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Clinicopathologic and Molecular Characterization of High-Risk Human Papillomavirus-Positive Carcinomas of the Urinary Tract
CONCLUSIONS.—: HPV+ UTCs show distinct clinical, morphologic, and molecular characteristics, suggesting important roles for HPV in UTC.PMID:38555943 | DOI:10.5858/arpa.2023-0285-OA (Source: Archives of Pathology and Laboratory Medicine)
Source: Archives of Pathology and Laboratory Medicine - March 31, 2024 Category: Laboratory Medicine Authors: Neslihan Kayraklioglu Bradley A Stohr Emily Chan Source Type: research

IL7 in combination with radiotherapy stimulates a memory T-cell response to improve outcomes in HNSCC models
AbstractClinically approved head and neck squamous cell carcinoma (HNSCC) immunotherapies manipulate the immune checkpoint blockade (ICB) axis but have had limited success outside of recurrent/metastatic disease. Interleukin-7 (IL7) has been shown to be essential for effector T-cell survival, activation, and proliferation. Here, we show that IL7 in combination with radiotherapy (RT) is effective in activating CD8 + T-cells for reducing tumor growth. Our studies were conducted using both human papillomavirus related and unrelated orthotopic HNSCC murine models. Immune populations from the tumor, draining lymph nodes, a...
Source: Cancer Immunology, Immunotherapy - March 30, 2024 Category: Cancer & Oncology Source Type: research

Insights into the management of penile squamous cell carcinoma: from conventional approaches to emerging novel therapies
Expert Opin Pharmacother. 2024 Mar 29. doi: 10.1080/14656566.2024.2337244. Online ahead of print.ABSTRACTINTRODUCTION: Penile squamous cell carcinoma (PSCC), a rare genitourinary cancer, is associated with poor outcomes due to limited treatment effectiveness, especially in advanced stages.AREAS COVERED: While chemotherapy and/or surgery remain the standard of care, emerging therapies like immunotherapy, targeted therapy, and human papillomavirus (HPV) directed therapies show promise. Key to advancing treatment is understanding the immune microenvironment to gain insights into tumor resistance mechanisms and potential thera...
Source: Expert Opinion on Pharmacotherapy - March 29, 2024 Category: Drugs & Pharmacology Authors: Houssein Safa Chiara Mercinelli Philippe E Spiess Andrea Necchi Jad Chahoud Source Type: research

Anti-NMDA Receptor Encephalitis, Human Papillomavirus, and microRNA
CONCLUSION: This finding suggests that in cases where individuals receiving HPV vaccination experience psychiatric or neurological symptoms, it should be considered to diagnose anti-NMDA receptor encephalitis, given the exclusion of other possible complications.PMID:38549528 | DOI:10.2174/0109298673264615231124072130 (Source: Current Medicinal Chemistry)
Source: Current Medicinal Chemistry - March 29, 2024 Category: Chemistry Authors: Hsiuying Wang Source Type: research

Insights into the management of penile squamous cell carcinoma: from conventional approaches to emerging novel therapies
Expert Opin Pharmacother. 2024 Apr 2:1-19. doi: 10.1080/14656566.2024.2337244. Online ahead of print.ABSTRACTINTRODUCTION: Penile squamous cell carcinoma (PSCC), a rare genitourinary cancer, is associated with poor outcomes due to limited treatment effectiveness, especially in advanced stages.AREAS COVERED: While chemotherapy and/or surgery remain the standard of care, emerging therapies like immunotherapy, targeted therapy, and human papillomavirus (HPV) directed therapies show promise. Key to advancing treatment is understanding the immune microenvironment to gain insights into tumor resistance mechanisms and potential t...
Source: Expert Opinion on Pharmacotherapy - March 29, 2024 Category: Drugs & Pharmacology Authors: Houssein Safa Chiara Mercinelli Philippe E Spiess Andrea Necchi Jad Chahoud Source Type: research

Viruses, Vol. 16, Pages 536: De-Escalated Therapy and Early Treatment of Recurrences in HPV-Associated Head and Neck Cancer: The Potential for Biomarkers to Revolutionize Personalized Therapy
Issaeva Human papillomavirus-associated (HPV+) head and neck squamous cell carcinoma (HNSCC) is the most common HPV-associated cancer in the United States, with a rapid increase in incidence over the last two decades. The burden of HPV+ HNSCC is likely to continue to rise, and given the long latency between infection and the development of HPV+ HNSCC, it is estimated that the effect of the HPV vaccine will not be reflected in HNSCC prevalence until 2060. Efforts have begun to decrease morbidity of standard therapies for this disease, and its improved characterization is being leveraged to identify and target molecular ...
Source: Viruses - March 29, 2024 Category: Virology Authors: Wendell G. Yarbrough Travis P. Schrank Barbara A. Burtness Natalia Issaeva Tags: Review Source Type: research

Assessing the Potential of HPV16 E6 Seroprevalence as a Biomarker for Anal Dysplasia and Cancer Screening-A Systematic Review and Meta-Analysis
In conclusion, while HPV16 E6 seroprevalence demonstrates specificity as a potential biomarker for HPV-related AC, its utility as a standalone screening tool may be limited. Instead, it could serve effectively as a confirmation test, particularly in high-risk populations, alongside other diagnostic methods. Further research is imperative to explore HPV16 E6 seroconversion dynamics and alternative screening algorithms.PMID:38542409 | DOI:10.3390/ijms25063437 (Source: Anal Sci)
Source: Anal Sci - March 28, 2024 Category: Chemistry Authors: Sara Tous Mariona Guillamet Tim Waterboer Laia Alemany Sonia Paytubi Source Type: research