Molecules, Vol. 28, Pages 6772: Phenolic Compounds and Capsaicinoids in Three Capsicum annuum Varieties: From Analytical Characterization to In Silico Hypotheses on Biological Activity
ia Carbone
The affinity of specific phenolic compounds (PCs) and capsaicinoids (CAPs) present in three Capsicum annuum varieties (Friariello, Cayenne and Dzuljunska Sipka) to the transient receptor potential vanilloid member 1 (TRPV1) was investigated by integrating an analytic approach for the simultaneous extraction and analysis through high-performance liquid chromatography coupled with ion trap mass spectrometry (HPLC/ITMS) and UV detection (HPLC-UV) of PCs and CAPs and structural bioinformatics based on the protein modelling and molecular simulations of protein–ligand docking. Overall, a total of 35 ...
Source: Molecules - September 22, 2023 Category: Chemistry Authors: Deborah Giordano Angelo Facchiano Paola Minasi Nunzio D ’Agostino Mario Parisi Virginia Carbone Tags: Article Source Type: research
Pesticide residue analysis in different spice samples by automatic µSPE clean-up workflow determination using LC-MS/MS
In this study, sample extracts from spice matrices (paprika/curry/turmeric/dry chilli/black pepper) were cleaned up by an automated µSPE clean-up method for multi-residue analysis of pesticides using LC-MS/MS. The automated µSPE clean-up method involves pre-filled cartridges containing various sorbent materials suitable for numerous co-extractives and the automated clean-up process was carried out using an autosampler. The regulatory limit for pesticides in spices varies with type, with a low MRL of 0.05 mg kg-1 or higher for 99% of the analytes. At spiking concentrations of 0.05 and 0.1 mg kg-1, good recoveries between ...
Source: Analytical and Bioanalytical Chemistry - September 12, 2023 Category: Chemistry Authors: Lorena Manzano-S ánchez Suganthi Angappan Jos é Antonio MartÃnez Ana Del Real Aguilera Amadeo Rodr Ãguez Fernández-Alba Source Type: research
The sustainable conversion of floral waste into natural snake repellent and docking studies for antiophidic activity
Toxicon. 2023 Aug 17:107254. doi: 10.1016/j.toxicon.2023.107254. Online ahead of print.ABSTRACTSnakes play an important role as predators, prey, ecosystem regulators and in advancing the human economy and pharmaceutical industries by producing venom-based medications such as anti-serums and anti-venoms. On the other hand, snakebites are responsible for over 120,000 annual fatalities; due to snakebites people lose their lives and suffer from diseases such as snake envenoming, epilepsy, and symptoms such as punctures, swelling, haemorrhage, bruising, blistering, and inflammation. Moreover, there are several challenges associ...
Source: Toxicon - August 19, 2023 Category: Toxicology Authors: Swati Punetha Suneetha Vuppu Source Type: research
The sustainable conversion of floral waste into natural snake repellent and docking studies for antiophidic activity
Toxicon. 2023 Aug 17:107254. doi: 10.1016/j.toxicon.2023.107254. Online ahead of print.ABSTRACTSnakes play an important role as predators, prey, ecosystem regulators and in advancing the human economy and pharmaceutical industries by producing venom-based medications such as anti-serums and anti-venoms. On the other hand, snakebites are responsible for over 120,000 annual fatalities; due to snakebites people lose their lives and suffer from diseases such as snake envenoming, epilepsy, and symptoms such as punctures, swelling, haemorrhage, bruising, blistering, and inflammation. Moreover, there are several challenges associ...
Source: Toxicon - August 19, 2023 Category: Toxicology Authors: Swati Punetha Suneetha Vuppu Source Type: research
The sustainable conversion of floral waste into natural snake repellent and docking studies for antiophidic activity
Toxicon. 2023 Aug 17;233:107254. doi: 10.1016/j.toxicon.2023.107254. Online ahead of print.ABSTRACTSnakes play an important role as predators, prey, ecosystem regulators and in advancing the human economy and pharmaceutical industries by producing venom-based medications such as anti-serums and anti-venoms. On the other hand, snakebites are responsible for over 120,000 annual fatalities; due to snakebites people lose their lives and suffer from diseases such as snake envenoming, epilepsy, and symptoms such as punctures, swelling, haemorrhage, bruising, blistering, and inflammation. Moreover, there are several challenges as...
Source: Toxicon - August 19, 2023 Category: Toxicology Authors: Swati Punetha Suneetha Vuppu Source Type: research
The sustainable conversion of floral waste into natural snake repellent and docking studies for antiophidic activity
Toxicon. 2023 Aug 17;233:107254. doi: 10.1016/j.toxicon.2023.107254. Online ahead of print.ABSTRACTSnakes play an important role as predators, prey, ecosystem regulators and in advancing the human economy and pharmaceutical industries by producing venom-based medications such as anti-serums and anti-venoms. On the other hand, snakebites are responsible for over 120,000 annual fatalities; due to snakebites people lose their lives and suffer from diseases such as snake envenoming, epilepsy, and symptoms such as punctures, swelling, haemorrhage, bruising, blistering, and inflammation. Moreover, there are several challenges as...
Source: Toxicon - August 19, 2023 Category: Toxicology Authors: Swati Punetha Suneetha Vuppu Source Type: research
Capsaicin, The Vanilloid Receptor TRPV1 Agonist in Neuroprotection: Mechanisms Involved and Significance
Neurochem Res. 2023 Jul 26. doi: 10.1007/s11064-023-03983-z. Online ahead of print.ABSTRACTHot peppers, also called chilli, chilli pepper, or paprika of the plant genus Capsicum (family Solanaceae), are one of the most used vegetables and spices worldwide. Capsaicin (8-methyl N-vanillyl-6-noneamide) is the main pungent principle of hot green and red peppers. By acting on the capsaicin receptor or transient receptor potential cation channel vanilloid subfamily member 1 (TRPV1), capsaicin selectively stimulates and in high doses defunctionalizes capsaicin-sensitive chemonociceptors with C and Aδ afferent fibers. This channe...
Source: Neurochemical Research - July 26, 2023 Category: Neuroscience Authors: Omar M E Abdel-Salam Gyula M ózsik Source Type: research
Capsaicin, The Vanilloid Receptor TRPV1 Agonist in Neuroprotection: Mechanisms Involved and Significance
Neurochem Res. 2023 Jul 26. doi: 10.1007/s11064-023-03983-z. Online ahead of print.ABSTRACTHot peppers, also called chilli, chilli pepper, or paprika of the plant genus Capsicum (family Solanaceae), are one of the most used vegetables and spices worldwide. Capsaicin (8-methyl N-vanillyl-6-noneamide) is the main pungent principle of hot green and red peppers. By acting on the capsaicin receptor or transient receptor potential cation channel vanilloid subfamily member 1 (TRPV1), capsaicin selectively stimulates and in high doses defunctionalizes capsaicin-sensitive chemonociceptors with C and Aδ afferent fibers. This channe...
Source: Cell Research - July 26, 2023 Category: Cytology Authors: Omar M E Abdel-Salam Gyula M ózsik Source Type: research
Capsaicin, The Vanilloid Receptor TRPV1 Agonist in Neuroprotection: Mechanisms Involved and Significance
Neurochem Res. 2023 Jul 26. doi: 10.1007/s11064-023-03983-z. Online ahead of print.ABSTRACTHot peppers, also called chilli, chilli pepper, or paprika of the plant genus Capsicum (family Solanaceae), are one of the most used vegetables and spices worldwide. Capsaicin (8-methyl N-vanillyl-6-noneamide) is the main pungent principle of hot green and red peppers. By acting on the capsaicin receptor or transient receptor potential cation channel vanilloid subfamily member 1 (TRPV1), capsaicin selectively stimulates and in high doses defunctionalizes capsaicin-sensitive chemonociceptors with C and Aδ afferent fibers. This channe...
Source: Neurochemical Research - July 26, 2023 Category: Neuroscience Authors: Omar M E Abdel-Salam Gyula M ózsik Source Type: research
Prospective observational study of stroke in Cayenne, Tours and Besan çon: The BECATOUR study
CONCLUSION: Despite some caveats, the profile of patients admitted for stroke in French Guiana is different from mainland France. The establishment of a stroke unit and an information campaign on the symptoms of stroke would allow better management.PMID:37487805 | DOI:10.1016/j.neurol.2023.02.068 (Source: Revue Neurologique)
Source: Revue Neurologique - July 24, 2023 Category: Neurology Authors: J Rhein G Charbonnier M Nacher M Gaudron T Moulin D R Rochemont J-P Cottier C Montagnac N Sabbah B de Toffol BECATOUR Study Group Source Type: research
Molecules, Vol. 28, Pages 5438: Carotenoids and Fatty Acids Obtained from Paprika Capsicum annuum by Supercritical Carbon Dioxide and Ethanol as Co-Extractant
³Åºwik
Paprika Capsicum annuum L. contains useful molecules such as carotenoids and polyunsaturated fatty acids, which are considered high-value functional and health ingredients. To obtain these compounds, paprika was extracted using different methods (Soxhlet, SC-CO2, and SC-CO2 with co-extractant) and at different parameters. The results showed that the carotenoid content decreased with the addition of the co-extractant while the fatty acid content and yield increased. It was found that the highest carotenoid content (capsanthin > β-carotene > capsorubin > zeaxanthin &am...
Source: Molecules - July 16, 2023 Category: Chemistry Authors: Dorota Kostrzewa Barbara Mazurek Marcin Kostrzewa Emilia J óźwik Tags: Article Source Type: research
Ultrasound-assisted pH-shifting to construct a stable aqueous solution of paprika oleoresin using egg yolk low-density lipoprotein as a natural liposome-like nano-emulsifier
In this study, a stable aqueous solution of paprika oleoresin (PO, the natural colorant extracted from the fruit peel of Capsicum annuum L) was constructed. The solubility of PO in an alkline aqueous solution (pH 10.95-11.10) increased rapidly. However, the aqueous solution of PO (pH 12.00) was unstable, obvious stratification was observed, and the color retention rate was only 52.99% after 28 days of storage. Chicken egg yolk low-density lipoprotein (LDL) was added combined with ultrasonic treatment to improve the stability of LDL-PO solution. The method could decrease the turbidity by 17.5 %, reduce the average particle ...
Source: Ultrasonics Sonochemistry - June 16, 2023 Category: Chemistry Authors: Haolong Ye Beibei Wang Di Xiao Hanmei Li Di Wu Jinqiu Wang Lei Cheng Fang Geng Source Type: research
Ultrasound-assisted pH-shifting to construct a stable aqueous solution of paprika oleoresin using egg yolk low-density lipoprotein as a natural liposome-like nano-emulsifier
In this study, a stable aqueous solution of paprika oleoresin (PO, the natural colorant extracted from the fruit peel of Capsicum annuum L) was constructed. The solubility of PO in an alkline aqueous solution (pH 10.95-11.10) increased rapidly. However, the aqueous solution of PO (pH 12.00) was unstable, obvious stratification was observed, and the color retention rate was only 52.99% after 28 days of storage. Chicken egg yolk low-density lipoprotein (LDL) was added combined with ultrasonic treatment to improve the stability of LDL-PO solution. The method could decrease the turbidity by 17.5 %, reduce the average particle ...
Source: Ultrasonics Sonochemistry - June 16, 2023 Category: Chemistry Authors: Haolong Ye Beibei Wang Di Xiao Hanmei Li Di Wu Jinqiu Wang Lei Cheng Fang Geng Source Type: research
