Evaluation of bezafibrate, gemfibrozil, indomethacin, sulfamethoxazole, and diclofenac removal by ligninolytic enzymes
(Source: Preparative Biochemistry)
Source: Preparative Biochemistry - July 10, 2020 Category: Biochemistry Authors: Camarillo Ravelo, Dante Loera Corral, Octavio Gonz ález-Martínez, Ignacio Chan Cupul, Wilberth Rodr íguez Nava, Celestino Odín Source Type: research
Pharmaceuticals' removal by constructed wetlands: a critical evaluation and meta-analysis on performance, risk reduction, and role of physicochemical properties on removal mechanisms.
Authors: Ilyas H, Masih I, van Hullebusch ED
Abstract
This paper presents a comprehensive and critical analysis of the removal of pharmaceuticals (PhCs), the governing physicochemical properties, and removal mechanisms in constructed wetlands (CWs). The average removal efficiency of the most widely studied 34 PhCs ranges from 21% to 93%, with the exception of one PhC that exhibited negative removal. Moreover, CWs are effective in significantly reducing the environmental risk caused by many PhCs. Based on risk assessment, 12 PhCs were classified under high risk category (oxytetracycline > ofloxacin > ...
Source: Journal of Water and Health - June 27, 2020 Category: Environmental Health Tags: J Water Health Source Type: research
Gemfibrozil improves lipid metabolism in Nile tilapia Oreochromis niloticus fed a high-carbohydrate diet through peroxisome proliferator activated receptor- α activation.
This study indicates that gemfibrozil can improve lipid metabolism and maintain high antioxidant and anti-inflammatory capacity through activating PPARα in Nile tilapia fed a high carbohydrate diet.
PMID: 32540489 [PubMed - as supplied by publisher] (Source: General and Comparative Endocrinology)
Source: General and Comparative Endocrinology - June 11, 2020 Category: Endocrinology Authors: Luo Y, Hu CT, Qiao F, Wang XD, Qin JG, Du ZY, Chen LQ Tags: Gen Comp Endocrinol Source Type: research
Matrix Effects on the Degradation of Gemfibrozil, Hydrochlorothiazide, and Naproxen by Heterogeneous Photocatalysis
The degradation of a pharmaceutical mixture (gemfibrozil, hydrochlorothiazide and naproxen) by TiO2/UV-A in different aqueous matrices was evaluated. The matrix components affected the operational conditions, rate constants, and removal efficiency of the pharmaceuticals, as well as toxicity. For sewage treatment plant effluent, a TiO2 concentration three-fold higher (450 mg L − 1) and an irradiation time 1.5-3 times longer were required to reach the same efficiency of degradation as the pharmaceuticals in deionized water and surface water matrices. An improvement in the rate constants and the removal efficiency of the ph...
Source: Journal of the Brazilian Chemical Society - June 8, 2020 Category: Chemistry Source Type: research
Rational design and biological evaluation of gemfibrozil modified Xenopus GLP-1 derivatives as long-acting hypoglycemic agents.
Abstract
Novel methods for peptides structural modification and bioactivity optimization are highly needed in peptide-based drug discovery. Herein, we explored the use gemfibrozil (GFZ) as an albumin binder to enhance the stability and improve the bioactivity of peptides. Short-acting Xenopus glucagon-like peptide-1 (xGLP-1) analogues with anti-diabetic activity were selected as the starting point. Mono-GFZ conjugation, peptide sequence hybridization, and dimeric-GFZ derivatization were successively used to generate novel GFZ-xGLP-1 conjugates, biologically screened by various in vitro and in vivo models...
Source: European Journal of Medicinal Chemistry - May 3, 2020 Category: Chemistry Authors: Han J, Fu J, Yang Q, Zhou F, Chen X, Li C, Yin J Tags: Eur J Med Chem Source Type: research
Pharmacokinetic Drug –Drug Interaction of Apalutamide, Part 2: Investigating Interaction Potential Using a Physiologically Based Pharmacokinetic Model
ConclusionsBased on our simulations, no major changes in the pharmacokinetics of apalutamide or pharmacologically active moieties are expected with strong CYP3A4/CYP2C8 inhibitors/inducers. This observation supports the existing recommendations that no dose adjustments are needed during coadministration of apalutamide and the known inhibitors or inducers of CYP2C8 or CYP3A4. (Source: Clinical Pharmacokinetics)
Source: Clinical Pharmacokinetics - April 26, 2020 Category: Drugs & Pharmacology Source Type: research
Pharmacokinetic Drug –Drug Interaction of Apalutamide, Part 1: Clinical Studies in Healthy Men and Patients with Castration-Resistant Prostate Cancer
ConclusionsCo-administration of apalutamide with CYP3A4, CYP2C19, CYP2C9, P-gp, BCRP or OATP1B1 substrates may cause loss of activity for these medications. Therefore, appropriate mitigation strategies are recommended. (Source: Clinical Pharmacokinetics)
Source: Clinical Pharmacokinetics - April 26, 2020 Category: Drugs & Pharmacology Source Type: research
Gemfibrozil attenuates doxorubicin induced toxicity in renal tissues of male rats by reducing the oxidative insult and inflammation.
Abstract
Nephrotoxicity is a significant side effect of doxorubicin (DXN) treatment. We investigated the protective effect of gemfibrozil (GEM) co-administration with DXN on DXN induced nephrotoxicity. We divided 28 male Wistar rats into four groups of seven. Group 1 received normal saline for 2 weeks. Group 2 received 15 mg/kg DXN for 2 weeks. Group 3 received DXN + GEM for 2 weeks. Group 4 received GEM for 2 weeks. On day 15 of the experiment, blood samples were collected, animals were sacrificed and kidneys were excised for biochemical and histological evaluation. We measured serum creatinine, blood...
Source: Biotechnic and Histochemistry - April 2, 2020 Category: Research Authors: Hosseinzadeh A, Goudarzi M, Fatemi I, Khodayar MJ, Mehrzadi S, Khalili HR, Karimi MA Tags: Biotech Histochem Source Type: research
Bempedoic Acid (Nexletol) for Lowering LDL-Cholesterol
Date: April 6, 2020
Issue #:
1595Summary:
The FDA has approved the oral adenosine triphosphate-citrate
lyase (ACL) inhibitor bempedoic acid for
use alone (Nexletol– Esperion) and in a fixed-dose
combination with the cholesterol absorption inhibitor
ezetimibe(Nexlizet) as an adjunct to diet and maximally
tolerated statin therapy in adults with heterozygous
familial hypercholesterolemia (HeFH) or established
atherosclerotic cardiovascular disease (ASCVD) who
require additional lowering of LDL-cholesterol (LDL-C).
Bempedoic acid is the first ACL inhibitor to be approved
in the US....
Source: The Medical Letter - March 4, 2020 Category: Drugs & Pharmacology Authors: admin Tags: alirocumab Altoprev Atorvastatin bempedoic acid Cholesterol Cholestyramine Colesevelam Colestid Colestipol Crestor evolocumab Ezetimibe Ezetrol Fenofibrate Flolipid Fluvastatin Gemfibrozil icosapent ethyl Lescol Lipit Source Type: research
Severe hypertriglyceridemia during treatment with intraperitoneal cisplatin and paclitaxel for advanced stage fallopian tube carcinoma
Publication date: Available online 20 February 2020Source: Gynecologic Oncology ReportsAuthor(s): Megan Lander, Yasmin Abedin, Sofia Gabrilovich, Jenna Z. MarcusAbstractThis case report describes a patient who developed severe hypertriglyceridemia (1871 mg/dL) and hyperlipidemia (LDL 132 mg/dL) during intraperitoneal (IP) administration of cisplatin and paclitaxel as adjuvant treatment for stage IIIC fallopian tube carcinoma. After an evaluation with her primary care physician, she was treated with gemfibrozil and rosuvastatin for the duration of her treatment. There was complete resolution of hypertriglyceridemia after co...
Source: Gynecologic Oncology Reports - February 21, 2020 Category: OBGYN Source Type: research
[ASAP] Influence of Annealing in the Close Vicinity of < italic toggle="yes" > T < /italic > < sub > g < /sub > on the Reorganization within Dimers and Its Impact on the Crystallization Kinetics of Gemfibrozil
Molecular PharmaceuticsDOI: 10.1021/acs.molpharmaceut.9b01244 (Source: Molecular Pharmaceutics)
Source: Molecular Pharmaceutics - February 6, 2020 Category: Drugs & Pharmacology Authors: Ewa Kamin ´ska*†, Aldona Minecka*†, Magdalena Tarnacka‡§, Barbara Hachula?, Kamil Kamin´ski‡§, and Marian Paluch‡§ Source Type: research
IJERPH, Vol. 17, Pages 687: Distribution and Removal of Pharmaceuticals in Liquid and Solid Phases in the Unit Processes of Sewage Treatment Plants
In this study, we analyzed 27 pharmaceuticals in liquid and solid phase samples collected from the unit processes of four different sewage treatment plants (STPs) to evaluate their distribution and behavior of the pharmaceuticals. The examination of the relative distributions of various categories of pharmaceuticals in the influent showed that non-steroidal anti-inflammatory drugs (NSAIDs) were the most dominant. While the relative distribution of antibiotics in the influent was not high (i.e., 3%&ndash;5%), it increased to 14%&ndash;30% in the effluent. In the four STPs, the mass load of the target pharmac...
Source: International Journal of Environmental Research and Public Health - January 20, 2020 Category: Environmental Health Authors: Park Kim Hong Lee Chung Jeong Kim Tags: Article Source Type: research
Molecules, Vol. 25, Pages 392: PPAR α-Dependent Modulation by Metformin of the Expression of OCT-2 and MATE-1 in the Kidney of Mice
Molecules, Vol. 25, Pages 392: PPARα-Dependent Modulation by Metformin of the Expression of OCT-2 and MATE-1 in the Kidney of Mice
Molecules doi: 10.3390/molecules25020392
Authors:
Adriano Cleis Arruda
Mauro Sérgio Perilhão
Warley Almeida Santos
Marcos Fernandes Gregnani
Alexandre Budu
José Cesar Rosa Neto
Gabriel Rufino Estrela
Ronaldo Carvalho Araujo
Metformin is the first-line drug for type 2 diabetes mellitus control. It is established that this drug traffics through OCT-2 and MATE-1 transporters in kidney tubular cells and is excreted in its unaltered form in the urine. Hereby, we provide evi...
Source: Molecules - January 16, 2020 Category: Chemistry Authors: Adriano Cleis Arruda Mauro S érgio Perilhão Warley Almeida Santos Marcos Fernandes Gregnani Alexandre Budu Jos é Cesar Rosa Neto Gabriel Rufino Estrela Ronaldo Carvalho Araujo Tags: Article Source Type: research
Lipid-lowering drugs and the risk of cataract: An Observational Post Marketing Study
ConclusionUsing a large real life database (18.5 million reports), we found for the first time a signal of cataract for all LLD, i.e. not only statins but also fibrates and other classes suggesting that a decrease in cholesterol is involved in the pathophysiology of C with LLD. (Source: Archives of Cardiovascular Diseases Supplements)
Source: Archives of Cardiovascular Diseases Supplements - January 7, 2020 Category: Cardiology Source Type: research
Optimization of chromatography to overcome matrix effect for reliable estimation of four small molecular drugs from biological fluids using LC-MS/MS.
Abstract
The article describes a systematic study to overcome matrix effect during chromatographic analysis of gemfibrozil, rivastigmine, telmisartan and tacrolimus from biological fluids using LC-ESI-MS/MS. All four methods were thoroughly developed by appropriate choice of analytical column, elution mode and pH of mobile phase for improved chromatography and overall method performance. Matrix effect was assessed by post column analyte infusion, slope of calibration line approach and post extraction spiking. The best chromatographic conditions established were, Acquity BEH C18 (50 × 2.1 mm, 1.7 μm) colu...
Source: Biomedical Chromatography : BMC - December 10, 2019 Category: Biomedical Science Authors: Trivedi V, Shah PA, Shrivastav PS, Sanyal M Tags: Biomed Chromatogr Source Type: research
