Updates in Management of Malignant Pleural Mesothelioma
Opinion statementMalignant pleural mesothelioma (MPM) is an aggressive asbestos-associated thoracic malignancy that is usually incurable. As demonstrated in the landmark MARS2 trial, surgical resection does not improve survival outcomes and its role in managing MPM is limited. Whilst platinum-pemetrexed chemotherapy in combination with bevacizumab was the standard first-line approach for unresectable disease, landmark phase 3 trials have now established the role of immune checkpoint inhibitors (CPIs) in the upfront management of unresectable disease: either nivolumab-ipilimumab or carboplatin-pemetrexed-pembrolizumab. Pa...
Source: Current Treatment Options in Oncology - November 17, 2023 Category: Cancer & Oncology Source Type: research
Stevens –Johnson syndrome induced by toripalimab in a previously EGFR-TKI-treated advanced lung adenocarcinoma patient harboring EGFR mutations 19 del/T790M/C797S in trans and cis: a case report
Conclusion: We reported the first case of SJS induced by toripalimab in a patient with lung adenocarcinoma harboring multiple EGFR mutations. The TKI treatment after SJS was well tolerated and effective. (Source: Frontiers in Pharmacology)
Source: Frontiers in Pharmacology - November 14, 2023 Category: Drugs & Pharmacology Source Type: research
Efficacy and safety of second-line camrelizumab combined with apatinib and chemotherapy in patients with advanced lung adenocarcinoma: A prospective, open-label, multicentric study
CONCLUSION: Second-line camrelizumab combined apatinib and chemotherapy might serve as a potential treatment with acceptable safety in patients with advanced LUAD.PMID:37956490 | DOI:10.1016/j.intimp.2023.111147 (Source: International Immunopharmacology)
Source: International Immunopharmacology - November 13, 2023 Category: Allergy & Immunology Authors: Yiwei Yao Yong Wang Yingying Du Fengshou Jiang Hui Liang Minghong Bi Hua Xie Wanren Peng Yueyin Pan Source Type: research
Efficacy and safety of second-line camrelizumab combined with apatinib and chemotherapy in patients with advanced lung adenocarcinoma: A prospective, open-label, multicentric study
CONCLUSION: Second-line camrelizumab combined apatinib and chemotherapy might serve as a potential treatment with acceptable safety in patients with advanced LUAD.PMID:37956490 | DOI:10.1016/j.intimp.2023.111147 (Source: International Immunopharmacology)
Source: International Immunopharmacology - November 13, 2023 Category: Allergy & Immunology Authors: Yiwei Yao Yong Wang Yingying Du Fengshou Jiang Hui Liang Minghong Bi Hua Xie Wanren Peng Yueyin Pan Source Type: research
Efficacy and safety of second-line camrelizumab combined with apatinib and chemotherapy in patients with advanced lung adenocarcinoma: A prospective, open-label, multicentric study
CONCLUSION: Second-line camrelizumab combined apatinib and chemotherapy might serve as a potential treatment with acceptable safety in patients with advanced LUAD.PMID:37956490 | DOI:10.1016/j.intimp.2023.111147 (Source: International Immunopharmacology)
Source: International Immunopharmacology - November 13, 2023 Category: Allergy & Immunology Authors: Yiwei Yao Yong Wang Yingying Du Fengshou Jiang Hui Liang Minghong Bi Hua Xie Wanren Peng Yueyin Pan Source Type: research
Efficacy and safety of second-line camrelizumab combined with apatinib and chemotherapy in patients with advanced lung adenocarcinoma: A prospective, open-label, multicentric study
CONCLUSION: Second-line camrelizumab combined apatinib and chemotherapy might serve as a potential treatment with acceptable safety in patients with advanced LUAD.PMID:37956490 | DOI:10.1016/j.intimp.2023.111147 (Source: International Immunopharmacology)
Source: International Immunopharmacology - November 13, 2023 Category: Allergy & Immunology Authors: Yiwei Yao Yong Wang Yingying Du Fengshou Jiang Hui Liang Minghong Bi Hua Xie Wanren Peng Yueyin Pan Source Type: research
Pemetrexed ameliorates Con A-induced hepatic injury by restricting M1 macrophage activation
Int Immunopharmacol. 2023 Nov 3;125(Pt A):111158. doi: 10.1016/j.intimp.2023.111158. Online ahead of print.ABSTRACTAutoimmune hepatitis (AIH), characterized by immune-driven liver destruction and cytokine production, is a progressive inflammatory liver condition that may progress to hepatic cirrhosis or tumors. However, the underlying mechanism is not well understood, and the treatment options for this disease are limited. Pemetrexed (PEM), a clinically used anti-folate drug for treating various tumors, was found to inhibit the nuclear factor (NF)-κB signaling pathways that exert an important role in the development of AI...
Source: International Immunopharmacology - November 5, 2023 Category: Allergy & Immunology Authors: Zhaiyi Liu Zhiyue Bao Bo Yu Lihong Chen Guangrui Yang Source Type: research
Pemetrexed ameliorates Con A-induced hepatic injury by restricting M1 macrophage activation
Int Immunopharmacol. 2023 Nov 3;125(Pt A):111158. doi: 10.1016/j.intimp.2023.111158. Online ahead of print.ABSTRACTAutoimmune hepatitis (AIH), characterized by immune-driven liver destruction and cytokine production, is a progressive inflammatory liver condition that may progress to hepatic cirrhosis or tumors. However, the underlying mechanism is not well understood, and the treatment options for this disease are limited. Pemetrexed (PEM), a clinically used anti-folate drug for treating various tumors, was found to inhibit the nuclear factor (NF)-κB signaling pathways that exert an important role in the development of AI...
Source: International Immunopharmacology - November 5, 2023 Category: Allergy & Immunology Authors: Zhaiyi Liu Zhiyue Bao Bo Yu Lihong Chen Guangrui Yang Source Type: research
Miliary brain metastases from lung adenocarcinoma with EGFR (L858R) and CTNNB1 mutations
In conclusion, co-mutations of EGFR (L858R) and CTNNB1 and the discontinuation of EGFR-tyrosine kinase inhibitor may contribute to the development of miliary brain metastases. Further case studies are warranted. (Source: Thoracic Cancer)
Source: Thoracic Cancer - November 4, 2023 Category: Cancer & Oncology Authors: Michihiro Kunishige,
Eiji Takeuchi Tags: CASE IMAGE Source Type: research
Histo-Molecular Factors of Response to Combined Chemotherapy and Immunotherapy in Non-Small Cell Lung Cancers
ConclusionThis study suggests that the efficacy of combining pembrolizumab with pemetrexed and platinum-based chemotherapy differs according to the histo-molecular biomarkers, which may help to identify patients liable to benefit from CIT. (Source: Targeted Oncology)
Source: Targeted Oncology - November 3, 2023 Category: Cancer & Oncology Source Type: research
Carboplatin/Nintedanib/Pemetrexed
(Source: Reactions Weekly)
Source: Reactions Weekly - November 1, 2023 Category: Drugs & Pharmacology Source Type: research
Predictive Impact of Diffuse Positivity for TTF-1 Expression in Patients Treated With Platinum-Doublet Chemotherapy Plus Immune Checkpoint Inhibitors for Advanced Nonsquamous NSCLC
CONCLUSIONS: The positive extent of diffuse TTF-1 expression associated with patient outcome was an independent predictive factor for better progression-free survival and OS in patients with advanced nonsquamous NSCLC receiving chemoimmunotherapy.PMID:37885809 | PMC:PMC10597755 | DOI:10.1016/j.jtocrr.2023.100578 (Source: Clinical Lung Cancer)
Source: Clinical Lung Cancer - October 27, 2023 Category: Cancer & Oncology Authors: Yuto Terashima Masaru Matsumoto Hiroki Iida Sae Takashima Aya Fukuizumi Susumu Takeuchi Akihiko Miyanaga Yasuhiro Terasaki Kazuo Kasahara Masahiro Seike Source Type: research
Patient-derived organoids of malignant pleural mesothelioma
Conclusions: The PDO-MPM could be a promising tool to assess the therapeutic response of approved drugs and to test new potential molecules. (Source: European Respiratory Journal)
Source: European Respiratory Journal - October 27, 2023 Category: Respiratory Medicine Authors: Gonnelli, F., Volpini, L., Monaco, F., Tomasetti, M., Barbisan, F., Goteri, G., Santarelli, L., Zuccatosta, L., Mei, F. Tags: Pleural and mediastinal malignancies Source Type: research
