Prenatal Exposure to Air Pollutants Associated with Allergic Diseases in Children: Which Pollutant, When Exposure, and What Disease? A Systematic Review and Meta-analysis
AbstractThis systematic review aims to identify the association between prenatal exposure to air pollutants and allergic diseases in children, focusing on specific pollutants, timing of exposure, and associated diseases. We searched PubMed, Scopus, and Web of Science for English articles until May 1, 2023, examining maternal exposure to outdoor air pollutants (PM1, PM2.5, PM10, NO, NO2, SO2, CO, and O3) during pregnancy and child allergic diseases (atopic dermatitis (AD), food allergy (FA), asthma (AT) and allergic rhinitis (AR)/hay fever (HF)). The final 38 eligible studies were included in the meta-analysis. Exposure ...
Source: Clinical Reviews in Allergy and Immunology - April 19, 2024 Category: Allergy & Immunology Source Type: research
Development of a method to evaluate the effects of external environments on drug stability in nails using micro ‐segmental analysis
An evaluation method using micro-segmental analysis (MSA) of a single nail was developed to examine the effects of external environments on drug stability in nails. MSA is indispensable for examining various experimental conditions and maintaining the original nail shapes from a limited number of reference nail samples. AbstractNails can be used as an alternative to hair for examining past drug use. However, daily hand-and-nail care can eliminate the internal drugs. Therefore, we developed an evaluation method to examine the effects of the external environment on drug stability in nails using micro-segmental analysis. Firs...
Source: Drug Testing and Analysis - April 18, 2024 Category: Drugs & Pharmacology Authors: Kenji Kuwayama,
Hajime Miyaguchi,
Tatsuyuki Kanamori,
Kenji Tsujikawa,
Tadashi Yamamuro,
Hiroki Segawa,
Yuki Okada,
Yuko T. Iwata Tags: RESEARCH ARTICLE Source Type: research
Hydrangea serrata extract attenuates PM-exacerbated airway inflammation in the CARAS model by modulating the IL-33/ST2/NF- κB signaling pathway
This study was conducted to investigate the efficacy of Hydrangea serrata extract (HSE) in airway inflammation in a mouse model of CARAS exacerbated by PM. In the CARAS mouse model worsened by PM, the airway inflammation improvement effect of HSE was evaluated by analyzing allergic nasal symptoms, changes in inflammatory cells, OVA-specific immunoglobulin (Ig) levels, cytokines, mast cell activation, and histopathological findings of both nasal mucosa and lung tissue. HSE effectively reduced OVA-specific IgE and IgG1 and inhibited the production of T helper type 2 (Th2)-related cytokines such as IL-4 and IL-5. Importantly,...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - April 17, 2024 Category: Drugs & Pharmacology Authors: Juan Jin Thi Van Nguyen Yuna Jiang Zhen Nan Yu Chang Ho Song So-Young Lee Hee Soon Shin Ok Hee Chai Source Type: research
LINC00998 Modulating M2 Macrophage Activation in Allergic Rhinitis by Stabilizing BOB.1 mRNA
(Source: Journal of Inflammation Research)
Source: Journal of Inflammation Research - April 16, 2024 Category: Allergy & Immunology Tags: Journal of Inflammation Research Source Type: research
The 2021 Global Initiative for Chronic Obstructive Pulmonary Disease (GOLD) guidelines and the outpatient management: Examining physician adherence and its effects on patient outcome
CONCLUSION: We found no significant difference in the patient outcomes, such as number of exacerbations of COPD and mortality, when comparing the 2021 GOLD guideline adherent versus GOLD guideline non-adherent management of COPD.PMID:38605771 | PMC:PMC11006038 | DOI:10.4103/jfmpc.jfmpc_1397_23 (Source: Primary Care)
Source: Primary Care - April 12, 2024 Category: Primary Care Authors: Ricardo J Orozco David Rodriguez Krystal Hunter Satyajeet Roy Source Type: research
The 2021 Global Initiative for Chronic Obstructive Pulmonary Disease (GOLD) guidelines and the outpatient management: Examining physician adherence and its effects on patient outcome
CONCLUSION: We found no significant difference in the patient outcomes, such as number of exacerbations of COPD and mortality, when comparing the 2021 GOLD guideline adherent versus GOLD guideline non-adherent management of COPD.PMID:38605771 | PMC:PMC11006038 | DOI:10.4103/jfmpc.jfmpc_1397_23 (Source: Primary Care)
Source: Primary Care - April 12, 2024 Category: Primary Care Authors: Ricardo J Orozco David Rodriguez Krystal Hunter Satyajeet Roy Source Type: research
The 2021 Global Initiative for Chronic Obstructive Pulmonary Disease (GOLD) guidelines and the outpatient management: Examining physician adherence and its effects on patient outcome
CONCLUSION: We found no significant difference in the patient outcomes, such as number of exacerbations of COPD and mortality, when comparing the 2021 GOLD guideline adherent versus GOLD guideline non-adherent management of COPD.PMID:38605771 | PMC:PMC11006038 | DOI:10.4103/jfmpc.jfmpc_1397_23 (Source: Primary Care)
Source: Primary Care - April 12, 2024 Category: Primary Care Authors: Ricardo J Orozco David Rodriguez Krystal Hunter Satyajeet Roy Source Type: research
Molecules, Vol. 29, Pages 1765: Evaluation of Urtica dioica Phytochemicals against Therapeutic Targets of Allergic Rhinitis Using Computational Studies
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Allergic rhinitis (AR) is a prevalent inflammatory condition affecting millions globally, with current treatments often associated with significant side effects. To seek safer and more effective alternatives, natural sources like Urtica dioica (UD) are being explored. However, UD’s mechanism of action remains unknown. Therefore, to elucidate it, we conducted an in silico evaluation of UD phytochemicals’ effects on known therapeutic targets of allergic rhinitis: histamine receptor 1 (HR1), neurokinin 1 receptor (NK1R), cysteinyl leukotriene receptor 1 (CLR1), chemoattractant receptor-homo...
Source: Molecules - April 12, 2024 Category: Chemistry Authors: Erick Bahena Culhuac Martiniano Bello Tags: Article Source Type: research
Current challenges with adherence to pharmacotherapy in allergic rhinitis
Expert Opin Pharmacother. 2024 Apr 11:1-4. doi: 10.1080/14656566.2024.2336082. Online ahead of print.NO ABSTRACTPMID:38602452 | DOI:10.1080/14656566.2024.2336082 (Source: Expert Opinion on Pharmacotherapy)
Source: Expert Opinion on Pharmacotherapy - April 11, 2024 Category: Drugs & Pharmacology Authors: Yuan Zhang Luo Zhang Source Type: research
Cyp2e1 protects against OVA-induced allergic rhinitis through the inhibition of Th2 cell activation and differentiation: Mediated by MAFB
Int Immunopharmacol. 2024 Apr 10;132:112003. doi: 10.1016/j.intimp.2024.112003. Online ahead of print.ABSTRACTAllergic rhinitis (AR) is a common allergic disease. Cytochrome P450, family 2, subfamily e, polypeptide 1 (Cyp2e1) is a member of the cytochrome P450 family of enzymes, while its role in AR is still unveiled. In AR mice, T cell-specific overexpression of Cyp2e1 relieved the AR symptoms. Overexpressed-Cyp2e1 restrained the infiltration of eosinophils and mast cells in the nasal mucosa of mice, and the inflammatory cells in nasal lavage fluid (NALF). Cyp2e1 overexpressed mice exhibited decreased goblet cell hyperpla...
Source: International Immunopharmacology - April 11, 2024 Category: Allergy & Immunology Authors: Weiliang Bai Hui Su Shengqun Xu Zhao Gao Ziwen Chang Xun Sun Tiancong Liu Source Type: research
Current challenges with adherence to pharmacotherapy in allergic rhinitis
Expert Opin Pharmacother. 2024 Apr 11:1-4. doi: 10.1080/14656566.2024.2336082. Online ahead of print.NO ABSTRACTPMID:38602452 | DOI:10.1080/14656566.2024.2336082 (Source: Expert Opinion on Pharmacotherapy)
Source: Expert Opinion on Pharmacotherapy - April 11, 2024 Category: Drugs & Pharmacology Authors: Yuan Zhang Luo Zhang Source Type: research
Cyp2e1 protects against OVA-induced allergic rhinitis through the inhibition of Th2 cell activation and differentiation: Mediated by MAFB
Int Immunopharmacol. 2024 Apr 10;132:112003. doi: 10.1016/j.intimp.2024.112003. Online ahead of print.ABSTRACTAllergic rhinitis (AR) is a common allergic disease. Cytochrome P450, family 2, subfamily e, polypeptide 1 (Cyp2e1) is a member of the cytochrome P450 family of enzymes, while its role in AR is still unveiled. In AR mice, T cell-specific overexpression of Cyp2e1 relieved the AR symptoms. Overexpressed-Cyp2e1 restrained the infiltration of eosinophils and mast cells in the nasal mucosa of mice, and the inflammatory cells in nasal lavage fluid (NALF). Cyp2e1 overexpressed mice exhibited decreased goblet cell hyperpla...
Source: International Immunopharmacology - April 11, 2024 Category: Allergy & Immunology Authors: Weiliang Bai Hui Su Shengqun Xu Zhao Gao Ziwen Chang Xun Sun Tiancong Liu Source Type: research
First-In-Human Study on Pharmacokinetics, Safety, and Tolerability of Single and Multiple Escalating Doses of PA9159 Nasal Spray, a Highly Potent Glucocorticoid in Healthy Chinese Volunteers
CONCLUSIONS: The PA9159 nasal spray was generally safe and well tolerated, and the effects of PA9159 on serum cortisol levels were limited. The plasma concentration and systemic exposure to PA9159 were very low. These findings support the necessity for further clinical studies on PA9159 nasal spray in patients suffering from allergic rhinitis.PMID:38599506 | DOI:10.1016/j.ejps.2024.106764 (Source: European Journal of Pharmaceutical Sciences)
Source: European Journal of Pharmaceutical Sciences - April 10, 2024 Category: Drugs & Pharmacology Authors: Shaojie Guo Yingchun Hu Chengshuo Wang Yuan Zhang Feng Wu Siyang Ni Yuyang Dai Ying Han Minwan Hu Chunping Lu Zhijian Xi Laichun Lu Xiuli Zhao Luo Zhang Source Type: research
First-In-Human Study on Pharmacokinetics, Safety, and Tolerability of Single and Multiple Escalating Doses of PA9159 Nasal Spray, a Highly Potent Glucocorticoid in Healthy Chinese Volunteers
CONCLUSIONS: The PA9159 nasal spray was generally safe and well tolerated, and the effects of PA9159 on serum cortisol levels were limited. The plasma concentration and systemic exposure to PA9159 were very low. These findings support the necessity for further clinical studies on PA9159 nasal spray in patients suffering from allergic rhinitis.PMID:38599506 | DOI:10.1016/j.ejps.2024.106764 (Source: European Journal of Pharmaceutical Sciences)
Source: European Journal of Pharmaceutical Sciences - April 10, 2024 Category: Drugs & Pharmacology Authors: Shaojie Guo Yingchun Hu Chengshuo Wang Yuan Zhang Feng Wu Siyang Ni Yuyang Dai Ying Han Minwan Hu Chunping Lu Zhijian Xi Laichun Lu Xiuli Zhao Luo Zhang Source Type: research
First-In-Human Study on Pharmacokinetics, Safety, and Tolerability of Single and Multiple Escalating Doses of PA9159 Nasal Spray, a Highly Potent Glucocorticoid in Healthy Chinese Volunteers
CONCLUSIONS: The PA9159 nasal spray was generally safe and well tolerated, and the effects of PA9159 on serum cortisol levels were limited. The plasma concentration and systemic exposure to PA9159 were very low. These findings support the necessity for further clinical studies on PA9159 nasal spray in patients suffering from allergic rhinitis.PMID:38599506 | DOI:10.1016/j.ejps.2024.106764 (Source: European Journal of Pharmaceutical Sciences)
Source: European Journal of Pharmaceutical Sciences - April 10, 2024 Category: Drugs & Pharmacology Authors: Shaojie Guo Yingchun Hu Chengshuo Wang Yuan Zhang Feng Wu Siyang Ni Yuyang Dai Ying Han Minwan Hu Chunping Lu Zhijian Xi Laichun Lu Xiuli Zhao Luo Zhang Source Type: research
