Incorporating measurement variability when comparing sets of high-resolution mass spectra
Anal Chim Acta. 2022 Oct 16;1230:340247. doi: 10.1016/j.aca.2022.340247. Epub 2022 Aug 15.ABSTRACTMass spectra are an important signature by which compounds can be identified. We recently formulated a mathematical approach for incorporating measurement variability when comparing sets of high-resolution mass spectra. Leveraging replicate mass spectra, we construct high-dimensional consensus mass spectra-representing each of the compared analytes-and compute the similarity between these data structures. In this paper, we present this approach and discuss its applications and limitations when trying to discriminate methamphet...
Source: Analytica Chimica Acta - October 3, 2022 Category: Chemistry Authors: Matthew J Roberts Arun S Moorthy Edward Sisco Anthony J Kearsley Source Type: research
Incorporating measurement variability when comparing sets of high-resolution mass spectra
Anal Chim Acta. 2022 Oct 16;1230:340247. doi: 10.1016/j.aca.2022.340247. Epub 2022 Aug 15.ABSTRACTMass spectra are an important signature by which compounds can be identified. We recently formulated a mathematical approach for incorporating measurement variability when comparing sets of high-resolution mass spectra. Leveraging replicate mass spectra, we construct high-dimensional consensus mass spectra-representing each of the compared analytes-and compute the similarity between these data structures. In this paper, we present this approach and discuss its applications and limitations when trying to discriminate methamphet...
Source: Analytica Chimica Acta - October 3, 2022 Category: Chemistry Authors: Matthew J Roberts Arun S Moorthy Edward Sisco Anthony J Kearsley Source Type: research
Incorporating measurement variability when comparing sets of high-resolution mass spectra
Anal Chim Acta. 2022 Oct 16;1230:340247. doi: 10.1016/j.aca.2022.340247. Epub 2022 Aug 15.ABSTRACTMass spectra are an important signature by which compounds can be identified. We recently formulated a mathematical approach for incorporating measurement variability when comparing sets of high-resolution mass spectra. Leveraging replicate mass spectra, we construct high-dimensional consensus mass spectra-representing each of the compared analytes-and compute the similarity between these data structures. In this paper, we present this approach and discuss its applications and limitations when trying to discriminate methamphet...
Source: Analytica Chimica Acta - October 3, 2022 Category: Chemistry Authors: Matthew J Roberts Arun S Moorthy Edward Sisco Anthony J Kearsley Source Type: research
Incorporating measurement variability when comparing sets of high-resolution mass spectra
Anal Chim Acta. 2022 Oct 16;1230:340247. doi: 10.1016/j.aca.2022.340247. Epub 2022 Aug 15.ABSTRACTMass spectra are an important signature by which compounds can be identified. We recently formulated a mathematical approach for incorporating measurement variability when comparing sets of high-resolution mass spectra. Leveraging replicate mass spectra, we construct high-dimensional consensus mass spectra-representing each of the compared analytes-and compute the similarity between these data structures. In this paper, we present this approach and discuss its applications and limitations when trying to discriminate methamphet...
Source: Analytica Chimica Acta - October 3, 2022 Category: Chemistry Authors: Matthew J Roberts Arun S Moorthy Edward Sisco Anthony J Kearsley Source Type: research
Incorporating measurement variability when comparing sets of high-resolution mass spectra
Anal Chim Acta. 2022 Oct 16;1230:340247. doi: 10.1016/j.aca.2022.340247. Epub 2022 Aug 15.ABSTRACTMass spectra are an important signature by which compounds can be identified. We recently formulated a mathematical approach for incorporating measurement variability when comparing sets of high-resolution mass spectra. Leveraging replicate mass spectra, we construct high-dimensional consensus mass spectra-representing each of the compared analytes-and compute the similarity between these data structures. In this paper, we present this approach and discuss its applications and limitations when trying to discriminate methamphet...
Source: Analytica Chimica Acta - October 3, 2022 Category: Chemistry Authors: Matthew J Roberts Arun S Moorthy Edward Sisco Anthony J Kearsley Source Type: research
Incorporating measurement variability when comparing sets of high-resolution mass spectra
Anal Chim Acta. 2022 Oct 16;1230:340247. doi: 10.1016/j.aca.2022.340247. Epub 2022 Aug 15.ABSTRACTMass spectra are an important signature by which compounds can be identified. We recently formulated a mathematical approach for incorporating measurement variability when comparing sets of high-resolution mass spectra. Leveraging replicate mass spectra, we construct high-dimensional consensus mass spectra-representing each of the compared analytes-and compute the similarity between these data structures. In this paper, we present this approach and discuss its applications and limitations when trying to discriminate methamphet...
Source: Analytica Chimica Acta - October 3, 2022 Category: Chemistry Authors: Matthew J Roberts Arun S Moorthy Edward Sisco Anthony J Kearsley Source Type: research
The use of virtual visits for obesity pharmacotherapy in patients with overweight or obesity compared with in-person encounters
CONCLUSIONS: These results indicate that the virtual obesity pharmacotherapy visits in adults aged 18 to 65 years prescribed phentermine are effective and noninferior in achieving meaningful weight loss after 12 weeks. Future clinical trials are needed to better assess the effectiveness of televisits for obesity pharmacotherapy.PMID:36156456 | DOI:10.1002/oby.23548 (Source: Obesity)
Source: Obesity - September 26, 2022 Category: Eating Disorders & Weight Management Authors: Marcio L Griebeler W Scott Butsch Paloma Rodriguez Laura Lomeli Matthew Kampert Vinni Makin Ula Abed Alwahab Elena Borukh Erin Daigle James Bena Kevin M Pantalone Bartolome Burguera Source Type: research
The use of virtual visits for obesity pharmacotherapy in patients with overweight or obesity compared with in-person encounters
CONCLUSIONS: These results indicate that the virtual obesity pharmacotherapy visits in adults aged 18 to 65 years prescribed phentermine are effective and noninferior in achieving meaningful weight loss after 12 weeks. Future clinical trials are needed to better assess the effectiveness of televisits for obesity pharmacotherapy.PMID:36156456 | DOI:10.1002/oby.23548 (Source: Obesity)
Source: Obesity - September 26, 2022 Category: Eating Disorders & Weight Management Authors: Marcio L Griebeler W Scott Butsch Paloma Rodriguez Laura Lomeli Matthew Kampert Vinni Makin Ula Abed Alwahab Elena Borukh Erin Daigle James Bena Kevin M Pantalone Bartolome Burguera Source Type: research
Phentermine/Topiramate: Pediatric First Approval
This article summarizes the milestones in the development of phentermine/topiramate leading to this pediatric first approval for chronic weight management in adolescents. (Source: Pediatric Drugs)
Source: Pediatric Drugs - September 5, 2022 Category: Pediatrics Source Type: research
Phentermine/Topiramate: Pediatric First Approval
This article summarizes the milestones in the development of phentermine/topiramate leading to this pediatric first approval for chronic weight management in adolescents.PMID:36059008 | DOI:10.1007/s40272-022-00532-z (Source: Paediatric Drugs)
Source: Paediatric Drugs - September 4, 2022 Category: Pediatrics Authors: Sohita Dhillon Source Type: research
Phentermine/Topiramate: Pediatric First Approval
This article summarizes the milestones in the development of phentermine/topiramate leading to this pediatric first approval for chronic weight management in adolescents.PMID:36059008 | DOI:10.1007/s40272-022-00532-z (Source: Paediatric Drugs)
Source: Paediatric Drugs - September 4, 2022 Category: Pediatrics Authors: Sohita Dhillon Source Type: research
Phentermine/Topiramate: Pediatric First Approval
This article summarizes the milestones in the development of phentermine/topiramate leading to this pediatric first approval for chronic weight management in adolescents.PMID:36059008 | DOI:10.1007/s40272-022-00532-z (Source: Paediatric Drugs)
Source: Paediatric Drugs - September 4, 2022 Category: Pediatrics Authors: Sohita Dhillon Source Type: research
Phentermine/Topiramate: Pediatric First Approval
This article summarizes the milestones in the development of phentermine/topiramate leading to this pediatric first approval for chronic weight management in adolescents.PMID:36059008 | DOI:10.1007/s40272-022-00532-z (Source: Paediatric Drugs)
Source: Paediatric Drugs - September 4, 2022 Category: Pediatrics Authors: Sohita Dhillon Source Type: research
Phentermine/Topiramate: Pediatric First Approval
This article summarizes the milestones in the development of phentermine/topiramate leading to this pediatric first approval for chronic weight management in adolescents.PMID:36059008 | DOI:10.1007/s40272-022-00532-z (Source: Paediatric Drugs)
Source: Paediatric Drugs - September 4, 2022 Category: Pediatrics Authors: Sohita Dhillon Source Type: research
