The Metabolism of the Orexin-1 Selective Receptor Antagonist Nivasorexant
Xenobiotica. 2024 Feb 15:1-15. doi: 10.1080/00498254.2024.2319811. Online ahead of print.ABSTRACT1. Nivasorexant was the first orexin-1 selective receptor antagonist entering clinical development. Despite encouraging preclinical evidence in animal models, a proof-of-concept trial in binge eating patients recently failed to demonstrate its clinical utility in this population.2. Across species, nivasorexant clearance was driven by metabolism along seven distinct pathways, five of which were hydroxylation reactions in various locations of the molecule. The exact sites of metabolism were identified by means of mass spectrometr...
Source: Xenobiotica - February 15, 2024 Category: Research Authors: Alexander Treiber Swen Seeland Belal Haschimi Aude Weigel Jodi T Williams Jerome Gabillet Source Type: research
The Metabolism of the Orexin-1 Selective Receptor Antagonist Nivasorexant
Xenobiotica. 2024 Feb 15:1-15. doi: 10.1080/00498254.2024.2319811. Online ahead of print.ABSTRACT1. Nivasorexant was the first orexin-1 selective receptor antagonist entering clinical development. Despite encouraging preclinical evidence in animal models, a proof-of-concept trial in binge eating patients recently failed to demonstrate its clinical utility in this population.2. Across species, nivasorexant clearance was driven by metabolism along seven distinct pathways, five of which were hydroxylation reactions in various locations of the molecule. The exact sites of metabolism were identified by means of mass spectrometr...
Source: Xenobiotica - February 15, 2024 Category: Research Authors: Alexander Treiber Swen Seeland Belal Haschimi Aude Weigel Jodi T Williams Jerome Gabillet Source Type: research
The Metabolism of the Orexin-1 Selective Receptor Antagonist Nivasorexant
Xenobiotica. 2024 Feb 15:1-15. doi: 10.1080/00498254.2024.2319811. Online ahead of print.ABSTRACT1. Nivasorexant was the first orexin-1 selective receptor antagonist entering clinical development. Despite encouraging preclinical evidence in animal models, a proof-of-concept trial in binge eating patients recently failed to demonstrate its clinical utility in this population.2. Across species, nivasorexant clearance was driven by metabolism along seven distinct pathways, five of which were hydroxylation reactions in various locations of the molecule. The exact sites of metabolism were identified by means of mass spectrometr...
Source: Xenobiotica - February 15, 2024 Category: Research Authors: Alexander Treiber Swen Seeland Belal Haschimi Aude Weigel Jodi T Williams Jerome Gabillet Source Type: research
The Metabolism of the Orexin-1 Selective Receptor Antagonist Nivasorexant
Xenobiotica. 2024 Feb 15:1-15. doi: 10.1080/00498254.2024.2319811. Online ahead of print.ABSTRACT1. Nivasorexant was the first orexin-1 selective receptor antagonist entering clinical development. Despite encouraging preclinical evidence in animal models, a proof-of-concept trial in binge eating patients recently failed to demonstrate its clinical utility in this population.2. Across species, nivasorexant clearance was driven by metabolism along seven distinct pathways, five of which were hydroxylation reactions in various locations of the molecule. The exact sites of metabolism were identified by means of mass spectrometr...
Source: Xenobiotica - February 15, 2024 Category: Research Authors: Alexander Treiber Swen Seeland Belal Haschimi Aude Weigel Jodi T Williams Jerome Gabillet Source Type: research
Correction: Food addiction and binge eating disorder are linked to shared and unique deficits in emotion regulation among female seeking bariatric surgery
(Source: Journal of Eating Disorders)
Source: Journal of Eating Disorders - February 15, 2024 Category: Eating Disorders & Weight Management Source Type: research
Visceral sensitivity, hunger responsiveness, and satiety responsiveness: Associations between facets of gastrointestinal interoception and disordered eating profiles in an undergraduate sample
Appetite. 2024 Feb 12:107252. doi: 10.1016/j.appet.2024.107252. Online ahead of print.ABSTRACTThis preregistered study examined associations between empirically derived profiles of disordered eating in a diverse nonclinical sample and three facets of gastrointestinal (GI) interoception (visceral sensitivity, hunger responsiveness, satiety responsiveness). University students (n = 591; 53.3% women; 23.0% Hispanic) completed the Visceral Sensitivity Index, Adult Eating Behavior Questionnaire, and Eating Pathology Symptom Inventory. Latent profile analysis was conducted in Mplus v8.3 with four behavioral indicators (restricti...
Source: Appetite - February 14, 2024 Category: Nutrition Authors: Kendall Poovey Diana Rancourt Source Type: research
Eating disorders in narcolepsy type 1: Evidence from a cross-sectional Italian study
This study showed that individuals with narcolepsy type 1 reported higher scores on the EDE-Q, I-NEQ, and a higher body mass index (BMI) than the controls. The logistic regression analysis results, with EDE-Q positivity as a dependent variable, demonstrate a significant association with antidepressant drugs, female sex, and the use of sodium oxybate. We found an association between antidepressant drug consumption, the NSS total score, and female sex with BES positivity as the dependent variable. The logistic regression analysis for I-NEQ positivity found an association with antidepressant drug use. This study shows that pa...
Source: Journal of Sleep Research - February 14, 2024 Category: Sleep Medicine Authors: Valentina Baldini Noemi Venezia Anna Iriti Silvia Quattrocchi Corrado Zenesini Francesco Biscarini Anna Rita Atti Marco Menchetti Christian Franceschini Giorgia Varallo Diana De Ronchi Giuseppe Plazzi Fabio Pizza Source Type: research
Visceral sensitivity, hunger responsiveness, and satiety responsiveness: Associations between facets of gastrointestinal interoception and disordered eating profiles in an undergraduate sample
Appetite. 2024 Feb 13;196:107252. doi: 10.1016/j.appet.2024.107252. Online ahead of print.ABSTRACTThis preregistered study examined associations between empirically derived profiles of disordered eating in a diverse nonclinical sample and three facets of gastrointestinal (GI) interoception (visceral sensitivity, hunger responsiveness, satiety responsiveness). University students (n = 591; 53.3% women; 23.0% Hispanic) completed the Visceral Sensitivity Index, Adult Eating Behavior Questionnaire, and Eating Pathology Symptom Inventory. Latent profile analysis was conducted in Mplus v8.3 with four behavioral indicators (restr...
Source: Appetite - February 14, 2024 Category: Nutrition Authors: Kendall Poovey Diana Rancourt Source Type: research
Therapeutic alliance in two forms of guided self-help for binge eating
Clin Psychol Psychother. 2024 Jan-Feb;31(1):e2959. doi: 10.1002/cpp.2959.ABSTRACTThe role of therapeutic alliance within psychological treatments for eating disorders (EDs), including those delivered remotely, is well established. However, few studies have investigated alliance in guided self-help, a widely recommended first-line treatment for EDs characterised by regular binge eating. Using data from a randomised controlled trial, the current study examined both facilitator and patient assessments of alliance within e-mail-assisted and face-to-face guided self-help and looked at associations between alliance, ED symptoms ...
Source: Clinical Psychology and Psychotherapy - February 12, 2024 Category: Psychiatry Authors: Paul E Jenkins Shannon Wake Source Type: research
Systematic Review of Mindfulness-Based Interventions for Weight Management Among Pre- and Post-bariatric Surgery Patients
CONCLUSIONS: Preliminary results suggest that mindfulness-based interventions can be useful in tackling eating disorders and in promoting weight loss among bariatric individuals. Further studies are warranted in this area to make explicit recommendations that inform pre- and post-bariatric guidelines. The field needs further well-developed studies to understand the impact of mindfulness on weight loss in the long term.PMID:38345771 (Source: Advances in Mind Body Medicine)
Source: Advances in Mind Body Medicine - February 12, 2024 Category: Psychiatry Authors: Yara Almuhtadi Samah Alageel Source Type: research
