Treatment of Impetigo with Antiseptics —Replacing Antibiotics (TIARA) trial: a single blind randomised controlled trial in school health clinics within socioeconomically disadvantaged communities in New Zealand
DiscussionSpecial note is made of the need to involve the communities most affected by impetigo in the design and implementation of the clinical trial to recruit the children most in need of safe and effective treatments.Trial registrationAustralian New Zealand Clinical Trials Registry (ANZCTR)12616000356460. Registered on March 10, 2016  Protocol amendment number: 05EB and AL contributed equally as senior authors. (Source: Trials)
Source: Trials - February 2, 2022 Category: Research Source Type: clinical trials

Clinical efficacy of Tailin formulation combined with continuous low-dose antimicrobial therapy for recurrent urinary tract infection: study protocol for a multicenter, double-blind, randomized, controlled clinical trial
This study will provide convictive research-derived data to evaluate clinical efficacy and safety of TLF combined with CLAT for rUTI, and provide an evidence-based recommendation for clinicians. Moreover, post-treatment changes in non-infection-related physical signs and subjective symptoms were included in the efficacy evaluation, which is important and more significant for assessing the clinical benefits for those rUTI patients.Trial registrationChinese Clinical Trial RegistryChiCTR2100041914. Registered on 10 January 2021. Protocol date and version: September 12, 2020; version 1. (Source: Trials)
Source: Trials - December 11, 2021 Category: Research Source Type: clinical trials

Investigator-Driven Randomised Controlled Trial of Cefiderocol versus Standard Therapy for Healthcare-Associated and Hospital-Acquired Gram-negative Bloodstream Infection: Study protocol (the GAME CHANGER trial): study protocol for an open-label, randomised controlled trial
This study will use a multicentre, open-label non-inferiority trial design comparing cefiderocol and standard of care antibiotics. Eligible participants will be adult inpatients who are diagnosed with a bloodstream infection with a Gram-negative organism on the basis of a positive blood culture result where the acquisition meets the definition for healthcare-associated or hospital-acquired. It will compare cefiderocol with the current standard of care (SOC) antibiotic regimen according to the patient ’s treating clinician. Eligible participants will be randomised 1:1 to cefiderocol or SOC and receive 5–14 days of ant...
Source: Trials - December 7, 2021 Category: Research Source Type: clinical trials

Microbiology, Antimicrobial Resistance and Outcomes of Neonatal Sepsis in China
Conditions:   Antimicrobial Resistance;   Neonatal Sepsis Intervention:   Other: No intervention Sponsors:   Children's Hospital of Fudan University;   Chinese Neonatal Network Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - October 22, 2021 Category: Research Source Type: clinical trials