Antimicrobial Resistance Clinical Trials This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Two versus five days of antibiotics after appendectomy for complex acute appendicitis (APPIC): study protocol for a randomized controlled trial
DiscussionThis trial will provide evidence on whether 48 h of postoperative antibiotics is non-inferior to a standard course of 5 days of antibiotics. If non-inferiority is established, longer intravenous administration following appendectomy for complex appendicitis can be abandoned, and guidelines need to be adjusted accordingly.Trial registrationDutch Trial Register,NTR6128. Registered on 20 December 2016. (Source: Trials)
Source: Trials - May 2, 2018 Category: Research Source Type: clinical trials

Short-course antimicrobial therapy for paediatric respiratory infections (SAFER): study protocol for a randomized controlled trial
The objective of this multicentre, randomized, non-inferiority, controlled trial is to investigate whether 5 days of high-dose amoxicillin is associated with lower rates of clinical cure 14 –21 days later as compared to 10 days of high-dose amoxicillin, the reference standard. Recruitment and enrolment will occur in the emergency departments of McMaster Children’s Hospital and the Children’s Hospital of Eastern Ontario. All children in the study will receive 5 days of amoxicillin after which point they will receive either 5 days of a different formulation of amoxicillin or a placebo. Assuming a clinical failure rate ...
Source: Trials - February 1, 2018 Category: Research Source Type: clinical trials

Azithromycin versus placebo for the treatment of HIV-associated chronic lung disease in children and adolescents (BREATHE trial): study protocol for a randomised controlled trial
DiscussionThe results of this trial will be of clinical relevance because there are no established guidelines on the treatment and management of HIV-associated CLD in children in sub-Saharan Africa, where 80% of the world ’s HIV-infected children live and where HIV-associated CLD is highly prevalent.Trial registrationClinicalTrials.gov,NCT02426112. Registered on 21 April 2015. (Source: Trials)
Source: Trials - December 28, 2017 Category: Research Source Type: clinical trials

General practitioner use of a C-reactive protein point-of-care test to help target antibiotic prescribing in patients with acute exacerbations of chronic obstructive pulmonary disease (the PACE study): study protocol for a randomised controlled trial
DiscussionIf shown to be effective (i.e. leads to a reduction in antibiotic use with no worse COPD health status), the use of the CRP POCT could lead to better outcomes for patients with AECOPD and help reduce selective pressures driving the development of antimicrobial resistance. PACE will be one of the first studies to evaluate the cost-effectiveness of a POCT biomarker to guide clinical decision-making in primary care on patient-reported outcomes, antibiotic prescribing and antibiotic resistance for AECOPD.Trial registrationISRCTN registry, ID:ISRCTN24346473. Registered on 20 August 2014. (Source: Trials)
Source: Trials - September 29, 2017 Category: Research Source Type: clinical trials

Amplification and Selection of Antimicrobial Resistance in the Intestine II
Condition: Antibiotic Selection Pressure Intervention: Drug: meropenem Sponsors: University Hospital Tuebingen; University Hospital of Cologne Not yet recruiting - verified May 2017 (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - May 2, 2017 Category: Research Source Type: clinical trials