Reducing antimicrobial overuse through targeted therapy for patients with community-acquired pneumonia: a study protocol for a cluster-randomized factorial controlled trial (CARE-CAP)
DiscussionOur study aims to determine whether identifying an etiological agent early and pharmacist-led de-escalation (calling attention to negative cultures) can safely reduce the use of ESA in patients with CAP. If successful, our findings should lead to better antimicrobial stewardship, as well as improved patient outcomes and reduced healthcare costs. Our findings may also inform clinical guidelines on the optimal management of CAP.Trial registrationClinicalTrials.govNCT05568654. Registered on October 4, 2022. (Source: Trials)
Source: Trials - September 16, 2023 Category: Research Source Type: clinical trials

Pivmecillinam with Amoxicillin/Clavulanic acid as step down oral therapy in febrile Urinary Tract  Infections caused by ESBL-producing Enterobacterales (PACUTI)
DiscussionIf the combination of pivmecillinam and amoxicillin/clavulanic acid is found to be non-inferior to the control drugs there are potential benefits in terms of tolerability, frequency of interactions, outpatient treatment, side effects, nosocomial infections and drive for further antimicrobial resistance compared to existing drugs.Trial registrationNCT05224401. Registered on February 4, 2022 (Source: Trials)
Source: Trials - September 2, 2023 Category: Research Source Type: clinical trials

A Novel Approach to Antimicrobial Resistance: Machine Learning Predictions for Carbapenem-Resistant Klebsiella in ICUs
Conditions:   Carbapenem Resistant Enterobacteriaceae Infection;   Artificial Intelligence;   Intensive Care Unit Intervention:   Other: Artificial intelligence Sponsor:   Kocaeli University Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - August 14, 2023 Category: Research Source Type: clinical trials

Interventions to Decrease CRE Colonization and Transmission Between Hospitals, Households, Communities and Domesticated Animals
Conditions:   Antibiotic Resistant Infection;   Carbapenem-Resistant Enterobacteriaceae Infection Interventions:   Behavioral: Hospital Cohort Care Intervention at the hospital;   Behavioral: , Household Education Communication Hygiene Intervention, Livestock Antibiotic Intervention Sponsors:   Hanoi University of Public Health;   Linkoping University;   Karolinska Institutet;   Universität Tübingen;   University of Copenhagen;   National Children's Hospital, Vietnam;   Centre de coopération internationale en recherche agronomique pour le développement (CIRAD);   International Centre for Ant...
Source: ClinicalTrials.gov - May 23, 2023 Category: Research Source Type: clinical trials