The History of Psychiatric Epidemiology in Finland: From National Needs to International Arenas, 1900s-1990s
This article discusses how Finnish epidemiologists reacted to local needs, which were born in specific circumstances and were controlled by science policy and funding opportunities. The development between the 1900s and 1990s is divided into three stages. The first Finnish studies in the field focused on the prevalence of mental illnesses in the country. The focus was to gain information for service planning, most of all to estimate the need for new hospitals and to set up the national social insurance system. After the Second World War, structural changes and social engineering fueled epidemiological interest. From the 19...
Source: Bulletin of the History of Medicine - April 8, 2024 Category: History of Medicine Authors: Mikko Myllykangas Katariina Parhi Source Type: research
The History of Psychiatric Epidemiology in Finland: From National Needs to International Arenas, 1900s-1990s
This article discusses how Finnish epidemiologists reacted to local needs, which were born in specific circumstances and were controlled by science policy and funding opportunities. The development between the 1900s and 1990s is divided into three stages. The first Finnish studies in the field focused on the prevalence of mental illnesses in the country. The focus was to gain information for service planning, most of all to estimate the need for new hospitals and to set up the national social insurance system. After the Second World War, structural changes and social engineering fueled epidemiological interest. From the 19...
Source: Bulletin of the History of Medicine - April 8, 2024 Category: History of Medicine Authors: Mikko Myllykangas Katariina Parhi Source Type: research
The History of Psychiatric Epidemiology in Finland: From National Needs to International Arenas, 1900s-1990s
This article discusses how Finnish epidemiologists reacted to local needs, which were born in specific circumstances and were controlled by science policy and funding opportunities. The development between the 1900s and 1990s is divided into three stages. The first Finnish studies in the field focused on the prevalence of mental illnesses in the country. The focus was to gain information for service planning, most of all to estimate the need for new hospitals and to set up the national social insurance system. After the Second World War, structural changes and social engineering fueled epidemiological interest. From the 19...
Source: Bulletin of the History of Medicine - April 8, 2024 Category: History of Medicine Authors: Mikko Myllykangas Katariina Parhi Source Type: research
The History of Psychiatric Epidemiology in Finland: From National Needs to International Arenas, 1900s-1990s
This article discusses how Finnish epidemiologists reacted to local needs, which were born in specific circumstances and were controlled by science policy and funding opportunities. The development between the 1900s and 1990s is divided into three stages. The first Finnish studies in the field focused on the prevalence of mental illnesses in the country. The focus was to gain information for service planning, most of all to estimate the need for new hospitals and to set up the national social insurance system. After the Second World War, structural changes and social engineering fueled epidemiological interest. From the 19...
Source: Bulletin of the History of Medicine - April 8, 2024 Category: History of Medicine Authors: Mikko Myllykangas Katariina Parhi Source Type: research
The History of Psychiatric Epidemiology in Finland: From National Needs to International Arenas, 1900s-1990s
This article discusses how Finnish epidemiologists reacted to local needs, which were born in specific circumstances and were controlled by science policy and funding opportunities. The development between the 1900s and 1990s is divided into three stages. The first Finnish studies in the field focused on the prevalence of mental illnesses in the country. The focus was to gain information for service planning, most of all to estimate the need for new hospitals and to set up the national social insurance system. After the Second World War, structural changes and social engineering fueled epidemiological interest. From the 19...
Source: Bulletin of the History of Medicine - April 8, 2024 Category: History of Medicine Authors: Mikko Myllykangas Katariina Parhi Source Type: research
Prediction model for anabolic androgenic steroid positivity in forensic autopsy cases – a new tool to the autopsy room
AbstractNon-prescription use of anabolic androgenic steroids (AAS) is associated with an increased risk of premature death. However, these substances are seldom screened in connection with forensic cause-of-death investigation, unless the forensic pathologist specifically suspects use, often based on a positive AAS use history. Since AAS use is often concealed from others, this practice may lead to mistargeting of these analyses and significant underestimation of the true number of AAS positive cases undergoing forensic autopsy. Thus, more accurate diagnostic tools are needed to identify these cases. The main objective of ...
Source: International Journal of Legal Medicine - April 8, 2024 Category: Medical Law Source Type: research
Mitotic abnormalities precede microsatellite instability in lynch syndrome-associated colorectal tumourigenesis
This study aimed to identify precancerous functional changes in colonic mucosa that could facilitate the monitoring and prevention of cancer development in LS.METHODS: The study material comprised colon biopsy specimens (n = 71) collected during colonoscopy examinations from LS carriers (tumour-free, or diagnosed with adenoma, or diagnosed with carcinoma) and a control group, which included sporadic cases without LS or neoplasia. The majority (80%) of LS carriers had an inherited genetic MLH1 mutation. The remaining 20% included MSH2 mutation carriers (13%) and MSH6 mutation carriers (7%). The transcriptomes were first ana...
Source: Cancer Control - April 7, 2024 Category: Cancer & Oncology Authors: Marjaana Pussila Aleksi Laiho Petri T örönen Pauliina Bj örkbacka Sonja Nyk änen Kirsi Pylv änäinen Liisa Holm Jukka-Pekka Mecklin Laura Renkonen-Sinisalo Taru Lehtonen Anna Lepist ö Jere Linden Satu M äki-Nevala P äivi Peltomäki Minna Nystr öm Source Type: research
Prostate Cancer Screening With PSA, Kallikrein Panel, and MRI: The ProScreen Randomized Trial
CONCLUSIONS AND RELEVANCE: In this preliminary descriptive report from an ongoing randomized clinical trial, 1 additional high-grade cancer per 196 men and 1 low-grade cancer per 909 men were detected among those randomized to be invited to undergo a single prostate cancer screening intervention compared with those not invited to undergo screening. These preliminary findings from a single round of screening should be interpreted cautiously, pending results of the study's primary mortality outcome.TRIAL REGISTRATION: ClinicalTrials.gov Identifier: NCT03423303.PMID:38581254 | DOI:10.1001/jama.2024.3841 (Source: Cancer Control)
Source: Cancer Control - April 6, 2024 Category: Cancer & Oncology Authors: Anssi Auvinen Teuvo L J Tammela Tuomas Mirtti Hans Lilja Teemu Tolonen Anu Kentt ämies Irina Rinta-Kiikka Terho Lehtim äki Kari Natunen Jaakko Nevalainen Jani Raitanen Johanna Ronkainen Theodorus van der Kwast Jarno Riikonen Anssi P étas Mika Matikaine Source Type: research
Musculoskeletal disorders and work ability among dentists and dental students in Finland
CONCLUSIONS: Despite all the ergonomic advances in modern dentistry, the occurrence of MSD symptoms is still high. MSDs seem to affect dentists' work ability significantly, but amount of sickness absence is relatively low, which may indicate a high level of presenteeism.PMID:38578913 | DOI:10.3233/WOR-230303 (Source: Work)
Source: Work - April 5, 2024 Category: Occupational Health Authors: Zahraa Al-Emara Terhi Karaharju-Suvanto Patrick Furu Heidi Furu Source Type: research
Incidence of vestibular schwannoma in Finland, 1990-2017
CONCLUSION: In contrast to the increasing incidence reported in some studies, we found a decreasing trend in VS incidence for both sexes in Finland.PMID:38578202 | DOI:10.2340/1651-226X.2024.20352 (Source: Acta Oncologica)
Source: Acta Oncologica - April 5, 2024 Category: Cancer & Oncology Authors: Aino Iivanainen Jani Raitanen Anssi Auvinen Source Type: research
CD3+ and CD8+ T cell-based immune cell score as a prognostic factor in clear-cell renal cell carcinoma
This study aims to assess the prognostic role of immune cell score in ccRCC.MATERIAL AND METHODS: All patients with ccRCC undergoing surgery between 2007 and 2020 in Central Finland Central Hospital were retrospectively identified. CD3+ and CD8+ cell densities were calculated from tissue samples to determine the immune cell score using Immunoscore® principles. Receiver-operating characteristic analysis, Kaplan-Meier survival curve, and Cox regression were used to evaluate the association between immune cell score and survival.RESULTS: A total of 203 patients (mean age 66.5 years) were identified. The median follow-up time...
Source: Acta Oncologica - April 5, 2024 Category: Cancer & Oncology Authors: Jonne Åkerla Olli Helminen Juha P V äyrynen Anne Parkkinen Hilma J ärvenpää Jan B öhm Maarit Ahtiainen Heikki Seikkula Source Type: research
Progressive Impairment of Prepubertal Growth in Children With APECED
CONCLUSIONS: Children with APECED had a progressive growth impairment from birth through prepuberty. Multiple predisposing risk factors were recognized, including disease severity and growth hormone deficiency. Timely interventions are needed to ensure optimal height attainment and new treatment options need to be developed.PMID:38578980 | DOI:10.1210/clinem/dgae209 (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - April 5, 2024 Category: Endocrinology Authors: Viivi Saari Venla Alanko Elina Holopainen Outi M äkitie Saila Laakso Source Type: research
Musculoskeletal disorders and work ability among dentists and dental students in Finland
CONCLUSIONS: Despite all the ergonomic advances in modern dentistry, the occurrence of MSD symptoms is still high. MSDs seem to affect dentists' work ability significantly, but amount of sickness absence is relatively low, which may indicate a high level of presenteeism.PMID:38578913 | DOI:10.3233/WOR-230303 (Source: Work)
Source: Work - April 5, 2024 Category: Occupational Health Authors: Zahraa Al-Emara Terhi Karaharju-Suvanto Patrick Furu Heidi Furu Source Type: research
CD3+ and CD8+ T cell-based immune cell score as a prognostic factor in clear-cell renal cell carcinoma
This study aims to assess the prognostic role of immune cell score in ccRCC.MATERIAL AND METHODS: All patients with ccRCC undergoing surgery between 2007 and 2020 in Central Finland Central Hospital were retrospectively identified. CD3+ and CD8+ cell densities were calculated from tissue samples to determine the immune cell score using Immunoscore® principles. Receiver-operating characteristic analysis, Kaplan-Meier survival curve, and Cox regression were used to evaluate the association between immune cell score and survival.RESULTS: A total of 203 patients (mean age 66.5 years) were identified. The median follow-up time...
Source: Acta Oncologica - April 5, 2024 Category: Cancer & Oncology Authors: Jonne Åkerla Olli Helminen Juha P V äyrynen Anne Parkkinen Hilma J ärvenpää Jan B öhm Maarit Ahtiainen Heikki Seikkula Source Type: research
Incidence of vestibular schwannoma in Finland, 1990-2017
CONCLUSION: In contrast to the increasing incidence reported in some studies, we found a decreasing trend in VS incidence for both sexes in Finland.PMID:38578202 | DOI:10.2340/1651-226X.2024.20352 (Source: Acta Oncologica)
Source: Acta Oncologica - April 5, 2024 Category: Cancer & Oncology Authors: Aino Iivanainen Jani Raitanen Anssi Auvinen Source Type: research
