Fetal alcohol spectrum disorder and attention deficit hyperactivity disorder stimulant trial in children: an N-of-1 pilot trial to compare stimulant to placebo (FASST): protocol
Introduction
Fetal alcohol spectrum disorder (FASD) is a neurodevelopmental disorder caused by alcohol exposure during pregnancy. FASD is associated with neurodevelopmental deviations, and 50%–94% of children with FASD meet the Diagnostic and Statistical Manual of Mental Disorders-fifth edition diagnostic criteria for attention deficit hyperactivity disorder (ADHD). There is a paucity of evidence around medication efficacy for ADHD symptoms in children with FASD. This series of N-of-1 trials aims to provide pilot data on the feasibility of conducting N-of-1 trials in children with FASD and ADHD.
Methods and analysis...
Source: BMJ Open - April 17, 2024 Category: General Medicine Authors: Crichton, A., Harris, K., McGree, J. M., Nikles, J., Anderson, P. J., Williams, K. Tags: Open access, Paediatrics Source Type: research
The Brain Gene Registry: a data snapshot
AbstractMonogenic disorders account for a large proportion of population-attributable risk for neurodevelopmental disabilities. However, the data necessary to infer a causal relationship between a given genetic variant and a particular neurodevelopmental disorder is often lacking. Recognizing this scientific roadblock, 13 Intellectual and Developmental Disabilities Research Centers (IDDRCs) formed a consortium to create the Brain Gene Registry (BGR), a repository pairing clinical genetic data with phenotypic data from participants with variants in putative brain genes. Phenotypic profiles are assembled from the electronic ...
Source: Journal of Neurodevelopmental Disorders - April 17, 2024 Category: Neurology Source Type: research
ADHD in older adults - a scoping review
CONCLUSION: Older adults with ADHD face various symptoms, comorbidities, and challenges that affect their quality of life. Age-related changes can amplify ADHD symptoms and increase the perceived burden of illness. More research is needed to understand the complex relationship between these factors and enable tailored interventions to improve their quality of life and well-being.PMID:38622905 | DOI:10.1080/13607863.2024.2339994 (Source: Aging and Mental Health)
Source: Aging and Mental Health - April 16, 2024 Category: Geriatrics Authors: Silke Fischer Charlotta Nilsen Source Type: research
DHCR7 links cholesterol synthesis with neuronal development and axonal integrity
Biochem Biophys Res Commun. 2024 Apr 12;712-713:149932. doi: 10.1016/j.bbrc.2024.149932. Online ahead of print.ABSTRACTThe DHCR7 enzyme converts 7-DHC into cholesterol. Mutations in DHCR7 can block cholesterol production, leading to abnormal accumulation of 7-DHC and causing Smith-Lemli-Opitz syndrome (SLOS). SLOS is an autosomal recessive disorder characterized by multiple malformations, including microcephaly, intellectual disability, behavior reminiscent of autism, sleep disturbances, and attention-deficit/hyperactivity disorder (ADHD)-like hyperactivity. Although 7-DHC affects neuronal differentiation in ex vivo experi...
Source: Biochemical and Biophysical Research communications - April 16, 2024 Category: Biochemistry Authors: Shuya Miyazaki Nobuyuki Shimizu Hiroaki Miyahara Hitoshi Teranishi Ryohei Umeda Shinji Yano Tatsuo Shimada Hiroshi Shiraishi Kosaku Komiya Akira Katoh Akihiko Yoshimura Reiko Hanada Toshikatsu Hanada Source Type: research
DHCR7 links cholesterol synthesis with neuronal development and axonal integrity
Biochem Biophys Res Commun. 2024 Apr 12;712-713:149932. doi: 10.1016/j.bbrc.2024.149932. Online ahead of print.ABSTRACTThe DHCR7 enzyme converts 7-DHC into cholesterol. Mutations in DHCR7 can block cholesterol production, leading to abnormal accumulation of 7-DHC and causing Smith-Lemli-Opitz syndrome (SLOS). SLOS is an autosomal recessive disorder characterized by multiple malformations, including microcephaly, intellectual disability, behavior reminiscent of autism, sleep disturbances, and attention-deficit/hyperactivity disorder (ADHD)-like hyperactivity. Although 7-DHC affects neuronal differentiation in ex vivo experi...
Source: Cell Research - April 16, 2024 Category: Cytology Authors: Shuya Miyazaki Nobuyuki Shimizu Hiroaki Miyahara Hitoshi Teranishi Ryohei Umeda Shinji Yano Tatsuo Shimada Hiroshi Shiraishi Kosaku Komiya Akira Katoh Akihiko Yoshimura Reiko Hanada Toshikatsu Hanada Source Type: research
Bright light therapy versus physical exercise to prevent co-occurring depression in adolescents and young adults with attention-deficit/hyperactivity disorder: a multicentre, three-arm, randomised controlled, pilot phase-IIa trial
Eur Arch Psychiatry Clin Neurosci. 2024 Apr 16. doi: 10.1007/s00406-024-01784-1. Online ahead of print.ABSTRACTDepression is common in attention-deficit/hyperactivity disorder (ADHD), but preventive behavioural interventions are lacking. This randomised controlled, pilot phase-IIa trial aimed to study a physical exercise intervention (EI) and bright light therapy (BLT)-both implemented and monitored in an individual, naturalistic setting via a mobile health (m-health) system-for feasibility of trial design and interventions, and to estimate their effects on depressive symptoms in young people with ADHD. Two hundred seven p...
Source: European Archives of Psychiatry and Clinical Neuroscience - April 16, 2024 Category: Psychiatry Authors: Jutta S Mayer Laura Kohlhas Jacek Stermann Juliane Medda Geva A Brandt Oliver Grimm Adam D Pawley Philip Asherson Judit Palacio Sanchez Vanesa Richarte Douwe Bergsma Elena D Koch Adri à Muntaner-Mas Ulrich W Ebner-Priemer Meinhard Kieser Wolfgang Retz Fr Source Type: research
ADHD in older adults - a scoping review
CONCLUSION: Older adults with ADHD face various symptoms, comorbidities, and challenges that affect their quality of life. Age-related changes can amplify ADHD symptoms and increase the perceived burden of illness. More research is needed to understand the complex relationship between these factors and enable tailored interventions to improve their quality of life and well-being.PMID:38622905 | DOI:10.1080/13607863.2024.2339994 (Source: Aging and Mental Health)
Source: Aging and Mental Health - April 16, 2024 Category: Geriatrics Authors: Silke Fischer Charlotta Nilsen Source Type: research
