The evaluations of the inhibition of orlistat on Clostridium perfringens sialidase (NanI) activity by in vitro and in silico approaches
Chem Biodivers. 2023 Dec 29:e202301634. doi: 10.1002/cbdv.202301634. Online ahead of print.ABSTRACTClostridium perfringens (C. perfringens) is a bacterium that causes serious problems in humans and animals such as food poisoning, gas gangrene and infections. C. perfringens has three sialidases (NanH, NanI, NanJ) and inhibition of NanI constitutes an approach in the treatment of C. perfringens since NanI provides the carbohydrate source necessary for the growth of bacteria. In our study, the inhibition effect of some drugs belonging to different drug groups on NanI activity was investigated. Among these drugs, orlistat (0.2...
Source: Chemistry and Biodiversity - December 29, 2023 Category: Biochemistry Authors: Onur Ertik Refiye Yanardag Source Type: research
The evaluations of the inhibition of orlistat on Clostridium perfringens sialidase (NanI) activity by in vitro and in silico approaches
Chem Biodivers. 2023 Dec 29:e202301634. doi: 10.1002/cbdv.202301634. Online ahead of print.ABSTRACTClostridium perfringens (C. perfringens) is a bacterium that causes serious problems in humans and animals such as food poisoning, gas gangrene and infections. C. perfringens has three sialidases (NanH, NanI, NanJ) and inhibition of NanI constitutes an approach in the treatment of C. perfringens since NanI provides the carbohydrate source necessary for the growth of bacteria. In our study, the inhibition effect of some drugs belonging to different drug groups on NanI activity was investigated. Among these drugs, orlistat (0.2...
Source: Chemistry and Biodiversity - December 29, 2023 Category: Biochemistry Authors: Onur Ertik Refiye Yanardag Source Type: research
The evaluations of the inhibition of orlistat on Clostridium perfringens sialidase (NanI) activity by in vitro and in silico approaches
Chem Biodivers. 2023 Dec 29:e202301634. doi: 10.1002/cbdv.202301634. Online ahead of print.ABSTRACTClostridium perfringens (C. perfringens) is a bacterium that causes serious problems in humans and animals such as food poisoning, gas gangrene and infections. C. perfringens has three sialidases (NanH, NanI, NanJ) and inhibition of NanI constitutes an approach in the treatment of C. perfringens since NanI provides the carbohydrate source necessary for the growth of bacteria. In our study, the inhibition effect of some drugs belonging to different drug groups on NanI activity was investigated. Among these drugs, orlistat (0.2...
Source: Chemistry and Biodiversity - December 29, 2023 Category: Biochemistry Authors: Onur Ertik Refiye Yanardag Source Type: research
The evaluations of the inhibition of orlistat on Clostridium perfringens sialidase (NanI) activity by in vitro and in silico approaches
Chem Biodivers. 2023 Dec 29:e202301634. doi: 10.1002/cbdv.202301634. Online ahead of print.ABSTRACTClostridium perfringens (C. perfringens) is a bacterium that causes serious problems in humans and animals such as food poisoning, gas gangrene and infections. C. perfringens has three sialidases (NanH, NanI, NanJ) and inhibition of NanI constitutes an approach in the treatment of C. perfringens since NanI provides the carbohydrate source necessary for the growth of bacteria. In our study, the inhibition effect of some drugs belonging to different drug groups on NanI activity was investigated. Among these drugs, orlistat (0.2...
Source: Chemistry and Biodiversity - December 29, 2023 Category: Biochemistry Authors: Onur Ertik Refiye Yanardag Source Type: research
Implementation and Evaluation of a Training Program for Traditional Healers to Improve Knowledge of Noma (Cancrum Oris) in Burkina Faso
Am J Trop Med Hyg. 2023 Dec 26:tpmd230407. doi: 10.4269/ajtmh.23-0407. Online ahead of print.ABSTRACTNoma (cancrum oris) is an orofacial gangrene affecting young children living in extreme poverty. The acute morbidity is high, and survivors suffer from physical and social sequelae. When diagnosed early, noma can be cured. Noma is especially prevalent in sub-Saharan Africa, where traditional medicine is the norm. The aim of this work was to provide 1-day training to traditional healers in Burkina Faso and to evaluate change in knowledge of noma across time. A sample of 78 healers who attended the training were asked to comp...
Source: The American Journal of Tropical Medicine and Hygiene - December 27, 2023 Category: Tropical Medicine Authors: Denise Baratti-Mayer Emilien Jeannot Marc Dupuis Source Type: research
Implementation and Evaluation of a Training Program for Traditional Healers to Improve Knowledge of Noma (Cancrum Oris) in Burkina Faso
Am J Trop Med Hyg. 2023 Dec 26:tpmd230407. doi: 10.4269/ajtmh.23-0407. Online ahead of print.ABSTRACTNoma (cancrum oris) is an orofacial gangrene affecting young children living in extreme poverty. The acute morbidity is high, and survivors suffer from physical and social sequelae. When diagnosed early, noma can be cured. Noma is especially prevalent in sub-Saharan Africa, where traditional medicine is the norm. The aim of this work was to provide 1-day training to traditional healers in Burkina Faso and to evaluate change in knowledge of noma across time. A sample of 78 healers who attended the training were asked to comp...
Source: Am J Trop Med Hyg - December 27, 2023 Category: Infectious Diseases Authors: Denise Baratti-Mayer Emilien Jeannot Marc Dupuis Source Type: research
Implementation and Evaluation of a Training Program for Traditional Healers to Improve Knowledge of Noma (Cancrum Oris) in Burkina Faso
Am J Trop Med Hyg. 2023 Dec 26:tpmd230407. doi: 10.4269/ajtmh.23-0407. Online ahead of print.ABSTRACTNoma (cancrum oris) is an orofacial gangrene affecting young children living in extreme poverty. The acute morbidity is high, and survivors suffer from physical and social sequelae. When diagnosed early, noma can be cured. Noma is especially prevalent in sub-Saharan Africa, where traditional medicine is the norm. The aim of this work was to provide 1-day training to traditional healers in Burkina Faso and to evaluate change in knowledge of noma across time. A sample of 78 healers who attended the training were asked to comp...
Source: The American Journal of Tropical Medicine and Hygiene - December 27, 2023 Category: Tropical Medicine Authors: Denise Baratti-Mayer Emilien Jeannot Marc Dupuis Source Type: research
Implementation and Evaluation of a Training Program for Traditional Healers to Improve Knowledge of Noma (Cancrum Oris) in Burkina Faso
Am J Trop Med Hyg. 2023 Dec 26:tpmd230407. doi: 10.4269/ajtmh.23-0407. Online ahead of print.ABSTRACTNoma (cancrum oris) is an orofacial gangrene affecting young children living in extreme poverty. The acute morbidity is high, and survivors suffer from physical and social sequelae. When diagnosed early, noma can be cured. Noma is especially prevalent in sub-Saharan Africa, where traditional medicine is the norm. The aim of this work was to provide 1-day training to traditional healers in Burkina Faso and to evaluate change in knowledge of noma across time. A sample of 78 healers who attended the training were asked to comp...
Source: Am J Trop Med Hyg - December 27, 2023 Category: Infectious Diseases Authors: Denise Baratti-Mayer Emilien Jeannot Marc Dupuis Source Type: research
Implementation and Evaluation of a Training Program for Traditional Healers to Improve Knowledge of Noma (Cancrum Oris) in Burkina Faso
Am J Trop Med Hyg. 2023 Dec 26:tpmd230407. doi: 10.4269/ajtmh.23-0407. Online ahead of print.ABSTRACTNoma (cancrum oris) is an orofacial gangrene affecting young children living in extreme poverty. The acute morbidity is high, and survivors suffer from physical and social sequelae. When diagnosed early, noma can be cured. Noma is especially prevalent in sub-Saharan Africa, where traditional medicine is the norm. The aim of this work was to provide 1-day training to traditional healers in Burkina Faso and to evaluate change in knowledge of noma across time. A sample of 78 healers who attended the training were asked to comp...
Source: The American Journal of Tropical Medicine and Hygiene - December 27, 2023 Category: Tropical Medicine Authors: Denise Baratti-Mayer Emilien Jeannot Marc Dupuis Source Type: research
Implementation and Evaluation of a Training Program for Traditional Healers to Improve Knowledge of Noma (Cancrum Oris) in Burkina Faso
Am J Trop Med Hyg. 2023 Dec 26:tpmd230407. doi: 10.4269/ajtmh.23-0407. Online ahead of print.ABSTRACTNoma (cancrum oris) is an orofacial gangrene affecting young children living in extreme poverty. The acute morbidity is high, and survivors suffer from physical and social sequelae. When diagnosed early, noma can be cured. Noma is especially prevalent in sub-Saharan Africa, where traditional medicine is the norm. The aim of this work was to provide 1-day training to traditional healers in Burkina Faso and to evaluate change in knowledge of noma across time. A sample of 78 healers who attended the training were asked to comp...
Source: Am J Trop Med Hyg - December 27, 2023 Category: Infectious Diseases Authors: Denise Baratti-Mayer Emilien Jeannot Marc Dupuis Source Type: research
Implementation and Evaluation of a Training Program for Traditional Healers to Improve Knowledge of Noma (Cancrum Oris) in Burkina Faso
Am J Trop Med Hyg. 2023 Dec 26:tpmd230407. doi: 10.4269/ajtmh.23-0407. Online ahead of print.ABSTRACTNoma (cancrum oris) is an orofacial gangrene affecting young children living in extreme poverty. The acute morbidity is high, and survivors suffer from physical and social sequelae. When diagnosed early, noma can be cured. Noma is especially prevalent in sub-Saharan Africa, where traditional medicine is the norm. The aim of this work was to provide 1-day training to traditional healers in Burkina Faso and to evaluate change in knowledge of noma across time. A sample of 78 healers who attended the training were asked to comp...
Source: The American Journal of Tropical Medicine and Hygiene - December 27, 2023 Category: Tropical Medicine Authors: Denise Baratti-Mayer Emilien Jeannot Marc Dupuis Source Type: research
Implementation and Evaluation of a Training Program for Traditional Healers to Improve Knowledge of Noma (Cancrum Oris) in Burkina Faso
Am J Trop Med Hyg. 2023 Dec 26:tpmd230407. doi: 10.4269/ajtmh.23-0407. Online ahead of print.ABSTRACTNoma (cancrum oris) is an orofacial gangrene affecting young children living in extreme poverty. The acute morbidity is high, and survivors suffer from physical and social sequelae. When diagnosed early, noma can be cured. Noma is especially prevalent in sub-Saharan Africa, where traditional medicine is the norm. The aim of this work was to provide 1-day training to traditional healers in Burkina Faso and to evaluate change in knowledge of noma across time. A sample of 78 healers who attended the training were asked to comp...
Source: Am J Trop Med Hyg - December 27, 2023 Category: Infectious Diseases Authors: Denise Baratti-Mayer Emilien Jeannot Marc Dupuis Source Type: research
Implementation and Evaluation of a Training Program for Traditional Healers to Improve Knowledge of Noma (Cancrum Oris) in Burkina Faso
Am J Trop Med Hyg. 2023 Dec 26:tpmd230407. doi: 10.4269/ajtmh.23-0407. Online ahead of print.ABSTRACTNoma (cancrum oris) is an orofacial gangrene affecting young children living in extreme poverty. The acute morbidity is high, and survivors suffer from physical and social sequelae. When diagnosed early, noma can be cured. Noma is especially prevalent in sub-Saharan Africa, where traditional medicine is the norm. The aim of this work was to provide 1-day training to traditional healers in Burkina Faso and to evaluate change in knowledge of noma across time. A sample of 78 healers who attended the training were asked to comp...
Source: The American Journal of Tropical Medicine and Hygiene - December 27, 2023 Category: Tropical Medicine Authors: Denise Baratti-Mayer Emilien Jeannot Marc Dupuis Source Type: research
Implementation and Evaluation of a Training Program for Traditional Healers to Improve Knowledge of Noma (Cancrum Oris) in Burkina Faso
Am J Trop Med Hyg. 2023 Dec 26:tpmd230407. doi: 10.4269/ajtmh.23-0407. Online ahead of print.ABSTRACTNoma (cancrum oris) is an orofacial gangrene affecting young children living in extreme poverty. The acute morbidity is high, and survivors suffer from physical and social sequelae. When diagnosed early, noma can be cured. Noma is especially prevalent in sub-Saharan Africa, where traditional medicine is the norm. The aim of this work was to provide 1-day training to traditional healers in Burkina Faso and to evaluate change in knowledge of noma across time. A sample of 78 healers who attended the training were asked to comp...
Source: Am J Trop Med Hyg - December 27, 2023 Category: Infectious Diseases Authors: Denise Baratti-Mayer Emilien Jeannot Marc Dupuis Source Type: research
Implementation and Evaluation of a Training Program for Traditional Healers to Improve Knowledge of Noma (Cancrum Oris) in Burkina Faso
Am J Trop Med Hyg. 2023 Dec 26:tpmd230407. doi: 10.4269/ajtmh.23-0407. Online ahead of print.ABSTRACTNoma (cancrum oris) is an orofacial gangrene affecting young children living in extreme poverty. The acute morbidity is high, and survivors suffer from physical and social sequelae. When diagnosed early, noma can be cured. Noma is especially prevalent in sub-Saharan Africa, where traditional medicine is the norm. The aim of this work was to provide 1-day training to traditional healers in Burkina Faso and to evaluate change in knowledge of noma across time. A sample of 78 healers who attended the training were asked to comp...
Source: The American Journal of Tropical Medicine and Hygiene - December 27, 2023 Category: Tropical Medicine Authors: Denise Baratti-Mayer Emilien Jeannot Marc Dupuis Source Type: research
