Effects of intrathecal pemetrexed on the survival of patients with leptomeningeal metastasis from lung adenocarcinoma: a propensity score matching analysis
ConclusionsIntrathecal pemetrexed did not enhance OS for the entire LUAC patient with LM compared to non-intrathecal chemotherapy. However, it exhibited the potential to reduce the risk of central nervous system-related mortality and improve survival in patients with poor ECOG PS. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - November 23, 2023 Category: Cancer & Oncology Source Type: research
Platinum-based chemotherapy attenuates the effector response of CD8 T cells to concomitant PD-1 blockade
CONCLUSIONS: In a translational context, we provide a proof-of-concept to consider optimizing the timing of chemo-immunotherapy strategies for improved CD8 T cell functions.PMID:37992307 | DOI:10.1158/1078-0432.CCR-23-1316 (Source: Cell Research)
Source: Cell Research - November 22, 2023 Category: Cytology Authors: Annapaola Mariniello Tahseen H Nasti Daniel Y Chang Masao Hashimoto Sakshi Malik Daniel McManus Judong Lee Donald McGuire Maria A Cardenas Pablo Umana Valeria Nicolini Rustom Antia Ananya Saha Zachary Buchwald Haydn Kissick Ehsan Ghorani Silvia Novello Da Source Type: research
Platinum-based chemotherapy attenuates the effector response of CD8 T cells to concomitant PD-1 blockade
CONCLUSIONS: In a translational context, we provide a proof-of-concept to consider optimizing the timing of chemo-immunotherapy strategies for improved CD8 T cell functions.PMID:37992307 | DOI:10.1158/1078-0432.CCR-23-1316 (Source: Clinical Cancer Research)
Source: Clinical Cancer Research - November 22, 2023 Category: Cancer & Oncology Authors: Annapaola Mariniello Tahseen H Nasti Daniel Y Chang Masao Hashimoto Sakshi Malik Daniel McManus Judong Lee Donald McGuire Maria A Cardenas Pablo Umana Valeria Nicolini Rustom Antia Ananya Saha Zachary Buchwald Haydn Kissick Ehsan Ghorani Silvia Novello Da Source Type: research
Platinum-based chemotherapy attenuates the effector response of CD8 T cells to concomitant PD-1 blockade
CONCLUSIONS: In a translational context, we provide a proof-of-concept to consider optimizing the timing of chemo-immunotherapy strategies for improved CD8 T cell functions.PMID:37992307 | DOI:10.1158/1078-0432.CCR-23-1316 (Source: Clinical Lung Cancer)
Source: Clinical Lung Cancer - November 22, 2023 Category: Cancer & Oncology Authors: Annapaola Mariniello Tahseen H Nasti Daniel Y Chang Masao Hashimoto Sakshi Malik Daniel McManus Judong Lee Donald McGuire Maria A Cardenas Pablo Umana Valeria Nicolini Rustom Antia Ananya Saha Zachary Buchwald Haydn Kissick Ehsan Ghorani Silvia Novello Da Source Type: research
Platinum-based chemotherapy attenuates the effector response of CD8 T cells to concomitant PD-1 blockade
CONCLUSIONS: In a translational context, we provide a proof-of-concept to consider optimizing the timing of chemo-immunotherapy strategies for improved CD8 T cell functions.PMID:37992307 | DOI:10.1158/1078-0432.CCR-23-1316 (Source: Cancer Control)
Source: Cancer Control - November 22, 2023 Category: Cancer & Oncology Authors: Annapaola Mariniello Tahseen H Nasti Daniel Y Chang Masao Hashimoto Sakshi Malik Daniel McManus Judong Lee Donald McGuire Maria A Cardenas Pablo Umana Valeria Nicolini Rustom Antia Ananya Saha Zachary Buchwald Haydn Kissick Ehsan Ghorani Silvia Novello Da Source Type: research
Platinum-based chemotherapy attenuates the effector response of CD8 T cells to concomitant PD-1 blockade
CONCLUSIONS: In a translational context, we provide a proof-of-concept to consider optimizing the timing of chemo-immunotherapy strategies for improved CD8 T cell functions.PMID:37992307 | DOI:10.1158/1078-0432.CCR-23-1316 (Source: Clinical Cancer Research)
Source: Clinical Cancer Research - November 22, 2023 Category: Cancer & Oncology Authors: Annapaola Mariniello Tahseen H Nasti Daniel Y Chang Masao Hashimoto Sakshi Malik Daniel McManus Judong Lee Donald McGuire Maria A Cardenas Pablo Umana Valeria Nicolini Rustom Antia Ananya Saha Zachary Buchwald Haydn Kissick Ehsan Ghorani Silvia Novello Da Source Type: research
Platinum-based chemotherapy attenuates the effector response of CD8 T cells to concomitant PD-1 blockade
CONCLUSIONS: In a translational context, we provide a proof-of-concept to consider optimizing the timing of chemo-immunotherapy strategies for improved CD8 T cell functions.PMID:37992307 | DOI:10.1158/1078-0432.CCR-23-1316 (Source: Clinical Cancer Research)
Source: Clinical Cancer Research - November 22, 2023 Category: Cancer & Oncology Authors: Annapaola Mariniello Tahseen H Nasti Daniel Y Chang Masao Hashimoto Sakshi Malik Daniel McManus Judong Lee Donald McGuire Maria A Cardenas Pablo Umana Valeria Nicolini Rustom Antia Ananya Saha Zachary Buchwald Haydn Kissick Ehsan Ghorani Silvia Novello Da Source Type: research
Platinum-based chemotherapy attenuates the effector response of CD8 T cells to concomitant PD-1 blockade
CONCLUSIONS: In a translational context, we provide a proof-of-concept to consider optimizing the timing of chemo-immunotherapy strategies for improved CD8 T cell functions.PMID:37992307 | DOI:10.1158/1078-0432.CCR-23-1316 (Source: Clinical Cancer Research)
Source: Clinical Cancer Research - November 22, 2023 Category: Cancer & Oncology Authors: Annapaola Mariniello Tahseen H Nasti Daniel Y Chang Masao Hashimoto Sakshi Malik Daniel McManus Judong Lee Donald McGuire Maria A Cardenas Pablo Umana Valeria Nicolini Rustom Antia Ananya Saha Zachary Buchwald Haydn Kissick Ehsan Ghorani Silvia Novello Da Source Type: research
Phase 1 study of Elraglusib (9-ING-41), a glycogen synthase kinase-3b inhibitor, as monotherapy or combined with chemotherapy in patients with advanced malignancies
CONCLUSIONS: Elraglusib had a favorable toxicity profile as monotherapy and combined with chemotherapy and was associated with clinical benefit supporting further clinical evaluation in combination with chemotherapy.PMID:37982822 | DOI:10.1158/1078-0432.CCR-23-1916 (Source: Clinical Cancer Research)
Source: Clinical Cancer Research - November 20, 2023 Category: Cancer & Oncology Authors: Benedito A Carneiro Ludimila Cavalcante Devalingam Mahalingam Anwaar Saeed Howard Safran Wen Wee Ma Andrew L Coveler Steven Powell Bruno Bastos Elizabeth Davis Vaibhav Sahai William Mikrut James Longstreth Sheri Smith Taylor Weiskittel Hu Li Brittany A Bo Source Type: research
Pemetrexed plus vinorelbine versus vinorelbine monotherapy in patients with metastatic breast cancer (KCSG-BR15-17): a randomized, open-label, multicenter, phase II trial
Metastatic breast cancer refractory to anthracycline and taxanes often shows rapid progression. The development of effective and tolerable combination regimens for these patients is needed. This phase II trial investigated the efficacy of pemetrexed plus vinorelbine in patients with metastatic breast cancer. (Source: European Journal of Cancer)
Source: European Journal of Cancer - November 20, 2023 Category: Cancer & Oncology Authors: Dae-Won Lee, Kyung Hae Jung, Kyung-Hun Lee, Yeon Hee Park, Keun Seok Lee, Joohyuk Sohn, Hee Kyung Ahn, Jae Ho Jeong, Su-Jin Koh, Jee Hyun Kim, Han Jo Kim, Kyoung Eun Lee, Hee-Jun Kim, Yae-Won Yang, Kyong Hwa Park, Jieun Lee, Hye Sung Won, Tae-Yong Kim, Se Tags: Original Research Source Type: research
Variation of Plasma Damage-Associated Molecular Patterns in Patients with Advanced Solid Tumors After Standard of Care Systemic Treatment
CONCLUSIONS: Signals of ICD were not observed. S100A8 behaves as an inflammatory marker with decreased concentration after treatment, mostly in RECIST-responders. PFS and OS were significantly prolonged in those patients who experienced a decrease of S100A8 compared with those patients who experienced increase of plasma S100A8 at three months.PMID:37975838 | DOI:10.1080/07357907.2023.2283458 (Source: Cancer Investigation)
Source: Cancer Investigation - November 17, 2023 Category: Cancer & Oncology Authors: Vicente Valent í Laia Capdevila Isabel Ruiz Francisco Javier Ramos Pascual Joan Badia Susana Bl ázquez Óscar Villuendas Cristina P érez Laura Fern ández-Sender M ónica Córdoba Carlos Alonso-Villaverde Source Type: research
