Viruses, Vol. 16, Pages 536: De-Escalated Therapy and Early Treatment of Recurrences in HPV-Associated Head and Neck Cancer: The Potential for Biomarkers to Revolutionize Personalized Therapy
Viruses, Vol. 16, Pages 536: De-Escalated Therapy and Early Treatment of Recurrences in HPV-Associated Head and Neck Cancer: The Potential for Biomarkers to Revolutionize Personalized Therapy
Viruses doi: 10.3390/v16040536
Authors:
Wendell G. Yarbrough
Travis P. Schrank
Barbara A. Burtness
Natalia Issaeva
Human papillomavirus-associated (HPV+) head and neck squamous cell carcinoma (HNSCC) is the most common HPV-associated cancer in the United States, with a rapid increase in incidence over the last two decades. The burden of HPV+ HNSCC is likely to continue to rise, and given the long latency between infection and the development of HPV+ HNSCC, it is estimated that the effect of the HPV vaccine will not be reflected in HNSCC prevalence until 2060. Efforts have begun to decrease morbidity of standard therapies for this disease, and its improved characterization is being leveraged to identify and target molecular vulnerabilities. Companion biomarkers for new therapies will identify responsive tumors. A more basic understanding of two mechanisms of HPV carcinogenesis in the head and neck has identified subtypes of HPV+ HNSCC that correlate with different carcinogenic programs and that identify tumors with good or poor prognosis. Current development of biomarkers that reliably identify these two subtypes, as well as biomarkers that can detect recurrent disease at an earlier time, will have immediate clinical application.
Source: Viruses - Category: Virology Authors: Wendell G. Yarbrough Travis P. Schrank Barbara A. Burtness Natalia Issaeva Tags: Review Source Type: research
More News: Cancer | Cancer & Oncology | Cancer Vaccines | Carcinoma | Cervical Cancer Vaccine | Genital Warts | Head and Neck Cancer | HNSCC | Human Papillomavirus (HPV) | Skin Cancer | Squamous Cell Carcinoma | USA Health | Vaccines | Virology