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I ’m retiring my first stethoscope
I retired my first stethoscope today. I bought my Littmann Cardiology III during my first term of medical school in 1999. It came with a penlight, otoscope, ophthalmoscope, manual blood pressure cuff, tuning forks and reflex hammer, all contained within a traditional black leather physician’s bag with my initials in gold. Receiving your medical student diagnostic kit is one of the rites of passage for all of us who enter this profession. I still own all of these items. Most are in that same black leather bag on a shelf in my office. But it was my stethoscope that I have used most often since then, well, until today. That...
Source: Kevin, M.D. - Medical Weblog - April 26, 2018 Category: General Medicine Authors: < a href="https://www.kevinmd.com/blog/post-author/matthew-bowdish" rel="tag" > Matthew Bowdish, MD < /a > Tags: Physician Allergies & Immunology Cardiology Source Type: blogs

A Lot of Buzz Around STING
By Gertrud U. Rey Gertrud Rey is a trained virologist residing in Atlanta, Georgia. During the day, she works as a consultant in a biotech patent law firm, but spends much of her free time as a science communicator. She was a guest on TWiV 179 and 424. The lack of a suitable animal model […] (Source: virology blog)
Source: virology blog - March 30, 2018 Category: Virology Authors: Vincent Racaniello Tags: Basic virology Gertrud Rey Information animal model dengue virus innate immunity interferon STING viral viruses Source Type: blogs

Funtabulously Frivolous Friday Five 230
LITFL • Life in the Fast Lane Medical Blog LITFL • Life in the Fast Lane Medical Blog - Emergency medicine and critical care medical education blog Just when you thought your brain could unwind on a Friday, you realise that it would rather be challenged with some good old fashioned medical trivia FFFF…introducing Funtabulously Frivolous Friday Five 230. Question 1: Braille refined ‘night writing’ so it could effectively be used in the blind population. Who originally commissioned ‘night writing’ for the military? + Reveal the Funtabulous Answer expand(document.getElementById('ddet134191...
Source: Life in the Fast Lane - March 15, 2018 Category: Emergency Medicine Authors: Neil Long Tags: Frivolous Friday Five beard bowel obstruction Braille Charles Barbier Faget's sign Hans Steininger Napoleon orthodontic wire Sutton's law Sutton's slip Source Type: blogs

TWiV 479: Trypsin the flight fantastic
The TWiVome explores induction of antiviral responses by repeating patterns of capsids, and a fungus in the mosquito gut that aids dengue virus replication. &lt;span data-mce-type=”bookmark” style=”disp...
Source: virology blog - February 4, 2018 Category: Virology Authors: Vincent Racaniello Tags: This Week in Virology aedes aegyptii capsid dengue virus foregut fungus innate immunity mosquito PAMP repeating pattern TLR toll-like receptor trypsin viral viruses Source Type: blogs

TWiV 475: Everything is viral
In the first episode for 2018, the TWiV team reviews the amazing virology stories of 2017. Click arrow to play Download TWiV 475 (67 MB .mp3, 110 min) Subscribe (free): iTunes, RSS, email Become a patron of TWiV! Show notes at microbe.tv/twiv (Source: virology blog)
Source: virology blog - January 8, 2018 Category: Virology Authors: Vincent Racaniello Tags: This Week in Virology dengue virus flavivirus giant virus klausneuvirus Noumeavirus puppet master RNA interference viral viruses viruses as tools year in review zika virus Source Type: blogs

TWiV 473: Assessing a risk and infecting you twice
The Fellowship of the Virus discuss enhancement of dengue disease in humans: the contribution of antibody concentration and increased binding to Fc receptors. &lt;span data-mce-type=”bookmark” style=”di...
Source: virology blog - December 24, 2017 Category: Virology Authors: Vincent Racaniello Tags: This Week in Virology antibody dependent enhancement Dengue DHF/DSS Fc receptor flavivirus fucosylation viral viruses Source Type: blogs

Antibodies mediate severe dengue in humans
Severe dengue virus disease, also known as dengue hemorrhagic fever/dengue shock syndrome (DHF/DSS), is most likely to occur in previously infected individuals experiencing a second encounter with a different serotype. A specific range of serum antibody titers has been shown to enhance viral replication in cell culture and in animal models, and now in humans. […] (Source: virology blog)
Source: virology blog - December 22, 2017 Category: Virology Authors: Vincent Racaniello Tags: Basic virology Information ADE antibody dependent enhancement dengue hemorrhagic fever dengue shock syndrome dengue virus DHF/DSS Fc receptor viral viruses Source Type: blogs

Immune 3: Two epitopes, four serotypes, and a partridge in a pear tree
Cindy, Steph, and Vincent discuss recent problems with dengue virus vaccine, and a bi-specific monoclonal antibody against Zika virus. Click arrow to play Download Immune 3 (48 MB .mp3, 79 min) Subscribe (free): iTunes, RSS...
Source: virology blog - December 16, 2017 Category: Virology Authors: Vincent Racaniello Tags: Immune ADE antibody dependent enhancement antibody therapy bispecific antibody dengue virus Dengvaxia immunology monoclonal antibody passive vaccine zika virus Source Type: blogs

TWiV 471: Songs of innocence and experience
The TWiVerinos discuss restriction of dengue virus vaccine by Sanofi, and data which suggest that Dengvaxia causes enhanced disease in previously uninfected recipients. &lt;span data-mce-type=”bookmark” style=”display: inline-block; width: 0px; overflow: hidden; line-height: 0;” class=̶...
Source: virology blog - December 10, 2017 Category: Virology Authors: Vincent Racaniello Tags: This Week in Virology ADE antibody dependent enhancement dengue virus Dengvaxia flavivirus TV003 vaccine enhanced disease viral yellow fever virus Source Type: blogs

A problem with dengue virus vaccine
A dengue virus vaccine was recently developed not only to prevent first infections, but to avoid severe disease that may occur upon second and third infections. This consequence, called antibody dependent enhancement (ADE), now appears to be caused by the vaccine itself. Primary dengue virus infection may lead to a disease that includes fever, headache, […] (Source: virology blog)
Source: virology blog - December 8, 2017 Category: Virology Authors: Vincent Racaniello Tags: Basic virology Commentary Information antibody dependent enhancement dengue hemorrhagic syndrome dengue shock syndrome dengue virus Dengvaxia Sanofi tetravalent vaccine TV003 viral viruses Source Type: blogs

A Clinical Trial By Any Other Name …
By ARTHUR CAPLAN and KELLY McBRIDE FOLKERS Mosquito borne illnesses pose a significant threat to human health. In the past several years, drug makers have begun developing vaccines for viruses like dengue, Zika, and chikungunya, all of which pose unique risks to billions across the globe. One of them just went terribly, terribly wrong. Sanofi Pasteur, the vaccine division of the multinational pharmaceutical company Sanofi, has the problem. In a press release distributed last Wednesday, Sanofi reported that new analysis of long-term safety data for its dengue vaccine, Dengvaxia®, revealed that the vaccine may not be safe ...
Source: The Health Care Blog - December 7, 2017 Category: Consumer Health News Authors: John Irvine Tags: Uncategorized Dengue Source Type: blogs

WMD Video w/ @edyong209: Wolbachia of Male Destruction adapted for fighting dengue, Zika
Another video from Tangled Bank Studios -------- This is from the "Tree of Life Blog" of Jonathan Eisen, an evolutionary biologist and Open Access advocate at the University of California, Davis. For short updates, follow me on Twitter. -------- (Source: The Tree of Life)
Source: The Tree of Life - November 30, 2017 Category: Microbiology Authors: Jonathan Eisen Source Type: blogs

Dengue hemorrhagic encephalitis: MRI
Discussion by Dr MGK Murthy, Dr GA PrasadDengue virus is a single-stranded RNA virus of the Flavivirus genus classified into four serotypes. Neurological manifestations, commonly seen with serotypes 2 and 3.Neurological manifestation in dengue hemorrhagic fever usually results from multisystem dysfunction secondary to liver failure, cerebral hypoperfusion, electrolyte imbalance, shock, cerebral edema, and hemorrhage related to vascular leak. Presentation as viral encephalitis is rare as the virus is non-neurotrophic.Patients can present with - stroke, mononeuropathies, polyneuropathies, Guillain-Ba...
Source: Sumer's Radiology Site - November 13, 2017 Category: Radiology Authors: Sumer Sethi Source Type: blogs

A Connection Between the Zika Virus and Curing Brain Cancer?
Not long ago, Zika virus was dominating headlines. A new infection was hardly ever heard about before then, yet is now affecting hundreds of thousands of people in Latin America, causing disfiguration and microcephalia in new-born babies. Microcephalia is caused by severe delayed and abnormal development of the brain, resulting in the range of intellectual disability, dwarfism, poor motor functions and speech. With no cure or even preventive vaccination available, many women in the most affected regions were reportedly considering postponing any planned pregnancies. The virus was actually discovered back in 1947 in Zika fo...
Source: World of Psychology - October 28, 2017 Category: Psychiatry & Psychology Authors: Psych Central Staff Tags: Brain and Behavior Brain Blogger Health-related Publishers Research brain cancer Delivery glioblastoma Immune System microcephalia Pregnancy Sexual Contact stem cells Zika virus Source Type: blogs

Rapid Phone-Based Test for Multiple Infectious Pathogens
Scientists at the University of Illinois at Urbana-Champaign and the University of Washington at Tacoma have partnered to develop a compact, portable, and easy to use system for simultaneously detecting a variety of bacteria and viruses that cause disease. The system provides results in about a half an hour, which are nearly as accurate as laboratory equipment, and the technology can be used in the field and at the point-of-care. The technology revolves around a microfluidic chip that contains loop-mediated isothermal amplification (LAMP) reagents. Each of the chip’s parallel channels is loaded with reagents design...
Source: Medgadget - October 23, 2017 Category: Medical Devices Authors: Editors Tags: Medicine Pathology Public Health Source Type: blogs