Markers of human endometrial hypoxia can be detected in vivo and ex vivo during physiological menstruation
This study examined thein vivo detection of endometrial hypoxic markers at specific timepoints in the menstrual cycle in women with a menstrual blood loss<80 ml/cycle and without significant uterine structural abnormalities. Further research is required to determine the presence of endometrial hypoxia in those experiencing abnormal uterine bleeding with and without fibroids/adenomyosis.WIDER IMPLICATIONS OF THE FINDINGSHeavy menstrual bleeding (HMB) is a common, debilitating condition. Understanding menstrual physiology may improve therapeutics. To our knowledge, this is the firstin vivo data supporting the presence of ...
Source: Human Reproduction - January 26, 2021 Category: Reproduction Medicine Source Type: research
Estimation of the Endometriosis Fertility Index prior to operative laparoscopy
AbstractSTUDY QUESTIONCan the Endometriosis Fertility Index (EFI) be estimated accurately before surgery?SUMMARY ANSWERThe EFI can be estimated accurately based on mere clinical/ultrasound information, with some improvement after adding data from diagnostic laparoscopy.WHAT IS KNOWN ALREADYThe EFI is a validated clinical instrument predicting the probability of pregnancy after endometriosis surgery without the use of ART. Being an end-of-surgery-score, it implies the decision for operative laparoscopy to be made in advance —hence, its role in the pre-surgical decision-making process remains to be established.STUDY DESIGN...
Source: Human Reproduction - December 26, 2020 Category: Reproduction Medicine Source Type: research
IJERPH, Vol. 18, Pages 103: The 4R ’s Framework of Nutritional Strategies for Post-Exercise Recovery: A Review with Emphasis on New Generation of Carbohydrates
IJERPH, Vol. 18, Pages 103: The 4R’s Framework of Nutritional Strategies for Post-Exercise Recovery: A Review with Emphasis on New Generation of Carbohydrates
International Journal of Environmental Research and Public Health doi: 10.3390/ijerph18010103
Authors:
Bonilla
Pérez-Idárraga
Odriozola-Martínez
Kreider
Post-exercise recovery is a broad term that refers to the restoration of training capacity. After training or competition, there is fatigue accumulation and a reduction in sports performance. In the hours and days following training, the body recovers and performance is expected to return to no...
Source: International Journal of Environmental Research and Public Health - December 25, 2020 Category: Environmental Health Authors: Bonilla P érez-Idárraga Odriozola-Mart ínez Kreider Tags: Review Source Type: research
Birthweight and other perinatal outcomes of singletons conceived after assisted reproduction compared to natural conceived singletons in couples with unexplained subfertility: follow-up of two randomized clinical trials
AbstractSTUDY QUESTIONDoes assisted reproduction, such as ovarian stimulation and/or laboratory procedures, have impact on perinatal outcomes of singleton live births compared to natural conception in couples with unexplained subfertility?SUMMARY ANSWERCompared to natural conception, singletons born after intrauterine insemination with ovarian stimulation (IUI-OS) had a lower birthweight, while singletons born after IVF had comparable birthweights, in couples with unexplained subfertility.WHAT IS KNOWN ALREADYSingletons conceived by assisted reproduction have different perinatal outcomes such as low birthweight and a highe...
Source: Human Reproduction - December 10, 2020 Category: Reproduction Medicine Source Type: research
Endometrial scratching in women with one failed IVF/ICSI cycle —outcomes of a randomised controlled trial (SCRaTCH)
This study was not blinded. Knowledge of allocation may have been an incentive for participants allocated to the scratch group to continue treatment in situations where they may otherwise have cancelled or stopped. In addition, this study was powered to detect a difference in live birth rate of 9%.WIDER IMPLICATIONS OF THE FINDINGSThe results of this study are an incentive for further assessment of the efficacy and clinical implications of endometrial scratching. If a true effect exists, it may be smaller than previously anticipated or may be limited to specific groups of women undergoing IVF/ICSI. Studying this will requi...
Source: Human Reproduction - December 8, 2020 Category: Reproduction Medicine Source Type: research
Blunting EU Regulation 1107/2009: following a regulation into a system of agricultural innovation
AbstractThis paper explores the role of regulation and legislation on influencing the development and diffusion of technologies and methods of crop production. To do this, the change in pesticide registration under European Regulation 1107/2009 ‘Placing Plant Protection Products on the Market’ was followed through the UK’s agricultural system of innovation. Fieldwork included: a series of interviews conducted with scientists, agronomists and industry organisations; a programme of visiting agricultural events; as well as sending an el ectronic survey to British potato growers. The innovation system is noted to have ma...
Source: Agriculture and Human Values - December 6, 2020 Category: Food Science Source Type: research
Building and Sustaining a Community Advisory Board of African American Older Adults as the Foundation for Volunteer Research Recruitment and Retention in Health Sciences.
Authors: Mitchell J, Perry T, Rorai V, Ilardo J, Lichtenberg PA, Jackson JS
Abstract
Older African Americans' participation in health-related research is severely limited; they are not involved in sufficient numbers to ensure the applicability of advancements in medical and behavioral health. This research participation gap exacerbates older African Americans' vulnerability to poor health outcomes and disparities. The Michigan Center for Urban African American Aging Research employs a progressive community-based participatory model that utilizes a structured community advisory board (CAB) of African Americ...
Source: Ethnicity and Disease - December 2, 2020 Category: International Medicine & Public Health Tags: Ethn Dis Source Type: research
Top 10 priorities for future infertility research: an international consensus development study †‡
AbstractSTUDY QUESTIONCan the priorities for future research in infertility be identified?SUMMARY ANSWERThe top 10 research priorities for the four areas of male infertility, female and unexplained infertility, medically assisted reproduction and ethics, access and organization of care for people with fertility problems were identified.WHAT IS KNOWN ALREADYMany fundamental questions regarding the prevention, management and consequences of infertility remain unanswered. This is a barrier to improving the care received by those people with fertility problems.STUDY DESIGN, SIZE, DURATIONPotential research questions were colla...
Source: Human Reproduction - November 30, 2020 Category: Reproduction Medicine Source Type: research
Developing a core outcome set for future infertility research: an international consensus development study †‡
AbstractSTUDY QUESTIONCan a core outcome set to standardize outcome selection, collection and reporting across future infertility research be developed?SUMMARY ANSWERA minimum data set, known as a core outcome set, has been developed for randomized controlled trials (RCTs) and systematic reviews evaluating potential treatments for infertility.WHAT IS KNOWN ALREADYComplex issues, including a failure to consider the perspectives of people with fertility problems when selecting outcomes, variations in outcome definitions and the selective reporting of outcomes on the basis of statistical analysis, make the results of infertil...
Source: Human Reproduction - November 30, 2020 Category: Reproduction Medicine Source Type: research
Standardizing definitions and reporting guidelines for the infertility core outcome set: an international consensus development study †‡
AbstractSTUDY QUESTIONCan consensus definitions for the core outcome set for infertility be identified in order to recommend a standardized approach to reporting?SUMMARY ANSWERConsensus definitions for individual core outcomes, contextual statements and a standardized reporting table have been developed.WHAT IS KNOWN ALREADYDifferent definitions exist for individual core outcomes for infertility. This variation increases the opportunities for researchers to engage with selective outcome reporting, which undermines secondary research and compromises clinical practice guideline development.STUDY DESIGN, SIZE, DURATIONPotenti...
Source: Human Reproduction - November 30, 2020 Category: Reproduction Medicine Source Type: research
Prioritizing IVF treatment in the post-COVID 19 era: a predictive modelling study based on UK national data
AbstractSTUDY QUESTIONCan we use prediction modelling to estimate the impact of coronavirus disease 2019 (COVID 19) related delay in starting IVF or ICSI in different groups of women?SUMMARY ANSWERYes, using a combination of three different models we can predict the impact of delaying access to treatment by 6 and 12 months on the probability of conception leading to live birth in women of different age groups with different categories of infertility.WHAT IS KNOWN ALREADYIncreased age and duration of infertility can prejudice the chances of success following IVF, but couples with unexplained infertility have a chance of ...
Source: Human Reproduction - November 23, 2020 Category: Reproduction Medicine Source Type: research
Patient experiences of fertility clinic closure during the COVID-19 pandemic: appraisals, coping and emotions
AbstractSTUDY QUESTIONWhat are appraisals, coping strategies and emotional reactions of patients to coronavirus disease 2019 (COVID-19) fertility clinic closures?SUMMARY ANSWERClinic closure was appraised as stressful due to uncertainty and threat to the attainability of the parenthood goal but patients were able to cope using strategies that fit the uncertainty of the situation.WHAT IS KNOWN ALREADYPsychological research on COVID-19 suggests that people are more anxious than historical norms and moderately to extremely upset about fertility treatment cancellation owing to COVID-19.STUDY DESIGN, SIZE, DURATIONThe study was...
Source: Human Reproduction - October 24, 2020 Category: Reproduction Medicine Source Type: research
[Immunotherapies in the German healthcare system : Economic aspects of established antibodies and recently available therapies].
This article presents an overview of the development and status of prescriptions and sales of selected immunotherapeutics in Germany. Data from 2015-2019 were analyzed, primarily from the GKV-Arzneimittel-Schnellinformation (GAmSi) and the consultancy IQVIA.In the group of older MABs, such as immunosuppressive and antineoplastic agents, biosimilars led to a (temporary) increase of applications, but reimbursement amounts are decreasing. Instruments of the SHI system like drug agreements, reference prices, and individual discount contracts intervene as expenditure control. Checkpoint inhibitors clearly show increasing presc...
Source: Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz - October 22, 2020 Category: International Medicine & Public Health Authors: Huppertz E Tags: Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz Source Type: research
Implementation and certification of ISO 9001:2015 seal in human tissue bank HCFMRP-USP
AbstractThe Quality Management System has been a management technology applied to guarantee the quality of processes and products of a given organization. Thus, ISO 9001:2015 certification assists organizations that want to develop, implement, maintain, and improve a quality management system to enable process improvements and assessments to meet the needs of its customers. This experience report addresses the implementation and certification of the ISO 9001:2015 quality management seal at the Human Tissue Bank of the Ribeir ão Preto Clinical Hospital (HCRP) at the University of São Paulo (USP) at Ribeirão Preto Medical...
Source: Cell and Tissue Banking - October 13, 2020 Category: Stem Cells Source Type: research
Knowing, relationships and trust —citizens’ perceptions of whole genome sequencing for the Genetics Clinic of the Future
The objective of this article is to present various views from different groups of citizens on the topic of whole genome sequencing (WGS). Sixteen focus groups were carried out in Italy and Austria which aimed at reflecting on the question of how to ensure that the implementation of WGS into the clinic is relevant and responsive to the needs of all members of society. In the qualitative analysis of the focus groups, three key themes (knowing, relationships and trust) were investigated. Although the majority of the participants favoured a person-centred care approach, we also found more radical perspectives in the relations...
Source: Journal of Community Genetics - September 29, 2020 Category: Genetics & Stem Cells Source Type: research
