10 Things You Can Definitely Expect From The Future Of Healthcare AI
The steady cadence of a heart monitor. The anxious wait for test results. These define a patient’s experience, but for healthcare professionals, they are also points of friction. Missed information, redundant diagnostics, or the struggle to make time for true connection… these burdens hinder the most skilled and compassionate providers.  Artificial intelligence promises material changes on both sides of the stethoscope. By streamlining processes, pinpointing insights, and augmenting decision-making, AI won’t just change how care is delivered – it will reshape the very experience of both giving a...
Source: The Medical Futurist - March 26, 2024 Category: Information Technology Authors: Andrea Koncz Tags: TMF Artificial Intelligence in Medicine AI digital health Source Type: blogs

Predicting the Order of Arrival of the First Rejuvenation Therapies
It has been going on eight years since I last speculated on the order of arrival of the first rejuvenation therapies. Tempus fugit, and time for an updated version! Eight years is a long enough span of time for the first of those rejuvenation therapies to now exist, albeit in a prototypical form, arguably proven in principle but not concretely. The world progresses but my biases remain much the same: the first rejuvenation therapies to work well enough to merit the name will be based on the SENS vision, that aging is at root caused by a few classes of accumulated cell and tissue damage, and biotechnologies that either repa...
Source: Fight Aging! - March 25, 2024 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs

Fight Aging! Newsletter, March 25th 2024
This study also reports the expansion of satellite cells in human muscle with CR. This finding is critical to suggest translational relevance to the rodent data observed for more than a decade. Moreover, the increased expression of the plasminogen receptor Plg-RKT observed on human satellite cells during CR provided additional support for the theory that our rodent model is relevant to human biology. « Back to Top Interesting Insight into the Relationship Between TP53, Telomerase, and Telomere Length https://www.fightaging.org/archives/2024/03/interesting-insight-into-the-relationship-between-t...
Source: Fight Aging! - March 24, 2024 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Human Exosomes Harvested from Stem Cells in Urine Produce Rejuvenation in Mice
In this study, we further analyzed these data and found that a class of USC-EVs-enriched proteins have been previously shown to possess anti-aging function, such as tissue inhibitor of metalloproteinases 1 (TIMP1), plasminogen activator urokinase (PLAU), insulin-like growth factor binding protein 5, senescence marker protein-30, and connective tissue growth factor. Thus, we hypothesized that USC-EVs might be capable of rejuvenating old organs from aging via transferring of anti-aging proteins. Here, we tested the effects of USC-EVs on cellular senescence in vitro and on the aging-related phenotypes in different orga...
Source: Fight Aging! - March 22, 2024 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs

TDP-43 Pathology May Extend to the Vasculature and Blood-Brain Barrier
TDP-43 is one of a small number of proteins that can become altered in ways that lead to the formation of solid aggregates that, directly and indirectly, cause cell dysfunction and death in the brain. In the case of TDP-43, this proteopathy contributes to amyotrophic lateral sclerosis (ALS), frontotemporal lobar degeneration (FTLD), and what is now called limbic predominant age-related TDP-43 encephalopathy (LATE). This was a more recent discovery than other aggregates involved in neurodegenerative conditions, such as amyloid-β, tau, and α-synuclein, and so the pace of discovery for TDP-43 is a little faster; more remain...
Source: Fight Aging! - March 21, 2024 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs

Beyond the workout: the hidden struggle of diabetic gastroparesis
The final three minutes of my hour-long elliptical workout were not easy. Pain spread across my stomach, causing me to row in a half-sitting motion, and my chest vacillated between violent coughs and the sorts of deep breaths people take when they think they’ve seen a ghost. Perspiration fell from my shirtless torso to the Read more… Beyond the workout: the hidden struggle of diabetic gastroparesis originally appeared in KevinMD.com. (Source: Kevin, M.D. - Medical Weblog)
Source: Kevin, M.D. - Medical Weblog - March 21, 2024 Category: General Medicine Authors: Tags: Conditions Endocrinology Gastroenterology Source Type: blogs

The Puzzling Lack of Autoimmunity in Centenarians
Today's open access paper presents an interesting discussion of the apparent lack of age-related autoimmunity in centenarians. The immune system becomes ever more dysfunctional with age, and some of that dysfunction can take the form of maladaptive changes that either (a) allow the immune system to direct attack tissues or (b) disrupt important relationships between immune cells and the rest of a tissue. Far from all of these issues are well understood or even well identified as discrete problems distinct from the rest of degenerative aging. A potential type 4 diabetes was only comparatively recently discovered, for exampl...
Source: Fight Aging! - March 20, 2024 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs

What Is the Microbiome?
Have you ever noticed a skin care product advertised as “microbiome friendly” and wondered what that meant? The microbiome is the collection of all the microbes—including bacteria, viruses, and fungi—that live in a specific environment, such as on the skin or in the digestive tract. Escherichia coli (E. coli) is a bacterial species commonly found in the human intestine. While some strains of E. coli cause foodborne illness, others are helpful members of the gut microbiome.Credit: Mark Ellisman and Thomas Deerinck, National Center for Microscopy and Imaging Research, University of California, San Diego. It’s ...
Source: Biomedical Beat Blog - National Institute of General Medical Sciences - March 20, 2024 Category: Research Authors: Chrissa Chverchko Tags: Cells Common questions Microbes Microbiome Source Type: blogs

Aging Affects the Neural Regulation of Metabolism and Desired Food Intake
Researchers here make an interesting discovery in rats, finding an age-related change in the structure of specific neurons that encourages greater intake of calories and dysfunctional metabolism by suppressing satiation feedback. In rats this mechanism can be manipulated by diet and genetics to alter the pace at which older rats become overweight and metabolically abnormal. As is often the case in research, this discovery is a proximate cause to the problem of metabolic regulation, and it is entirely unclear as to how the deeper mechanisms of aging, such as chronic inflammation, mitochondrial dysfunction, and so forth, are...
Source: Fight Aging! - March 20, 2024 Category: Research Authors: Reason Tags: Daily News Source Type: blogs

Four Steps to Success in Implementing AI Within Healthcare Organizations
The following is a guest article by Ben Cushing, Chief Architect of Health and Life Sciences at Red Hat Artificial intelligence (AI) is showing up in more healthcare contexts, from drug discovery to diagnostic imaging to robot-assisted surgery. But one area where AI can have a tremendous impact is in the reduction of provider burden. For instance, the Veterans Health Administration (VHA) is exploring automated, AI-assisted documentation of patient visits with clinicians. The system records the conversation between clinician and patient, and then automatically produces a clinical note. The AI system can apply accurate medic...
Source: EMR and HIPAA - March 19, 2024 Category: Information Technology Authors: Guest Author Tags: AI/Machine Learning Ambulatory C-Suite Leadership Health IT Company Healthcare IT Hospital - Health System IT Infrastructure and Dev Ops LTPAC AI Implementation Artificial Intelligence Ben Cushing Healthcare AI Process Automation Source Type: blogs

Revolutionary Diet Change Regulates Blood Sugar In Type 2 Diabetes
Shifting to these type of foods keeps your blood sugar levels steady and increases fat metabolism. (Source: PsyBlog | Psychology Blog)
Source: PsyBlog | Psychology Blog - March 18, 2024 Category: Psychiatry & Psychology Authors: Mina Dean Tags: Diabetes Source Type: blogs

Will Americans Get PBM Reform in 2024? Maybe, But Many Things Need to Happen I Order to Get There. On the Upside: Insulin Has Opted Out of PBM Sales.
At the core of this post is a YouTube video which can be viewed in the middle of this blog post. The subject is about whether we ' ll get much-needed legislation passed into law to reform corrupt Pharmacy Benefit Managers (PBMs) which we know with absolute certainty were at fault for runaway insulin prices. At least that was true until March 2023, when the three largest insulin manufacturers, starting withLilly, followed byNovo Nordisk and shortly thereafter,Sanofi all announced major insulin list price reductions in the range of 70% to 78%. Think about that for a second: Imagine being able to instantly...
Source: Scott's Web Log - March 17, 2024 Category: Endocrinology Tags: 2024 Congress insulin prices PBM rebates reform Source Type: blogs

Will Americans Get PBM Reform in 2024? Maybe, But Many Things Need to Happen In Order to Get There. On the Upside: Insulin Has Opted Out of PBM Sales.
At the core of this post is a YouTube video which can be viewed in the middle of this blog post. The subject is about whether we ' ll get much-needed legislation passed into law to reform corrupt Pharmacy Benefit Managers (PBMs) which we know with absolute certainty were at fault for runaway insulin prices. At least that was true until March 2023, when the three largest insulin manufacturers, starting withLilly, followed byNovo Nordisk and shortly thereafter,Sanofi all announced major insulin list price reductions in the range of 70% to 78%. Think about that for a second: Imagine being able to instantly...
Source: Scott's Web Log - March 17, 2024 Category: Endocrinology Tags: 2024 Congress insulin prices PBM rebates reform Source Type: blogs

9amHealth Raises $9.5M Series A Extension Led by The Cigna Group Ventures to Expand to Employers Nationwide
After Being Selected by Leading PBMs, Benefits Navigators, and Health Plans as the Virtual Cardiometabolic Provider of Choice, 9amHealth Increases the Round’s Total to $25M 9amHealth, the leading virtual provider for cardiometabolic health, announced it has raised $9.5 million in a Series A extension round today. The financing round was led by The Cigna Group Ventures, with additional support from existing institutional investors, including 7Wire Ventures, Define Ventures, Leaps by Bayer, and Founders Fund. A recent survey conducted by 9amHealth found that 48% of Americans are on or want to be on a GLP-1 medicati...
Source: EMR and HIPAA - March 15, 2024 Category: Information Technology Authors: Healthcare IT News Tags: Health IT Company Healthcare IT 7Wire Ventures 9amHealth Craig Cimini Define Ventures Founders Fund Frank Westermann Health IT Funding Health IT Fundings Health IT Investment Leaps by Bayer The Cigna Group Ventures Source Type: blogs

What could we do if GLP-1 weight loss drugs were free? Would our obesity epidemic be solved for good?
By CECI CONNOLY and SAMI INKINEN Unless you have been living under a rock, you likely have heard the names Ozempic, Wegovy or Mounjaro. Or perhaps been humming the jingle. Rarely has a class of drugs (in this case, GLP-1s) achieved such widespread attention in popular culture and the media, which has people clamoring for them in every doctor’s office in the nation. And for good reason. What we know is that the efficacy and safety profile of these medications is substantially better than any weight loss drug in the past, while our obesity epidemic has only ballooned. As organizations committed to sound science and h...
Source: The Health Care Blog - March 13, 2024 Category: Consumer Health News Authors: matthew holt Tags: Health Policy ACHP Ceci Connoly GLP-1s Obesity Sami Inkinen virta Source Type: blogs