome (CARAS): Clinical significance and mechanistic insights into airway inflammation
This study found that inhibiting the expression of miR-4454 can improve HDM-induced cell injury, which may be related to miR-4454 regulating the activation of IL-17/NF-кB inflammatory axis.PMID:38650129 | DOI:10.14715/cmb/2024.70.3.34 (Source: Cellular and Molecular Biology)
Source: Cellular and Molecular Biology - April 23, 2024 Category: Molecular Biology Authors: Zhiguang Liu Chuang Sun Yujia Shi Zhipeng Wang Lianzheng Zhou Qian Zhang Zhengdao Mao Source Type: research
Nasal nitric oxide measurement in allergic rhinitis and non-allergic rhinitis: a meta-analysis
Acta Otorhinolaryngol Ital. 2024 Apr;44(2):100-112. doi: 10.14639/0392-100X-N2634.ABSTRACTThe goal of this meta-analysis was to study nasal nitric oxide (nNO) measurements in allergic rhinitis (AR) and non-allergic rhinitis (non-AR). The protocol was registered with PROSPERO (no: CRD4202124828). Electronic databases from PubMed, Google Scholar, Scopus, Web of Science, and Cochrane were all thoroughly searched and studies were chosen based on the qualifying requirements. The quality of the studies was evaluated by Joanna Briggs Institute evaluation tools, and publication bias using funnel plots. The meta-analysis included 1...
Source: Acta Otorhinolaryngologica Italica - April 23, 2024 Category: ENT & OMF Authors: Ahmad Faiz Dahlan Md Asiful Islam Norasnieda Md Shukri Baharudin Abdullah Source Type: research
A systematic review of randomised controlled trials on topical nasal steroids
CONCLUSIONS: BDP nasal spray is one of the most frequently prescribed INC for rhinitis and rhinosinusitis. Treatment with BDP resulted in significant and clinically meaningful improvements in nasal symptoms associated with AR and CRS. BDP is well tolerated, and the safety profile is similar to that of placebo in most patients. These results, in conjunction with the significant benefit reported in subjects with CRS and AR, provide convincing evidence of the overall effectiveness of BDP for the treatment of the full spectrum of sinonasal disease.PMID:38651550 | PMC:PMC11042551 | DOI:10.14639/0392-100X-N2745 (Source: Acta Oto...
Source: Acta Otorhinolaryngologica Italica - April 23, 2024 Category: ENT & OMF Authors: Chiara Zeroli Armela Gorica Giulia Monti Paolo Giocondo Maria Castelnuovo Maurizio Bignami Alberto Macchi Source Type: research
MiR-4454 in Combined Allergic Rhinitis and Asthma Syndrome (CARAS): Clinical significance and mechanistic insights into airway inflammation
This study found that inhibiting the expression of miR-4454 can improve HDM-induced cell injury, which may be related to miR-4454 regulating the activation of IL-17/NF-кB inflammatory axis.PMID:38650129 | DOI:10.14715/cmb/2024.70.3.34 (Source: Cellular and Molecular Biology)
Source: Cellular and Molecular Biology - April 23, 2024 Category: Molecular Biology Authors: Zhiguang Liu Chuang Sun Yujia Shi Zhipeng Wang Lianzheng Zhou Qian Zhang Zhengdao Mao Source Type: research
Nasal nitric oxide measurement in allergic rhinitis and non-allergic rhinitis: a meta-analysis
Acta Otorhinolaryngol Ital. 2024 Apr;44(2):100-112. doi: 10.14639/0392-100X-N2634.ABSTRACTThe goal of this meta-analysis was to study nasal nitric oxide (nNO) measurements in allergic rhinitis (AR) and non-allergic rhinitis (non-AR). The protocol was registered with PROSPERO (no: CRD4202124828). Electronic databases from PubMed, Google Scholar, Scopus, Web of Science, and Cochrane were all thoroughly searched and studies were chosen based on the qualifying requirements. The quality of the studies was evaluated by Joanna Briggs Institute evaluation tools, and publication bias using funnel plots. The meta-analysis included 1...
Source: Acta Otorhinolaryngologica Italica - April 23, 2024 Category: ENT & OMF Authors: Ahmad Faiz Dahlan Md Asiful Islam Norasnieda Md Shukri Baharudin Abdullah Source Type: research
A systematic review of randomised controlled trials on topical nasal steroids
CONCLUSIONS: BDP nasal spray is one of the most frequently prescribed INC for rhinitis and rhinosinusitis. Treatment with BDP resulted in significant and clinically meaningful improvements in nasal symptoms associated with AR and CRS. BDP is well tolerated, and the safety profile is similar to that of placebo in most patients. These results, in conjunction with the significant benefit reported in subjects with CRS and AR, provide convincing evidence of the overall effectiveness of BDP for the treatment of the full spectrum of sinonasal disease.PMID:38651550 | PMC:PMC11042551 | DOI:10.14639/0392-100X-N2745 (Source: Acta Oto...
Source: Acta Otorhinolaryngologica Italica - April 23, 2024 Category: ENT & OMF Authors: Chiara Zeroli Armela Gorica Giulia Monti Paolo Giocondo Maria Castelnuovo Maurizio Bignami Alberto Macchi Source Type: research
MiR-4454 in Combined Allergic Rhinitis and Asthma Syndrome (CARAS): Clinical significance and mechanistic insights into airway inflammation
This study found that inhibiting the expression of miR-4454 can improve HDM-induced cell injury, which may be related to miR-4454 regulating the activation of IL-17/NF-кB inflammatory axis.PMID:38650129 | DOI:10.14715/cmb/2024.70.3.34 (Source: Cellular and Molecular Biology)
Source: Cellular and Molecular Biology - April 23, 2024 Category: Molecular Biology Authors: Zhiguang Liu Chuang Sun Yujia Shi Zhipeng Wang Lianzheng Zhou Qian Zhang Zhengdao Mao Source Type: research
Nasal nitric oxide measurement in allergic rhinitis and non-allergic rhinitis: a meta-analysis
Acta Otorhinolaryngol Ital. 2024 Apr;44(2):100-112. doi: 10.14639/0392-100X-N2634.ABSTRACTThe goal of this meta-analysis was to study nasal nitric oxide (nNO) measurements in allergic rhinitis (AR) and non-allergic rhinitis (non-AR). The protocol was registered with PROSPERO (no: CRD4202124828). Electronic databases from PubMed, Google Scholar, Scopus, Web of Science, and Cochrane were all thoroughly searched and studies were chosen based on the qualifying requirements. The quality of the studies was evaluated by Joanna Briggs Institute evaluation tools, and publication bias using funnel plots. The meta-analysis included 1...
Source: Acta Otorhinolaryngologica Italica - April 23, 2024 Category: ENT & OMF Authors: Ahmad Faiz Dahlan Md Asiful Islam Norasnieda Md Shukri Baharudin Abdullah Source Type: research
A systematic review of randomised controlled trials on topical nasal steroids
CONCLUSIONS: BDP nasal spray is one of the most frequently prescribed INC for rhinitis and rhinosinusitis. Treatment with BDP resulted in significant and clinically meaningful improvements in nasal symptoms associated with AR and CRS. BDP is well tolerated, and the safety profile is similar to that of placebo in most patients. These results, in conjunction with the significant benefit reported in subjects with CRS and AR, provide convincing evidence of the overall effectiveness of BDP for the treatment of the full spectrum of sinonasal disease.PMID:38651550 | PMC:PMC11042551 | DOI:10.14639/0392-100X-N2745 (Source: Acta Oto...
Source: Acta Otorhinolaryngologica Italica - April 23, 2024 Category: ENT & OMF Authors: Chiara Zeroli Armela Gorica Giulia Monti Paolo Giocondo Maria Castelnuovo Maurizio Bignami Alberto Macchi Source Type: research
