Current treatment landscape for obesity in Singapore
Singapore Med J. 2023 Mar;64(3):172-181. doi: 10.4103/singaporemedj.SMJ-2022-216.ABSTRACTThe rising prevalence of obesity in Singapore is a harbinger for a corresponding increase in obesity-related complications such as type 2 diabetes mellitus (T2DM) and coronary heart disease. Obesity is a complex disease driven by multiple factors, and hence, treatment cannot follow a 'one-size-fits-all' approach. Lifestyle modifications involving dietary interventions, physical activity and behavioural changes remain the cornerstone of obesity management. However, similar to other chronic diseases such as T2DM and hypertension, lifesty...
Source: Singapore Medical Journal - March 6, 2023 Category: General Medicine Authors: Phong Ching Lee Chin Hong Lim Ravishankar Asokkumar Marvin Wei Jie Chua Source Type: research
Current treatment landscape for obesity in Singapore
Singapore Med J. 2023 Mar;64(3):172-181. doi: 10.4103/singaporemedj.SMJ-2022-216.ABSTRACTThe rising prevalence of obesity in Singapore is a harbinger for a corresponding increase in obesity-related complications such as type 2 diabetes mellitus (T2DM) and coronary heart disease. Obesity is a complex disease driven by multiple factors, and hence, treatment cannot follow a 'one-size-fits-all' approach. Lifestyle modifications involving dietary interventions, physical activity and behavioural changes remain the cornerstone of obesity management. However, similar to other chronic diseases such as T2DM and hypertension, lifesty...
Source: Singapore Medical Journal - March 6, 2023 Category: General Medicine Authors: Phong Ching Lee Chin Hong Lim Ravishankar Asokkumar Marvin Wei Jie Chua Source Type: research
Estimated minimum prices and lowest available national prices for antiobesity medications: Improving affordability and access to treatment
CONCLUSIONS: This study shows that certain weight loss treatments can be manufactured and sold profitably at low costs, but prices currently range widely between countries, limiting access for those in need.PMID:36815242 | DOI:10.1002/oby.23725 (Source: Obesity)
Source: Obesity - February 23, 2023 Category: Eating Disorders & Weight Management Authors: Jacob Levi Junzheng Wang Francois Venter Andrew Hill Source Type: research
Estimated minimum prices and lowest available national prices for antiobesity medications: Improving affordability and access to treatment
CONCLUSIONS: This study shows that certain weight loss treatments can be manufactured and sold profitably at low costs, but prices currently range widely between countries, limiting access for those in need.PMID:36815242 | DOI:10.1002/oby.23725 (Source: Obesity)
Source: Obesity - February 23, 2023 Category: Eating Disorders & Weight Management Authors: Jacob Levi Junzheng Wang Francois Venter Andrew Hill Source Type: research
Impact on Cardiovascular Health of Using Phentermine/Topiramate in Combination With Laparoscopic Sleeve Gastrectomy in Super Obesity
Management of patients with BMI ≥50 kg/m2 is challenging. In previous work, pre and postoperative pharmacotherapy with phentermine/topiramate plus laparoscopic sleeve gastrectomy (PT + SG) promoted greater weight loss than sleeve gastrectomy (SG) alone at 24 mo postoperatively. This current secondary analysis studied the im pact of PT + SG on blood pressure (BP), heart rate, and antihypertensive usage. (Source: Journal of Surgical Research)
Source: Journal of Surgical Research - February 6, 2023 Category: Surgery Authors: Marionette S. Jayaprakash, Daniel P. Beavers, Gary D. Miller, Stephen McNatt, Adolfo Fernandez, Shenelle A. Edwards –Hampton, Jamy D. Ard Tags: Gastrointestinal Surgery Source Type: research
Pharmacologic management of weight regain following bariatric surgery
While bariatric surgery restults in significant long-term weight loss for most patients with obesity, post-surgical weight gain affects a considerable percentage of patients to varying degrees of severity. Furthermore, a small but significant percentage of patients experience inadequate post-surgical weight loss. Although many studies have examined the role of anti-obesity medications to address post-operative weight regain, an evidence-based consensus has not yet been achieved because of the heterogeneity of populations studied and the studies themselves. Observational studies in the post-bariatric surgery population cons...
Source: Frontiers in Endocrinology - January 9, 2023 Category: Endocrinology Source Type: research
Lorcaserin and phentermine exert anti-obesity effects with modulation of the gut microbiota
In conclusion, LS and PT can modulate the gut microbiota dysbiosis and the gut microbiota plays a role in mediating the anti-obesity effect of drugs. (Source: Frontiers in Microbiology)
Source: Frontiers in Microbiology - January 5, 2023 Category: Microbiology Source Type: research
Real-World Experience of the Efficacy and Safety of Phentermine Use in Adolescents: A Case Series
Conclusions: Phentermine monotherapy is an effective and safe means for weight loss in pediatric patients when combined with lifestyle interventions. Twenty-one of 30 (70%) patients achieved at least a 5% decrease in %BMIp95 within a mean duration of treatment of 10 months. We noted no severe adverse events.PMID:36576420 | DOI:10.1089/chi.2022.0147 (Source: Childhood Obesity)
Source: Childhood Obesity - December 28, 2022 Category: Eating Disorders & Weight Management Authors: Awab I Ali Ibrahim Brenna Mendoza Fatima Cody Stanford Sonali Malhotra Source Type: research
IJERPH, Vol. 20, Pages 281: Anti-Obesity Effect of Chitoglucan in High-Fat-Induced Obesity Mice
Conclusion: Collectively, these data suggest that chitoglucan from the Flammulina velutipes may be useful in the treatment of high diet-induced obesity and metabolic syndrome. (Source: International Journal of Environmental Research and Public Health)
Source: International Journal of Environmental Research and Public Health - December 24, 2022 Category: Environmental Health Authors: Hyun-Jung Park SunYoung Lee Minsook Ye Bong Hee Han Hyun Soo Shim Daehyuk Jang Insop Shim Tags: Article Source Type: research
Genes, Vol. 13, Pages 2267: Effect of the Melanocortin 4-Receptor Ile269Asn Mutation on Weight Loss Response to Dietary, Phentermine and Bariatric Surgery Interventions
ruz
Luis E. González-Salazar
Rocío Guizar-Heredia
Edgar Pichardo-Ontiveros
Leonor Jacobo-Albavera
Rosalinda Posadas-Sánchez
Gilberto Vargas-Alarcón
Rafael Velazquez-Cruz
Ruth Gutiérrez-Aguilar
Carlos Zerrweck
Héctor Isaac Rocha-González
Juan Gerardo Reyes-García
Miriam del C. Carrasco-Portugal
Francisco Javier Flores-Murrieta
Armando R. Tovar
Lorena Orozco
Teresa Villarreal-Molina
Samuel Canizales-Quinteros
The loss of function melanocortin 4-receptor (MC4R) Ile269Asn mutation has been proposed as one of the most important genetic contributors to obesity in the Mexican populati...
Source: Genes - December 1, 2022 Category: Genetics & Stem Cells Authors: Itzel G. Salazar-Valencia Hugo Villamil-Ram írez Francisco Barajas-Olmos Martha Guevara-Cruz Luis R. Macias-Kauffer Humberto Garc ía-Ortiz Omar Hern ández-Vergara David Alberto D íaz de Sandy-Galán Paola Le ón-Mimila Federico Centeno-Cruz Luis E. Go Tags: Article Source Type: research
Topiramate Utilization After Phentermine/Topiramate Approval for Obesity Management: Risk Minimization in the Era of Drug Repurposing
ConclusionPhentermine/topiramate approval was associated with increased topiramate use among patients with obesity. Prescribers are encouraged to enhance patient education and monitoring in such clinical use since topiramate prescribing information, compared with REMS for phentermine/topiramate, has less emphasis on preventing prenatal exposure. (Source: Drug Safety)
Source: Drug Safety - November 1, 2022 Category: Drugs & Pharmacology Source Type: research
