Gastrointestinal Stromal Tumour (GIST) Research This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Hand2 Immunohistochemistry in the Diagnosis of Paragangliomas and Other Neuroendocrine Neoplasms
AbstractHand2 is a core transcription factor responsible for chromaffin cell differentiation. However, its potential utility in surgical pathology has not been studied. Thus, we aimed to investigate its expression in paragangliomas, other neuroendocrine neoplasms (NENs), and additional non-neuroendocrine tumors. We calibrated Hand2 immunohistochemistry on adrenal medulla cells and analyzedH-scores in 46 paragangliomas (PGs), 9 metastatic PGs, 21 cauda equina neuroendocrine tumors (CENETs), 48 neuroendocrine carcinomas (NECs), 8 olfactory neuroblastomas (ONBs), 110 well-differentiated NETs (WDNETs), 10 adrenal cortical carc...
Source: Endocrine Pathology - February 28, 2024 Category: Pathology Source Type: research

Cancers, Vol. 16, Pages 947: Advancing Precision Oncology in Hereditary Paraganglioma-Pheochromocytoma Syndromes: Integrated Interpretation and Data Sharing of the Germline and Tumor Genomes
INT²GRATE Oncology Consortium Standard methods of variant assessment in hereditary cancer susceptibility genes are limited by the lack of availability of key supporting evidence. In cancer, information derived from tumors can serve as a useful source in delineating the tumor behavior and the role of germline variants in tumor progression. We have previously demonstrated the value of integrating tumor and germline findings to comprehensively assess germline variants in hereditary cancer syndromes. Building on this work, herein, we present the development and application of the INT&sup2;GRATE|HPPGL platform. IN...
Source: Cancers - February 26, 2024 Category: Cancer & Oncology Authors: Rana Koeller Walker Unal Levine Chittenden Isidro Hayes Manam Buehler Manning Barletta Hornick Garber Ghazani INT ²GRATE Oncology Consortium Tags: Article Source Type: research

Advanced gastrointestinal stromal tumor: reliable classification of imatinib plasma trough concentration via machine learning
Patients with advanced gastrointestinal stromal tumors (GISTs) exhibiting an imatinib plasma trough concentration (IM Cmin) under 1100 ng/ml may show a reduced drug response rate, leading to the suggestion of mon... (Source: BMC Cancer)
Source: BMC Cancer - February 24, 2024 Category: Cancer & Oncology Authors: Pan Ran, Tao Tan, Jinjin Li, Hao Yang, Juan Li and Jun Zhang Tags: Research Source Type: research

Cancers, Vol. 16, Pages 904: Outcomes of Late-Line Systemic Treatment in GIST: Does Sequence Matter?
a A. Zarzour Elise F. Nassif Haddad Michael S. Nakazawa Xiao Zhou Michael C. Heinrich Neeta Somaiah Ripretinib and avapritinib have demonstrated activity in the late-line treatment of gastrointestinal stomal tumors (GISTs). We investigated whether patients previously treated with ripretinib benefit from avapritinib, and vice versa. Patients diagnosed with metastatic/unresectable GIST and treated with both drugs at two institutions in 2000&ndash;2021 were included. Patients were grouped by drug sequence: ripretinib&ndash;avapritinib (RA) or avapritinib&ndash;ripretinib (AR). Radiographi...
Source: Cancers - February 23, 2024 Category: Cancer & Oncology Authors: Prapassorn Thirasastr Thomas L. Sutton Cissimol P. Joseph Heather Lin Behrang Amini Skye C. Mayo Dejka Araujo Robert S. Benjamin Anthony P. Conley John A. Livingston Joseph Ludwig Shreyaskumar Patel Ravin Ratan Vinod Ravi Maria A. Zarzour Elise F. Nassif Tags: Article Source Type: research

Clinical characteristics and prognostic analysis of postoperative recurrence or metastasis of low-risk gastrointestinal stromal tumors
This study aimed to investigate the clinical characteristics and prognosis of postoperative recurrence or ... (Source: World Journal of Surgical Oncology)
Source: World Journal of Surgical Oncology - February 23, 2024 Category: Cancer & Oncology Authors: Lianlian Cao, Chen Lin, Yu Liu, Chao Sui, Zhaoping Li, Li Chen, Wenxian Guan, Liang Tao, Tingting Tao, Meng Wang and Feng Wang Tags: Research Source Type: research

Glycaemic abnormalities induced by small molecule tryosine kinase inhibitors: a review
Front Pharmacol. 2024 Feb 1;15:1355171. doi: 10.3389/fphar.2024.1355171. eCollection 2024.ABSTRACTIn light of the expected increase in the prevalence of diabetes mellitus due to an aging population, sedentary lifestyles, an increase in obesity, and unhealthy diets, there is a need to identify potential pharmacological agents that can heighten the risk of developing diabetes. Similarly, it is equally important to also identify those agents that show blood glucose-lowering properties. Amongst these agents are tyrosine kinase inhibitors used to treat certain types of cancers. Over the last two decades, there has been an incre...
Source: Cancer Control - February 16, 2024 Category: Cancer & Oncology Authors: Takudzwa Mugiya Mamosheledi Mothibe Andile Khathi Phikelelani Ngubane Ntethelelo Sibiya Source Type: research

Radiofrequency ablation vs. hepatectomy for liver metastases from gastrointestinal stromal tumors
In conclusion, hepatectomy combined with TKI therapy improved prognosis for patients with liver metastases to a greater extent than RFA combined with TKI therapy. For this type of patient, hepatectomy may be a preferable option.PMID:38362234 | PMC:PMC10867732 | DOI:10.3892/ol.2024.14266 (Source: Oncology Letters)
Source: Oncology Letters - February 16, 2024 Category: Cancer & Oncology Authors: Yi Zeng Yudong Ling Xiaojiang Chen Chao Ding Yukai Jin Shoucheng Feng Zhenchong Chen Jianrong Guo Haibo Qiu Source Type: research

Endoscopic resection of gastric gastrointestinal stromal tumor using clip-and-cut endoscopic full-thickness resection: a single-center, retrospective cohort in Korea
CONCLUSIONS: Cc-EFTR displayed high R0 resection rates as the procedure safely and successfully removed small gastric GISTs.PMID:38356170 | DOI:10.5946/ce.2023.144 (Source: Clinical Endoscopy)
Source: Clinical Endoscopy - February 15, 2024 Category: Gastroenterology Authors: Yuri Kim Ji Yong Ahn Hwoon-Yong Jung Seokin Kang Ho June Song Kee Don Choi Do Hoon Kim Jeong Hoon Lee Hee Kyong Na Young Soo Park Source Type: research