Antimicrobial Resistance Clinical Trials This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Development and evaluation of an electronic algorithm using a combination of a two-step malaria RDT and other rapid diagnostic tools for the management of febrile illness in children under 5 attending outpatient facilities in Burkina Faso
DiscussionIf successful, this study could contribute to improve the management of febrile diseases and reduce inappropriate use of antimicrobials.Trial registrationThe trial is registered at ClinicalTrial.gov, NCT05285657. Enrolment started on 4 March 2022 with long-term outcome being assessed completely by 2023. (Source: Trials)
Source: Trials - September 15, 2022 Category: Research Source Type: clinical trials

Doxycycline post-exposure prophylaxis for prevention of sexually transmitted infections among Kenyan women using HIV pre-exposure prophylaxis: study protocol for an open-label randomized trial
DiscussionThe results of this trial may have immediate implications for the global epidemic of STIs and sexual health. If effective, dPEP could put STI prevention into women ’s hands. While dPEP may be able to prevent STIs, it carries important risks that could counter its benefits; global debate about the balance of these potential risks and benefits requires data to inform policy and implementation and our study aims to fill this gap.Trial registrationClinicalTrials.govNCT04050540. (Source: Trials)
Source: Trials - June 16, 2022 Category: Research Source Type: clinical trials

A randomized, placebo-controlled, double-blinded trial of MRSA throat carriage treatment, with either standard decolonization alone or in combination with oral clindamycin
DiscussionDue to the lack of consistent scientific evidence of clindamycin ’s effect in MRSA decolonization and the worldwide urgent need to reduce the use of antibiotics, we judged that a 30% increase in the decolonization success rate in carriers treated with clindamycin is appropriate to justify prescribing clindamycin as part of the decolonization treatment of asympt omatic MRSA carriers.Trial registrationEudraCT number 2019-002631-29 (Source: Trials)
Source: Trials - June 16, 2022 Category: Research Source Type: clinical trials

Behavioural intervention to promote the uptake of planned care in urgent dental care attenders: study protocol for the RETURN randomised controlled trial
DiscussionThis is a pragmatic trial, evaluating the effectiveness of the intervention under the usual condition in which it might be applied. Since dental practices work as independent contractors to the NHS, this brings implementation and fidelity challenges which will be explored and described in embedded qualitative work.Trial registrationISRCTN registry identifier ISRCTN84666712. Registered 12/04/2021. (Source: Trials)
Source: Trials - June 7, 2022 Category: Research Source Type: clinical trials

A multimodal intervention to optimise antimicrobial use in residential aged care facilities (ENGAGEMENT): protocol for a stepped-wedge cluster randomised trial
This study aims to identify the impact of a set of sustainable, multimodal interventions in residential aged care targeting three common infection types.MethodsThis protocol details a 20-month stepped-wedge cluster-randomised trial conducted across 18 RACFs (as 18 clusters). A multimodal multi-disciplinary set of interventions, the ‘AMS ENGAGEMENT bundle’, will be tailored to meet the identified needs of participating RACFs. The key elements of the intervention bundle include education for nurses and general practitioners, telehealth support and formation of an antimicrobial stewardship team in each facility. Prior to ...
Source: Trials - May 21, 2022 Category: Research Source Type: clinical trials

Prevalence and Trends of Antimicrobial Resistance of Helicobacter Pylori in Korea
Conditions: Helicobacter Pylori Infection; Helicobacter Pylori Associated Gastrointestinal Disease; Helicobacter Pylori Infection, Susceptibility to; Helicobacter Pylori 23S rRNA Clarithromycin Resistance Mutation Intervention: Sponsor: Seoul National University Bundang Hospital Recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - February 18, 2022 Category: Research Source Type: clinical trials