Twin Health Secures $50M to Expand its Groundbreaking Whole Body Digital Twin Technology and Service to Reverse Chronic Metabolic Disease
Investment Fuels Twin Health’s Mission to Revolutionize Chronic Metabolic Disease Prevention and Reversal with Cutting-Edge Science, Precision Guidance, and Licensed Clinical Care Team
Twin Health, creators of the Whole Body Digital Twin service for reversing, improving, and preventing chronic metabolic diseases, announced securing $50 million in funding to continue expanding its groundbreaking technology and clinical service solutions for more members across the United States.
Twin Health introduced the Whole Body Digital Twin, a dynamic model of each individual’s unique metabolism, powered by artificial int...
Source: EMR and HIPAA - January 4, 2024 Category: Information Technology Authors: Healthcare IT News Tags: Health IT Company Healthcare IT Health IT Funding Health IT Fundings Health IT Investment Helena ICONIQ Growth Jahangir Mohammed Kevin Johnson Peak XV Sofina Temasek Twin Health Source Type: blogs
Aptamers to Reduce Inflammatory AGE-RAGE Interaction
Researchers here discuss the use of aptamers that can bind to advanced glycation endproducts (AGEs). This prevents the AGEs from themselves binding to the receptor for AGEs (RAGE), an interaction that provokes inflammation. A sizable presence of circulating, short-lived AGEs is characteristic of the abnormal metabolism of obesity and obesity-related conditions such as type 2 diabetes. It is an open question as to how much of a contribution to the chronic inflammation of aging is provided by AGEs in people of a normal weight, eating a basically sensible diet, however. The only way to find out is to test a therapy of this na...
Source: Fight Aging! - January 2, 2024 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Econoclasm continued: What's this pre-existing conditions deal?
Since I interrupted this series, I will remind you that previously, we discussed the problem of adverse selection -- that people who are unhealthy are more likely to buy health insurance in a hypothetical Free Market. ™ But sellers of health insurance must find ways of predicting
and limiting their losses. The problem of adverse selection would not exist if
we had a universal system, as all other wealthy countries and some
not-so-wealthy do. Everybody would pay into the system, preferably according to
their mea ns. That way people who are healthy today subsidize the costs for
people who are not. If that strikes you as un...
Source: Stayin' Alive - January 1, 2024 Category: American Health Source Type: blogs
Physical Examination as a Helpful Aid in Decision-Making in Challenging ECGs
Discussion continuedThe absence of pace spikes suggests this is not a pacemaker/ICD-related rhythm in this patient with an ICD.The presence of thinned myocardium and known large amount of scar tissue makes for a nidus for VT. Thus VT is very probable.A wide native QRS can be expected in a patient with a dilated heart and a history of heart failure, even if it is sinus rhythm. so the question of whether those are P-waves is critical.Additionally, the qR morphology, particularly in a patient with right bundle branch block (RBBB) type wide QRS complex tachycardia (WQCT), lends further support for VT.Furthermore, a pertinent p...
Source: Dr. Smith's ECG Blog - January 1, 2024 Category: Cardiology Authors: Emre Aslanger Source Type: blogs
High-deductible health plans: a barrier to care for chronic conditions
At the peak of the coronavirus crisis in 2020, American policymakers were faced with the critical challenge of how to encourage as many Americans as possible to be tested for and vaccinated against the COVID-19 virus. Fortunately, Congress rose to this challenge by passing legislation that, in addition to providing these services to the uninsured,
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High-deductible health plans: a barrier to care for chronic conditions originally appeared in KevinMD.com. (Source: Kevin, M.D. - Medical Weblog)
Source: Kevin, M.D. - Medical Weblog - December 31, 2023 Category: General Medicine Authors: Shirin Hund, MD Tags: Policy Diabetes Endocrinology Source Type: blogs
Fight Aging! Newsletter, January 1st 2024
Discussion of What is Need to Speed the Pace at which Drugs to Treat Aging Arrive in the Clinic
Cellular Senescence in the Aging Brain, a Contributing Cause of Cognitive Decline
Reviewing What is Known of the Mechanisms of Taurine Supplementation Relevant to Aging and Metabolism
Blunt Thoughts on Calculating the Revealed Value of Human Life
A Look Back at 2023: Progress Towards the Treatment of Aging as a Medical Condition
Towards Adjustment of the Gut Microbiome to Slow Aging
Gene Therapy Enhances Object Recognition Memory in Young and Old Mice
Benefits of Sem...
Source: Fight Aging! - December 31, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
A Look Back at 2023: Progress Towards the Treatment of Aging as a Medical Condition
The market has been in the doldrums and it has been a tough year for fundraising, both for non-profits and biotech startups. The conferences have exhibited more of an academic focus as companies tightened belts and postponed investment rounds, while investors stayed home. Not that this halts the flow of hype for some projects, and nor has it slowed media commentary on the longevity industry as it presently stands. A few of the articles in that commmentary are even interesting to read! The field has grown and is more mature now than has ever been the case. Biotech of all forms is a challenging field with a high failure rate...
Source: Fight Aging! - December 29, 2023 Category: Research Authors: Reason Tags: Of Interest Source Type: blogs
Reviewing What is Known of the Mechanisms of Taurine Supplementation Relevant to Aging and Metabolism
Taurine is a semi-essential amino acid. Dietary taurine supplementation has been shown to modestly slow aging in mice, though as for all such interventions there is always the question of whether it will prove to be less useful in humans, and also whether these results in mice will be disproved by the much more rigorous Interventions Testing Program (ITP), once that group gets around to assessing taurine supplementation. Few of the numerous interventions thought to modestly slow aging in mice on the basis of earlier research actually held up once subjected to the ITP degree of experimental rigor.
Speculatively, taur...
Source: Fight Aging! - December 27, 2023 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Understanding the difference between diabetes distress and depression
In conclusion, it is essential to differentiate between diabetes distress and depression to provide people with the correct support and intervention. While depression rates among people with diabetes are not as high as previously believed, diabetes distress is remarkably prevalent. Recognizing the distinction between these two emotional challenges empowers healthcare professionals and individuals alike to manage their emotional well-being more effectively.
You already know that living with diabetes is a continuous journey, and it is normal to struggle emotionally along the way. But by understand...
Source: Scott's Diabetes Blog - December 27, 2023 Category: Endocrinology Authors: Scott K. Johnson Tags: Blog Posts Source Type: blogs
Acute OMI or " Benign " Early Repolarization?
Written by Willy FrickA man in his 50s with a history of hypertension, dyslipidemia, type 2 diabetes mellitus, and prior inferior OMI status post DES to his proximal RCA 3 years prior presented to the emergency department at around 3 AM complaining of chest pain onset around 9 PM the evening prior. He described it as severe, sharp, and substernal with associated nausea, vomiting, chills, and diaphoresis. The following ECG was obtained. Note that the machine read is" normal sinus rhythm, normal ECG. " Cardiology over read the tracing and signed the interpretation without modification.ECG 1What do you think?The Queen of Hear...
Source: Dr. Smith's ECG Blog - December 27, 2023 Category: Cardiology Authors: Willy Frick Source Type: blogs
Benefits of Semaglutide in Heart Failure are not Just Due to Weight Loss, in Mice at Least
This study investigated semaglutide, a glucagon-like peptide-1 receptor agonist that induces significant weight loss in patients with obesity and/or type 2 diabetes mellitus and has been associated with improved cardiovascular outcomes.
In a mouse model of HFpEF that was caused by advanced aging, female sex, obesity, and type 2 diabetes mellitus, semaglutide, compared with weight loss induced by pair feeding, improved the cardiometabolic profile, cardiac structure, and cardiac function. Mechanistically, transcriptomic, and proteomic analyses revealed that semaglutide improved left ventricular cytoskeleton function a...
Source: Fight Aging! - December 26, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Fight Aging! Newsletter, December 25th 2023
This study generates a comprehensive single-cell transcriptomic atlas of human atherosclerosis including 118,578 high-quality cells from atherosclerotic coronary and carotid arteries. By performing systematic benchmarking of integration methods, we mitigated data overcorrection while separating major cell lineages. Notably, we define cell subtypes that have not been previously identified from individual human atherosclerosis scRNA-seq studies.
Besides characterizing granular cell-type diversity and communication, we leverage this atlas to provide insights into smooth muscle cell (SMC) modulation. We integrate genome...
Source: Fight Aging! - December 24, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
The hidden costs of “ free ” medical interpretation
He is a typical patient of our academic primary care internal medicine practice: elderly, frail, and with several complex conditions, including a history of a liver transplant requiring chronic immunosuppression, recurrent venous thrombosis requiring treatment with blood thinners, and type 2 diabetes. But in one very important way, he is different: our doctors don’t speak
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The hidden costs of “free” medical interpretation originally appeared in KevinMD.com. (Source: Kevin, M.D. - Medical Weblog)
Source: Kevin, M.D. - Medical Weblog - December 22, 2023 Category: General Medicine Authors: Victoria Johnson, MD, MPH and Maria Isabel Angulo, MD Tags: Physician Primary Care Source Type: blogs
Existing Geroprotective Drugs May Not Interact Well with Exercise
The big disadvantage of the geroprotective approach to aging, which is essentially to undertake the long-term use of supplements and small molecule drugs to alter metabolism in ways that slow aging over years and decades, is that distinct supplements and small molecules and adjustments tend to combine in unexpected ways. Short of testing every combination in laboratory species, something that Brian Kennedy's team has been working on, one can never know the outcome of combining a treatment. Based on presentations and interviews given by Kennedy in the last few years, the result of combining two geroprotectors that individua...
Source: Fight Aging! - December 21, 2023 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Season Health Announces Strategic Asset Acquisition from Wellory to Expand Clinical Network of Registered Dietitians and Insurance Coverage
Season Health, the leading integrated food-as-medicine platform, today announced the closing of a strategic acquisition of clinical assets from Wellory, one of the largest networks of registered dietitians in the country providing medical nutrition therapy to patients nationwide. This accelerates Season’s growth by significantly expanding its provider network and its ability to offer comprehensive, personalized nutrition care to more patients, including those looking for in-network benefits.
Since its founding in 2019 by Emily Hochman and Jeni Fahy, Wellory has focused on unlocking access to quality nutrition care se...
Source: EMR and HIPAA - December 21, 2023 Category: Information Technology Authors: Healthcare IT News Tags: Health IT Company Healthcare IT 8VC Andreessen Horowitz Emily Hochman Health IT Acquisitions Healthcare M&A Jeni Fahy Josh Hix LRVHealth Season Season Health Wellory Source Type: blogs
